ATE197672T1 - Arzneimittel gegen nervöse erkrankungen - Google Patents
Arzneimittel gegen nervöse erkrankungenInfo
- Publication number
- ATE197672T1 ATE197672T1 AT94922369T AT94922369T ATE197672T1 AT E197672 T1 ATE197672 T1 AT E197672T1 AT 94922369 T AT94922369 T AT 94922369T AT 94922369 T AT94922369 T AT 94922369T AT E197672 T1 ATE197672 T1 AT E197672T1
- Authority
- AT
- Austria
- Prior art keywords
- nervous diseases
- peripheral
- nervous
- medicinal products
- alkyl
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 230000002093 peripheral effect Effects 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 210000003050 axon Anatomy 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000002270 gangliosides Chemical class 0.000 abstract 1
- 150000002339 glycosphingolipids Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 210000000225 synapse Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Surgical Instruments (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22051893 | 1993-08-13 | ||
| PCT/JP1994/001342 WO1995005177A1 (en) | 1993-08-13 | 1994-08-12 | Remedy for nervous diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE197672T1 true ATE197672T1 (de) | 2000-12-15 |
Family
ID=16752277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94922369T ATE197672T1 (de) | 1993-08-13 | 1994-08-12 | Arzneimittel gegen nervöse erkrankungen |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5707649A (de) |
| EP (1) | EP0720852B1 (de) |
| JP (1) | JP3778926B2 (de) |
| KR (1) | KR960703598A (de) |
| CN (1) | CN1128951A (de) |
| AT (1) | ATE197672T1 (de) |
| AU (1) | AU676361B2 (de) |
| DE (1) | DE69426331T2 (de) |
| HU (1) | HUT73527A (de) |
| NO (1) | NO960380L (de) |
| NZ (1) | NZ269847A (de) |
| WO (1) | WO1995005177A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT73527A (en) * | 1993-08-13 | 1996-08-28 | Seikagaku Kogyo Co Ltd | Remedy for nervous diseases |
| US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
| US5863902A (en) * | 1995-01-06 | 1999-01-26 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
| US6890949B1 (en) * | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| NO965193L (no) * | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
| US5972928A (en) * | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
| US6440455B1 (en) * | 1997-09-02 | 2002-08-27 | Children's Medical Center Corporation | Methods for modulating the axonal outgrowth of central nervous system neurons |
| US6723838B1 (en) | 1998-04-22 | 2004-04-20 | Johns Hopkins University | Signal transducing synaptic molecules and uses thereof |
| AU4724599A (en) | 1998-06-29 | 2000-01-17 | Children's Hospital Of Los Angeles | Treatment of hyperproliferative disorders |
| US6368831B1 (en) | 1998-06-29 | 2002-04-09 | Childrens Hospital Los Angeles | Treatment of hyperproliferative disorders |
| ATE358473T1 (de) * | 1998-07-27 | 2007-04-15 | Univ Johns Hopkins | Diamino-propanol-verbindungen zur behandlung von ischaemien |
| US6635281B2 (en) * | 1998-12-23 | 2003-10-21 | Alza Corporation | Gastric retaining oral liquid dosage form |
| JP5009459B2 (ja) * | 1999-12-06 | 2012-08-22 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| US6407064B2 (en) | 1999-12-06 | 2002-06-18 | Seikagaku Corporation | Aminoalcohol derivative and medicament comprising the same |
| US20100261159A1 (en) * | 2000-10-10 | 2010-10-14 | Robert Hess | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| JP2004531478A (ja) * | 2001-01-10 | 2004-10-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | アミノセラミド様化合物および治療目的での使用方法 |
| JP3742602B2 (ja) * | 2001-05-09 | 2006-02-08 | 株式会社カネカ | 還元型補酵素ｑの安定な溶液 |
| EP2067775B1 (de) | 2001-07-16 | 2012-04-25 | Genzyme Corporation | N-Acylsphingosinglucosyltransferase-Inhibitor |
| US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
| US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| US7834147B2 (en) * | 2003-04-28 | 2010-11-16 | Childrens Hospital Medical Center | Saposin C-DOPS: a novel anti-tumor agent |
| DE10352449A1 (de) * | 2003-11-07 | 2005-06-16 | Ruprecht-Karls-Universität Heidelberg | Mittel zur prophylaktischen und/oder therapeutischen Behandlung von Morbus Alzheimer |
| DE10352450A1 (de) * | 2003-11-07 | 2005-06-23 | Ruprecht-Karls-Universität Heidelberg | Neues Mittel zur prophylaktischen und/oder therapeutischen Behandlung von Morbus Alzheimer |
| US8912144B2 (en) * | 2003-12-16 | 2014-12-16 | Children's Medical Center Corporation | Method for treating stroke via administration of NEP1-40 and inosine |
| US20090111812A1 (en) * | 2004-06-14 | 2009-04-30 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
| EP1811991B1 (de) * | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Behandlung von Typ 2 Diabetes mit Inhibitoren der Glycosphigolipid-Synthese |
| US20090088433A1 (en) | 2005-01-26 | 2009-04-02 | Bertrand Leblond | Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| EP1857112B1 (de) * | 2005-03-09 | 2013-05-15 | Sunstar Inc. | Mittel gegen krebs mit phytosterol-haltigen liposomen |
| EP2020988B1 (de) * | 2006-04-28 | 2017-08-16 | Children's Hospital Medical Center | Zusammensetzungen mit fusogenen proteinen oder polypeptiden aus prosaposin zur anwendung auf transmembrane wirkstofffreisetzungssysteme |
| SI2032134T1 (sl) | 2006-05-09 | 2015-10-30 | Genzyme Corporation | Postopki zdravljenja bolezni zamaščenih jeter, ki obsegajo inhibicijo sintezo glukosfingolipida |
| WO2008011487A2 (en) * | 2006-07-19 | 2008-01-24 | Allergan, Inc. | L-benzyl-l-hydr0xy-2, 3-diamin0-propyl amines and 3-benzyl-3-hydroxy-2-amino-propionicacid amides for chronic pain |
| WO2008011483A2 (en) * | 2006-07-19 | 2008-01-24 | Allergan, Inc. | Methods for treating chronic pain using 1- (hetero) aryl-1-hydroxy 2,3-diamino-propyl amines and related compounds |
| WO2008109287A1 (en) * | 2007-03-06 | 2008-09-12 | Allergan, Inc. | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| EP2594564B1 (de) | 2007-05-31 | 2016-09-28 | Genzyme Corporation | Glukosylceramid-Synthase-Hemmer vom 2-Acylaminpropanol-Typ |
| CN101888840A (zh) | 2007-10-05 | 2010-11-17 | 简詹姆公司 | 使用脑酰胺衍生物治疗多囊性肾疾病的方法 |
| CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| EP3078373A1 (de) | 2008-10-03 | 2016-10-12 | Genzyme Corporation | Glucosylceramidsynthaseinhibitoren vom 2-acylaminoanoltyp |
| JPWO2010087313A1 (ja) * | 2009-01-29 | 2012-08-02 | 株式会社林原生物化学研究所 | 神経突起伸展促進剤 |
| JP2013510878A (ja) * | 2009-11-12 | 2013-03-28 | テキサス テック ユニバーシティー | 高増殖性障害を処置する組成物および方法 |
| CA3140959A1 (en) | 2009-11-27 | 2011-06-03 | Genzyme Corporation | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| WO2011099980A1 (en) | 2010-02-12 | 2011-08-18 | The Johns Hopkins University | Use of the lactosylceramide synthase isoform b1, 4galt-v as a biomarker for cancer |
| WO2016126572A2 (en) | 2015-02-02 | 2016-08-11 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| US12611419B2 (en) | 2017-12-21 | 2026-04-28 | Innomedica Holding Ag | Liposomal composition for use in a method of treating Parkinson's disease |
| EP3501495A1 (de) * | 2017-12-21 | 2019-06-26 | InnoMedica Holding AG | Liposomen mit sphingomyelin |
| EP4048397B1 (de) | 2019-10-23 | 2023-08-16 | The Regents Of The University Of Michigan | Glucosylceramidsynthasehemmer für therapeutische anwendungen |
| EP4142878B1 (de) | 2020-04-28 | 2024-06-26 | The Regents of The University of Michigan | Pyridinhemmer der glucosylceramidsynthase und therapeutische verfahren damit |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4963297A (en) * | 1987-12-22 | 1990-10-16 | The Liposome Company, Inc. | Spontaneous vesticulation of multilamellar liposomes |
| US5041441A (en) * | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
| HUT73527A (en) * | 1993-08-13 | 1996-08-28 | Seikagaku Kogyo Co Ltd | Remedy for nervous diseases |
-
1994
- 1994-08-12 HU HU9600278A patent/HUT73527A/hu unknown
- 1994-08-12 AU AU73506/94A patent/AU676361B2/en not_active Expired
- 1994-08-12 WO PCT/JP1994/001342 patent/WO1995005177A1/ja not_active Ceased
- 1994-08-12 DE DE69426331T patent/DE69426331T2/de not_active Expired - Lifetime
- 1994-08-12 CN CN94193077A patent/CN1128951A/zh active Pending
- 1994-08-12 US US08/464,683 patent/US5707649A/en not_active Expired - Lifetime
- 1994-08-12 EP EP94922369A patent/EP0720852B1/de not_active Expired - Lifetime
- 1994-08-12 KR KR1019960700688A patent/KR960703598A/ko not_active Withdrawn
- 1994-08-12 NZ NZ269847A patent/NZ269847A/en unknown
- 1994-08-12 AT AT94922369T patent/ATE197672T1/de not_active IP Right Cessation
- 1994-08-12 JP JP50686095A patent/JP3778926B2/ja not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/466,243 patent/US5849326A/en not_active Expired - Lifetime
-
1996
- 1996-01-30 NO NO960380A patent/NO960380L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3778926B2 (ja) | 2006-05-24 |
| NO960380L (no) | 1996-03-14 |
| KR960703598A (ko) | 1996-08-31 |
| AU676361B2 (en) | 1997-03-06 |
| CN1128951A (zh) | 1996-08-14 |
| HUT73527A (en) | 1996-08-28 |
| NZ269847A (en) | 1996-11-26 |
| WO1995005177A1 (en) | 1995-02-23 |
| DE69426331T2 (de) | 2001-06-21 |
| NO960380D0 (no) | 1996-01-30 |
| US5707649A (en) | 1998-01-13 |
| HU9600278D0 (en) | 1996-04-29 |
| DE69426331D1 (de) | 2000-12-28 |
| AU7350694A (en) | 1995-03-14 |
| US5849326A (en) | 1998-12-15 |
| EP0720852A1 (de) | 1996-07-10 |
| EP0720852A4 (de) | 1997-07-23 |
| EP0720852B1 (de) | 2000-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |