ATE197710T1 - Chinazolin-derivate - Google Patents

Chinazolin-derivate

Info

Publication number
ATE197710T1
ATE197710T1 AT95929231T AT95929231T ATE197710T1 AT E197710 T1 ATE197710 T1 AT E197710T1 AT 95929231 T AT95929231 T AT 95929231T AT 95929231 T AT95929231 T AT 95929231T AT E197710 T1 ATE197710 T1 AT E197710T1
Authority
AT
Austria
Prior art keywords
lower alkyl
represent hydrogen
aralkyl
quinazoline derivatives
hydrogen
Prior art date
Application number
AT95929231T
Other languages
English (en)
Inventor
Shigeki Fujiwara
Yuko Okamura
Haruku Taki
Hiromi Nonaka
Takahiro Moriyama
Kozo Yao
Akira Karasawa
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE197710T1 publication Critical patent/ATE197710T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Furan Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Fireproofing Substances (AREA)
AT95929231T 1994-08-26 1995-08-25 Chinazolin-derivate ATE197710T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6202018A JPH09165385A (ja) 1994-08-26 1994-08-26 キナゾリン誘導体
PCT/JP1995/001694 WO1996006841A1 (en) 1994-08-26 1995-08-25 Quinazoline derivative

Publications (1)

Publication Number Publication Date
ATE197710T1 true ATE197710T1 (de) 2000-12-15

Family

ID=16450565

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95929231T ATE197710T1 (de) 1994-08-26 1995-08-25 Chinazolin-derivate

Country Status (14)

Country Link
US (1) US5948784A (de)
EP (1) EP0726267B1 (de)
JP (1) JPH09165385A (de)
KR (1) KR960705810A (de)
CN (1) CN1043991C (de)
AT (1) ATE197710T1 (de)
AU (1) AU689304B2 (de)
CA (1) CA2174854C (de)
DE (1) DE69519469T2 (de)
ES (1) ES2153491T3 (de)
FI (1) FI961758L (de)
NO (1) NO310658B1 (de)
NZ (1) NZ291506A (de)
WO (1) WO1996006841A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2744451B1 (fr) * 1996-02-01 1998-04-24 Pf Medicament Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique
AU1732697A (en) * 1996-02-19 1997-09-02 Kyowa Hakko Kogyo Co. Ltd. Therapeutic agent for kidney diseases
AU5679398A (en) * 1997-01-31 1998-08-25 Kyowa Hakko Kogyo Co. Ltd. Piperidine derivatives
CA2234342A1 (en) * 1997-04-10 1998-10-10 Kyowa Hakko Kogyo Co., Ltd. Pancreatitis remedy
WO1999019326A1 (en) * 1997-10-15 1999-04-22 Kyowa Hakko Kogyo Co., Ltd. Piperidine derivatives
WO1999053924A1 (en) * 1998-04-17 1999-10-28 Kyowa Hakko Kogyo Co., Ltd. Analgetic agent
US6706721B1 (en) 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
US6545004B1 (en) * 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
US7009049B2 (en) * 2002-02-15 2006-03-07 Cytokinetics, Inc. Syntheses of quinazolinones
US7166595B2 (en) * 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
AU2003270015A1 (en) 2002-05-09 2003-12-02 Cytokinetics, Inc. Compounds, compositions, and methods
US20040053948A1 (en) * 2002-05-10 2004-03-18 Cytokinetics, Inc. Compounds, compositions and methods
WO2003103575A2 (en) * 2002-05-23 2003-12-18 Cytokinetics, Inc. Compounds, compositions, and methods
CA2489367A1 (en) * 2002-06-14 2003-12-24 Cytokinetics, Inc. Compounds, compositions, and methods
WO2004009036A2 (en) * 2002-07-23 2004-01-29 Cytokinetics, Inc. Compounds compositions and methods
EP1539180A4 (de) * 2002-08-21 2006-08-30 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
WO2004034972A2 (en) * 2002-09-30 2004-04-29 Cytokinetics, Inc. Compounds, compositions, and methods
EP1571146A4 (de) * 2002-12-10 2010-09-01 Ono Pharmaceutical Co Stickstoffhaltige heterocyclischeverbindungen und deren medizinische verwendung
JP2007510652A (ja) * 2003-11-03 2007-04-26 サイトキネティクス・インコーポレーテッド ピリミジン−４−オン化合物、組成物、および方法
WO2005046588A2 (en) * 2003-11-07 2005-05-26 Cytokinetics, Inc. Compounds, compositions, and methods
EP1692112A4 (de) * 2003-12-08 2008-09-24 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
EP2520567A3 (de) * 2006-02-23 2012-12-12 Shionogi & Co., Ltd. Mit cyclischen Gruppen substituierte, stickstoffhaltige heterocyclische Derivate
US9040533B2 (en) 2012-12-27 2015-05-26 Purdue Pharma L.P. Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators
EP3028703B1 (de) 2013-07-29 2019-12-04 Kyowa Kirin Co., Ltd. Piperidin abkömmlinge als wnt-signalisierungsinhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH583225A5 (de) * 1972-09-25 1976-12-31 Sandoz Ag
US5296487A (en) * 1990-01-02 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Quinazoline derivatives and their preparation
CA2118117A1 (en) * 1993-02-18 1994-08-19 Shigeki Fujiwara Adenosine uptake inhibitor

Also Published As

Publication number Publication date
AU689304B2 (en) 1998-03-26
NO961601L (no) 1996-04-22
FI961758A0 (fi) 1996-04-24
CN1134150A (zh) 1996-10-23
NO961601D0 (no) 1996-04-22
DE69519469D1 (de) 2000-12-28
FI961758A7 (fi) 1996-04-24
EP0726267A4 (de) 1996-12-11
ES2153491T3 (es) 2001-03-01
WO1996006841A1 (en) 1996-03-07
NZ291506A (en) 1997-03-24
US5948784A (en) 1999-09-07
EP0726267A1 (de) 1996-08-14
CA2174854A1 (en) 1996-03-07
DE69519469T2 (de) 2001-07-26
EP0726267B1 (de) 2000-11-22
NO310658B1 (no) 2001-08-06
CN1043991C (zh) 1999-07-07
JPH09165385A (ja) 1997-06-24
CA2174854C (en) 2001-11-20
FI961758L (fi) 1996-04-24
KR960705810A (ko) 1996-11-08
AU3265595A (en) 1996-03-22

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties