ATE198190T1 - Modulatoren von durch aminosäuren anregbare rezeptoren - Google Patents

Modulatoren von durch aminosäuren anregbare rezeptoren

Info

Publication number
ATE198190T1
ATE198190T1 AT98303730T AT98303730T ATE198190T1 AT E198190 T1 ATE198190 T1 AT E198190T1 AT 98303730 T AT98303730 T AT 98303730T AT 98303730 T AT98303730 T AT 98303730T AT E198190 T1 ATE198190 T1 AT E198190T1
Authority
AT
Austria
Prior art keywords
modulators
amino acids
receptors stimulated
stimulated
receptors
Prior art date
Application number
AT98303730T
Other languages
English (en)
Inventor
Steven Marc Massey
James Allen Monn
Matthew John Valli
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE198190T1 publication Critical patent/ATE198190T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/14—Compounds containing azido groups with azido groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/383—Cycloaliphatic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98303730T 1997-05-14 1998-05-13 Modulatoren von durch aminosäuren anregbare rezeptoren ATE198190T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4701197P 1997-05-14 1997-05-14

Publications (1)

Publication Number Publication Date
ATE198190T1 true ATE198190T1 (de) 2001-01-15

Family

ID=21946570

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98303730T ATE198190T1 (de) 1997-05-14 1998-05-13 Modulatoren von durch aminosäuren anregbare rezeptoren

Country Status (30)

Country Link
US (3) US5958960A (de)
EP (1) EP0878463B1 (de)
JP (1) JP4191263B2 (de)
KR (1) KR20010012489A (de)
CN (1) CN1125807C (de)
AR (1) AR015664A1 (de)
AT (1) ATE198190T1 (de)
AU (1) AU729632B2 (de)
BR (1) BR9808787A (de)
CA (1) CA2289472C (de)
CO (1) CO4950558A1 (de)
DE (1) DE69800430T2 (de)
DK (1) DK0878463T3 (de)
EA (1) EA199901029A1 (de)
ES (1) ES2152738T3 (de)
GR (1) GR3035156T3 (de)
HU (1) HUP0001404A3 (de)
ID (1) ID23183A (de)
IL (1) IL132894A0 (de)
NO (1) NO995480L (de)
NZ (1) NZ500954A (de)
PE (1) PE73599A1 (de)
PL (1) PL336793A1 (de)
PT (1) PT878463E (de)
SI (1) SI0878463T1 (de)
SV (1) SV1998000056A (de)
TR (1) TR199902777T2 (de)
TW (1) TW505623B (de)
WO (1) WO1998051655A1 (de)
ZA (1) ZA983930B (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
DE69906492T2 (de) * 1998-01-28 2003-12-18 Taisho Pharmaceutical Co., Ltd. Fluorhaltige aminosäurederivate
KR100469182B1 (ko) * 1998-08-31 2005-02-02 다이쇼 세이야꾸 가부시끼가이샤 6-플루오로비시클로[3.1.0]헥산 유도체
PE20001236A1 (es) * 1998-11-13 2000-11-10 Lilly Co Eli Moduladores del receptor de aminoacidos excitadores
HK1047430B (zh) * 1998-12-18 2005-06-10 大正制药株式会社 中间体及使用该中间体的含氟氨基酸化合物的制造方法
EP1164121B1 (de) 1999-03-25 2008-10-29 Taisho Pharmaceutical Co., Ltd Carbonsäurederivate und verfahren zu ihrer herstellung
JP4505926B2 (ja) * 1999-03-25 2010-07-21 大正製薬株式会社 新規カルボン酸誘導体及びその製造方法
US6528499B1 (en) 2000-04-27 2003-03-04 Georgetown University Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
AU773915B2 (en) 1999-04-28 2004-06-10 Georgetown University Ligands for metabotropic glutamate receptors
US6417366B2 (en) 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
JP4783967B2 (ja) * 1999-07-21 2011-09-28 大正製薬株式会社 含フッ素アミノ酸誘導体を有効成分とする医薬
WO2001042203A1 (en) * 1999-12-08 2001-06-14 Eli Lilly And Company Cyclopentyl sulfonamide derivatives
US6639107B1 (en) 1999-12-08 2003-10-28 Eli Lilly And Company Cyclopentyl sulfonamide derivatives
US7038077B2 (en) * 2001-01-11 2006-05-02 Eli Lilly And Company Prodrugs of excitatory amino acids
HUP0400620A3 (en) * 2001-01-11 2012-09-28 Lilly Co Eli Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds
WO2002068380A1 (en) * 2001-02-22 2002-09-06 Eli Lilly And Company Synthetic excitatory amino acids
KR20090031962A (ko) * 2001-12-27 2009-03-30 다이쇼 세이야꾸 가부시끼가이샤 6-플루오로비시클로[3.1.0]헥산 유도체
US20040116489A1 (en) * 2002-02-12 2004-06-17 Massey Steven Marc Synthetic excitatory amino acids
US20050192273A1 (en) * 2002-04-03 2005-09-01 Johnson Bryan G. Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist
KR20080058509A (ko) 2002-06-11 2008-06-25 일라이 릴리 앤드 캄파니 흥분성 아미노산의 전구약물
PL1637517T3 (pl) 2003-06-26 2011-04-29 Taisho Pharmaceutical Co Ltd Pochodne estrowe kwasu 2-aminobicyklo[3.1.0]heksano-2,6-dikarboksylowego
RU2349580C2 (ru) * 2003-06-26 2009-03-20 Таишо Фармасьютикал Ко., Лтд Сложноэфирное производное 2-амино-бицикло[3.1.0]гексан-2,6-дикарбоновой кислоты, обладающее свойствами антагониста метаботропных глутаматных рецепторов ii группы
ES2355144T3 (es) 2003-06-26 2011-03-23 Taisho Pharmaceutical Co., Ltd. Derivado de éster 2-aminobiciclo 3.1.0 hexano-2,6-dicarboxílico.
US7381746B2 (en) 2003-06-26 2008-06-03 Taisho Pharmaceutical Co., Ltd. 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative
AU2004289652B8 (en) * 2003-11-07 2011-01-20 Taisho Pharmaceutical Co., Ltd. Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP1915146A4 (de) 2005-07-27 2010-06-02 Dov Pharmaceutical Inc Neuartige 1-aryl-3-azabicyclo[3.1.0]hexane. herstellung und verwendung zur behandlung von neuropsychiatrischen erkrankungen
EP2275095A3 (de) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
EP2258358A3 (de) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP1940389A2 (de) 2005-10-21 2008-07-09 Braincells, Inc. Modulation von neurogenese durch pde-hemmung
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
EP2382975A3 (de) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenese mittels Angiotensin-Modulation
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
EP2097111B1 (de) 2006-11-08 2015-07-15 Molecular Insight Pharmaceuticals, Inc. Heterodimere von glutaminsäure
US8586619B2 (en) * 2007-03-12 2013-11-19 Vm Therapeutics Llc Agents of calcium ion channel modulators
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
EP2167083B1 (de) * 2007-06-06 2015-10-28 Euthymics Bioscience, Inc. 1- heteroaryl-3-azabicyclo[3.1.0]hexane, verfahren zu ihrer herstellung und ihre verwendung als medikamente
US8562945B2 (en) 2008-01-09 2013-10-22 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
JPWO2009142184A1 (ja) * 2008-05-21 2011-09-29 大正製薬株式会社 酵素を用いたビシクロ［３．１．０］ヘキサン誘導体の製造方法
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia
AU2010260195B2 (en) 2009-06-15 2014-11-20 Molecular Insight Pharmaceuticals, Inc. Process for production of heterodimers of glutamic acid
AR079343A1 (es) 2009-12-21 2012-01-18 Lilly Co Eli Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico
CN103209954B (zh) * 2010-11-18 2015-09-02 伊莱利利公司 作为mGluR2/3拮抗剂的4-取代的-3-苄氧基-双环[3.1.0]己烷化合物
AR083845A1 (es) * 2010-11-18 2013-03-27 Lilly Co Eli COMPUESTOS 3-FENILSULFANILMETIL-BICICLO[3.1.0]HEXANO 4-SUSTITUIDOS COMO ANTAGONISTAS DE mGluR2/3
DK2721012T3 (en) * 2011-06-17 2016-08-15 Lilly Co Eli Biclo (3.1.0) hexane-2,6-dicarboxylic acid derivatives as MGLU2 receptor agonist
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
EP2800471A4 (de) 2012-01-06 2015-11-04 Molecular Insight Pharm Inc Metallkomplexe von poly(carboxyl)aminhaltigen liganden mit einer affinität für carboanhydrase ix
AR089718A1 (es) 2012-02-01 2014-09-10 Lilly Co Eli AGONISTAS DE mGlu2/3
EP3939972A1 (de) 2013-01-14 2022-01-19 Molecular Insight Pharmaceuticals, Inc. Triazinbasierte radiopharmazeutika und strahlungsbildgebungsmittel
FR3050021B1 (fr) 2016-04-06 2018-10-19 Nitrates & Innovation Ensemble de deux reservoirs prets a etre assembles par vissage pour former une cartouche d'explosif bi-composant

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750566A (en) * 1994-08-12 1998-05-12 Eli Lilly And Company Synthetic excitatory amino acids
PL182285B1 (pl) * 1994-08-12 2001-12-31 Lilly Co Eli Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL
ATE206915T1 (de) * 1994-08-12 2001-11-15 Lilly Co Eli Behandlung von angstzuständen
WO1996004900A1 (en) * 1994-08-12 1996-02-22 Eli Lilly And Company Composition and method for protection against drug dependency
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
GB9605429D0 (en) * 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
US5912248A (en) 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
ZA969485B (en) 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.

Also Published As

Publication number Publication date
US5958960A (en) 1999-09-28
ZA983930B (en) 1999-11-08
HUP0001404A2 (hu) 2000-08-28
CA2289472A1 (en) 1998-11-19
NZ500954A (en) 2001-06-29
JP4191263B2 (ja) 2008-12-03
IL132894A0 (en) 2001-03-19
GR3035156T3 (en) 2001-04-30
PE73599A1 (es) 1999-08-14
EA199901029A1 (ru) 2000-06-26
NO995480D0 (no) 1999-11-09
WO1998051655A1 (en) 1998-11-19
PL336793A1 (en) 2000-07-17
DE69800430D1 (de) 2001-01-25
JP2001525825A (ja) 2001-12-11
ID23183A (id) 2000-03-23
CA2289472C (en) 2007-04-24
TR199902777T2 (xx) 2000-07-21
AU7386998A (en) 1998-12-08
US6160009A (en) 2000-12-12
EP0878463A1 (de) 1998-11-18
HUP0001404A3 (en) 2000-09-28
NO995480L (no) 1999-11-09
PT878463E (pt) 2001-04-30
TW505623B (en) 2002-10-11
AR015664A1 (es) 2001-05-16
SV1998000056A (es) 1999-01-18
CN1255117A (zh) 2000-05-31
AU729632B2 (en) 2001-02-08
DK0878463T3 (da) 2001-02-19
ES2152738T3 (es) 2001-02-01
US6268507B1 (en) 2001-07-31
KR20010012489A (ko) 2001-02-15
EP0878463B1 (de) 2000-12-20
CO4950558A1 (es) 2000-09-01
BR9808787A (pt) 2000-07-11
DE69800430T2 (de) 2001-06-13
CN1125807C (zh) 2003-10-29
SI0878463T1 (en) 2001-06-30

Similar Documents

Publication Publication Date Title
ATE198190T1 (de) Modulatoren von durch aminosäuren anregbare rezeptoren
ATE242198T1 (de) Modulatoren von exzitatorischen aminosäure rezeptoren
FI962932A7 (fi) Ankkuriproteiinifunktion modulaattoreita
DE69821072D1 (de) Echtzeit bildgesteuerte Positionierung von Verankerungseinheiten
DE19882672T1 (de) Sicheres Verbinden von Bauteilen mittels Federringen
DE19882125T1 (de) Direkte Abscheidung von Palladium
DE19681286T1 (de) Neue Kristallform von Olanzapin
DE69826705D1 (de) Verfahren zur dermalen verabreichung von polypeptiden
DE19882126T1 (de) Hydrierung von Kohlenwasserstoffen
DE69623360D1 (de) Schätzung von Anregungsparametern
EE03424B1 (et) Allergiavastase valguhüdrolüsaadipreparaadi valmistamise meetod
DE69633333D1 (de) Diphosphonatderivate von therapeutischen substanzen
DE69841002D1 (de) Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln
FI945704A0 (fi) Eksitatorisen aminohapporeseptorin antagonisteja
DK1533303T3 (da) Substituerede aminosalicylsyreamider (mellemprodukter)
ATE207065T1 (de) Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid
DE69801676D1 (de) Wässrige emulsionen von fischer-tropschparaffinen
DE69810761D1 (de) Synergistische mischungen von ausgewählten aminosäuren
DE19681439T1 (de) Modifizierung von Polypeptidarzneimitteln zur Erhöhung des Elektrotransportflusses
BR9609671A (pt) Amino uracilas substituídas
BR9611521A (pt) Antagonistas de receptor de aminoácido excitador
DE59607328D1 (de) Verwendung von modifizierten polyasparaginsäuren in waschmitteln
DE69834262D1 (de) Neue pharnazeutische verwendung von c-c chemokin produktionsinhibitoren
DE59807008D1 (de) Aluminiumsalze von alkylhydroxymethylphosphinsäuren
DE69838838D1 (de) Lactoferrinrezeptorgen von moraxella

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee