ATE198602T1 - Makrocyclische difluorostatonderivate als antivirale mittel - Google Patents

Makrocyclische difluorostatonderivate als antivirale mittel

Info

Publication number
ATE198602T1
ATE198602T1 AT95903633T AT95903633T ATE198602T1 AT E198602 T1 ATE198602 T1 AT E198602T1 AT 95903633 T AT95903633 T AT 95903633T AT 95903633 T AT95903633 T AT 95903633T AT E198602 T1 ATE198602 T1 AT E198602T1
Authority
AT
Austria
Prior art keywords
pct
hiv
antiviral agents
macrocyclic
sec
Prior art date
Application number
AT95903633T
Other languages
English (en)
Inventor
Robert A Farr
Brent L Podlogar
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE198602T1 publication Critical patent/ATE198602T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95903633T 1994-02-04 1994-11-28 Makrocyclische difluorostatonderivate als antivirale mittel ATE198602T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19208094A 1994-02-04 1994-02-04
PCT/US1994/013711 WO1995021186A1 (en) 1994-02-04 1994-11-28 Macrocyclic difluorostatone derivatives useful as antiviral agents

Publications (1)

Publication Number Publication Date
ATE198602T1 true ATE198602T1 (de) 2001-01-15

Family

ID=22708156

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95903633T ATE198602T1 (de) 1994-02-04 1994-11-28 Makrocyclische difluorostatonderivate als antivirale mittel

Country Status (20)

Country Link
US (1) US5969132A (de)
EP (1) EP0742791B1 (de)
JP (1) JP3574455B2 (de)
KR (1) KR100367379B1 (de)
CN (1) CN1142830A (de)
AT (1) ATE198602T1 (de)
AU (1) AU684875B2 (de)
CA (1) CA2182476C (de)
DE (1) DE69426574T2 (de)
DK (1) DK0742791T3 (de)
ES (1) ES2155515T3 (de)
FI (1) FI963073L (de)
GR (1) GR3035623T3 (de)
HU (1) HUT74384A (de)
IL (1) IL112514A0 (de)
NO (1) NO963254L (de)
NZ (1) NZ277410A (de)
PT (1) PT742791E (de)
WO (1) WO1995021186A1 (de)
ZA (1) ZA95756B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2528375C (en) 2003-06-18 2013-11-19 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672792A5 (de) * 1985-02-19 1989-12-29 Sandoz Ag
DE3674131D1 (de) * 1985-04-19 1990-10-18 Upjohn Co Substituierte dihalo-statin-reninhemmungsmittel.
FI910084A0 (fi) * 1988-07-08 1991-01-07 Smithkline Beckman Corp Retrovirala proteaser bindande peptider.
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
NZ241099A (en) * 1991-01-02 1994-08-26 Merrell Dow Pharma Difluorostatone analogues and derivatives and pharmaceutical compositions
EP0773926A1 (de) * 1994-07-15 1997-05-21 Merrell Pharmaceuticals Inc. Difluorostatone als antivirale mittel

Also Published As

Publication number Publication date
ZA95756B (en) 1995-10-05
NO963254D0 (no) 1996-08-02
PT742791E (pt) 2001-06-29
AU1262295A (en) 1995-08-21
HUT74384A (en) 1996-12-30
KR100367379B1 (ko) 2003-04-11
HU9602158D0 (en) 1996-09-30
FI963073A0 (fi) 1996-08-02
CA2182476C (en) 2000-12-26
GR3035623T3 (en) 2001-06-29
CN1142830A (zh) 1997-02-12
JPH09508417A (ja) 1997-08-26
FI963073A7 (fi) 1996-08-02
NZ277410A (en) 1997-02-24
JP3574455B2 (ja) 2004-10-06
IL112514A0 (en) 1995-05-26
ES2155515T3 (es) 2001-05-16
DE69426574D1 (de) 2001-02-15
EP0742791B1 (de) 2001-01-10
AU684875B2 (en) 1998-01-08
DE69426574T2 (de) 2001-08-09
DK0742791T3 (da) 2001-04-02
US5969132A (en) 1999-10-19
EP0742791A1 (de) 1996-11-20
WO1995021186A1 (en) 1995-08-10
FI963073L (fi) 1996-08-02
NO963254L (no) 1996-08-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee