ATE199543T1 - Bibphenylamid-derivate als 5-ht1d-antagonisten - Google Patents

Bibphenylamid-derivate als 5-ht1d-antagonisten

Info

Publication number: ATE199543T1
Authority: AT; Austria
Prior art keywords: 6alkyl; independently hydrogen; 6alkoxy; pct; hydroxyc1
Prior art date: 1994-08-23

Application number

AT95929872T

Other languages

English (en)

Inventor

Laramie Mary Gaster

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-23

Filing date

1995-08-14

Publication date

2001-03-15

1995-08-14 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2001-03-15 Application granted granted Critical

2001-03-15 Publication of ATE199543T1 publication Critical patent/ATE199543T1/de

Links

102100027493 5-hydroxytryptamine receptor 1D Human genes 0.000 title 1
101710138068 5-hydroxytryptamine receptor 1D Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
239000001257 hydrogen Substances 0.000 abstract 9
229910052739 hydrogen Inorganic materials 0.000 abstract 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
239000005864 Sulphur Chemical group 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
-1 COC1-6alkyl Chemical group 0.000 abstract 1
101000585507 Solanum tuberosum Cytochrome b-c1 complex subunit 7 Proteins 0.000 abstract 1
101100006938 Zea mays CNR10 gene Proteins 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000004001 serotonin 1D antagonist Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Lubricants (AREA)

AT95929872T 1994-08-23 1995-08-14 Bibphenylamid-derivate als 5-ht1d-antagonisten ATE199543T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9416972A GB9416972D0 (en)	1994-08-23	1994-08-23	Carbon side chain/indole/indolene
PCT/EP1995/003226 WO1996006079A1 (en)	1994-08-23	1995-08-14	Biphenylamide derivatives as 5ht1d antagonists

Publications (1)

Publication Number	Publication Date
ATE199543T1 true ATE199543T1 (de)	2001-03-15

Family

ID=10760239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95929872T ATE199543T1 (de)	1994-08-23	1995-08-14	Bibphenylamid-derivate als 5-ht1d-antagonisten

Country Status (7)

Country	Link
US (1)	US5817833A (de)
EP (1)	EP0777650B1 (de)
JP (1)	JPH10504315A (de)
AT (1)	ATE199543T1 (de)
DE (1)	DE69520279T2 (de)
GB (1)	GB9416972D0 (de)
WO (1)	WO1996006079A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9421003D0 (en) *	1994-10-18	1994-12-07	Smithkline Beecham Plc	Novel compounds
GB9507203D0 (en) *	1995-04-07	1995-05-31	Smithkline Beecham Plc	Novel compounds
WO1997007120A1 (en) *	1995-08-11	1997-02-27	Smithkline Beecham Plc	Biphenyl(thio)amide and biphenylethan(thi)one derivatives, their preparation and their use as 5-ht1d receptor antagonists
JP2000502051A (ja) *	1995-11-22	2000-02-22	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	５ｈｔ▲下１ｄ▼レセプターアンタゴニストとしての三環系スピロ化合物
GB9707830D0 (en) *	1997-04-18	1997-06-04	Smithkline Beecham Plc	Novel compounds
US7229986B2 (en)	2000-05-16	2007-06-12	Takeda Pharmaceutical Company Ltd.	Melanin-concentrating hormone antagonist
US20020049211A1 (en) *	2000-09-06	2002-04-25	Sobolov-Jaynes Susan Beth	Combination treatment for depression and anxiety
DE10059418A1 (de) *	2000-11-30	2002-06-20	Aventis Pharma Gmbh	Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
TW593278B (en) *	2001-01-23	2004-06-21	Wyeth Corp	1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
US7271180B2 (en) *	2001-01-23	2007-09-18	Wyeth	1-Aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
WO2003068749A1 (en)	2002-02-15	2003-08-21	Glaxo Group Limited	Vanilloid receptor modulators
KR102007796B1 (ko)	2013-11-18	2019-08-07	포르마 세라퓨틱스 인크.	Bet 브로모도메인 저해제로서 테트라하이드로퀴놀린 조성물
WO2015074081A1 (en)	2013-11-18	2015-05-21	Bair Kenneth W	Benzopiperazine compositions as bet bromodomain inhibitors
WO2020183011A1 (en)	2019-03-14	2020-09-17	Institut Curie	Htr1d inhibitors and uses thereof in the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3470203A (en) *	1964-02-01	1969-09-30	Merck & Co Inc	Intermediates for preparing 1-aroylindole-3-alkanoic acids
US3860609A (en) *	1969-05-27	1975-01-14	Novo Terapeutisk Labor As	3-aminoalkyloxyindoles
GB1306230A (de) *	1969-05-27	1973-02-07
US4059583A (en) *	1975-11-13	1977-11-22	Mcneil Laboratories, Incorporated	Substituted indoles
US5481005A (en) *	1990-07-31	1996-01-02	Sanofi	N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
GB9119932D0 (en) *	1991-09-18	1991-10-30	Glaxo Group Ltd	Chemical compounds
GB9119920D0 (en) *	1991-09-18	1991-10-30	Glaxo Group Ltd	Chemical compounds
DE69417427T2 (de) *	1993-09-03	1999-11-25	Smithkline Beecham P.L.C., Brentford	Indol- und indolin-derivate als 5ht1d rezeptor antagonisten

1994
- 1994-08-23 GB GB9416972A patent/GB9416972D0/en active Pending
1995
- 1995-08-14 WO PCT/EP1995/003226 patent/WO1996006079A1/en not_active Ceased
- 1995-08-14 US US08/793,428 patent/US5817833A/en not_active Expired - Fee Related
- 1995-08-14 AT AT95929872T patent/ATE199543T1/de not_active IP Right Cessation
- 1995-08-14 JP JP8507762A patent/JPH10504315A/ja not_active Withdrawn
- 1995-08-14 DE DE69520279T patent/DE69520279T2/de not_active Expired - Fee Related
- 1995-08-14 EP EP95929872A patent/EP0777650B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69520279T2 (de)	2001-10-31
EP0777650B1 (de)	2001-03-07
EP0777650A1 (de)	1997-06-11
US5817833A (en)	1998-10-06
WO1996006079A1 (en)	1996-02-29
GB9416972D0 (en)	1994-10-12
DE69520279D1 (de)	2001-04-12
JPH10504315A (ja)	1998-04-28

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Legal Events

Date	Code	Title	Description
2001-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties