ATE199730T1 - Oberflächenaktives lungenprotein und verwandte polypeptide - Google Patents

Oberflächenaktives lungenprotein und verwandte polypeptide

Info

Publication number
ATE199730T1
ATE199730T1 AT93119102T AT93119102T ATE199730T1 AT E199730 T1 ATE199730 T1 AT E199730T1 AT 93119102 T AT93119102 T AT 93119102T AT 93119102 T AT93119102 T AT 93119102T AT E199730 T1 ATE199730 T1 AT E199730T1
Authority
AT
Austria
Prior art keywords
amino acid
acid residue
related polypeptides
lung protein
polypeptides
Prior art date
Application number
AT93119102T
Other languages
English (en)
Inventor
Charles G Cochrane
Susan D Revak
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE199730T1 publication Critical patent/ATE199730T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT93119102T 1988-01-06 1989-01-05 Oberflächenaktives lungenprotein und verwandte polypeptide ATE199730T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14120088A 1988-01-06 1988-01-06
US07/293,201 US5164369A (en) 1988-01-06 1989-01-04 Pulmonary surfactant protein and related polypeptide

Publications (1)

Publication Number Publication Date
ATE199730T1 true ATE199730T1 (de) 2001-03-15

Family

ID=26838883

Family Applications (2)

Application Number Title Priority Date Filing Date
AT93119102T ATE199730T1 (de) 1988-01-06 1989-01-05 Oberflächenaktives lungenprotein und verwandte polypeptide
AT89901885T ATE196298T1 (de) 1988-01-06 1989-01-05 Oberflächenaktives lungenprotein und verwandte polypeptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT89901885T ATE196298T1 (de) 1988-01-06 1989-01-05 Oberflächenaktives lungenprotein und verwandte polypeptide

Country Status (8)

Country Link
US (1) US5164369A (de)
EP (2) EP0593094B1 (de)
JP (2) JP3009690B2 (de)
AT (2) ATE199730T1 (de)
DE (2) DE68929287T2 (de)
DK (1) DK174818B1 (de)
FI (1) FI102180B1 (de)
WO (1) WO1989006657A1 (de)

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JPH03505865A (ja) * 1987-11-07 1991-12-19 アグリカルチュラル・アンド・フード・リサーチ・カウンシル 乳化剤
US6613734B2 (en) * 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US6013619A (en) * 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
US5238920A (en) * 1989-08-22 1993-08-24 Abbott Laboratories Pulmonary surfactant protein fragments
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
DE69332654T2 (de) * 1992-04-10 2003-09-25 Abbott Laboratories, Abbott Park Fragmente eines oberflächenaktiven lungenproteins
US6129934A (en) * 1995-06-07 2000-10-10 Ony, Inc. Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction
JP3856343B2 (ja) * 1995-11-20 2006-12-13 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 肺胞界面活性物質ペプチドの可溶化法
US6315983B1 (en) 1996-01-24 2001-11-13 Byk Gulden Lomberg Chemische Fabrik Gmbh Process for the production of powdered pulmonary surfactant preparations
US6031075A (en) * 1996-02-05 2000-02-29 Children's Hospital Medical Center Mature alveolar SP-B and a process for producing the same
AU2322097A (en) * 1996-03-27 1997-10-17 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
US6013764A (en) 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
DE50214446D1 (de) 2001-10-11 2010-07-01 Nycomed Gmbh Neue verwendung von lungensurfactant
MXPA04010560A (es) * 2002-04-25 2005-08-15 Scripps Research Inst Tratamiento y prevencion de condiciones pulmonares.
CA2549160A1 (en) * 2003-12-04 2005-06-23 The Scripps Research Institute Treatment and preventions of asthma
CA2567334A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
JP5108515B2 (ja) 2004-08-06 2012-12-26 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺サーファクタント及びｔｎｆ由来ペプチドを含有する組成物
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
EP2298349A1 (de) 2005-01-06 2011-03-23 Discovery Laboratories, Inc. Dosierungsschema für Tenside zur Behandlung oder Verhinderung von bronchopulmonären Dysplasien
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
RS55526B1 (sr) 2006-02-08 2017-05-31 Morphotek Inc Antigenski gm-csf peptidi i antitela gm-csf
WO2008036293A1 (en) * 2006-09-19 2008-03-27 Discovery Laboratories, Inc. Pulmonary surfactant formulations and methods for promoting mucus clearance
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
CN101754747A (zh) * 2007-06-05 2010-06-23 Paka肺部医药公司 用于向肺脏递送药物的方法以及组合物
US8048043B2 (en) 2007-06-08 2011-11-01 Chiesi Farmaceutici S. P. A. Method of administration of a pulmonary surfactant
SI2265309T1 (sl) 2008-03-17 2016-04-29 Discovery Laboratories, Inc. Adapter za cevje ventilatorja in sistem za proksimalno dovajanje aerosola
US8596265B2 (en) 2008-10-22 2013-12-03 Trudell Medical International Modular aerosol delivery system
EP2370068A4 (de) 2008-12-10 2015-09-23 Paka Pulmonary Pharmaceuticals Inc Verfahren und zusammensetzungen zur abgabe von medikamenten an die lunge
WO2011029525A1 (en) 2009-09-08 2011-03-17 Chiesi Farmaceutici S.P.A. A therapeutic combination comprising a pulmonary surfactant and antioxidant enzymes
WO2011035140A1 (en) 2009-09-18 2011-03-24 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of contrast moieties to the lungs
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
EP3106090A1 (de) 2015-06-15 2016-12-21 CHIESI FARMACEUTICI S.p.A. System zur effektiven und atemsynchronisierten abgabe eines medikaments in die lungen
HK1247140A1 (zh) 2015-04-22 2018-09-21 奇斯药制品公司 用於药物有效地呼吸同步递送到肺部的方法和系统
US11311691B2 (en) 2015-04-28 2022-04-26 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
JP2018514545A (ja) 2015-04-30 2018-06-07 ユニバーシティ オブ ブレーメン 医療用および美容用の新規な皮膚ケア製造物
CN109496159A (zh) 2016-07-28 2019-03-19 奇斯药制品公司 用于递送雾化药剂的方法和系统
ES2892903T3 (es) 2016-10-26 2022-02-07 Chiesi Farm Spa Dispositivo para facilitar la administración de un medicamento a los pulmones por medio de un catéter
BR112019012922A2 (pt) 2016-12-22 2019-12-10 Chiesi Farm Spa combinação de um surfactante pulmonar, uso de uma combinação de um surfactante pulmonar e kit
TW201927286A (zh) 2017-12-15 2019-07-16 義大利商凱西製藥公司 用於噴霧投藥之包含肺表面張力素的藥學調配物
WO2019115771A1 (en) 2017-12-15 2019-06-20 Pari Pharma Gmbh Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method
JP7378425B2 (ja) 2018-04-23 2023-11-13 シエシー ファルマセウティチィ ソシエタ ペル アチオニ 肺サーファクタントおよびｂｐｄの予防のためのステロイドを含む治療的組合せ
EP3666315A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3666316A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3843105A1 (de) 2019-12-23 2021-06-30 PARI Pharma GmbH Steuerungsvorrichtung für aerosolzerstäubersystem
US12606609B2 (en) 2020-01-28 2026-04-21 Chiesi Farmaceutici S.P.A. Polypeptides having improved properties
EP4411745A1 (de) 2023-02-01 2024-08-07 Pari Medical Holding GmbH Medizinisches beurteilungsverfahren, aerosolzerstäuber und medizinisches beurteilungssystem
EP4464354A1 (de) 2023-05-15 2024-11-20 Pari Medical Holding GmbH Verfahren zum betreiben einer inhalationsvorrichtung, inhalationsvorrichtung und inhalationsvorrichtungssystem zur bereitstellung eines inhalationsverfahrens/ einer atemführung
EP4464236A1 (de) 2023-05-15 2024-11-20 Pari Medical Holding GmbH Verfahren zum betreiben einer inhalationsvorrichtung, inhalationsvorrichtung und inhalationsvorrichtungssystem zur bereitstellung von inhalationsverfahrensrückmeldung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
JPS63503222A (ja) * 1986-05-06 1988-11-24 サイオス　ノバ　インコーポレイテッド 肺の疎水性界面活性物質に結合した分子量６，０００ダルトンのタンパク質及びその多量体
EP0290516A4 (de) * 1986-10-24 1989-11-14 Jeffrey A Whitsett Proteine, die mit oberflächenwirksamen hydrophoben lungenwirkstoffen verbunden sind.
ATE163013T1 (de) * 1987-11-04 1998-02-15 Byk Gulden Lomberg Chem Fab Alveolare oberflächenaktive proteine
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant

Also Published As

Publication number Publication date
JPH11262389A (ja) 1999-09-28
DE68929248D1 (de) 2000-10-19
EP0350506B1 (de) 2000-09-13
DK174818B1 (da) 2003-12-01
DE68929287D1 (de) 2001-04-19
DK439089D0 (da) 1989-09-05
EP0593094A3 (de) 1994-11-02
AU629233B2 (en) 1992-10-01
FI894187A0 (fi) 1989-09-05
DE68929287T2 (de) 2001-07-05
AU3960089A (en) 1989-08-11
FI102180B (fi) 1998-10-30
ATE196298T1 (de) 2000-09-15
JP3009690B2 (ja) 2000-02-14
DE68929248T2 (de) 2001-01-25
EP0350506A4 (en) 1992-01-22
DK439089A (da) 1989-09-05
WO1989006657A1 (en) 1989-07-27
JPH02502917A (ja) 1990-09-13
EP0593094A2 (de) 1994-04-20
US5164369A (en) 1992-11-17
EP0350506A1 (de) 1990-01-17
EP0593094B1 (de) 2001-03-14
FI102180B1 (fi) 1998-10-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time