ATE199902T1 - N-benzylpiperazinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen - Google Patents
N-benzylpiperazinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungenInfo
- Publication number
- ATE199902T1 ATE199902T1 AT97402934T AT97402934T ATE199902T1 AT E199902 T1 ATE199902 T1 AT E199902T1 AT 97402934 T AT97402934 T AT 97402934T AT 97402934 T AT97402934 T AT 97402934T AT E199902 T1 ATE199902 T1 AT E199902T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- optionally substituted
- alkoxy
- halo
- phenyl
- Prior art date
Links
- IQXXEPZFOOTTBA-UHFFFAOYSA-N 1-benzylpiperazine Chemical class C=1C=CC=CC=1CN1CCNCC1 IQXXEPZFOOTTBA-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 3
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- -1 4-(2,3-dithiacyclopent-1-yl)-butyl Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9615415A FR2757164B1 (fr) | 1996-12-16 | 1996-12-16 | Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199902T1 true ATE199902T1 (de) | 2001-04-15 |
Family
ID=9498696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97402934T ATE199902T1 (de) | 1996-12-16 | 1997-12-04 | N-benzylpiperazinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5849745A (de) |
| EP (1) | EP0847999B1 (de) |
| JP (1) | JPH10175967A (de) |
| CN (1) | CN1192436A (de) |
| AT (1) | ATE199902T1 (de) |
| AU (1) | AU720803B2 (de) |
| BR (1) | BR9706360A (de) |
| CA (1) | CA2225780C (de) |
| DE (1) | DE69704329T2 (de) |
| DK (1) | DK0847999T3 (de) |
| ES (1) | ES2157541T3 (de) |
| FR (1) | FR2757164B1 (de) |
| GR (1) | GR3035855T3 (de) |
| HU (1) | HUP9702481A3 (de) |
| NO (1) | NO975903L (de) |
| NZ (1) | NZ329394A (de) |
| PL (1) | PL323767A1 (de) |
| PT (1) | PT847999E (de) |
| ZA (1) | ZA9711253B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1366015A4 (de) * | 2001-03-01 | 2008-03-26 | Tech Resources Pty Ltd | Benzol-1,2-diol-mannichbasen-ligandenpolymere und verfahren zur selektiven entfernung von metallionen |
| FR2827284B1 (fr) * | 2001-07-16 | 2003-10-31 | Servier Lab | Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN102993122B (zh) * | 2012-12-24 | 2015-03-04 | 武汉武药制药有限公司 | 盐酸曲美他嗪的合成新路线 |
| CN111093662B (zh) | 2017-06-20 | 2023-10-03 | 安布里亚制药公司 | 用于提高心脏代谢效率的组合物和方法 |
| WO2020081361A1 (en) | 2018-10-17 | 2020-04-23 | Imbria Pharmaceuticals, Inc. | Methods of treating rheumatic diseases using trimetazidine-based compounds |
| EP3976101A4 (de) | 2019-05-31 | 2023-06-21 | Imbria Pharmaceuticals, Inc. | Verfahren zur behandlung von fibrose unter verwendung von verbindungen zur förderung der glucoseoxidation |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3262852A (en) * | 1966-07-26 | Vasodilator and anti-anginose com- pounds containing methoxy benzyl piperazines and method of using the same | ||
| US2927924A (en) * | 1958-04-03 | 1960-03-08 | Lilly Co Eli | Novel phenethyl-substituted piperazines |
| FR805M (de) * | 1960-06-30 | 1961-09-01 | ||
| FR1302958A (fr) * | 1961-03-21 | 1962-09-07 | Science Union & Cie | Préparations des dérivés trialcoxylés de la benzyl-1 pipérazine |
| FR1303080A (fr) * | 1961-07-25 | 1962-09-07 | Science Union Et Compagnie Soc | Pipérazines disubstituées |
| KR890011868A (ko) * | 1988-01-26 | 1989-08-23 | 원본미기재 | 간질환 치료제 및 피페라진 유도체 |
| FR2681324B1 (fr) * | 1991-09-18 | 1993-10-29 | Adir Cie | Nouveaux derives de la trimetazidine, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| FR2703048B1 (fr) * | 1993-03-24 | 1996-01-05 | Adir | Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
-
1996
- 1996-12-16 FR FR9615415A patent/FR2757164B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-04 EP EP97402934A patent/EP0847999B1/de not_active Expired - Lifetime
- 1997-12-04 ES ES97402934T patent/ES2157541T3/es not_active Expired - Lifetime
- 1997-12-04 DE DE69704329T patent/DE69704329T2/de not_active Expired - Fee Related
- 1997-12-04 AT AT97402934T patent/ATE199902T1/de not_active IP Right Cessation
- 1997-12-04 DK DK97402934T patent/DK0847999T3/da active
- 1997-12-04 PT PT97402934T patent/PT847999E/pt unknown
- 1997-12-15 US US08/990,611 patent/US5849745A/en not_active Expired - Fee Related
- 1997-12-15 ZA ZA9711253A patent/ZA9711253B/xx unknown
- 1997-12-15 PL PL97323767A patent/PL323767A1/xx unknown
- 1997-12-15 JP JP9344823A patent/JPH10175967A/ja active Pending
- 1997-12-15 NZ NZ329394A patent/NZ329394A/xx unknown
- 1997-12-16 BR BR9706360A patent/BR9706360A/pt not_active Application Discontinuation
- 1997-12-16 AU AU48422/97A patent/AU720803B2/en not_active Ceased
- 1997-12-16 HU HU9702481A patent/HUP9702481A3/hu unknown
- 1997-12-16 CN CN97107273A patent/CN1192436A/zh active Pending
- 1997-12-16 CA CA002225780A patent/CA2225780C/fr not_active Expired - Fee Related
- 1997-12-16 NO NO975903A patent/NO975903L/no not_active Application Discontinuation
-
2001
- 2001-05-11 GR GR20010400707T patent/GR3035855T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0847999A1 (de) | 1998-06-17 |
| FR2757164B1 (fr) | 1999-01-22 |
| HU9702481D0 (en) | 1998-03-02 |
| HUP9702481A3 (en) | 1999-03-01 |
| DE69704329D1 (de) | 2001-04-26 |
| DE69704329T2 (de) | 2001-09-20 |
| DK0847999T3 (da) | 2001-04-30 |
| FR2757164A1 (fr) | 1998-06-19 |
| US5849745A (en) | 1998-12-15 |
| AU4842297A (en) | 1998-06-18 |
| CA2225780A1 (fr) | 1998-06-16 |
| NZ329394A (en) | 1998-10-28 |
| NO975903L (no) | 1998-06-17 |
| HUP9702481A2 (hu) | 1998-07-28 |
| CN1192436A (zh) | 1998-09-09 |
| AU720803B2 (en) | 2000-06-15 |
| PT847999E (pt) | 2001-08-30 |
| NO975903D0 (no) | 1997-12-16 |
| PL323767A1 (en) | 1998-06-22 |
| JPH10175967A (ja) | 1998-06-30 |
| ES2157541T3 (es) | 2001-08-16 |
| ZA9711253B (en) | 1998-06-23 |
| GR3035855T3 (en) | 2001-08-31 |
| EP0847999B1 (de) | 2001-03-21 |
| BR9706360A (pt) | 1999-06-01 |
| CA2225780C (fr) | 2002-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |