ATE199908T1 - Verfahren zur kupplung von polysacchariden und proteinen - Google Patents
Verfahren zur kupplung von polysacchariden und proteinenInfo
- Publication number
- ATE199908T1 ATE199908T1 AT96203556T AT96203556T ATE199908T1 AT E199908 T1 ATE199908 T1 AT E199908T1 AT 96203556 T AT96203556 T AT 96203556T AT 96203556 T AT96203556 T AT 96203556T AT E199908 T1 ATE199908 T1 AT E199908T1
- Authority
- AT
- Austria
- Prior art keywords
- chr
- hydrogen
- carbamoyl
- integer
- amino
- Prior art date
Links
- 230000008878 coupling Effects 0.000 title abstract 2
- 238000010168 coupling process Methods 0.000 title abstract 2
- 238000005859 coupling reaction Methods 0.000 title abstract 2
- 150000004676 glycans Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229920001282 polysaccharide Polymers 0.000 title abstract 2
- 239000005017 polysaccharide Substances 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- -1 amino, hydroxyl Chemical group 0.000 abstract 1
- 229920001222 biopolymer Polymers 0.000 abstract 1
- ZBZMKIRXPGQRFJ-UHFFFAOYSA-N n-oxomethanimidamide Chemical compound N=CN=O ZBZMKIRXPGQRFJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cooling Or The Like Of Semiconductors Or Solid State Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96203556A EP0848011B1 (de) | 1996-12-16 | 1996-12-16 | Verfahren zur Kupplung von Polysacchariden und Proteinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199908T1 true ATE199908T1 (de) | 2001-04-15 |
Family
ID=8224703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96203556T ATE199908T1 (de) | 1996-12-16 | 1996-12-16 | Verfahren zur kupplung von polysacchariden und proteinen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6361777B1 (de) |
| EP (1) | EP0848011B1 (de) |
| JP (1) | JP4619459B2 (de) |
| AT (1) | ATE199908T1 (de) |
| AU (1) | AU5347898A (de) |
| CA (1) | CA2274852C (de) |
| DE (1) | DE69612205T2 (de) |
| DK (1) | DK0848011T3 (de) |
| ES (1) | ES2156611T3 (de) |
| GR (1) | GR3035918T3 (de) |
| PT (1) | PT848011E (de) |
| WO (1) | WO1998027107A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248334B1 (en) * | 1997-01-08 | 2001-06-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process |
| CN1671400A (zh) * | 2002-07-03 | 2005-09-21 | 派瑞克科学公司 | 透明质酸组合物以及使用方法 |
| BRPI0417744B8 (pt) | 2003-12-17 | 2021-05-25 | Wyeth Corp | método para produzir um conjugado imunogênico, e,conjugado imunogênico |
| MY144231A (en) | 2003-12-17 | 2011-08-15 | Wyeth Corp | Aß IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME |
| CN103816870B (zh) | 2008-12-03 | 2016-11-23 | 株式会社钟化 | 含有甲酰基的多孔性载体、使用该多孔性载体的吸附体以及它们的制造方法 |
| EP2924053B1 (de) * | 2012-11-22 | 2020-11-11 | Glytech, Inc. | Glykosylierter linker, verbindung mit glykosyliertem linkerteil und physiologischem wirkstoffteil oder salz davon sowie verfahren zur herstellung dieser verbindung bzw. des salzes davon |
| EP2926829B1 (de) | 2012-11-30 | 2018-07-25 | Glytech, Inc. | An zuckerkette angehängter linker, verbindung mit an zuckerkette angehängtem linker und physiologisch aktiver stoff oder salz davon und verfahren zur herstellung davon |
| JP2017505792A (ja) * | 2014-02-14 | 2017-02-23 | ファイザー・インク | 免疫原性糖タンパク質コンジュゲート |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| EP4303224A4 (de) * | 2021-03-03 | 2025-02-19 | Tohoku University | Proteinfaltungsmittel |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2549051B1 (fr) | 1983-06-22 | 1986-05-16 | Centre Nat Rech Scient | Nouveaux agents radioprotecteurs ayant une structure amino-thioalkyle et procede pour leur preparation |
| US4762713A (en) | 1983-07-05 | 1988-08-09 | The University Of Rochester | Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers |
| EP0326111A3 (de) * | 1988-01-29 | 1989-12-27 | New York Blood Center, Inc. | Peptid-Derivate, immunogenisch gemacht bei Verabreichung zusammen mit Alaun als Zusatzmittel |
| US5738855A (en) * | 1994-10-17 | 1998-04-14 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Synthesis of typhoid fever vaccine from a plant or fruit polysaccharide |
-
1996
- 1996-12-16 AT AT96203556T patent/ATE199908T1/de active
- 1996-12-16 EP EP96203556A patent/EP0848011B1/de not_active Expired - Lifetime
- 1996-12-16 PT PT96203556T patent/PT848011E/pt unknown
- 1996-12-16 DK DK96203556T patent/DK0848011T3/da active
- 1996-12-16 DE DE69612205T patent/DE69612205T2/de not_active Expired - Lifetime
- 1996-12-16 ES ES96203556T patent/ES2156611T3/es not_active Expired - Lifetime
-
1997
- 1997-12-16 JP JP52756498A patent/JP4619459B2/ja not_active Expired - Fee Related
- 1997-12-16 AU AU53478/98A patent/AU5347898A/en not_active Abandoned
- 1997-12-16 US US09/331,029 patent/US6361777B1/en not_active Expired - Fee Related
- 1997-12-16 WO PCT/NL1997/000700 patent/WO1998027107A1/en not_active Ceased
- 1997-12-16 CA CA002274852A patent/CA2274852C/en not_active Expired - Fee Related
-
2001
- 2001-05-22 GR GR20010400772T patent/GR3035918T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69612205T2 (de) | 2001-08-30 |
| EP0848011B1 (de) | 2001-03-21 |
| DK0848011T3 (da) | 2001-07-16 |
| ES2156611T3 (es) | 2001-07-01 |
| PT848011E (pt) | 2001-08-30 |
| CA2274852C (en) | 2008-06-17 |
| GR3035918T3 (en) | 2001-08-31 |
| JP4619459B2 (ja) | 2011-01-26 |
| DE69612205D1 (de) | 2001-04-26 |
| EP0848011A1 (de) | 1998-06-17 |
| JP2001509144A (ja) | 2001-07-10 |
| WO1998027107A1 (en) | 1998-06-25 |
| WO1998027107A8 (en) | 2000-01-20 |
| US6361777B1 (en) | 2002-03-26 |
| CA2274852A1 (en) | 1998-06-25 |
| AU5347898A (en) | 1998-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |