ATE200631T1 - IMPROVED TISSUE ADHESIVE PREPARED FROM CRYOPRECIPATE - Google Patents

IMPROVED TISSUE ADHESIVE PREPARED FROM CRYOPRECIPATE

Info

Publication number
ATE200631T1
ATE200631T1 AT92114942T AT92114942T ATE200631T1 AT E200631 T1 ATE200631 T1 AT E200631T1 AT 92114942 T AT92114942 T AT 92114942T AT 92114942 T AT92114942 T AT 92114942T AT E200631 T1 ATE200631 T1 AT E200631T1
Authority
AT
Austria
Prior art keywords
component
cryoprecipate
tissue glue
tissue adhesive
adhesive prepared
Prior art date
Application number
AT92114942T
Other languages
German (de)
Inventor
Uri Dr Martinowitz
Frederic Bal
Original Assignee
Omrix Biopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8165612&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE200631(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Omrix Biopharm Sa filed Critical Omrix Biopharm Sa
Application granted granted Critical
Publication of ATE200631T1 publication Critical patent/ATE200631T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Materials For Medical Uses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Packages (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A tissue glue is described comprising a component A which comprises a cryoprecipitate of whole blood and a component B comprising a proteolytic enzyme being capable of cleaving specifically fibrinogen present in component A, and causing the formation of a fibrine polymer, in a preferred embodiment component A of the tissue glue comprises 3,000 to 5,000 KIU/ml of aprotinin. In another preferred embodiment component B of the tissue glue is a protease derived from the venom of the South American pit viper. This protease is known under the name batroxobin.
AT92114942T 1991-09-27 1992-09-02 IMPROVED TISSUE ADHESIVE PREPARED FROM CRYOPRECIPATE ATE200631T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1991/001850 WO1993005822A1 (en) 1991-09-27 1991-09-27 Tissue glue prepared by using cryoprecipitate

Publications (1)

Publication Number Publication Date
ATE200631T1 true ATE200631T1 (en) 2001-05-15

Family

ID=8165612

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92114942T ATE200631T1 (en) 1991-09-27 1992-09-02 IMPROVED TISSUE ADHESIVE PREPARED FROM CRYOPRECIPATE

Country Status (15)

Country Link
JP (1) JP2668762B2 (en)
AT (1) ATE200631T1 (en)
AU (1) AU648198B2 (en)
BR (1) BR9203763A (en)
CA (1) CA2079077C (en)
CZ (1) CZ280540B6 (en)
DE (1) DE69231791T2 (en)
ES (1) ES2155437T3 (en)
FI (1) FI924306L (en)
HU (2) HUT67051A (en)
IL (1) IL103118A (en)
NO (1) NO316155B1 (en)
SK (1) SK294292A3 (en)
WO (1) WO1993005822A1 (en)
ZA (1) ZA927360B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0602173B1 (en) * 1991-09-05 1999-05-26 Baxter International Inc. Topical fibrinogen complex
ITMI20021917A1 (en) * 2002-09-10 2004-03-11 New Dawn Consultores E Servicos L Da ACTIVATOR FOR THE FORMATION OF PLASTIC GEL, PLASMA GEL POOR OF PLATES OR PLASMA GEL RICH IN PLATES.
EP2011524A1 (en) 2007-07-02 2009-01-07 Omrix Biopharmaceuticals Ltd. Fibrin glue with a visualization agent
EP2034010A1 (en) 2007-08-30 2009-03-11 Omrix Biopharmaceuticals Ltd. Compositions suitable for repair and/or treatment of injured spinal tissue
WO2010032246A2 (en) 2008-09-22 2010-03-25 Omrix Biopharmaceuticals Ltd. Implantable device comprising a substrate pre-coated with stabilized fibrin
WO2011092694A2 (en) 2010-01-28 2011-08-04 Omrix Biopharmaceuticals Ltd. Method for improved fibrin sealing
IL213864A0 (en) 2011-06-30 2011-08-31 Omrix Biopharmaceuticals Ltd Method for removing a lytic enzyme from a heterogeneous mixture
US10130346B2 (en) 2012-07-24 2018-11-20 Omrix Biopharmaceuticals Ltd. Device and method for the application of a curable fluid composition to a bodily organ
BR112015015703A2 (en) 2012-12-30 2020-02-04 Omrix Biopharmaceuticals Ltd device and method for applying a curable fluid composition to a portion of an organ of the body
USD754325S1 (en) 2013-06-06 2016-04-19 Omrix Biopharmaceuticals Ltd. Device of a curable fluid composition to a bodily organ
IL230150A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One component fibrin glue comprising zymogens
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One component fibrin glue comprising a polymerization inhibitor
IL231230A0 (en) 2014-02-27 2014-08-31 Omrix Biopharmaceuticals Ltd Fibrinogen formulation
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for preparing and administering one-component fibrin sealant
IL234246A0 (en) 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
EP3258945B1 (en) 2015-02-16 2020-10-07 Nayacure Therapeutics Ltd. Modified blood clots
EP3313418B1 (en) 2015-06-26 2024-03-13 Cerus Corporation Cryoprecipitate compositions and methods of preparation thereof
IL247821A0 (en) 2016-09-14 2017-01-31 Omrix Biopharmaceuticals Ltd Sealant formulations and uses thereof
IL249725A0 (en) 2016-12-22 2017-03-30 Omrix Biopharmaceuticals Ltd Hemostatic composition comprising an anion exchanger and a calcium salt
IL263679A (en) * 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and ingredients for preventing tissue adhesion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT359652B (en) * 1979-02-15 1980-11-25 Immuno Ag METHOD FOR PRODUCING A TISSUE ADHESIVE
ATE20824T1 (en) * 1981-06-25 1986-08-15 Serapharm Gmbh & Co Kg ENRICHED PLASMA DERIVES TO SUPPORT WOUND CLOSURE AND HEALING.
US4627879A (en) * 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
DE3622642A1 (en) * 1986-07-05 1988-01-14 Behringwerke Ag ONE-COMPONENT TISSUE ADHESIVE AND METHOD FOR THE PRODUCTION THEREOF
ES2064439T3 (en) * 1988-05-02 1995-02-01 Project Hear SURGICAL ADHESIVE MATERIAL.
FR2650508A1 (en) * 1989-08-01 1991-02-08 Fondation Nale Transfusion San PASTEURIZED ADHESIVE FOR JOINING HUMAN OR ANIMAL TISSUES

Also Published As

Publication number Publication date
JPH05194263A (en) 1993-08-03
DE69231791D1 (en) 2001-05-23
SK294292A3 (en) 1994-06-08
WO1993005822A1 (en) 1993-04-01
DE69231791T2 (en) 2001-11-22
FI924306A7 (en) 1993-03-28
CZ280540B6 (en) 1996-02-14
FI924306A0 (en) 1992-09-25
HUT67051A (en) 1995-01-30
BR9203763A (en) 1993-04-20
NO923737D0 (en) 1992-09-25
IL103118A0 (en) 1993-02-21
CA2079077C (en) 1999-11-30
NO923737L (en) 1993-03-29
CZ294292A3 (en) 1994-02-16
ES2155437T3 (en) 2001-05-16
FI924306L (en) 1993-03-28
AU648198B2 (en) 1994-04-14
HU211631A9 (en) 1995-12-28
IL103118A (en) 1996-11-14
HU9203070D0 (en) 1992-12-28
AU2528892A (en) 1993-04-01
JP2668762B2 (en) 1997-10-27
NO316155B1 (en) 2003-12-22
CA2079077A1 (en) 1993-03-28
ZA927360B (en) 1993-05-03

Similar Documents

Publication Publication Date Title
ATE200631T1 (en) IMPROVED TISSUE ADHESIVE PREPARED FROM CRYOPRECIPATE
DE69610712D1 (en) ADHESIVES
ATE187651T1 (en) TWO-COMPONENT FIBRIN ADHESIVE
ATE47963T1 (en) DEBRIDEMENT BAND.
DK0399666T3 (en) Fusion proteins containing N-terminal fragments of human serum albumin
DE68918155D1 (en) Surgical adhesive material.
WO1999015209A3 (en) Fibrin sponge
DE69229272D1 (en) TOPICAL FIBRINOGEN COMPLEX
DE68929484D1 (en) Proteolytic enzymes and their use in detergents
DK0477274T3 (en) Factor Xa based anticoagulation preparations
WO2001004146A3 (en) Ecarin polypeptides, polynucleotides encoding ecarin, and methods for use thereof
DE69025247D1 (en) Proteins with anticoagulant properties
DK0907724T3 (en) Von Willebrand factor multimerase
NO931224D0 (en) PROCEDURE FOR DIVISION OF PROTEINS
ATE151295T1 (en) TWO-COMPONENT FIBRIN ADHESIVE TO IMPROVE IN-VITRO FERTILIZATION
EP0942996B8 (en) Thrombolytic agents with antithrombotic activity
AU2353688A (en) Modified tissue plasminogen activator
ATE119571T1 (en) NEW BLOOD CLOT DISSOLVING PROTEINS AND THEIR PRODUCTION FROM THE LEECH HIRUDO MEDICINALIS.
KR930005636A (en) Improved tissue glue made using cryoprecipitate
IE890270L (en) Proteins derived from human alpha 2 plasmin inhibitor

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification