ATE200671T1 - 2-amino-3-aroyl-benzo beta thiophene und verfahren zu deren herstellung - Google Patents

2-amino-3-aroyl-benzo beta thiophene und verfahren zu deren herstellung

Info

Publication number
ATE200671T1
ATE200671T1 AT95922292T AT95922292T ATE200671T1 AT E200671 T1 ATE200671 T1 AT E200671T1 AT 95922292 T AT95922292 T AT 95922292T AT 95922292 T AT95922292 T AT 95922292T AT E200671 T1 ATE200671 T1 AT E200671T1
Authority
AT
Austria
Prior art keywords
benzo
beta
thiophene
amino
aroyl
Prior art date
Application number
AT95922292T
Other languages
English (en)
Inventor
Alexander Glenn Godfrey
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE200671T1 publication Critical patent/ATE200671T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Child & Adolescent Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Cephalosporin Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Thermal Insulation (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
AT95922292T 1994-06-10 1995-06-07 2-amino-3-aroyl-benzo beta thiophene und verfahren zu deren herstellung ATE200671T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/257,859 US5466810A (en) 1994-06-10 1994-06-10 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
PCT/US1995/007397 WO1995034557A1 (en) 1994-06-10 1995-06-07 2-AMINO-3-AROYL-BENZO[β]THIOPHENES AND METHOD OF MAKING THE SAME

Publications (1)

Publication Number Publication Date
ATE200671T1 true ATE200671T1 (de) 2001-05-15

Family

ID=22978079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95922292T ATE200671T1 (de) 1994-06-10 1995-06-07 2-amino-3-aroyl-benzo beta thiophene und verfahren zu deren herstellung

Country Status (14)

Country Link
US (3) US5466810A (de)
EP (1) EP0765321B1 (de)
JP (1) JPH10502057A (de)
AT (1) ATE200671T1 (de)
AU (1) AU2702995A (de)
BR (1) BR9507956A (de)
CA (1) CA2192097A1 (de)
DE (1) DE69520738T2 (de)
DK (1) DK0765321T3 (de)
ES (1) ES2155891T3 (de)
FI (1) FI964914L (de)
GR (1) GR3036028T3 (de)
PT (1) PT765321E (de)
WO (1) WO1995034557A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
EP0833624B1 (de) 1995-06-07 2007-11-07 Poniard Pharmaceuticals, Inc. Vorbeugung und behandlung von kardiovaskulären beschwerden mit tamoxifen-analogen
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
CA2207141A1 (en) * 1996-07-15 1998-01-15 David Thompson Berg Benzothiophene compounds, and uses and formulations thereof
US5792798A (en) * 1996-07-29 1998-08-11 Eli Lilly And Company Method for inhibiting plasminogen activator inhibitor 1
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
AU6959898A (en) * 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
IL146284A0 (en) 1999-05-04 2002-07-25 Strakan Ltd Androgen glycosides and pharmaceutical compositions containing the same
US6232260B1 (en) 1999-10-14 2001-05-15 Equistar Chemicals, L.P. Single-site catalysts for olefin polymerization
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US7351735B2 (en) * 2002-02-22 2008-04-01 Bayer Pharmaceuticals Corporation Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
US7144885B2 (en) * 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
EP2316468A1 (de) 2002-02-22 2011-05-04 Shire LLC Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
EP2056817A1 (de) * 2006-09-01 2009-05-13 Bayer HealthCare AG Benzofuran und benzothiophen-derivate zur behandlung von krebs im zentralen nervensystem
WO2011109679A2 (en) * 2010-03-05 2011-09-09 Amira Pharmaceuticals, Inc. Inhibitors of 5-lipoxygenase
CN102653520A (zh) * 2012-04-10 2012-09-05 苏州大学 一种2-羟基-2-芳基硫代乙酰胺的制备方法
US11400639B2 (en) * 2016-09-27 2022-08-02 Dsm Ip Assets B.V. Transparent drawn article

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US5420349A (en) * 1994-06-10 1995-05-30 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[β]thiophenes

Also Published As

Publication number Publication date
US5466810A (en) 1995-11-14
FI964914A0 (fi) 1996-12-09
WO1995034557A1 (en) 1995-12-21
DK0765321T3 (da) 2001-05-07
FI964914A7 (fi) 1996-12-09
EP0765321A4 (de) 1997-05-02
EP0765321A1 (de) 1997-04-02
GR3036028T3 (en) 2001-09-28
JPH10502057A (ja) 1998-02-24
DE69520738T2 (de) 2001-09-13
CA2192097A1 (en) 1995-12-21
BR9507956A (pt) 1997-08-12
ES2155891T3 (es) 2001-06-01
PT765321E (pt) 2001-07-31
FI964914L (fi) 1996-12-09
US5554755A (en) 1996-09-10
AU2702995A (en) 1996-01-05
EP0765321B1 (de) 2001-04-18
US5792870A (en) 1998-08-11
DE69520738D1 (de) 2001-05-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee