ATE200986T1 - Material zur vermehrung von weichgewebe - Google Patents

Material zur vermehrung von weichgewebe

Info

Publication number
ATE200986T1
ATE200986T1 AT93904945T AT93904945T ATE200986T1 AT E200986 T1 ATE200986 T1 AT E200986T1 AT 93904945 T AT93904945 T AT 93904945T AT 93904945 T AT93904945 T AT 93904945T AT E200986 T1 ATE200986 T1 AT E200986T1
Authority
AT
Austria
Prior art keywords
augmentation
soft tissue
biocompatible
treatment
site
Prior art date
Application number
AT93904945T
Other languages
English (en)
Inventor
William G Hubbard
Original Assignee
Bioform Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioform Inc filed Critical Bioform Inc
Application granted granted Critical
Publication of ATE200986T1 publication Critical patent/ATE200986T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0004—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse
    • A61F2/0031—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra
    • A61F2/0036—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra implantable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A61L27/105—Ceramics or glasses containing Al2O3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C04B35/636—Polysaccharides or derivatives thereof
    • C04B35/6365—Cellulose or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Organic Chemistry (AREA)
  • Composite Materials (AREA)
  • Urology & Nephrology (AREA)
  • Structural Engineering (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
AT93904945T 1992-02-11 1993-02-05 Material zur vermehrung von weichgewebe ATE200986T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83387492A 1992-02-11 1992-02-11
PCT/US1993/001067 WO1993015721A1 (en) 1992-02-11 1993-02-05 Soft tissue augmentation material

Publications (1)

Publication Number Publication Date
ATE200986T1 true ATE200986T1 (de) 2001-05-15

Family

ID=25265495

Family Applications (4)

Application Number Title Priority Date Filing Date
AT00121050T ATE236672T1 (de) 1992-02-11 1993-02-05 Träger für material zur vermehrung von weichgewebe
AT00121049T ATE236587T1 (de) 1992-02-11 1993-02-05 Verfahren zur herstellung von keramikpartikeln
AT00121048T ATE236586T1 (de) 1992-02-11 1993-02-05 Material zur vermehrung von weichgewebe
AT93904945T ATE200986T1 (de) 1992-02-11 1993-02-05 Material zur vermehrung von weichgewebe

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AT00121050T ATE236672T1 (de) 1992-02-11 1993-02-05 Träger für material zur vermehrung von weichgewebe
AT00121049T ATE236587T1 (de) 1992-02-11 1993-02-05 Verfahren zur herstellung von keramikpartikeln
AT00121048T ATE236586T1 (de) 1992-02-11 1993-02-05 Material zur vermehrung von weichgewebe

Country Status (15)

Country Link
EP (4) EP1080737B1 (de)
JP (1) JP3569525B2 (de)
AT (4) ATE236672T1 (de)
AU (1) AU665812B2 (de)
CA (1) CA2129993C (de)
DE (4) DE69330204T2 (de)
DK (1) DK0631499T3 (de)
ES (4) ES2197046T3 (de)
GR (1) GR3036310T3 (de)
NO (1) NO313736B1 (de)
NZ (2) NZ280026A (de)
PT (1) PT631499E (de)
SG (1) SG47024A1 (de)
WO (1) WO1993015721A1 (de)
ZA (1) ZA93506B (de)

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US7968110B2 (en) 1992-02-11 2011-06-28 Merz Aesthetics, Inc. Tissue augmentation material and method
DE69331096T2 (de) * 1992-02-28 2002-08-14 Cohesion Technologies, Inc. Injektierbare, keramische verbindungen sowie verfahren zur deren herstellung und anwendung
US6335383B1 (en) 1994-10-18 2002-01-01 Ethicon, Inc. Microdispersions for coating surgical devices
US5599852A (en) * 1994-10-18 1997-02-04 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
US5702677A (en) * 1996-07-10 1997-12-30 Osteotech, Inc. Spherical hydroxyapatite particles and process for the production thereof
EP0973562B1 (de) 1997-04-05 2005-10-26 Tyco Healthcare Group LP Implantatmaterial mit glaspartikeln
FR2764514B1 (fr) 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
ATE224213T1 (de) 1997-10-21 2002-10-15 Augmentec Ag Implantat aus resorbierbaren phosphatglas
US6660301B1 (en) * 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
FR2785811B1 (fr) * 1998-11-18 2002-12-06 Procytech Composition comprenant des microparticules poreuses et un agent de suspension et son utilisation en tant qu'implant
US8389017B1 (en) 1999-07-08 2013-03-05 Cap Biotechnology, Inc. Calcium-containing structures and methods of making and using the same
KR20020043557A (ko) * 1999-08-13 2002-06-10 바이오폼 인크. 조직 증대 물질 및 방법
US7338657B2 (en) 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
EP1274472A2 (de) 2000-03-20 2003-01-15 Biosphere Medical, Inc. Injizierbare und schwellfähige mikrokügelchen zur gewebeverstärkung
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
EP1411861B1 (de) 2001-06-29 2012-04-04 Medgraft Microtech, Inc. Biologisch abbaubare injizierbare implantate und verwandte herstellungs- und verwendungsmethoden
EP1416886A4 (de) * 2001-07-16 2007-04-18 Depuy Products Inc Gerüst und verfahren für die knorpelreparatur und regeneration
WO2003007839A2 (en) * 2001-07-16 2003-01-30 Depuy Products, Inc. Devices form naturally occurring biologically derived
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
JP5449638B2 (ja) 2002-07-31 2014-03-19 デンツプライ インターナショナル インコーポレーテッド 多孔性粒子およびキャリアゲルを含む骨修復パテ
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
JP4210231B2 (ja) * 2004-03-25 2009-01-14 株式会社資生堂 皮膚のシワを改善する美容方法及びシワ改善具
DE602005014860D1 (de) * 2004-04-23 2009-07-23 Jacobus Adriaan Albertus Kotze Keramisches bulking-mittel
EP1893174A2 (de) * 2005-05-10 2008-03-05 Cytophil, Inc. Injizierbare hydrogele und verfahren zu deren herstellung und anwendung
US20070184087A1 (en) * 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
KR20090038025A (ko) * 2006-08-02 2009-04-17 코리오닉스 조직 보강 및 반흔 형성에 특히 유용한 이식용 제제
DE102006042142A1 (de) 2006-09-06 2008-03-27 Curasan Ag Phasen- und sedimentationsstabile, plastisch verformbare Zubereitung mit intrinsischer Porenbildung, bspw. zum Auffüllen von Knochendefekten bzw. zur Verwendung als Knochenersatzmaterial, und Verfahren zu deren Herstellung
US20100136117A1 (en) 2006-10-05 2010-06-03 De Groot Klaas Hydroxyapatite tissue filler and its preparation and use
FR2908775B1 (fr) 2006-11-17 2012-08-31 Biomatlante Hydrogel et ses applications biomedicales
AU2011250934B2 (en) 2010-05-11 2016-02-25 Howmedica Osteonics Corp., Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
DE102011015687A1 (de) * 2011-03-31 2012-10-04 Arne Briest Medizinisches Füllmaterial zur Volumenauffüllung von Gewebe und/oder Haut
MY195088A (en) 2014-03-05 2023-01-10 Hempel As Anti-Corrosive Zinc Primer Coating Compositions
DE102016107223B4 (de) * 2016-04-19 2018-05-24 Karl Leibinger Medizintechnik Gmbh & Co. Kg Hybridimplantat aus einem Kompositmaterial
WO2019197608A1 (en) 2018-04-13 2019-10-17 Merz Pharma Gmbh & Co. Kgaa Dermal filler based on crosslinked hyaluronic acid, calcium phosphate material particles and carboxymethyl cellulose, a process for preparing same and uses thereof
US11324512B2 (en) 2018-10-26 2022-05-10 Torax Medical, Inc. Magnetic sphincter augmentation device for urinary incontinence
US11051931B2 (en) 2018-10-31 2021-07-06 Cilag Gmbh International Active sphincter implant to re-route flow through gastrointestinal tract
US11478347B2 (en) 2018-12-17 2022-10-25 Cilag Gmbh International Sphincter sizing instrument
US10842496B2 (en) 2018-12-17 2020-11-24 Ethicon Llc Implantable sphincter assistance device with tuned magnetic features
US11376146B2 (en) 2018-12-17 2022-07-05 Cilag Gmbh International Tissue interface features for implantable sphincter assistance device
US11071619B2 (en) 2018-12-17 2021-07-27 Cilag Gmbh International Coupling assembly for implantable sphincter assistance device
US11399928B2 (en) 2018-12-19 2022-08-02 Cilag Gmbh International Linking elements for implantable sphincter assistance device
US11298136B2 (en) 2018-12-19 2022-04-12 Cilag Gmbh International Implantable sphincter assistance device with deformable elements
NO347849B1 (en) * 2021-09-29 2024-04-22 Watbots As Subsea assembly for adhering to and navigating across a submerged net

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Also Published As

Publication number Publication date
HK1002386A1 (en) 1998-08-21
DE69332873T2 (de) 2004-01-22
DE69332870D1 (de) 2003-05-15
ZA93506B (en) 1994-05-11
ES2197045T3 (es) 2004-01-01
EP0631499A4 (de) 1995-02-15
WO1993015721A1 (en) 1993-08-19
DE69332871D1 (de) 2003-05-15
ATE236587T1 (de) 2003-04-15
EP0631499B1 (de) 2001-05-09
ATE236586T1 (de) 2003-04-15
AU3612593A (en) 1993-09-03
ES2157922T3 (es) 2001-09-01
EP0631499A1 (de) 1995-01-04
EP1080699B1 (de) 2003-04-09
ATE236672T1 (de) 2003-04-15
NZ280026A (en) 2004-11-26
CA2129993C (en) 2008-08-05
DE69332870T2 (de) 2004-02-05
DE69332873D1 (de) 2003-05-15
DE69330204T2 (de) 2001-11-08
GR3036310T3 (en) 2001-10-31
NO942966L (no) 1994-08-10
JPH06506862A (ja) 1994-08-04
JP3569525B2 (ja) 2004-09-22
DE69332871T2 (de) 2004-01-22
NO942966D0 (no) 1994-08-10
NO313736B1 (no) 2002-11-25
CA2129993A1 (en) 1993-08-19
EP1080698A1 (de) 2001-03-07
ES2197047T3 (es) 2004-01-01
SG47024A1 (en) 1998-03-20
EP1080698B1 (de) 2003-04-09
EP1080737B1 (de) 2003-04-09
EP1080737A1 (de) 2001-03-07
AU665812B2 (en) 1996-01-18
DK0631499T3 (da) 2001-07-16
ES2197046T3 (es) 2004-01-01
DE69330204D1 (de) 2001-06-13
PT631499E (pt) 2001-10-31
NZ249381A (en) 1995-12-21
EP1080699A1 (de) 2001-03-07

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