ATE201025T1 - Verfahren zur herstellung von cephalosporinen und zwischenprodukte in diesem verfahren - Google Patents

Verfahren zur herstellung von cephalosporinen und zwischenprodukte in diesem verfahren

Info

Publication number: ATE201025T1
Authority: AT; Austria
Prior art keywords: intermediate products; producing cephalosporins; cephalosporins; producing; vinylcephalosporin
Prior art date: 1991-03-08

Application number

AT92103666T

Other languages

English (en)

Inventor

Gerd Ascher

Johannes Ludescher

Hubert Sturm

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-08

Filing date

1992-03-04

Publication date

2001-05-15

1991-03-08 Priority claimed from AT50491A external-priority patent/AT396106B/de

1991-05-17 Priority claimed from AT101891A external-priority patent/AT396238B/de

1992-03-04 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

2001-05-15 Application granted granted Critical

2001-05-15 Publication of ATE201025T1 publication Critical patent/ATE201025T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
229930186147 Cephalosporin Natural products 0.000 title 1
229940124587 cephalosporin Drugs 0.000 title 1
HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92103666T 1991-03-08 1992-03-04 Verfahren zur herstellung von cephalosporinen und zwischenprodukte in diesem verfahren ATE201025T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT50491A AT396106B (de)	1991-03-08	1991-03-08	Neues verfahren zur herstellung von 3-vinylcephalosporinverbindungen
AT101891A AT396238B (de)	1991-05-17	1991-05-17	Neues verfahren und zwischenprodukte zur herstellung von 3-vinylcephalosporinverbindungen

Publications (1)

Publication Number	Publication Date
ATE201025T1 true ATE201025T1 (de)	2001-05-15

Family

ID=25592974

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92103666T ATE201025T1 (de)	1991-03-08	1992-03-04	Verfahren zur herstellung von cephalosporinen und zwischenprodukte in diesem verfahren

Country Status (9)

Country	Link
US (1)	US5401841A (de)
EP (1)	EP0503453B1 (de)
JP (2)	JP2766116B2 (de)
AT (1)	ATE201025T1 (de)
DE (1)	DE69231815T2 (de)
DK (1)	DK0503453T3 (de)
ES (1)	ES2157199T3 (de)
GR (1)	GR3036070T3 (de)
PT (1)	PT503453E (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6248881B1 (en)	1991-03-08	2001-06-19	Biochemie Gmbh	Intermediates and process for the production of 3-vinyl cephalosporins
AT400436B (de) *	1992-11-10	1995-12-27	Biochemie Gmbh	Neues verfahren zur herstellung von 3-vinylcephalosporinverbindungen
ATE205214T1 (de) *	1992-02-05	2001-09-15	Biochemie Gmbh	Verfahren zur reinigung eines 3-cephem-4-carboxyl säure derivates
AT399876B (de) *	1992-02-05	1995-08-25	Biochemie Gmbh	Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure
JPH07173168A (ja) *	1993-07-14	1995-07-11	Sumitomo Chem Co Ltd	セフェム系化合物、その製法、およびそれのセフェム系抗生物質製造への利用
EP0658558B1 (de)	1993-11-17	2001-01-24	Biochemie Gesellschaft M.B.H.	Trennung von Cephalosporinisomeren
US5856474A (en) *	1994-04-25	1999-01-05	Biochemie Gesellschaft, M.B.H.	Cephalosporin synthesis
AT403049B (de) *	1995-08-14	1997-10-27	Biochemie Gmbh	Abreicherung von 7-adca in 3-vinyl-aca
KR100414336B1 (ko)	1998-06-22	2004-01-07	바실리어 파마슈티카 아게	프로페닐 세팔로스포린 유도체
KR100441901B1 (ko) *	2001-07-02	2004-07-27	일동제약주식회사	세팔로스포린 유도체의 개선된 제조방법
WO2004033464A1 (en) *	2002-10-08	2004-04-22	Ranbaxy Laboratories Limited	Process for the preparation of (z)-isomer enriched 7-amino-3-propen-1-yl-3-cephem-4- carboxylic acid
US7544797B2 (en)	2003-10-30	2009-06-09	Cj Cheiljedang Corporation	Processes for the preparation of cephem derivatives
JP2006096679A (ja) *	2004-09-28	2006-04-13	Meiji Seika Kaisha Ltd	セファロスポリン化合物の製造方法
WO2007013043A2 (en) *	2005-07-29	2007-02-01	Ranbaxy Laboratories Limited	Processes for the preparation of 7-amino-3-vinyl cephalosporanic acid
WO2009049086A1 (en) *	2007-10-09	2009-04-16	Larry Sutton	Broad spectrum beta-lactamase inhibitors
WO2010082108A1 (en) *	2009-01-16	2010-07-22	Nectar Lifesciences Ltd.	Improved process for preparation of key intermediate of cephalosporins
JP6403289B2 (ja)	2013-03-12	2018-10-10	グラディウスファーマシューティカルズコーポレーションＧｌａｄｉｕｓＰｈａｒｍａｃｅｕｔｉｃａｌｓＣｏｒｐｏｒａｔｉｏｎ	誘導体化３−スチリル−セファロスポリン

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4110534A (en) *	1970-01-23	1978-08-29	Glaxo Laboratories Limited	Process for the preparation of 3-vinyl and substituted vinyl cephalosporins
US3769277A (en)	1970-01-23	1973-10-30	Glaxo Lab Ltd	Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
GB1532682A (en)	1976-04-27	1978-11-22	Bristol Myers Co	Process for the preparation of cephadroxil
CA1213882A (en)	1982-03-04	1986-11-12	Jun Okumura	Cephalosporins
GB2152497B (en)	1983-11-28	1987-08-05	Otsuka Kagaku Kk	Process for the preparation of azetidinone derivatives
US4705851A (en)	1984-09-28	1987-11-10	Fujisawa Pharmaceutical Co., Ltd.	Process for the preparation of 3-phosphoniummethyl-3-cephem compounds
AT382873B (de)	1984-11-23	1987-04-27	Biochemie Gmbh	Verfahren zur herstellung von cephalosporinderivaten
US4703118A (en) *	1985-04-08	1987-10-27	Eli Lilly And Company	Synthesis of 3-iodomethyl cephalosporins
FR2580652B1 (fr) *	1985-04-22	1989-01-06	Bristol Myers Co	Acide 7-amino-3-propenylcephalosporanique et ses esters
DE3734004A1 (de)	1987-05-26	1988-12-15	Bayer Ag	Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3933934A1 (de) *	1989-10-03	1991-04-11	Bayer Ag	Verfahren zur herstellung von 7-amino-3-((z)-1-propen-1-yl)-3-cephem-4-carbonsaeure

1992
- 1992-03-04 DE DE69231815T patent/DE69231815T2/de not_active Expired - Fee Related
- 1992-03-04 DK DK92103666T patent/DK0503453T3/da not_active Application Discontinuation
- 1992-03-04 EP EP92103666A patent/EP0503453B1/de not_active Expired - Lifetime
- 1992-03-04 AT AT92103666T patent/ATE201025T1/de not_active IP Right Cessation
- 1992-03-04 ES ES92103666T patent/ES2157199T3/es not_active Expired - Lifetime
- 1992-03-04 PT PT92103666T patent/PT503453E/pt unknown
- 1992-03-06 JP JP4049427A patent/JP2766116B2/ja not_active Expired - Lifetime
1993
- 1993-05-28 US US08/069,239 patent/US5401841A/en not_active Expired - Lifetime
1996
- 1996-04-17 JP JP8095567A patent/JP2740497B2/ja not_active Expired - Lifetime
2001
- 2001-06-19 GR GR20010400913T patent/GR3036070T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH04327590A (ja)	1992-11-17
DE69231815D1 (de)	2001-06-13
ES2157199T3 (es)	2001-08-16
DK0503453T3 (da)	2001-07-16
GR3036070T3 (en)	2001-09-28
JP2740497B2 (ja)	1998-04-15
US5401841A (en)	1995-03-28
JP2766116B2 (ja)	1998-06-18
PT503453E (pt)	2001-10-31
DE69231815T2 (de)	2001-09-27
EP0503453B1 (de)	2001-05-09
JPH08283273A (ja)	1996-10-29
EP0503453A2 (de)	1992-09-16
EP0503453A3 (en)	1992-12-09

Legal Events

Date	Code	Title	Description
2001-11-15	UEP	Publication of translation of european patent specification
2010-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE137493T1 (de)	1996-05-15	Verfahren zur herstellung von zwischenprodukten zur verwendung in der herstellung von alkoxyiminoacetamide
DE69200983D1 (de)	1995-02-09	Verfahren zur Herstellung von Wasserstoffsuperoxyd.
DE69204484D1 (de)	1995-10-12	Verfahren zur Herstellung von Wasserstoffperoxyd.
DE3580803D1 (de)	1991-01-17	Neue zwischenprodukte und verfahren zur herstellung von 3-acylamino-1-hydroxy-2-azetidinonen.
DE69101775D1 (de)	1994-05-26	Verfahren zur Herstellung von Wasserstoffperoxid.
DE69203959D1 (de)	1995-09-14	Verfahren zur Herstellung von Prepregs.
DE69203767D1 (de)	1995-09-07	Verfahren zur Herstellung von organischen Düngemitteln.
DE69409148D1 (de)	1998-04-30	Verfahren zur Herstellung von Wasserstoffperoxid
DE69231815D1 (de)	2001-06-13	Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren
DE69233106D1 (de)	2003-07-31	Verfahren zur Herstellung von Einzelsträndigen "stem-loop" DNS
DE69407653D1 (de)	1998-02-12	Verfahren zur Herstellung von Wasserstoffsuperoxyd
DE69424024D1 (de)	2000-05-25	Verfahren zur Herstellung von Laktamen
ATE154003T1 (de)	1997-06-15	Verfahren zur herstellung von (e)-alkoximino- oder hydroxyiminoacetamidverbindungen und zwischenprodukte
DE69202680D1 (de)	1995-06-29	Verfahren zur Herstellung von Wasserstoffperoxyd.
DE69217346D1 (de)	1997-03-20	Verfahren zur Herstellung von Mikroleuchtkörpern
DE69202419D1 (de)	1995-06-14	Verfahren zur Herstellung von Fulleren.
ATE175957T1 (de)	1999-02-15	Verfahren zur herstellung von alkoxyiminoacetamid-verbindungen
DE69225560D1 (de)	1998-06-25	Verfahren zur Herstellung von Lactonen
DE69103175D1 (de)	1994-09-08	Verfahren zur Herstellung von Terpenketonen.
DE69017510D1 (de)	1995-04-13	Verfahren zur Herstellung von Nylonstapelfasern.
DE69204501D1 (de)	1995-10-12	Verfahren zur Herstellung von Oxamid.
ATE233732T1 (de)	2003-03-15	Verfahren zur herstellung von azetidin-2- carbonsäure und zwischenprodukten davon
DE59201325D1 (de)	1995-03-16	Verbessertes Verfahren zur Herstellung von Polyenen.
DE69317237D1 (de)	1998-04-09	Verfahren zur Herstellung von abriebfesten, transparenten Teilen
ATE233267T1 (de)	2003-03-15	Verfahren zur herstellung von 3- vinylcephalosporinen