ATE201204T1 - Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel - Google Patents
Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittelInfo
- Publication number
- ATE201204T1 ATE201204T1 AT97917549T AT97917549T ATE201204T1 AT E201204 T1 ATE201204 T1 AT E201204T1 AT 97917549 T AT97917549 T AT 97917549T AT 97917549 T AT97917549 T AT 97917549T AT E201204 T1 ATE201204 T1 AT E201204T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- thiazolidine
- derivatives
- cytoprotective agents
- carbonic acid
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 230000001120 cytoprotective effect Effects 0.000 title abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000007760 free radical scavenging Effects 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical compound OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Detergent Compositions (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cigarettes, Filters, And Manufacturing Of Filters (AREA)
- Stringed Musical Instruments (AREA)
- Packages (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1402796P | 1996-03-25 | 1996-03-25 | |
| PCT/US1997/004387 WO1997035852A1 (en) | 1996-03-25 | 1997-03-19 | Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE201204T1 true ATE201204T1 (de) | 2001-06-15 |
Family
ID=21763110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97917549T ATE201204T1 (de) | 1996-03-25 | 1997-03-19 | Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5846988A (de) |
| EP (1) | EP0842165B1 (de) |
| JP (1) | JPH11507081A (de) |
| AT (1) | ATE201204T1 (de) |
| CA (1) | CA2220024C (de) |
| DE (1) | DE69704833T2 (de) |
| DK (1) | DK0842165T3 (de) |
| ES (1) | ES2156633T3 (de) |
| GR (1) | GR3036142T3 (de) |
| PT (1) | PT842165E (de) |
| WO (1) | WO1997035852A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6413999B1 (en) | 1999-08-17 | 2002-07-02 | University Of Saskatchewan Technologies Inc. | Treatment for acute physical insult to the central nervous system |
| US20060189497A1 (en) * | 2002-07-30 | 2006-08-24 | Earl Jenevein | Wood preservative |
| US6511950B1 (en) * | 2002-07-30 | 2003-01-28 | Earl Jenevein | Cleaning composition comprising a salt, chelant, and polyvinyl alcohol |
| US7045492B2 (en) * | 2002-07-30 | 2006-05-16 | Earl Jenevein | Cleaning composition comprising cationic surfactants, chelant, and an alcohol solvent mixture |
| CA2580584C (en) | 2003-09-19 | 2015-07-28 | Galileo Pharmaceuticals, Inc. | Use of alpha-tocotrienol for treatment of mitochondrial diseases |
| CN101120002A (zh) | 2005-02-17 | 2008-02-06 | 惠氏公司 | 环烷基稠合的吲哚、苯并噻吩、苯并呋喃和茚衍生物 |
| CA2610152C (en) * | 2005-06-01 | 2018-04-10 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| ES2823728T3 (es) * | 2005-09-15 | 2021-05-10 | Ptc Therapeutics Inc | Variantes de cola de agentes terapéuticos con actividad redox para el tratamiento de enfermedades mitocondriales y otras afecciones y la modulación de biomarcadores de energía |
| EA019675B1 (ru) | 2006-02-22 | 2014-05-30 | Эдисон Фармасьютикалз, Инк. | Редокс-активные терапевтические средства для лечения митохондриальных заболеваний и модуляции биомаркера коэнзима q |
| US20080188573A1 (en) * | 2007-02-02 | 2008-08-07 | Alcon Research, Ltd. | Use of thy1-fp transgenic mouse for the identification of ophthalmic agents |
| US8685951B2 (en) * | 2007-03-27 | 2014-04-01 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods for cytoprotection |
| BRPI0918139B1 (pt) | 2008-09-10 | 2024-04-30 | Ptc Therapeutics, Inc | Composição, alimento medicinal ou funcional, suplemento alimentar ou dietético para tratamento de distúrbios de desenvolvimento pervasivos com terapêuticos redox-ativos |
| KR101395146B1 (ko) | 2011-02-09 | 2014-05-16 | 부산대학교 산학협력단 | 피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도 |
| CN113024369A (zh) | 2015-12-17 | 2021-06-25 | Ptc医疗公司 | 用于治疗氧化应急障碍的化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3002989A1 (de) * | 1980-01-29 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
| US4550022A (en) * | 1981-10-05 | 1985-10-29 | Alcon Laboratories, Inc. | Tissue irrigating solution |
| FR2547729B1 (fr) * | 1983-06-24 | 1986-05-02 | Riker Laboratories Inc | Medicament a base d'acide dl thiazolidine carboxylique |
| FR2547728B1 (fr) * | 1983-06-24 | 1986-05-02 | Riker Laboratories Inc | Medicament a base d'acide d thiazolidine carboxylique |
| US4868114A (en) * | 1987-08-05 | 1989-09-19 | Regents Of The University Of Minnesota | Method for elevating glutathione levels |
| IT1223565B (it) * | 1987-12-21 | 1990-09-19 | Zambon Spa | Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica |
| DE68921436T2 (de) * | 1988-12-09 | 1995-08-10 | Allergan Inc | Verwendung von 2-substituierten Thiazolidin-4-carbonsäuren zur Behandlung von Katarakt. |
| US5589464A (en) * | 1992-09-01 | 1996-12-31 | Allergan | Use of 2-substituted-thiazolidine-4-carboxylic acids for treatment of cataract |
| US5424321A (en) * | 1993-12-08 | 1995-06-13 | Alcon Laboratories, Inc. | Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents |
| PT682664E (pt) * | 1993-12-08 | 2001-06-29 | Alcon Laboratoires Inc | Compostos possuindo actividade potente como antagonistas do calcio e anti-oxidantes e sua utilizacao como agentes citoprotectores |
-
1997
- 1997-03-19 WO PCT/US1997/004387 patent/WO1997035852A1/en not_active Ceased
- 1997-03-19 CA CA002220024A patent/CA2220024C/en not_active Expired - Fee Related
- 1997-03-19 PT PT97917549T patent/PT842165E/pt unknown
- 1997-03-19 ES ES97917549T patent/ES2156633T3/es not_active Expired - Lifetime
- 1997-03-19 JP JP9534485A patent/JPH11507081A/ja not_active Withdrawn
- 1997-03-19 DE DE69704833T patent/DE69704833T2/de not_active Expired - Fee Related
- 1997-03-19 DK DK97917549T patent/DK0842165T3/da active
- 1997-03-19 US US08/945,132 patent/US5846988A/en not_active Expired - Fee Related
- 1997-03-19 EP EP97917549A patent/EP0842165B1/de not_active Expired - Lifetime
- 1997-03-19 AT AT97917549T patent/ATE201204T1/de not_active IP Right Cessation
-
2001
- 2001-06-27 GR GR20010400996T patent/GR3036142T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU713581B2 (en) | 1999-12-02 |
| AU2584097A (en) | 1997-10-17 |
| CA2220024A1 (en) | 1997-10-02 |
| GR3036142T3 (en) | 2001-09-28 |
| WO1997035852A1 (en) | 1997-10-02 |
| DK0842165T3 (da) | 2001-08-06 |
| CA2220024C (en) | 2002-06-25 |
| JPH11507081A (ja) | 1999-06-22 |
| DE69704833T2 (de) | 2001-09-13 |
| PT842165E (pt) | 2001-08-30 |
| DE69704833D1 (en) | 2001-06-21 |
| EP0842165A1 (de) | 1998-05-20 |
| ES2156633T3 (es) | 2001-07-01 |
| EP0842165B1 (de) | 2001-05-16 |
| US5846988A (en) | 1998-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |