ATE201204T1 - Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel - Google Patents
Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittelInfo
- Publication number
- ATE201204T1 ATE201204T1 AT97917549T AT97917549T ATE201204T1 AT E201204 T1 ATE201204 T1 AT E201204T1 AT 97917549 T AT97917549 T AT 97917549T AT 97917549 T AT97917549 T AT 97917549T AT E201204 T1 ATE201204 T1 AT E201204T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- thiazolidine
- derivatives
- cytoprotective agents
- carbonic acid
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 230000001120 cytoprotective effect Effects 0.000 title abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000007760 free radical scavenging Effects 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical compound OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Stringed Musical Instruments (AREA)
- Packages (AREA)
- Cigarettes, Filters, And Manufacturing Of Filters (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1402796P | 1996-03-25 | 1996-03-25 | |
| PCT/US1997/004387 WO1997035852A1 (en) | 1996-03-25 | 1997-03-19 | Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE201204T1 true ATE201204T1 (de) | 2001-06-15 |
Family
ID=21763110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97917549T ATE201204T1 (de) | 1996-03-25 | 1997-03-19 | Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5846988A (de) |
| EP (1) | EP0842165B1 (de) |
| JP (1) | JPH11507081A (de) |
| AT (1) | ATE201204T1 (de) |
| CA (1) | CA2220024C (de) |
| DE (1) | DE69704833T2 (de) |
| DK (1) | DK0842165T3 (de) |
| ES (1) | ES2156633T3 (de) |
| GR (1) | GR3036142T3 (de) |
| PT (1) | PT842165E (de) |
| WO (1) | WO1997035852A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001012166A2 (en) | 1999-08-17 | 2001-02-22 | University Of Saskatchewan Technologies Inc. | Improved treatment for acute physical insult to the central nervous system |
| US20060189497A1 (en) * | 2002-07-30 | 2006-08-24 | Earl Jenevein | Wood preservative |
| US6511950B1 (en) * | 2002-07-30 | 2003-01-28 | Earl Jenevein | Cleaning composition comprising a salt, chelant, and polyvinyl alcohol |
| US7045492B2 (en) * | 2002-07-30 | 2006-05-16 | Earl Jenevein | Cleaning composition comprising cationic surfactants, chelant, and an alcohol solvent mixture |
| CA2583084C (en) | 2003-09-19 | 2010-12-07 | Galileo Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
| CA2597616A1 (en) | 2005-02-17 | 2006-08-24 | Wyeth | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
| EP1888059B1 (de) * | 2005-06-01 | 2014-12-17 | Edison Pharmaceuticals, Inc. | Redoxaktive therapeutik zur behandlung von mitochondrialen erkrankungen und anderen zuständen sowie modulation von energie-biomarkern |
| PL1933821T3 (pl) * | 2005-09-15 | 2021-01-11 | Ptc Therapeutics, Inc. | Warianty łańcucha końcowego środków terapeutycznych o aktywności redoks do leczenia chorób mitochondrialnych i innych stanów oraz do modulacji biomarkerów energetycznych |
| JP5374162B2 (ja) | 2006-02-22 | 2013-12-25 | エジソン ファーマシューティカルズ， インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
| US20080188573A1 (en) * | 2007-02-02 | 2008-08-07 | Alcon Research, Ltd. | Use of thy1-fp transgenic mouse for the identification of ophthalmic agents |
| US8685951B2 (en) | 2007-03-27 | 2014-04-01 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods for cytoprotection |
| LT3827815T (lt) | 2008-09-10 | 2023-10-10 | Ptc Therapeutics, Inc. | Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais |
| KR101395146B1 (ko) | 2011-02-09 | 2014-05-16 | 부산대학교 산학협력단 | 피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도 |
| JP6905527B2 (ja) | 2015-12-17 | 2021-07-21 | ピーティーシー セラピューティクス， インコーポレイテッド | 酸化ストレス障害を処置するためのフルオロアルキル、フルオロアルコキシ、フェノキシ、ヘテロアリールオキシ、アルコキシ、およびアミノ１，４−ベンゾキノン誘導体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3002989A1 (de) * | 1980-01-29 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
| US4550022A (en) * | 1981-10-05 | 1985-10-29 | Alcon Laboratories, Inc. | Tissue irrigating solution |
| FR2547729B1 (fr) * | 1983-06-24 | 1986-05-02 | Riker Laboratories Inc | Medicament a base d'acide dl thiazolidine carboxylique |
| FR2547728B1 (fr) * | 1983-06-24 | 1986-05-02 | Riker Laboratories Inc | Medicament a base d'acide d thiazolidine carboxylique |
| US4868114A (en) * | 1987-08-05 | 1989-09-19 | Regents Of The University Of Minnesota | Method for elevating glutathione levels |
| IT1223565B (it) * | 1987-12-21 | 1990-09-19 | Zambon Spa | Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica |
| EP0373002B1 (de) * | 1988-12-09 | 1995-03-01 | Allergan, Inc | Verwendung von 2-substituierten Thiazolidin-4-carbonsäuren zur Behandlung von Katarakt |
| US5589464A (en) * | 1992-09-01 | 1996-12-31 | Allergan | Use of 2-substituted-thiazolidine-4-carboxylic acids for treatment of cataract |
| PT682664E (pt) * | 1993-12-08 | 2001-06-29 | Alcon Laboratoires Inc | Compostos possuindo actividade potente como antagonistas do calcio e anti-oxidantes e sua utilizacao como agentes citoprotectores |
| US5424321A (en) * | 1993-12-08 | 1995-06-13 | Alcon Laboratories, Inc. | Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents |
-
1997
- 1997-03-19 CA CA002220024A patent/CA2220024C/en not_active Expired - Fee Related
- 1997-03-19 AT AT97917549T patent/ATE201204T1/de not_active IP Right Cessation
- 1997-03-19 US US08/945,132 patent/US5846988A/en not_active Expired - Fee Related
- 1997-03-19 WO PCT/US1997/004387 patent/WO1997035852A1/en not_active Ceased
- 1997-03-19 JP JP9534485A patent/JPH11507081A/ja not_active Withdrawn
- 1997-03-19 EP EP97917549A patent/EP0842165B1/de not_active Expired - Lifetime
- 1997-03-19 ES ES97917549T patent/ES2156633T3/es not_active Expired - Lifetime
- 1997-03-19 PT PT97917549T patent/PT842165E/pt unknown
- 1997-03-19 DK DK97917549T patent/DK0842165T3/da active
- 1997-03-19 DE DE69704833T patent/DE69704833T2/de not_active Expired - Fee Related
-
2001
- 2001-06-27 GR GR20010400996T patent/GR3036142T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69704833D1 (en) | 2001-06-21 |
| CA2220024C (en) | 2002-06-25 |
| US5846988A (en) | 1998-12-08 |
| CA2220024A1 (en) | 1997-10-02 |
| JPH11507081A (ja) | 1999-06-22 |
| DK0842165T3 (da) | 2001-08-06 |
| AU2584097A (en) | 1997-10-17 |
| WO1997035852A1 (en) | 1997-10-02 |
| DE69704833T2 (de) | 2001-09-13 |
| PT842165E (pt) | 2001-08-30 |
| EP0842165A1 (de) | 1998-05-20 |
| AU713581B2 (en) | 1999-12-02 |
| EP0842165B1 (de) | 2001-05-16 |
| GR3036142T3 (en) | 2001-09-28 |
| ES2156633T3 (es) | 2001-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |