ATE201677T1 - 4-imidomethyl-1-(2'-phenyl-2-oxoethyl)-piperidi e als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung - Google Patents

4-imidomethyl-1-(2'-phenyl-2-oxoethyl)-piperidi e als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung

Info

Publication number
ATE201677T1
ATE201677T1 AT93908559T AT93908559T ATE201677T1 AT E201677 T1 ATE201677 T1 AT E201677T1 AT 93908559 T AT93908559 T AT 93908559T AT 93908559 T AT93908559 T AT 93908559T AT E201677 T1 ATE201677 T1 AT E201677T1
Authority
AT
Austria
Prior art keywords
serotonin
antagonists
imidomethyl
piperidi
oxoethyl
Prior art date
Application number
AT93908559T
Other languages
English (en)
Inventor
Thaddeus R Nieduzak
Mark W Dudley
John H Kehne
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE201677T1 publication Critical patent/ATE201677T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT93908559T 1992-04-23 1993-03-24 4-imidomethyl-1-(2'-phenyl-2-oxoethyl)-piperidi e als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung ATE201677T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87256692A 1992-04-23 1992-04-23
US2250293A 1993-03-10 1993-03-10
PCT/US1993/002771 WO1993022309A1 (en) 1992-04-23 1993-03-24 4-imidomethyl-1-[2'phenyl-2'oxoethyl-] piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy

Publications (1)

Publication Number Publication Date
ATE201677T1 true ATE201677T1 (de) 2001-06-15

Family

ID=26695998

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93908559T ATE201677T1 (de) 1992-04-23 1993-03-24 4-imidomethyl-1-(2'-phenyl-2-oxoethyl)-piperidi e als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung

Country Status (15)

Country Link
US (3) US20020002174A1 (de)
EP (1) EP0637306B1 (de)
JP (1) JP3333878B2 (de)
KR (1) KR100259107B1 (de)
AT (1) ATE201677T1 (de)
AU (1) AU671274B2 (de)
CA (1) CA2134077C (de)
DE (1) DE69330272T2 (de)
DK (1) DK0637306T3 (de)
ES (1) ES2158861T3 (de)
GR (1) GR3036458T3 (de)
MX (1) MX9302378A (de)
NZ (1) NZ251610A (de)
PT (1) PT637306E (de)
WO (1) WO1993022309A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0881220A4 (de) * 1996-02-15 1999-04-21 Mitsubishi Chem Corp Diarylsultam-derivate
GB0004549D0 (en) * 2000-02-25 2000-04-19 Isis Innovation Degradation fragments
EA011211B1 (ru) 2003-11-20 2009-02-27 Янссен Фармацевтика Н. В. 7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы
AU2004295058B9 (en) 2003-11-20 2011-06-30 Janssen Pharmaceutica N.V. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
EP1709012B1 (de) * 2003-12-05 2015-07-29 Janssen Pharmaceutica NV 6-substituierte 2-chinolinone und 2-chinoxalinone als inhibitoren von poly(adp-ribose)polymerase
SG154432A1 (en) * 2004-06-30 2009-08-28 Janssen Pharmaceutica Nv Quinazolinedione derivatives as parp inhibitors
WO2006003150A1 (en) 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Substituted 2-alkyl quinazolinone derivatives as parp inhibitors
JP4852540B2 (ja) 2004-06-30 2012-01-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐ阻害剤としてのフタラジン誘導体
HRP20120346T1 (hr) 2007-03-08 2012-05-31 Janssen Pharmaceutica N.V. Derivati kinolinona kao parp i tank inhibitori
PL2215075T3 (pl) 2007-10-26 2014-04-30 Janssen Pharmaceutica Nv Pochodne chinolinonu jako inhibitory PARP
JP5492183B2 (ja) 2008-03-27 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびチューブリン重合阻害剤としてのテトラヒドロフェナントリジノンおよびテトラヒドロシクロペンタキノリノン
AU2009228945B2 (en) 2008-03-27 2013-05-02 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
WO2012012543A1 (en) * 2010-07-20 2012-01-26 Cyrenaic Pharmaceuticals Inc. Methods of use cyclic amide derivatives to treat sigma receptor-mediated disorders
US10179776B2 (en) 2014-06-09 2019-01-15 Intra-Cellular Therapies, Inc. Compounds and methods of use to treat schizophrenia
CA3067031A1 (en) 2017-06-21 2018-12-27 Minerva Neurosciences, Inc. Gastro-resistant controlled release oral dosage forms
CN117820199A (zh) * 2022-09-28 2024-04-05 瀚远医药有限公司 一种酰胺类化合物及其制备Sigma2和5HT2A抑制剂的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU593194B2 (en) * 1986-09-26 1990-02-01 Sumitomo Pharmaceuticals Company, Limited Imide derivatives ,and their production and use
FR2643373B1 (fr) * 1989-01-10 1993-12-31 Adir Cie Nouveaux derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
KR927002347A (ko) * 1989-10-27 1992-09-03 레이몬드 지. 아너 (n-프탈이미도알킬) 피페리딘
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
PT509398E (pt) * 1991-04-15 2002-02-28 Aventis Pharma Gmbh Quinoxalinas processo para a sua preparacao e sua utilizacao
US5231099A (en) * 1991-04-15 1993-07-27 Du Pont Merck Pharmaceutical Company Use of sigma receptor antagonists to enhance the effects of antipsychotic drugs

Also Published As

Publication number Publication date
KR950701332A (ko) 1995-03-23
CA2134077C (en) 2002-05-21
PT637306E (pt) 2001-10-30
EP0637306B1 (de) 2001-05-30
JPH07506107A (ja) 1995-07-06
NZ251610A (en) 1996-02-27
US20030083325A1 (en) 2003-05-01
EP0637306A1 (de) 1995-02-08
CA2134077A1 (en) 1993-11-11
DK0637306T3 (da) 2001-07-30
GR3036458T3 (en) 2001-11-30
ES2158861T3 (es) 2001-09-16
AU3934193A (en) 1993-11-29
DE69330272D1 (de) 2001-07-05
DE69330272T2 (de) 2001-10-25
AU671274B2 (en) 1996-08-22
US20030212141A1 (en) 2003-11-13
KR100259107B1 (ko) 2000-07-01
JP3333878B2 (ja) 2002-10-15
MX9302378A (es) 1994-05-31
WO1993022309A1 (en) 1993-11-11
US20020002174A1 (en) 2002-01-03

Similar Documents

Publication Publication Date Title
DE69330272D1 (de) 4-imidomethyl-1-[2'-phenyl-2-oxoethyl]-piperidine als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung
NO924619D0 (no) (+)-alfa-(2,3-dimetoksyfenyl)-1-(2-(4-fluorfenyl)ethyl)-4-piperidinmetanol
FI933946A7 (fi) Hypoglykeemisinä aineina ja Alzheimerin taudin hoidossa käyttökelpoisia yhdisteitä
ATE150015T1 (de) Substituierte tetrahydroisochinolin-derivate und ihre anwendung in der therapie
DE3684190D1 (de) Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
SE9604786D0 (sv) New compounds
DE69721766D1 (de) Neue arzneiformulierung
NO914300L (no) Fremgangsmaate for fremstilling av 3-amidoindolderivater
CA2129995A1 (en) Piperidinyl thiacyclic derivatives
ATE188965T1 (de) Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln
ATE208620T1 (de) Kombinationspräparat zur anwendung bei immunologischen erkrankungen
SE9502893L (sv) Användning av kollagenas
DE69420251D1 (de) Löslicher Interferon-Rezeptor, seine Herstellung und Anwendung
DE3875866D1 (de) Sulfonamidolphenyl-derivate und diese enthaltende therapeutische und vorbeugend wirkende mittel gegen arrhythmie.
EE200200337A (et) Uued ühendid ning nende kasutamine
DE69808921D1 (de) 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOL-1-ACETAMID-DERIVATE, IHRE HERSTELLUNG UND THERAPEUTISCHE ANWENDUNG
LV11940A (lv) Melatonina pielietojums personu arstesanai kuras cies no zalu atkaribas
DE69120933D1 (de) Topische Anwendung von Glycosaminoglykane zur Prävention und Behandlung der Zervikal- oder Vaginalerkrankungen
MD1140B1 (en) Remedy possessing a regenerative and cytoprotective activity
ATE205841T1 (de) Derivate von 5-naphthalin-1-yl-1,3-dioxanen, ihre herstellung und therapeutische anwendung
DE69424415D1 (de) Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung parkinsonscher krankheit
RU94024337A (ru) Антиметастатическое средство
ATE230608T1 (de) Verwendung von bradykinin-antagonisten zur herstellung von arzneimitteln zur behandlung und prävention der alzheimer'schen krankheit
RU92007680A (ru) Средство, обладающее тонизирующим действием на гладкую мускулатуру вен, мочевого пузыря и предстательной железы
ATE221528T1 (de) Neue 1,4-dihydropyridinderivate und deren therapeutische anwendung

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee