ATE201677T1 - 4-imidomethyl-1-(2'-phenyl-2-oxoethyl)-piperidi e als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung - Google Patents

4-imidomethyl-1-(2'-phenyl-2-oxoethyl)-piperidi e als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung

Info

Publication number
ATE201677T1
ATE201677T1 AT93908559T AT93908559T ATE201677T1 AT E201677 T1 ATE201677 T1 AT E201677T1 AT 93908559 T AT93908559 T AT 93908559T AT 93908559 T AT93908559 T AT 93908559T AT E201677 T1 ATE201677 T1 AT E201677T1
Authority
AT
Austria
Prior art keywords
serotonin
antagonists
imidomethyl
piperidi
oxoethyl
Prior art date
Application number
AT93908559T
Other languages
English (en)
Inventor
Thaddeus R Nieduzak
Mark W Dudley
John H Kehne
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE201677T1 publication Critical patent/ATE201677T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT93908559T 1992-04-23 1993-03-24 4-imidomethyl-1-(2'-phenyl-2-oxoethyl)-piperidi e als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung ATE201677T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87256692A 1992-04-23 1992-04-23
US2250293A 1993-03-10 1993-03-10
PCT/US1993/002771 WO1993022309A1 (en) 1992-04-23 1993-03-24 4-imidomethyl-1-[2'phenyl-2'oxoethyl-] piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy

Publications (1)

Publication Number Publication Date
ATE201677T1 true ATE201677T1 (de) 2001-06-15

Family

ID=26695998

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93908559T ATE201677T1 (de) 1992-04-23 1993-03-24 4-imidomethyl-1-(2'-phenyl-2-oxoethyl)-piperidi e als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung

Country Status (15)

Country Link
US (3) US20020002174A1 (de)
EP (1) EP0637306B1 (de)
JP (1) JP3333878B2 (de)
KR (1) KR100259107B1 (de)
AT (1) ATE201677T1 (de)
AU (1) AU671274B2 (de)
CA (1) CA2134077C (de)
DE (1) DE69330272T2 (de)
DK (1) DK0637306T3 (de)
ES (1) ES2158861T3 (de)
GR (1) GR3036458T3 (de)
MX (1) MX9302378A (de)
NZ (1) NZ251610A (de)
PT (1) PT637306E (de)
WO (1) WO1993022309A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030038A1 (en) * 1996-02-15 1997-08-21 Mitsubishi Chemical Corporation Diarylsultam derivatives
GB0004549D0 (en) 2000-02-25 2000-04-19 Isis Innovation Degradation fragments
CA2546002C (en) 2003-11-20 2012-09-18 Janssen Pharmaceutica N.V. 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
BRPI0416206A (pt) 2003-11-20 2006-12-26 Janssen Pharmaceutica Nv 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose)
SG151249A1 (en) * 2003-12-05 2009-04-30 Janssen Pharmaceutica Nv 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
SG154433A1 (en) 2004-06-30 2009-08-28 Janssen Pharmaceutica Nv Phthalazine derivatives as parp inhibitors
EA011552B1 (ru) * 2004-06-30 2009-04-28 Янссен Фармацевтика Н.В. Производные хиназолиндиона в качестве ингибиторов parp
ATE540936T1 (de) 2004-06-30 2012-01-15 Janssen Pharmaceutica Nv Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
CN101981013B (zh) 2008-03-27 2013-05-29 詹森药业有限公司 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮
ES2367760T3 (es) 2008-03-27 2011-11-08 Janssen Pharmaceutica, N.V. Derivados de quinazolinona como inhibidores de la polimerización de la tubulina.
TWI520949B (zh) * 2010-07-20 2016-02-11 錫蘭尼克藥物有限公司 使用環醯胺衍生物治療σ受體介導之病症的方法
WO2015191554A1 (en) * 2014-06-09 2015-12-17 Intra-Cellular Therapies, Inc. Compounds and methods of use to treat schizophrenia
IL319156A (en) 2017-06-21 2025-04-01 Minerva Neurosciences Inc Controlled-release oral dosage forms are resistant to gastric acid.
CN117820199A (zh) * 2022-09-28 2024-04-05 瀚远医药有限公司 一种酰胺类化合物及其制备Sigma2和5HT2A抑制剂的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
FR2643373B1 (fr) * 1989-01-10 1993-12-31 Adir Cie Nouveaux derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
ZA908641B (en) * 1989-10-27 1992-06-24 Du Pont (n-phthalimidoalkyl)piperidines
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
ATE205837T1 (de) * 1991-04-15 2001-10-15 Aventis Pharma Gmbh Chinoxaline, verfahren zu ihrer herstellung und ihre verwendung
US5231099A (en) * 1991-04-15 1993-07-27 Du Pont Merck Pharmaceutical Company Use of sigma receptor antagonists to enhance the effects of antipsychotic drugs

Also Published As

Publication number Publication date
US20020002174A1 (en) 2002-01-03
WO1993022309A1 (en) 1993-11-11
JPH07506107A (ja) 1995-07-06
NZ251610A (en) 1996-02-27
AU671274B2 (en) 1996-08-22
US20030212141A1 (en) 2003-11-13
ES2158861T3 (es) 2001-09-16
EP0637306A1 (de) 1995-02-08
KR950701332A (ko) 1995-03-23
CA2134077A1 (en) 1993-11-11
MX9302378A (es) 1994-05-31
CA2134077C (en) 2002-05-21
AU3934193A (en) 1993-11-29
US20030083325A1 (en) 2003-05-01
DK0637306T3 (da) 2001-07-30
GR3036458T3 (en) 2001-11-30
KR100259107B1 (ko) 2000-07-01
DE69330272D1 (de) 2001-07-05
PT637306E (pt) 2001-10-30
JP3333878B2 (ja) 2002-10-15
EP0637306B1 (de) 2001-05-30
DE69330272T2 (de) 2001-10-25

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