ATE202337T1 - Cyclopropylalkansäurederivate - Google Patents
CyclopropylalkansäurederivateInfo
- Publication number
- ATE202337T1 ATE202337T1 AT97915937T AT97915937T ATE202337T1 AT E202337 T1 ATE202337 T1 AT E202337T1 AT 97915937 T AT97915937 T AT 97915937T AT 97915937 T AT97915937 T AT 97915937T AT E202337 T1 ATE202337 T1 AT E202337T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopropylalkanic
- acid derivatives
- formula
- compounds
- antagonizing
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000008607 Integrin beta3 Human genes 0.000 abstract 1
- 108010020950 Integrin beta3 Proteins 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1441196P | 1996-03-29 | 1996-03-29 | |
| PCT/US1997/003987 WO1997036858A1 (en) | 1996-03-29 | 1997-03-20 | Cyclopropyl alkanoic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE202337T1 true ATE202337T1 (de) | 2001-07-15 |
Family
ID=21765323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97915937T ATE202337T1 (de) | 1996-03-29 | 1997-03-20 | Cyclopropylalkansäurederivate |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5773644A (de) |
| EP (1) | EP0889875B1 (de) |
| JP (1) | JP2000507575A (de) |
| AT (1) | ATE202337T1 (de) |
| AU (1) | AU2323897A (de) |
| CA (1) | CA2250695A1 (de) |
| DE (1) | DE69705300T2 (de) |
| DK (1) | DK0889875T3 (de) |
| ES (1) | ES2158537T3 (de) |
| GR (1) | GR3036253T3 (de) |
| PT (1) | PT889875E (de) |
| WO (1) | WO1997036858A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| CA2327673C (en) | 1998-04-09 | 2009-08-25 | Meiji Seika Kaisha, Ltd. | Aminopiperidine derivatives as integrin .alpha.v.beta.3 antagonists |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| AU3449899A (en) * | 1998-08-13 | 2000-03-06 | G.D. Searle & Co. | Multivalent avb3 and Metastasis-Associated Receptor Ligands |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| CZ20012321A3 (cs) | 1998-12-23 | 2002-10-16 | G. D. Searle & Co. | Léčivo s obsahem inhibitoru cyklooxygenázy-2 a inhibitoru matricové metaloproteinázy pro kombinační terapii při léčení neoplasie |
| US6291503B1 (en) | 1999-01-15 | 2001-09-18 | Bayer Aktiengesellschaft | β-phenylalanine derivatives as integrin antagonists |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| WO2001010844A1 (fr) | 1999-08-05 | 2001-02-15 | Meiji Seika Kaisha, Ltd. | DERIVES D'ACIDE φ-AMINO-α-HYDROXYCARBOXYLIQUE POSSEDANT UN ANTAGONISME αvβ3 D'INTEGRINE |
| DE19940389A1 (de) * | 1999-08-25 | 2001-03-01 | Wilex Biotechnology Gmbh | Selektive Inhibitoren des Urokinase-Plasminogen Aktivators |
| US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| WO2001054726A1 (en) * | 2000-01-25 | 2001-08-02 | Meiji Seika Kaisha, Ltd. | REMEDIES FOR REPERFUSION INJURY CONTAINING INTEGRIN αvβ3 ANTAGONIST |
| US20040018192A1 (en) | 2000-02-03 | 2004-01-29 | Toshiaki Wakabayashi | Integrin expression inhibitors |
| WO2001079173A2 (en) | 2000-04-17 | 2001-10-25 | Celltech R & D Limited | Enamine derivatives as cell adhesion molecules |
| US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
| US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
| PE20020665A1 (es) * | 2000-06-15 | 2002-08-14 | Pharmacia Corp | ACIDO CICLOALQUIL FENIL ALCANOICO COMO ANTAGONISTA DE INTEGRINAS OVß3 |
| EP1294685A1 (de) * | 2000-06-29 | 2003-03-26 | Abbott Laboratories | Arylphenycyclopropyl-sulfid-derivate und ihre anwendung als zelladhäsionshemmende entzündungshemmende und immunosuppressive mittel |
| EP1301488A1 (de) | 2000-07-07 | 2003-04-16 | Celltech R&D Limited | Bicyclische heteroaromatische ring enthaltende quadratsäure-derivate als integrin-antagonisten |
| EP1305291A1 (de) | 2000-08-02 | 2003-05-02 | Celltech R&D Limited | 3-substituierte isochinolin-1-yl-derivate |
| US20040043988A1 (en) * | 2001-06-15 | 2004-03-04 | Khanna Ish Kurmar | Cycloalkyl alkanoic acids as intergrin receptor antagonists |
| JP4750360B2 (ja) | 2001-10-22 | 2011-08-17 | ザ スクリプス リサーチ インスティチュート | 抗体ターゲッティング化合物 |
| WO2003075957A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
| CA2478317A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | Methods of preventing or treating disorders by administering an integrin .alpha.v.beta.3 antagonist in combination with an hmg-coa reductase inhibitor or a bisphosphonate |
| JP2006516635A (ja) * | 2003-01-30 | 2006-07-06 | メディミューン，インコーポレーテッド | インテグリンαｖβ３アンタゴニストの使用 |
| WO2005051890A1 (en) * | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| EP1945262A2 (de) * | 2005-10-20 | 2008-07-23 | The Scripps Research Institute | Fc-etikettierung für immunostaining und immunotargeting |
| BRPI0821090B8 (pt) | 2007-12-21 | 2021-05-25 | Ligand Pharm Inc | moduladores seletivos de receptores de androgênio (sarms) e uso do mesmo |
| US8518927B2 (en) | 2009-02-10 | 2013-08-27 | The Scripps Research Institute | Chemically programmed vaccination |
| RU2559526C2 (ru) | 2009-02-24 | 2015-08-10 | Алексион Фармасьютикалз, Инк. | Антитела, содержащие терапевтические пептиды-миметики тро/еро |
| EP2560949B1 (de) * | 2010-04-20 | 2015-12-02 | Università degli Studi di Roma "La Sapienza" | Tranylcyprominderivate als hemmer der histondemethylase lsd1 und/oder lsd2 |
| CA2950390C (en) | 2014-05-30 | 2020-09-22 | Pfizer Inc. | Carbonitrile derivatives as selective androgen receptor modulators |
| EP3956309A4 (de) | 2019-04-19 | 2023-06-07 | Ligand Pharmaceuticals Inc. | Kristalline formen und verfahren zur herstellung kristalliner formen einer verbindung |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1905813A1 (de) * | 1968-07-04 | 1970-03-05 | Akad Wissenschaften Ddr | 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren |
| FR2456731A1 (fr) * | 1979-05-16 | 1980-12-12 | Choay Sa | Nouveaux derives substitues d'ary |
| ES2039356T3 (es) * | 1985-11-12 | 1993-10-01 | Ono Pharmaceutical Co., Ltd. | Un procedimiento para la preparacion de derivados del acido p-guanidinobenzoico. |
| IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
| NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
| WO1992008464A1 (en) * | 1990-11-15 | 1992-05-29 | Tanabe Seiyaku Co. Ltd. | Substituted urea and related cell adhesion modulation compounds |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| ES2186720T3 (es) * | 1994-05-27 | 2003-05-16 | Merck & Co Inc | Composiciones para inhibir la reabsorcion osea mediada por osteoclastos. |
-
1997
- 1997-03-20 WO PCT/US1997/003987 patent/WO1997036858A1/en not_active Ceased
- 1997-03-20 JP JP9535279A patent/JP2000507575A/ja not_active Ceased
- 1997-03-20 DK DK97915937T patent/DK0889875T3/da active
- 1997-03-20 AU AU23238/97A patent/AU2323897A/en not_active Abandoned
- 1997-03-20 DE DE69705300T patent/DE69705300T2/de not_active Expired - Fee Related
- 1997-03-20 ES ES97915937T patent/ES2158537T3/es not_active Expired - Lifetime
- 1997-03-20 CA CA002250695A patent/CA2250695A1/en not_active Abandoned
- 1997-03-20 AT AT97915937T patent/ATE202337T1/de not_active IP Right Cessation
- 1997-03-20 EP EP97915937A patent/EP0889875B1/de not_active Expired - Lifetime
- 1997-03-20 PT PT97915937T patent/PT889875E/pt unknown
- 1997-03-27 US US08/825,040 patent/US5773644A/en not_active Expired - Fee Related
-
2001
- 2001-07-24 GR GR20010401102T patent/GR3036253T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT889875E (pt) | 2001-10-30 |
| EP0889875A1 (de) | 1999-01-13 |
| US5773644A (en) | 1998-06-30 |
| CA2250695A1 (en) | 1997-10-09 |
| ES2158537T3 (es) | 2001-09-01 |
| EP0889875B1 (de) | 2001-06-20 |
| GR3036253T3 (en) | 2001-10-31 |
| DE69705300D1 (de) | 2001-07-26 |
| AU2323897A (en) | 1997-10-22 |
| WO1997036858A1 (en) | 1997-10-09 |
| DK0889875T3 (da) | 2001-09-03 |
| JP2000507575A (ja) | 2000-06-20 |
| DE69705300T2 (de) | 2002-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |