ATE203273T1 - Inhibitoren einer protease, die den löslichen p55-tnf-rezeptor vom zellgebundenen tnf-rezeptor abspaltet - Google Patents

Inhibitoren einer protease, die den löslichen p55-tnf-rezeptor vom zellgebundenen tnf-rezeptor abspaltet

Info

Publication number
ATE203273T1
ATE203273T1 AT94116018T AT94116018T ATE203273T1 AT E203273 T1 ATE203273 T1 AT E203273T1 AT 94116018 T AT94116018 T AT 94116018T AT 94116018 T AT94116018 T AT 94116018T AT E203273 T1 ATE203273 T1 AT E203273T1
Authority
AT
Austria
Prior art keywords
tnf receptor
cell
inhibitors
bound
soluble
Prior art date
Application number
AT94116018T
Other languages
English (en)
Inventor
David Wallach
Cord Brackebusch
Eugene Varfolomeev
Michael Batkin
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE203273T1 publication Critical patent/ATE203273T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AT94116018T 1993-10-12 1994-10-11 Inhibitoren einer protease, die den löslichen p55-tnf-rezeptor vom zellgebundenen tnf-rezeptor abspaltet ATE203273T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL107268A IL107268A0 (en) 1993-10-12 1993-10-12 Molecules influencing the shedding of the tnf receptor, their preparation and their use

Publications (1)

Publication Number Publication Date
ATE203273T1 true ATE203273T1 (de) 2001-08-15

Family

ID=11065340

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94116018T ATE203273T1 (de) 1993-10-12 1994-10-11 Inhibitoren einer protease, die den löslichen p55-tnf-rezeptor vom zellgebundenen tnf-rezeptor abspaltet

Country Status (13)

Country Link
US (2) US5665859A (de)
EP (1) EP0657536B1 (de)
JP (1) JPH07194376A (de)
AT (1) ATE203273T1 (de)
AU (1) AU679559B2 (de)
CA (1) CA2133872A1 (de)
DE (1) DE69427740T2 (de)
DK (1) DK0657536T3 (de)
ES (1) ES2163418T3 (de)
GR (1) GR3036782T3 (de)
IL (1) IL107268A0 (de)
PT (1) PT657536E (de)
ZA (1) ZA947962B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03164179A (ja) * 1989-04-21 1991-07-16 Boehringer Ingelheim Internatl Gmbh Ｔｎｆレセプター、ｔｎｆ結合たん白質およびこれらをコードするｄｎａ
US7264944B1 (en) * 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
US5837458A (en) * 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US20050191661A1 (en) * 1996-11-06 2005-09-01 Tetsuya Gatanaga Treatment of inflammatory disease by cleaving TNF receptors
US6930084B1 (en) 1996-11-06 2005-08-16 The Regents Of The University Of California Treating arthritis with TNF receptor releasing enzyme
JP2001508648A (ja) 1996-11-06 2001-07-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 腫瘍壊死因子レセプター放出酵素、酵素を含む組成物、およびその使用方法
US6593456B1 (en) * 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US6989435B2 (en) * 1997-09-11 2006-01-24 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6406907B1 (en) * 1999-02-26 2002-06-18 Iowa State University Research Foundation Bovine tumor necrosis factor receptor-1 and methods of use
WO2001064856A2 (en) * 2000-02-28 2001-09-07 The Government Of The United States Of America, A S Represented By The Secretary, Department Of Hea Lth And Human Services Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding
AU2002338947B2 (en) * 2001-11-30 2007-09-13 Laboratoires Serono Sa Methods of increasing protein expression levels
WO2007058894A2 (en) * 2005-11-10 2007-05-24 The University Of North Carolina At Chapel Hill Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease
US7785834B2 (en) * 2005-11-10 2010-08-31 Ercole Biotech, Inc. Soluble TNF receptors and their use in treatment of disease
US8268635B2 (en) * 2006-05-19 2012-09-18 Antonio Ferrante Methods of identifying agents that selectively activate p38 and/or NKkB signaling
US20090264353A1 (en) * 2007-10-19 2009-10-22 Santaris Pharma A/S Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease
EP2492281B1 (de) * 2009-10-19 2018-04-11 HanAll Biopharma Co., Ltd. Modifiziertes menschliches tumornekrose-faktor-rezeptor-1-polypeptid oder fragment davon sowie herstellungsverfahren dafür
US11021339B2 (en) 2017-05-22 2021-06-01 Bedford Industries, Inc. Elastic band dispenser
US10723532B2 (en) 2017-05-22 2020-07-28 Bedford Insutries, Inc. Elastic band package

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101769A (en) * 1992-05-03 2007-02-11 Yeda Res & Dev Modulation of TNF receptor action

Also Published As

Publication number Publication date
PT657536E (pt) 2001-12-28
DE69427740D1 (de) 2001-08-23
EP0657536B1 (de) 2001-07-18
AU7574294A (en) 1995-05-04
AU679559B2 (en) 1997-07-03
IL107268A0 (en) 1994-01-25
JPH07194376A (ja) 1995-08-01
GR3036782T3 (en) 2002-01-31
CA2133872A1 (en) 1995-04-13
DK0657536T3 (da) 2001-09-17
ES2163418T3 (es) 2002-02-01
ZA947962B (en) 1995-11-21
US5766917A (en) 1998-06-16
US5665859A (en) 1997-09-09
EP0657536A1 (de) 1995-06-14
DE69427740T2 (de) 2002-05-23

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