ATE204324T1 - Herstellung von tryptophan mittels dem bakterium escherichia coli - Google Patents

Herstellung von tryptophan mittels dem bakterium escherichia coli

Info

Publication number
ATE204324T1
ATE204324T1 AT96109802T AT96109802T ATE204324T1 AT E204324 T1 ATE204324 T1 AT E204324T1 AT 96109802 T AT96109802 T AT 96109802T AT 96109802 T AT96109802 T AT 96109802T AT E204324 T1 ATE204324 T1 AT E204324T1
Authority
AT
Austria
Prior art keywords
tryptophan
mtr
strains
fermentation
absence
Prior art date
Application number
AT96109802T
Other languages
English (en)
Inventor
Helen Dr Camakaris
Peter Dr Cowan
James Prof Pittard
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Application granted granted Critical
Publication of ATE204324T1 publication Critical patent/ATE204324T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/22Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT96109802T 1995-09-05 1996-06-19 Herstellung von tryptophan mittels dem bakterium escherichia coli ATE204324T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9518076A GB2304718B (en) 1995-09-05 1995-09-05 The production of tryptophan by the bacterium escherichia coli

Publications (1)

Publication Number Publication Date
ATE204324T1 true ATE204324T1 (de) 2001-09-15

Family

ID=10780212

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96109802T ATE204324T1 (de) 1995-09-05 1996-06-19 Herstellung von tryptophan mittels dem bakterium escherichia coli

Country Status (13)

Country Link
US (1) US5756345A (de)
EP (1) EP0789073B1 (de)
JP (1) JPH09121846A (de)
KR (1) KR100452572B1 (de)
AT (1) ATE204324T1 (de)
AU (1) AU712821B2 (de)
BR (1) BR9603654A (de)
CA (1) CA2184760A1 (de)
DE (1) DE69614498T2 (de)
GB (1) GB2304718B (de)
MX (1) MX9603641A (de)
SK (1) SK282954B6 (de)
ZA (1) ZA967474B (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6118047A (en) 1993-08-25 2000-09-12 Dekalb Genetic Corporation Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction
CA2334170A1 (en) 1998-07-27 2000-02-10 Genentech, Inc. Improved transformation efficiency in phage display through modification of a coat protein
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
DE60236684D1 (de) 2001-11-23 2010-07-22 Ajinomoto Kk Verfahren zur l-aminosäureproduktion mit escherichia
ES2356132T3 (es) 2002-04-23 2011-04-05 Cargill, Incorporated Polipéptidos y rutas biosintéticas.
US20070065906A1 (en) * 2003-03-05 2007-03-22 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for producing heterologous protein in e. coli
US20050112260A1 (en) 2003-08-01 2005-05-26 Cargill, Inc. Monatin tabletop sweetener compositions and methods of making same
US8206955B2 (en) * 2003-10-21 2012-06-26 Cargill, Incorporated Production of monatin and monatin precursors
KR101142885B1 (ko) * 2003-12-15 2012-05-10 씨제이제일제당 (주) 트립토판 생합성 관련 변이유전자를 함유한 대장균 변이주및 이를 이용한 트립토판 제조방법
DE102005018835A1 (de) 2005-04-22 2006-11-02 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung verbesserter Stämme der Familie Enterobacteriaceae
DE102005019040A1 (de) 2005-04-23 2006-10-26 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung verbesserter Stämme der Familie Enterobacteriaceae
JP2009118740A (ja) 2006-03-03 2009-06-04 Ajinomoto Co Inc L−アミノ酸の製造法
WO2007119574A2 (en) 2006-03-23 2007-10-25 Ajinomoto Co., Inc. A method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna
JP2009165355A (ja) 2006-04-28 2009-07-30 Ajinomoto Co Inc L−アミノ酸を生産する微生物及びl−アミノ酸の製造法
JP2010017082A (ja) 2006-10-10 2010-01-28 Ajinomoto Co Inc L−アミノ酸の製造法
RU2006143864A (ru) 2006-12-12 2008-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНОВ cynT, cynS, cynX, ИЛИ cynR, ИЛИ ИХ КОМБИНАЦИИ
KR100850853B1 (ko) * 2006-12-13 2008-08-06 씨제이제일제당 (주) nrfE 유전자가 불활성화된 L-트립토판 생산 미생물 및이를 이용한 L-트립토판 제조방법
KR100792095B1 (ko) * 2006-12-29 2008-01-04 씨제이 주식회사 L-페닐알라닌 생산능을 갖는 대장균 변이주로부터유전자조작된 l-트립토판 생산능을 갖는 재조합 대장균균주 및 이를 이용한 트립토판 제조방법
BRPI0806790B1 (pt) 2007-01-22 2017-02-14 Ajinomoto Kk microorganismo, e, método para produzir um l-aminoácido
JP2010110216A (ja) 2007-02-20 2010-05-20 Ajinomoto Co Inc L−アミノ酸または核酸の製造方法
JP2010110217A (ja) 2007-02-22 2010-05-20 Ajinomoto Co Inc L−アミノ酸生産菌及びl−アミノ酸の製造法
DE102007051024A1 (de) 2007-03-05 2008-09-11 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
EP1975241A1 (de) 2007-03-29 2008-10-01 Evonik Degussa GmbH Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
WO2009031565A1 (ja) 2007-09-04 2009-03-12 Ajinomoto Co., Inc. アミノ酸生産微生物及びアミノ酸の製造法
DE102007044134A1 (de) 2007-09-15 2009-03-19 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
RU2396336C2 (ru) 2007-09-27 2010-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
DE102007052270A1 (de) 2007-11-02 2009-05-07 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
EP2060636A1 (de) 2007-11-14 2009-05-20 Evonik Degussa GmbH Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
JP5526785B2 (ja) 2008-01-23 2014-06-18 味の素株式会社 L−アミノ酸の製造法
RU2008105793A (ru) 2008-02-19 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ конструирования оперонов, содержащих трансляционно сопряженные гены, бактерия, содержащая такой оперон, способ продукции полезного метаболита и способ мониторинга экспрессии гена
EP2098597A1 (de) 2008-03-04 2009-09-09 Evonik Degussa GmbH Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
DE102008002309A1 (de) 2008-06-09 2009-12-10 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
DE102008040352A1 (de) 2008-07-11 2010-01-14 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Tryptophan unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
DE102008044768A1 (de) 2008-08-28 2010-03-04 Evonik Degussa Gmbh Verfahren zur Herstellung von organisch-chemischen Verbindungen unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
WO2010027045A1 (ja) 2008-09-08 2010-03-11 味の素株式会社 L-アミノ酸を生産する微生物及びl-アミノ酸の製造法
WO2010084995A2 (en) 2009-01-23 2010-07-29 Ajinomoto Co.,Inc. A method for producing an l-amino acid
EP2267145A1 (de) 2009-06-24 2010-12-29 Evonik Degussa GmbH Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
DE102009030342A1 (de) 2009-06-25 2010-12-30 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von organisch chemischen Verbindungen
EP2460883A4 (de) 2009-07-29 2013-01-16 Ajinomoto Kk Verfahren zur herstellung von l-aminosäure
JP2012223092A (ja) 2009-08-28 2012-11-15 Ajinomoto Co Inc L−アミノ酸の製造法
JP2013013329A (ja) 2009-11-06 2013-01-24 Ajinomoto Co Inc L−アミノ酸の製造法
RU2460793C2 (ru) 2010-01-15 2012-09-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae
RU2587632C2 (ru) 2010-01-26 2016-06-20 Мейдзи Сейка Фарма Ко., Лтд. Способ получения пирипиропена
JP2013074795A (ja) 2010-02-08 2013-04-25 Ajinomoto Co Inc 変異型rpsA遺伝子及びL−アミノ酸の製造法
RU2471868C2 (ru) 2010-02-18 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Мутантная аденилатциклаза, днк, кодирующая ее, бактерия семейства enterobacteriaceae, содержащая указанную днк, и способ получения l-аминокислот
RU2482188C2 (ru) 2010-07-21 2013-05-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ РОДА Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ОПЕРОН astCADBE
RU2501858C2 (ru) 2010-07-21 2013-12-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae
JP2014036576A (ja) 2010-12-10 2014-02-27 Ajinomoto Co Inc L−アミノ酸の製造法
DE102011006716A1 (de) 2011-04-04 2012-10-04 Evonik Degussa Gmbh Mikroorganismus und Verfahren zur fermentativen Herstellung einer organisch-chemischen Verbindung
DE102011118019A1 (de) 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
RU2011134436A (ru) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Способ получения l-аминокислоты с использованием бактерии семейства enterobacteriaceae, обладающей повышенной экспрессией генов каскада образования флагелл и клеточной подвижности
MY173848A (en) * 2012-01-10 2020-02-24 Cj Cheiljedang Corp A microorganism of the genus escherichia having enhanced l-tryptophan productivity and a method for producing l-tryptophan using the same
EP2628792A1 (de) 2012-02-17 2013-08-21 Evonik Industries AG Zelle mit verringerter ppGppase-Aktivität
BR112014021439B1 (pt) 2012-04-27 2021-12-21 Evonik Technochemie Gmbh Polipeptídeo de isopropilmalato sintase e a sequência de nucleotídeos que o codifica, vetor, microrganismo do gênero corynebacterium e uso do mesmo, bem como processo fermentativo para a produção de kic ou l-leucina
DE102012024435A1 (de) 2012-12-14 2014-07-10 Forschungszentrum Jülich GmbH Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren
EP2762571A1 (de) 2013-01-30 2014-08-06 Evonik Industries AG Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren
RU2013118637A (ru) 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ РАЗРЕГУЛИРОВАН ГЕН yjjK
HUE032752T2 (en) 2013-06-03 2017-10-30 Evonik Degussa Gmbh A method for the preparation of L-valine using recombinant corynebacteria containing propionate-inducible ilvBN operon
RU2013140115A (ru) 2013-08-30 2015-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ НАРУШЕНА ЭКСПРЕССИЯ КЛАСТЕРА ГЕНОВ znuACB
JP2016192903A (ja) 2013-09-17 2016-11-17 味の素株式会社 海藻由来バイオマスからのl−アミノ酸の製造方法
RU2013144250A (ru) 2013-10-02 2015-04-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА, КОДИРУЮЩЕГО ФОСФАТНЫЙ ТРАНСПОРТЕР
EP3053999B1 (de) 2013-10-02 2019-11-20 Ajinomoto Co., Inc. Vorrichtung und verfahren zur ammoniakkontrolle
ES2694011T3 (es) 2013-10-21 2018-12-17 Ajinomoto Co., Inc. Método para producir L-aminoácido
RU2014105547A (ru) 2014-02-14 2015-08-20 Адзиномото Ко., Инк. СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, ИМЕЮЩЕЙ СВЕРХЭКСПРЕССИРУЕМЫЙ ГЕН yajL
WO2015175793A1 (en) 2014-05-16 2015-11-19 University Of Georgia Research Foundation, Inc. Microbial approach for the production of 5-hydroxytryptophan
US9663768B2 (en) 2014-09-02 2017-05-30 University Of Georgia Research Foundation, Inc. Precursor-directed biosynthesis of 5-hydroxytryptophan
RU2015120052A (ru) 2015-05-28 2016-12-20 Аджиномото Ко., Инк. Способ получения L-аминокислоты с использованием бактерии семейства Enterobacteriaceae, в которой ослаблена экспрессия гена gshA
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
CA3007635A1 (en) 2015-12-07 2017-06-15 Zymergen Inc. Promoters from corynebacterium glutamicum
WO2017146195A1 (en) 2016-02-25 2017-08-31 Ajinomoto Co., Inc. A method for producing l-amino acids using a bacterium of the family enterobacteriaceae overexpressing a gene encoding an iron exporter
JP2019519241A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド グルコース透過酵素ライブラリーを生成するための方法およびその使用
KR102345899B1 (ko) 2016-06-30 2021-12-31 지머젠 인코포레이티드 박테리아 헤모글로빈 라이브러리를 생성하는 방법 및 이의 용도
CA3048992A1 (en) 2016-12-30 2018-07-05 Quidel Corporation Phage-mediated immunoassay and methods for determining susceptibility of bacteria to antibiotic or probiotic agents
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 L-アミノ酸の製造法
EP3385275B1 (de) 2017-04-07 2019-10-23 Evonik Degussa GmbH Verfahren zur herstellung von aromatischen l-aminosäuren unter verwendung von verbesserten stämmen der familie enterobacteriaceae
CN110869504A (zh) 2017-06-07 2020-03-06 齐默尔根公司 来自谷氨酸棒状杆菌的启动子及其在调节辅助基因表达中的用途
US20190100811A1 (en) 2017-10-02 2019-04-04 Quidel Corporation Phage-based detection method for antimicrobial susceptibility testing and identification of bacterial species
EP3608409A1 (de) 2018-08-09 2020-02-12 Evonik Operations GmbH Verfahren zur herstellung von l-aminosäuren unter verwendung verbesserter stämme aus der familie der enterobacteriaceae
US11053526B2 (en) 2018-08-09 2021-07-06 Evonik Operations Gmbh Process for preparing L amino acids using improved strains of the enterobacteriaceae family
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
EP3677594A1 (de) 2019-01-07 2020-07-08 Evonik Operations GmbH Verfahren zur herstellung von l-tryptophan unter verwendung verbesserter stämme aus der familie der enterobacteriaceae
WO2020171227A1 (en) 2019-02-22 2020-08-27 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE
JP7524909B2 (ja) 2019-04-05 2024-07-30 味の素株式会社 L-アミノ酸の製造方法
JP7655312B2 (ja) 2019-09-25 2025-04-02 味の素株式会社 細菌の発酵によるl-アミノ酸の製造方法
US20230340428A1 (en) 2020-07-15 2023-10-26 Evonik Operations Gmbh Polynucleotide encoding an amino acid sequence, encoding an oxidoreductase
WO2023016895A1 (en) 2021-08-09 2023-02-16 Evonik Operations Gmbh Polynucleotide encoding a bacterial collagen-like protein
CN117836314A (zh) 2021-08-09 2024-04-05 赢创运营有限公司 用于生产重组细菌胶原样蛋白(clp)的方法
CN117813315A (zh) 2021-08-09 2024-04-02 赢创运营有限公司 用于生产重组细菌胶原样蛋白(clp)的方法
CN117999103A (zh) 2021-09-20 2024-05-07 赢创运营有限公司 非粘附性胶原蛋白样水凝胶
CN114480173B (zh) * 2021-12-27 2024-02-09 江苏澳创生物科技有限公司 一株大肠埃希氏菌及其在发酵生产l-色氨酸中的应用
CN118742338A (zh) 2022-02-25 2024-10-01 赢创运营有限公司 基于胶原样蛋白的海绵
WO2023165952A1 (en) 2022-03-01 2023-09-07 Evonik Operations Gmbh Biotechnological production of collagen proteins and bacterial collagen-like proteins by recombinant microorganisms
JPWO2023195475A1 (de) 2022-04-04 2023-10-12
CN121263216A (zh) 2023-06-06 2026-01-02 赢创运营有限公司 由胶原样蛋白(clp)制备的水凝胶贴剂
CN121548436A (zh) 2023-07-20 2026-02-17 赢创运营有限公司 包含重组胶原样肽(clp)和生物活性玻璃的海绵
CN118256477A (zh) * 2023-12-31 2024-06-28 杭州欧合生物科技有限公司 一种邻氨基苯甲酸合酶突变体及其应用
WO2025186007A1 (en) 2024-03-08 2025-09-12 Evonik Operations Gmbh Collagen-like protein coated medical devices and coating method thereof
WO2026052373A1 (en) 2024-09-05 2026-03-12 Evonik Operations Gmbh Non-woven article comprising collagen-like protein fibers and a production process thereof
WO2026052478A1 (en) 2024-09-05 2026-03-12 Evonik Operations Gmbh Hybrid scaffolds comprising collagen-like protein and resorbable polymers for medical applications

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4371614A (en) * 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
US4743546A (en) * 1985-02-13 1988-05-10 Biotechnica International, Inc. Controlled gene excision
JPS61247393A (ja) * 1985-04-26 1986-11-04 Res Assoc Util Of Light Oil L−トリプトフアンの製造方法
JPS62208284A (ja) * 1986-03-10 1987-09-12 Sanraku Inc 新規なプラスミド
DK0578754T3 (da) * 1991-04-05 1995-11-06 Upjohn Co TrpR-mutationer, der er virksomme ved ekspressionen af små proteiner og peptider
TW258753B (en) * 1992-06-30 1995-10-01 Dev Center Biotechnology Direct fermentation of L-tryptophan by a recombinant microbe
DE4232468A1 (de) * 1992-09-28 1994-03-31 Consortium Elektrochem Ind Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
GB9518076D0 (en) 1995-11-08
SK111096A3 (en) 1997-05-07
JPH09121846A (ja) 1997-05-13
ZA967474B (en) 1998-02-27
EP0789073B1 (de) 2001-08-16
EP0789073A2 (de) 1997-08-13
CA2184760A1 (en) 1997-03-06
GB2304718B (en) 2000-01-19
BR9603654A (pt) 1998-05-19
DE69614498D1 (de) 2001-09-20
GB2304718A (en) 1997-03-26
AU6445296A (en) 1997-03-13
KR100452572B1 (ko) 2005-02-07
DE69614498T2 (de) 2002-05-23
EP0789073A3 (de) 1998-09-23
KR970015739A (ko) 1997-04-28
MX9603641A (es) 1997-03-29
SK282954B6 (sk) 2003-01-09
US5756345A (en) 1998-05-26
AU712821B2 (en) 1999-11-18

Similar Documents

Publication Publication Date Title
ATE204324T1 (de) Herstellung von tryptophan mittels dem bakterium escherichia coli
RU2111247C1 (ru) Способ получения штамма микроорганизма, способ продуцирования триптофана
CN101622338B (zh) 原产l-苯丙氨酸的产l-色氨酸的基因工程重组大肠杆菌以及用所述微生物来生产l-色氨酸的方法
HU196843B (en) Process for producing l-lysine
US7582460B2 (en) 3-phosphoglycerate dehydrogenase variants whose inhibition by L-serine is reduced, and genes encoding them
AU784733B2 (en) Process for producing a target fermentation product
Pauli et al. Fatty acid degradation in Escherichia coli: requirement of cyclic adenosine monophosphate and cyclic adenosine monophosphate receptor protein for enzyme synthesis
CN111471669A (zh) 一种肝素裂解酶突变体及其重组表达的方法
JP2002512802A5 (ja) 芳香族代謝からの物質の微生物による製造
CA1217158A (en) Enzymatic synthesis of l-serine
Bloom et al. Positive control in the D-serine deaminase system of Escherichia coli K-12
WO2015199406A1 (ko) L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
US5017481A (en) Coryneform bacteria carrying recombinant DNA and process for producing an aromatic amino acid by using the same
EP0180192B1 (de) Plasmide
CN101300344A (zh) 经修饰的转酮酶及其用途
CN103436504A (zh) 抗l-丝氨酸反馈抑制的谷氨酸棒杆菌syps-062的构建方法及应用
EP0397097A1 (de) Züchtung von transformierten Mikroorganismen
EP0293207A2 (de) Rekombinantes Plasmid enthaltende Escherichia coli für die Herstellung von Tryptophan
Guardiola et al. Dual autogenous regulatory role of threonine deaminase in Escherichia coli K-12
Nagy et al. Iron-requiring mutant of Escherichia coli carrying a deletion in the aroG-nadA region of the chromosome
WO2024210280A1 (ko) 포스포에놀피루베이트 카르복실라아제 신규 변이체 및 이를 이용한 5'-이노신산 생산 방법
JPH0468909B2 (de)
JPS62107788A (ja) 新規プラスミド
BLOOM THE ISOLATION AND CHARACTERIZATION OF REGULATORY MUTANTS IN THE D-SERINE DEAMINASE SYSTEM OF ESCHERICHIA COLI K12.
JPH06133781A (ja) L−トリプトフアンの製造法

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee