ATE204333T1 - Verfahren zur dämpfung der fluoreszenz von fluoreszenzmarkierten oligonukleotiden in lösung - Google Patents
Verfahren zur dämpfung der fluoreszenz von fluoreszenzmarkierten oligonukleotiden in lösungInfo
- Publication number
- ATE204333T1 ATE204333T1 AT95117981T AT95117981T ATE204333T1 AT E204333 T1 ATE204333 T1 AT E204333T1 AT 95117981 T AT95117981 T AT 95117981T AT 95117981 T AT95117981 T AT 95117981T AT E204333 T1 ATE204333 T1 AT E204333T1
- Authority
- AT
- Austria
- Prior art keywords
- fluorescence
- label
- oligonucleotide
- labled
- oligonucleotides
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 238000003556 assay Methods 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 2
- 230000004568 DNA-binding Effects 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000002751 oligonucleotide probe Substances 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/347,657 US5571673A (en) | 1994-11-23 | 1994-11-23 | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204333T1 true ATE204333T1 (de) | 2001-09-15 |
Family
ID=23364666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95117981T ATE204333T1 (de) | 1994-11-23 | 1995-11-15 | Verfahren zur dämpfung der fluoreszenz von fluoreszenzmarkierten oligonukleotiden in lösung |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5571673A (de) |
| EP (1) | EP0713921B1 (de) |
| JP (1) | JP3600333B2 (de) |
| KR (1) | KR100431421B1 (de) |
| CN (1) | CN1131320C (de) |
| AT (1) | ATE204333T1 (de) |
| AU (1) | AU700885B2 (de) |
| CA (1) | CA2163388C (de) |
| DE (1) | DE69522176T2 (de) |
| DK (1) | DK0713921T3 (de) |
| ES (1) | ES2162630T3 (de) |
| NZ (1) | NZ280506A (de) |
| PT (1) | PT713921E (de) |
| RU (1) | RU2149186C1 (de) |
Families Citing this family (77)
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|---|---|---|---|---|
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
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| FR2627590A1 (fr) * | 1988-02-24 | 1989-08-25 | Ire Celltarg Sa | Sonde d'acides nucleiques comportant un nucleotide terminal modifie chimiquement en 5(prime) (oh) en vue de son marquage non radioactif et procedes de preparation |
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| US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5994056A (en) * | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| JP3494646B2 (ja) * | 1992-06-08 | 2004-02-09 | ジェン−プローブ・インコーポレイテッド | 単核細胞からの核酸の調製 |
| US5491063A (en) * | 1994-09-01 | 1996-02-13 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
-
1994
- 1994-11-23 US US08/347,657 patent/US5571673A/en not_active Expired - Lifetime
-
1995
- 1995-11-15 AT AT95117981T patent/ATE204333T1/de active
- 1995-11-15 DE DE69522176T patent/DE69522176T2/de not_active Expired - Lifetime
- 1995-11-15 EP EP95117981A patent/EP0713921B1/de not_active Expired - Lifetime
- 1995-11-15 DK DK95117981T patent/DK0713921T3/da active
- 1995-11-15 ES ES95117981T patent/ES2162630T3/es not_active Expired - Lifetime
- 1995-11-15 PT PT95117981T patent/PT713921E/pt unknown
- 1995-11-21 NZ NZ280506A patent/NZ280506A/en not_active IP Right Cessation
- 1995-11-21 CA CA002163388A patent/CA2163388C/en not_active Expired - Lifetime
- 1995-11-22 AU AU39010/95A patent/AU700885B2/en not_active Expired
- 1995-11-22 JP JP30430795A patent/JP3600333B2/ja not_active Expired - Lifetime
- 1995-11-23 CN CN95121850A patent/CN1131320C/zh not_active Expired - Lifetime
- 1995-11-23 RU RU95120014A patent/RU2149186C1/ru active
- 1995-11-23 KR KR1019950043097A patent/KR100431421B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT713921E (pt) | 2002-02-28 |
| EP0713921A3 (de) | 1996-09-11 |
| ES2162630T3 (es) | 2002-01-01 |
| DE69522176T2 (de) | 2002-05-29 |
| CN1131320C (zh) | 2003-12-17 |
| JPH08220092A (ja) | 1996-08-30 |
| NZ280506A (en) | 1997-07-27 |
| CN1133888A (zh) | 1996-10-23 |
| AU3901095A (en) | 1996-05-30 |
| EP0713921A2 (de) | 1996-05-29 |
| KR100431421B1 (ko) | 2004-12-03 |
| EP0713921B1 (de) | 2001-08-16 |
| DK0713921T3 (da) | 2001-11-12 |
| KR960017858A (ko) | 1996-06-17 |
| CA2163388A1 (en) | 1996-05-24 |
| JP3600333B2 (ja) | 2004-12-15 |
| RU2149186C1 (ru) | 2000-05-20 |
| AU700885B2 (en) | 1999-01-14 |
| DE69522176D1 (de) | 2001-09-20 |
| CA2163388C (en) | 2008-01-15 |
| US5571673A (en) | 1996-11-05 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |