ATE204470T1 - Mikroverkapselung von zellen - Google Patents

Mikroverkapselung von zellen

Info

Publication number
ATE204470T1
ATE204470T1 AT93914247T AT93914247T ATE204470T1 AT E204470 T1 ATE204470 T1 AT E204470T1 AT 93914247 T AT93914247 T AT 93914247T AT 93914247 T AT93914247 T AT 93914247T AT E204470 T1 ATE204470 T1 AT E204470T1
Authority
AT
Austria
Prior art keywords
pct
capsule
date dec
microcapsules
sec
Prior art date
Application number
AT93914247T
Other languages
English (en)
Inventor
Shiong Patrick Soon
Roswitha E Heintz
Gudmund Skjak-Braek
Original Assignee
Vivorx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vivorx Inc filed Critical Vivorx Inc
Application granted granted Critical
Publication of ATE204470T1 publication Critical patent/ATE204470T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Materials For Medical Uses (AREA)
AT93914247T 1992-05-29 1993-05-28 Mikroverkapselung von zellen ATE204470T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89127492A 1992-05-29 1992-05-29
PCT/US1993/005122 WO1993024112A1 (en) 1992-05-29 1993-05-28 Microencapsulation of cells

Publications (1)

Publication Number Publication Date
ATE204470T1 true ATE204470T1 (de) 2001-09-15

Family

ID=25397889

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93914247T ATE204470T1 (de) 1992-05-29 1993-05-28 Mikroverkapselung von zellen

Country Status (6)

Country Link
US (1) US5762959A (de)
EP (1) EP0641196B1 (de)
AT (1) ATE204470T1 (de)
AU (1) AU4397593A (de)
DE (1) DE69330640T2 (de)
WO (1) WO1993024112A1 (de)

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US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US5578314A (en) * 1992-05-29 1996-11-26 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
JPH08507747A (ja) * 1992-12-30 1996-08-20 クローバー コンソリデイテッド，リミテッド 生物学的活性物質用の細包を保護し生体に適合する、再利用可能なマクロカプセル封入システム
AU687386B2 (en) * 1993-04-08 1998-02-26 Human Cell Cultures, Inc. Cell culturing method and medium
US6008047A (en) * 1993-04-08 1999-12-28 Livercell L.L.C. Cell culturing method and medium
US5463677A (en) * 1993-05-27 1995-10-31 At&T Corp. Method and apparatus for facilitating the making of collect calls
US5876742A (en) * 1994-01-24 1999-03-02 The Regents Of The University Of California Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
US5514377A (en) * 1994-03-08 1996-05-07 The Regents Of The University Of California In situ dissolution of alginate coatings of biological tissue transplants
DE4426396A1 (de) * 1994-07-26 1996-02-01 Ulrich Prof Dr Zimmermann Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form
CA2214088A1 (en) * 1995-03-03 1996-09-12 Metabolex Inc. Novel encapsulation process by a gelling polymer
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
US6126936A (en) * 1995-03-10 2000-10-03 Biohybrid Technologies Llc Microcapsules and composite microreactors for immunoisolation of cells
HU220588B1 (hu) * 1996-09-05 2002-03-28 Bay Zoltán Alkalmazott Kutatási Alapítvány Biotechnológiai Intézet Eljárás és bioreaktortöltet L(-)-almasav előállítására fumársavból
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6287558B1 (en) 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
AU6226799A (en) * 1998-10-13 2000-05-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Hydrocolloid coating of cells
US6713293B1 (en) 1999-02-08 2004-03-30 Friedrich Grummt Encapsulated cells containing an amplified expression vector as a drug delivery device
US6495161B1 (en) * 1999-03-09 2002-12-17 Vivorx, Inc. Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6592566B2 (en) * 2000-02-03 2003-07-15 Arizona Board Of Regents Method for forming an endovascular occlusion
CA2410965C (en) 2000-05-31 2010-09-14 Encelle, Inc. Method of stimulating hair growth
EP1281767A3 (de) * 2001-07-31 2003-05-28 Aladar A. Szalay Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren
US7101546B2 (en) * 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
EP1369491A1 (de) * 2002-06-05 2003-12-10 Aladar A. Szalay Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe
US20030228261A1 (en) * 2002-06-05 2003-12-11 Aladar Szalay Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
US20040022771A1 (en) * 2002-07-30 2004-02-05 Ferree Bret A. Transfer of cells, tissue, and other substances to bone
ES2295274T3 (es) * 2002-09-24 2008-04-16 Cognis Ip Management Gmbh Procedimiento para la obtencion de macrocapsulas.
ATE420160T1 (de) * 2003-06-18 2009-01-15 Genelux Corp Modifizierte rekombinante vacciniaviren, verwendungen davon
WO2005087287A1 (en) * 2004-03-05 2005-09-22 University Of Florida Research Foundation Inc. Novel tissue engineered scaffolds derived from copper capillary alginate gels
DE602005025718D1 (de) * 2004-08-23 2011-02-17 Procter & Gamble Mikrokapseln
EP1669437A1 (de) * 2004-12-03 2006-06-14 The Procter & Gamble Company Mikrokapseln
EP1632560B1 (de) * 2004-08-23 2011-01-05 The Procter & Gamble Company Mikrokapseln
EP1634944A1 (de) * 2004-08-23 2006-03-15 The Procter & Gamble Company Mikrokapseln
CA2583308C (en) * 2004-10-08 2020-01-07 Georgia Tech Research Corporation Microencapsulation of cells in hydrogels using electrostatic potentials
AU2006223063B2 (en) 2005-03-11 2011-11-17 Wake Forest University Health Sciences Tissue engineered blood vessels
US20080292690A1 (en) * 2006-04-07 2008-11-27 Technology Center Multi-membrane immunoisolation system for cellular transplant
US20070237749A1 (en) 2006-04-07 2007-10-11 Wang Taylor G Multi-membrane immunoisolation system for cellular transplant
WO2007127231A2 (en) * 2006-04-24 2007-11-08 The Johns Hopkins University Magnetic resonance-detectable, ultrasound-detectable and/or radiopaque microcapsules and uses thereof
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
WO2009137829A2 (en) 2008-05-09 2009-11-12 Wake Forest University Health Sciences Directed stem cell recruitment
US8728520B2 (en) * 2008-12-08 2014-05-20 University Of Miami Cross-linked alginate-polyalkylene glycol polymer coatings for encapsulation and methods of making the same
US9198872B2 (en) 2008-12-08 2015-12-01 University Of Miami Dendritic and hyperbranched polymers for cellular encapsulation and functionalization
CN102008925B (zh) * 2010-12-17 2012-11-28 天津大学 制备无机/有机复合微球的方法
EP2680862B1 (de) 2011-03-04 2016-07-20 Wake Forest University Health Sciences Eingekapselte zellen für eine hormonersatztherapie
EA201301082A1 (ru) * 2011-03-29 2014-01-30 Бета-Селл Нв Способ изготовления инкапсулированных терапевтических продуктов и их применение
US9781936B2 (en) * 2013-10-09 2017-10-10 University Of Central Florida Research Foundation, Inc. Compositions, methods of making a composition, and methods of use
US12584104B2 (en) 2019-03-29 2026-03-24 Wake Forest University Health Sciences Ovarian follicle cells and constructs for fertility treatment and hormone replacement therapy

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Also Published As

Publication number Publication date
DE69330640T2 (de) 2002-07-04
EP0641196A4 (de) 1995-05-03
EP0641196A1 (de) 1995-03-08
US5762959A (en) 1998-06-09
EP0641196B1 (de) 2001-08-22
DE69330640D1 (de) 2001-09-27
AU4397593A (en) 1993-12-30
WO1993024112A1 (en) 1993-12-09

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