ATE204752T1 - Therapeutische anwendungen von 2',5'- oligoadenylat-derivaten - Google Patents

Therapeutische anwendungen von 2',5'- oligoadenylat-derivaten

Info

Publication number
ATE204752T1
ATE204752T1 AT96101815T AT96101815T ATE204752T1 AT E204752 T1 ATE204752 T1 AT E204752T1 AT 96101815 T AT96101815 T AT 96101815T AT 96101815 T AT96101815 T AT 96101815T AT E204752 T1 ATE204752 T1 AT E204752T1
Authority
AT
Austria
Prior art keywords
therapeutic uses
oligoadenylate
derivatives
analogs
oligoadenylate derivatives
Prior art date
Application number
AT96101815T
Other languages
English (en)
Inventor
Robert J Suhadolnik
Wolfgang Pfleiderer
Original Assignee
Univ Temple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple filed Critical Univ Temple
Application granted granted Critical
Publication of ATE204752T1 publication Critical patent/ATE204752T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT96101815T 1988-06-09 1989-05-24 Therapeutische anwendungen von 2',5'- oligoadenylat-derivaten ATE204752T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20465988A 1988-06-09 1988-06-09

Publications (1)

Publication Number Publication Date
ATE204752T1 true ATE204752T1 (de) 2001-09-15

Family

ID=22758878

Family Applications (2)

Application Number Title Priority Date Filing Date
AT96101815T ATE204752T1 (de) 1988-06-09 1989-05-24 Therapeutische anwendungen von 2',5'- oligoadenylat-derivaten
AT89906575T ATE141796T1 (de) 1988-06-09 1989-05-24 2',5'-oligoadenylat-derivate zur verwendung als heilmittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT89906575T ATE141796T1 (de) 1988-06-09 1989-05-24 2',5'-oligoadenylat-derivate zur verwendung als heilmittel

Country Status (14)

Country Link
EP (2) EP0716856B1 (de)
JP (1) JP2947580B2 (de)
KR (1) KR0141684B1 (de)
CN (1) CN1107508C (de)
AT (2) ATE204752T1 (de)
AU (1) AU637975B2 (de)
CA (1) CA1335356C (de)
DE (2) DE68929321T2 (de)
DK (1) DK174025B1 (de)
ES (1) ES2016464A6 (de)
IL (1) IL90499A (de)
NZ (1) NZ229422A (de)
PT (1) PT90816B (de)
WO (1) WO1989012380A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550111A (en) * 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
AU7920491A (en) * 1990-06-21 1992-01-02 Patrick T. Prendergast Administering particular compounds against various parasites, mycoplasmas, other indications and other infections
US5594121A (en) * 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
EP0695306A1 (de) * 1993-04-19 1996-02-07 Gilead Sciences, Inc. Erhoehte bildung von tripel-und doppel-helix mit modifizierte purine enthaltenden oligomeren
AU7804798A (en) 1997-06-12 1998-12-30 Temple University - Of The Commonwealth System Of Higher Education Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof
US6362171B1 (en) 1997-06-12 2002-03-26 Temple University-Of The Commonwealth System Of Higher Education Aminoaklanoyl-linked conjugates of 2′,5′-oligoadenylate and antiviral uses thereof
WO2001000641A1 (fr) * 1999-06-25 2001-01-04 Sankyo Company, Limited Nouveaux dérivés de bicyclonucléoside
TWI347948B (en) 2002-11-19 2011-09-01 Sankyo Co Novel 2',5'-oligoadenylic acid compositions
GB201019043D0 (en) 2010-11-10 2010-12-22 Protea Biopharma N V Use of 2',5'-oligoadenylate derivative compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210746A (en) * 1978-08-10 1980-07-01 National Research Development Corporation Nucleotide inhibitor of protein synthesis
US4539313A (en) 1981-04-10 1985-09-03 Research Corporation (2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof
US4464359A (en) * 1981-04-10 1984-08-07 Research Corporation (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof
US4824941A (en) * 1983-03-10 1989-04-25 Julian Gordon Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
US4859768A (en) * 1984-07-11 1989-08-22 Temple University Of The Commonwealth System Of Higher Education Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof
US4654326A (en) * 1984-07-12 1987-03-31 Yair Devash Inhibition of plant viruses with oligonucleotides

Also Published As

Publication number Publication date
WO1989012380A2 (en) 1989-12-28
PT90816B (pt) 1994-11-30
EP0420872B1 (de) 1996-08-28
CN1107508C (zh) 2003-05-07
PT90816A (pt) 1989-12-29
DE68929321T2 (de) 2002-05-08
AU637975B2 (en) 1993-06-17
DE68929321D1 (de) 2001-10-04
NZ229422A (en) 1992-12-23
EP0420872A4 (en) 1992-10-21
DE68927055D1 (de) 1996-10-02
DK291390D0 (da) 1990-12-07
JPH03504970A (ja) 1991-10-31
JP2947580B2 (ja) 1999-09-13
KR900701279A (ko) 1990-12-01
IL90499A0 (en) 1990-01-18
EP0716856A3 (de) 1996-10-30
ATE141796T1 (de) 1996-09-15
WO1989012380A3 (en) 1990-06-28
CA1335356C (en) 1995-04-25
DE68927055T2 (de) 1997-04-10
KR0141684B1 (ko) 1998-06-01
IL90499A (en) 1994-05-30
EP0420872A1 (de) 1991-04-10
ES2016464A6 (es) 1990-11-01
EP0716856B1 (de) 2001-08-29
CN1040321A (zh) 1990-03-14
DK174025B1 (da) 2002-04-29
DK291390A (da) 1990-12-07
AU3740389A (en) 1990-01-12
EP0716856A2 (de) 1996-06-19

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