ATE205196T1 - Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation - Google Patents

Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation

Info

Publication number: ATE205196T1
Authority: AT; Austria
Prior art keywords: styrylbenzimidazole; inhibitors; derivatives; cell proliferation; smooth muscle
Prior art date: 1995-06-06

Application number

AT96916978T

Other languages

English (en)

Inventor

Sie-Yearl Chai

Hassan Mahmoud Elokdah

Theodore Sylvester Sulkowski

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1996-06-03

Publication date

2001-09-15

1996-06-03 Application filed by American Home Prod filed Critical American Home Prod

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE205196T1 publication Critical patent/ATE205196T1/de

Links

QQLPPRIZUPEKMV-UHFFFAOYSA-N 2-(2-phenylethenyl)-1h-benzimidazole Chemical class N=1C2=CC=CC=C2NC=1C=CC1=CC=CC=C1 QQLPPRIZUPEKMV-UHFFFAOYSA-N 0.000 title 1
230000004663 cell proliferation Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
210000000329 smooth muscle myocyte Anatomy 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT96916978T 1995-06-06 1996-06-03 Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation ATE205196T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/468,271 US6444694B1 (en)	1995-06-06	1995-06-06	Styryl benzimidazole derivatives
PCT/US1996/008375 WO1996039391A1 (en)	1995-06-06	1996-06-03	Styryl benzimidazole derivatives as inhibitors of smooth muscle cell proliferation

Publications (1)

Publication Number	Publication Date
ATE205196T1 true ATE205196T1 (de)	2001-09-15

Family

ID=23859136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96916978T ATE205196T1 (de)	1995-06-06	1996-06-03	Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation

Country Status (19)

Country	Link
US (1)	US6444694B1 (de)
EP (1)	EP0830345B1 (de)
JP (1)	JPH11506753A (de)
KR (1)	KR19990022266A (de)
CN (1)	CN1192206A (de)
AR (1)	AR002749A1 (de)
AT (1)	ATE205196T1 (de)
AU (1)	AU711965B2 (de)
BR (1)	BR9609153A (de)
CA (1)	CA2223585A1 (de)
DE (1)	DE69615023T2 (de)
DK (1)	DK0830345T3 (de)
ES (1)	ES2162063T3 (de)
HU (2)	HUP9900914A2 (de)
IL (1)	IL118385A0 (de)
NZ (1)	NZ309499A (de)
PT (1)	PT830345E (de)
WO (1)	WO1996039391A1 (de)
ZA (1)	ZA964693B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6448281B1 (en)	2000-07-06	2002-09-10	Boehringer Ingelheim (Canada) Ltd.	Viral polymerase inhibitors
EP2335700A1 (de)	2001-07-25	2011-06-22	Boehringer Ingelheim (Canada) Ltd.	Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur
US7098231B2 (en)	2003-01-22	2006-08-29	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
US7223785B2 (en)	2003-01-22	2007-05-29	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
CN1922174A (zh)	2004-02-20	2007-02-28	贝林格尔·英格海姆国际有限公司	病毒聚合酶抑制剂
CA2618682C (en)	2005-08-12	2011-06-21	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
NZ574028A (en)	2006-07-05	2010-10-29	Fibrotech Therapeutics Pty Ltd	Tranilast analogues (substituted cinnamoyl anthranilate compounds) for treatment of conditions associated with firbrosis
EP2947073B1 (de) *	2009-10-22	2019-04-03	Fibrotech Therapeutics Pty Ltd	Analoga von antifibriotischen mitteln mit kondensierten ringen
EP3577103A1 (de)	2017-02-03	2019-12-11	Certa Therapeutics Pty Ltd.	Antifibrotische verbindungen
KR102853258B1 (ko) *	2023-06-20	2025-09-01	이원다이애그노믹스(주)	암의 예방, 치료 또는 개선에 유효한 효과를 나타내는 신규한 화합물, 이의 제조방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3575956A (en) *	1967-07-24	1971-04-20	Sterling Drug Inc	2-substituted-benz-x-azol-6-ylazo-aminonaphthalene compounds
DE1670908A1 (de) *	1967-08-16	1971-04-29	Hoechst Ag	Neue Benzimidazolverbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung als optische Aufhellungsmittel
FR2104717A1 (en) *	1970-09-28	1972-04-21	Dynachim Sarl	Organophosphorus pesticides stabilised with benzimidazole derivs - - for controlling insects and internal parasites of animals
DE3505609A1 (de)	1985-02-19	1986-08-21	Merck Patent Gmbh, 6100 Darmstadt	Benzimidazolyl-pyridazinone
US5196446A (en)	1990-04-16	1993-03-23	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Certain indole compounds which inhibit EGF receptor tyrosine kinase
CA2080582A1 (en)	1990-04-16	1991-10-17	Alfred P. Spada	Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase
DE4212748A1 (de)	1992-04-16	1993-10-21	Thomae Gmbh Dr K	Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5387600A (en)	1992-07-30	1995-02-07	Fuji Photo Film Co., Ltd.	Treating arteriosclerosis using benzimidazole compositions

1995
- 1995-06-06 US US08/468,271 patent/US6444694B1/en not_active Expired - Fee Related
1996
- 1996-05-22 IL IL11838596A patent/IL118385A0/xx unknown
- 1996-05-30 AR ARP960102799A patent/AR002749A1/es unknown
- 1996-06-03 BR BR9609153A patent/BR9609153A/pt unknown
- 1996-06-03 DK DK96916978T patent/DK0830345T3/da active
- 1996-06-03 JP JP9500994A patent/JPH11506753A/ja active Pending
- 1996-06-03 DE DE69615023T patent/DE69615023T2/de not_active Expired - Fee Related
- 1996-06-03 ES ES96916978T patent/ES2162063T3/es not_active Expired - Lifetime
- 1996-06-03 CA CA002223585A patent/CA2223585A1/en not_active Abandoned
- 1996-06-03 AU AU59684/96A patent/AU711965B2/en not_active Ceased
- 1996-06-03 NZ NZ309499A patent/NZ309499A/xx unknown
- 1996-06-03 AT AT96916978T patent/ATE205196T1/de not_active IP Right Cessation
- 1996-06-03 CN CN96195860A patent/CN1192206A/zh active Pending
- 1996-06-03 KR KR1019970708745A patent/KR19990022266A/ko not_active Withdrawn
- 1996-06-03 PT PT96916978T patent/PT830345E/pt unknown
- 1996-06-03 WO PCT/US1996/008375 patent/WO1996039391A1/en not_active Ceased
- 1996-06-03 HU HU9900914A patent/HUP9900914A2/hu unknown
- 1996-06-03 EP EP96916978A patent/EP0830345B1/de not_active Expired - Lifetime
- 1996-06-03 HU HU9900679A patent/HUP9900679A3/hu unknown
- 1996-06-05 ZA ZA9604693A patent/ZA964693B/xx unknown

Also Published As

Publication number	Publication date
DE69615023T2 (de)	2002-06-06
PT830345E (pt)	2002-01-30
BR9609153A (pt)	1999-05-04
ZA964693B (en)	1997-12-05
JPH11506753A (ja)	1999-06-15
DE69615023D1 (de)	2001-10-11
HUP9900679A2 (hu)	1999-09-28
CA2223585A1 (en)	1996-12-12
EP0830345A1 (de)	1998-03-25
AR002749A1 (es)	1998-04-29
HUP9900914A2 (hu)	1999-07-28
AU711965B2 (en)	1999-10-28
NZ309499A (en)	2000-08-25
WO1996039391A1 (en)	1996-12-12
DK0830345T3 (da)	2001-11-19
US6444694B1 (en)	2002-09-03
MX9709647A (es)	1998-07-31
EP0830345B1 (de)	2001-09-05
AU5968496A (en)	1996-12-24
IL118385A0 (en)	1996-09-12
ES2162063T3 (es)	2001-12-16
KR19990022266A (ko)	1999-03-25
HUP9900679A3 (en)	2001-07-30
CN1192206A (zh)	1998-09-02

Legal Events

Date	Code	Title	Description
2001-12-15	UEP	Publication of translation of european patent specification
2003-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE275428T1 (de)	2004-09-15	Verwendung von 4-h-1-benzopyran-4-on-derivaten als inhibitoren der proliferation von glatten muskelzellen
EP0777478A4 (de)	1998-07-08	Inhibitoren der rotamase-enzymaktivität
PL323473A1 (en)	1998-03-30	Derivatives of aryl sulphonylaminobenzene and their application as factor xa inhibitors
DE69720886D1 (de)	2003-05-22	Gewichtsmessgerät von Kapseln
BR9609200A (pt)	1999-05-11	Derivados de alta treonina de alpha-hordotionina
BR9611130A (pt)	1999-03-30	Derivados de 3-aril-5-halógeno-pirona
FI971935A7 (fi)	1997-05-06	Polyanioniset bentsyyliglykosidit sileän lihaskudoksen solujen lisääntymisen estäjinä
HUP9900851A3 (en)	1999-11-29	Use of benzotiophene derivatives for producing pharmaceuticals for inhibiting vascular smooth muscle cell migration
ATE283702T1 (de)	2004-12-15	Leptin als inhibitor der tumorzellenproliferation
DE69603269D1 (de)	1999-08-19	Derivate von inulin
FI971934A7 (fi)	1997-05-06	Asyloituja bentsyyliglykosideja sileälihassolulisääntymisen inhibiittoreina
MX9100998A (es)	1992-05-04	Novedosos inhibidores de escualen sintetasa
DE69615023D1 (de)	2001-10-11	Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation
DE69632936D1 (de)	2004-08-26	Verwendung von Pyrrolverbindungen als Antifouling-Wirkstoff
FI971936A7 (fi)	1997-05-06	Sileän lihaskudoksen solujen lisääntymisen estäjät
NO933699D0 (no)	1993-10-14	Sulfaterte polysakkarider som hemmere av glatt muskelcelleproliferasjon
BR9607046A (pt)	1997-12-30	Derivados de 3-pirrolidiliden-2-ona-cefalosporinas
ATE209635T1 (de)	2001-12-15	2-substituierte benzimidazolderivate als inhibitoren der glatten muskelzellenproliferation
DE69617686D1 (de)	2002-01-17	Dihetrocyclische acrylonitrile als inhibitoren der glatten muskelzellen-proliferation
EP1024813A4 (de)	2002-08-28	Verwendung von sulfatierten oligosacchariden als inhibitoren von kardiovaskularen krankheiten
BR9609723A (pt)	1999-03-16	Derivados da tricetona
NO980862D0 (no)	1998-02-27	Zwitterinoformer av trovafloxacin
ZA959440B (en)	1997-05-07	Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation
AU5967396A (en)	1996-12-24	Benzimidazole derivatives as inhibitors of smooth muscle cell proliferation
DE69418656D1 (de)	1999-07-01	2-acyloxycephemderivate als elastaseinhibitoren