ATE205206T1 - Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren - Google Patents

Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren

Info

Publication number: ATE205206T1
Authority: AT; Austria
Prior art keywords: hydrogen; compounds; formula; alkyl; benzylidenthiazolidine
Prior art date: 1990-04-27

Application number

AT91303853T

Other languages

English (en)

Inventor

Toyonori Takebayashi

Takayuki Onodera

Kazuo Hasegawa

Takashi Fujita

Takao Yoshioka

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-27

Filing date

1991-04-29

Publication date

2001-09-15

1991-04-29 Application filed by Sankyo Co filed Critical Sankyo Co

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE205206T1 publication Critical patent/ATE205206T1/de

Links

NBDXUGXYPPZVBB-UHFFFAOYSA-N 2-benzylidene-1,3-thiazolidine Chemical class N1CCSC1=CC1=CC=CC=C1 NBDXUGXYPPZVBB-UHFFFAOYSA-N 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
150000002978 peroxides Chemical class 0.000 title 1
-1 formyloxy Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000005129 aryl carbonyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
OJMCHODKAHUBRT-UHFFFAOYSA-N 2-benzyl-1,3-thiazolidine Chemical class C=1C=CC=CC=1CC1NCCS1 OJMCHODKAHUBRT-UHFFFAOYSA-N 0.000 abstract 1
206010003210 Arteriosclerosis Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
125000005199 aryl carbonyloxy group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037765 diseases and disorders Diseases 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002218 hypoglycaemic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT91303853T 1990-04-27 1991-04-29 Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren ATE205206T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP11356690		1990-04-27

Publications (1)

Publication Number	Publication Date
ATE205206T1 true ATE205206T1 (de)	2001-09-15

Family

ID=14615508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91303853T ATE205206T1 (de)	1990-04-27	1991-04-29	Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren

Country Status (4)

Country	Link
US (1)	US5387596A (de)
EP (2)	EP0454501B1 (de)
AT (1)	ATE205206T1 (de)
DE (1)	DE69132713D1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2151145C1 (ru) *	1994-04-11	2000-06-20	Санкио Компани Лимитед	Промежуточное соединение для получения гетероциклических соединений, обладающих антидиабетической активностью
CZ293016B6 (cs) *	1995-06-01	2004-01-14	Sankyo Company Limited	Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
US5747528A (en) *	1996-02-21	1998-05-05	Warner-Lambert Company	Chroman derivatives as anti-oxidants
US5889025A (en) *	1996-05-06	1999-03-30	Reddy's Research Foundation	Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) *	1996-05-06	1999-07-06	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) *	1996-05-06	1997-12-02	Reddy Research Foundation	Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5801173A (en) *	1996-05-06	1998-09-01	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
WO1997043283A1 (de) *	1996-05-16	1997-11-20	Boehringer Mannheim Gmbh	Neues verfahren zur herstellung von troglitazone
US6372750B2 (en)	1996-07-01	2002-04-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en)	1996-07-01	2006-09-05	Dr. Reddy's Laboratories, Limited	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) *	1996-07-01	2000-09-05	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5985884A (en) *	1996-07-01	1999-11-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) *	1996-07-01	1999-03-23	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6632947B2 (en)	1997-02-18	2003-10-14	Smithkline Beecham Plc	Process for the preparation of substituted thiazolidinedione
UY24886A1 (es) *	1997-02-18	2001-08-27	Smithkline Beecham Plc	Tiazolidindiona
DE19711616A1 (de) *	1997-03-20	1998-09-24	Boehringer Mannheim Gmbh	Verbessertes Verfahren zur Herstellung von Thiazolidindionen
IN187716B (de) *	1998-09-14	2002-06-15	Reddy Research Foundation
FR2786485A1 (fr) *	1998-11-27	2000-06-02	Rhodia Chimie Sa	Procede de preparation de derives du 3-chromene, nouveaux derives du 3-chromene et utilisation de ces derives pour la preparation de thiazolidinones
FR2820742B1 (fr) *	2001-02-14	2005-03-11	Ppg Sipsy	Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
AU2002366812A1 (en) *	2001-12-20	2003-07-09	Teva Pharmaceutical Industries Ltd.	Hydrogenation of precursors to thiazolidinedione antihyperglycemics
CN1319956C (zh) *	2003-09-12	2007-06-06	深圳市海粤门生物科技开发有限公司	一种噻唑烷二酮的衍生物及其药用制剂的制备方法和应用
US7566787B2 (en) *	2004-12-22	2009-07-28	The Ohio State University	Small molecule cyclin D1 ablative agents
WO2006069186A2 (en) *	2004-12-22	2006-06-29	The Ohio State Research Foundation	Small molecule bcl-xl/bcl-2 binding inhibitors
US7973062B2 (en)	2008-02-22	2011-07-05	The Ohio State University Research Foundation	Androgen receptor-ablative agents
CA2777406A1 (en)	2009-10-09	2011-04-14	The Ohio State University Research Foundation	Thiazolidinedione energy restriction-mimetic agents
FR2986231B1 (fr) *	2012-01-26	2014-07-04	Centre Nat Rech Scient	Derives de thiazolidinedione, leur preparation et leur utilisation dans le traitement des cancers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en) *	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
JPS6051189A (ja) *	1983-08-30	1985-03-22	Sankyo Co Ltd	チアゾリジン誘導体およびその製造法
CN1003445B (zh) *	1984-10-03	1989-03-01	武田药品工业株式会社	噻唑烷二酮衍生物，其制备方法和用途
AR240698A1 (es) *	1985-01-19	1990-09-28	Takeda Chemical Industries Ltd	Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
HU210339B (en) *	1985-05-21	1995-03-28	Pfizer	Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect
US4812570A (en) *	1986-07-24	1989-03-14	Takeda Chemical Industries, Ltd.	Method for producing thiazolidinedione derivatives
US4873255A (en) *	1987-02-04	1989-10-10	Sankyo Company Limited	Thiazolidinone derivatives, their preparation and their use
US4933355A (en) *	1988-04-14	1990-06-12	Sankyo Company Limited	Thiazole derivatives, their preparation and their use in the treatment of diabetes complications

1991
- 1991-04-29 EP EP91303853A patent/EP0454501B1/de not_active Expired - Lifetime
- 1991-04-29 EP EP98100205A patent/EP0839812A1/de not_active Withdrawn
- 1991-04-29 DE DE69132713T patent/DE69132713D1/de not_active Expired - Lifetime
- 1991-04-29 AT AT91303853T patent/ATE205206T1/de not_active IP Right Cessation
1993
- 1993-07-21 US US08/095,311 patent/US5387596A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0454501A3 (en)	1992-04-08
US5387596A (en)	1995-02-07
EP0454501B1 (de)	2001-09-05
EP0454501A2 (de)	1991-10-30
DE69132713D1 (de)	2001-10-11
EP0839812A1 (de)	1998-05-06

Legal Events

Date	Code	Title	Description
2002-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE205206T1 (de)	2001-09-15	Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren
IE940525L (en)	1989-11-25	Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
DE69426331D1 (de)	2000-12-28	Arzneimittel gegen nervöse erkrankungen
DE69418243D1 (de)	1999-06-10	N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung
HU9301155D0 (en)	1993-07-28	Methods for producing steroide derivatives and for their application in medical treatment
NO914960L (no)	1991-12-16	Medikamenter for canserterapi med antihistaminegenskaper
ATE25682T1 (de)	1987-03-15	Indol-3-carboxamid-derivate.
ATE104145T1 (de)	1994-04-15	4-substituierten imidazolen zur senkung des intraokularen druckes.
ATE156119T1 (de)	1997-08-15	2-formylpyridin-thiosemicarbazonderivate, ihre herstellung und ihre verwendung als antitumor mittel
DE69828197D1 (de)	2005-01-20	Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut
DE3870167D1 (de)	1992-05-21	N-(vinblastinoyl-23)-derivate von 1-aminomethylposphonsaeure, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
ATE63541T1 (de)	1991-06-15	N-phenylethylaminoalkyl-benzamide als antiarrhythmische mittel.
FI895229A0 (fi)	1989-11-03	Foereningar foer behandling av urininkontinens och framstaellning daerav.
DE3572814D1 (en)	1989-10-12	1, 3-benzoxathiole derivatives, their use and their preparation
ATE18761T1 (de)	1986-04-15	Carbamoyloxybenzhydrol-derivate, ihre herstellung und ihre pharmazeutische zusammensetzungen.
NO20003138L (no)	2000-08-18	Ny anvendelse av lokalanestetika mot vaskulære hodepiner
FI932188A0 (fi)	1993-05-13	Oktahydronaftalenoximderivat foer inhibering av kolesterolbiosyntesen, deras framstaellning och anvaendning
HU9602534D0 (en)	1996-11-28	Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity
NO20020475D0 (no)	2002-01-29	2-aminotetralinderivater for terapi av glaukom
NO165593C (no)	1991-03-06	Analogifremgangsmaate ved fremstilling av nye tetracykliske indolderivater.
EP0461264A4 (en)	1992-02-19	Ethynylphenyl derivative, production thereof, and remedy for diseases of circulatory organs containing the same as active ingredient
WO2001035938A3 (de)	2002-02-14	Pharmakologisch aktive tetrahydrothiopyran-4-ol-derivate, verfahren zu ihrer herstellung und verwendung
ATE81465T1 (de)	1992-10-15	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
ES2037825T3 (es)	1993-07-01	Uso farmaceutico de tioeteres aromaticos.