ATE205484T1 - Aminotetrazol-derivate verwendbar als stickstoff- oxid-synthase inhibitoren - Google Patents

Aminotetrazol-derivate verwendbar als stickstoff- oxid-synthase inhibitoren

Info

Publication number: ATE205484T1
Authority: AT; Austria
Prior art keywords: oxide synthase; synthase inhibitors; nitrogen oxide; derivatives usable; aminotetrazole derivatives
Prior art date: 1994-11-09

Application number

AT95937674T

Other languages

English (en)

Inventor

Ann E Hallinan

Donald W Hansen Jr

Sofya Tsymbalov

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-09

Filing date

1995-11-08

Publication date

2001-09-15

1995-11-08 Application filed by Searle & Co filed Critical Searle & Co

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE205484T1 publication Critical patent/ATE205484T1/de

Links

MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title 3
ULRPISSMEBPJLN-UHFFFAOYSA-N 2h-tetrazol-5-amine Chemical class NC1=NN=NN1 ULRPISSMEBPJLN-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
239000000236 nitric oxide synthase inhibitor Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

AT95937674T 1994-11-09 1995-11-08 Aminotetrazol-derivate verwendbar als stickstoff- oxid-synthase inhibitoren ATE205484T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/336,596 US5684008A (en)	1994-11-09	1994-11-09	Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
PCT/US1995/014001 WO1996015120A1 (en)	1994-11-09	1995-11-08	Aminotetrazole derivatives useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number	Publication Date
ATE205484T1 true ATE205484T1 (de)	2001-09-15

Family

ID=23316811

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT95937674T ATE205484T1 (de)	1994-11-09	1995-11-08	Aminotetrazol-derivate verwendbar als stickstoff- oxid-synthase inhibitoren
AT01104598T ATE334974T1 (de)	1994-11-09	1995-11-08	Aminotetrazolderivate als stickstoffmonoxid- synthaseinhibitoren

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT01104598T ATE334974T1 (de)	1994-11-09	1995-11-08	Aminotetrazolderivate als stickstoffmonoxid- synthaseinhibitoren

Country Status (16)

Country	Link
US (5)	US5684008A (de)
EP (2)	EP0790987B1 (de)
JP (1)	JP3278165B2 (de)
KR (1)	KR970707107A (de)
CN (1)	CN1065531C (de)
AT (2)	ATE205484T1 (de)
AU (1)	AU696527B2 (de)
BR (1)	BR9509629A (de)
CA (1)	CA2203237C (de)
DE (2)	DE69522703T2 (de)
DK (2)	DK0790987T3 (de)
ES (2)	ES2164164T3 (de)
NZ (1)	NZ296019A (de)
PT (2)	PT790987E (de)
RU (1)	RU2152927C1 (de)
WO (1)	WO1996015120A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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US5684008A (en) *	1994-11-09	1997-11-04	G. D. Searle & Co.	Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
US5919940A (en) *	1995-01-20	1999-07-06	British Biotech Pharmaceuticals Limited	Metalloproteinase inhibitors
US5981511A (en) *	1996-03-06	1999-11-09	G.D. Searle & Co.	Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) *	1996-03-06	1999-08-31	G.D. Searle & Co.	Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US6552052B2 (en)	1998-06-10	2003-04-22	Monsanto/G.D. Searle	Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors
CN1420769A (zh) *	1998-09-08	2003-05-28	孟山都公司	用可诱导的氧化氮合成酶的抑制剂治疗骨关节炎的方法
AU1308400A (en) *	1998-10-30	2000-05-22	G.D. Searle & Co.	Novel amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors
AU2847200A (en) *	1999-01-27	2000-08-18	G.D. Searle & Co.	Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors
WO2000063195A1 (en) *	1999-04-19	2000-10-26	G.D. Searle & Co.	Novel heterocyclic amino carbonyl derivatives useful as nitric oxide synthase inhibitors
WO2001005748A1 (en) *	1999-07-15	2001-01-25	Monsanto Company	Oligomeric amino acid derivatives useful as nitric oxide synthase inhibitors
GEP20094625B (en)	2000-03-24	2009-03-10	Pharmacia Corp	Amidino compound and salts thereof useful as nitric oxide synthase inhibitors
US6956131B2 (en)	2000-04-13	2005-10-18	Pharmacia Corporation	2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
AR032318A1 (es)	2000-04-13	2003-11-05	Pharmacia Corp	Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
US6545170B2 (en)	2000-04-13	2003-04-08	Pharmacia Corporation	2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR030416A1 (es)	2000-04-13	2003-08-20	Pharmacia Corp	COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
AR034120A1 (es)	2000-04-13	2004-02-04	Pharmacia Corp	Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
US6787668B2 (en)	2000-04-13	2004-09-07	Pharmacia Corporation	2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
TWI290130B (en)	2000-09-15	2007-11-21	Pharmacia Corp	2-Amino-2alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
TWI243164B (en) *	2001-02-13	2005-11-11	Aventis Pharma Gmbh	Acylated indanyl amines and their use as pharmaceuticals
US7012098B2 (en) *	2001-03-23	2006-03-14	Pharmacia Corporation	Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US20030109522A1 (en) *	2001-09-24	2003-06-12	Manning Pamela T.	Ophthalmologic treatment methods using selective iNOS inhibitors
BR0313204A (pt) *	2002-08-02	2005-06-28	Pharmacia Corp	Métodos para tratamento e prevenção de condições gastrointestinais
ES2384969T3 (es) *	2002-08-23	2012-07-16	Pharmacia Corporation	Forma sólida cristalina del ácido (2S-5Z)-2-amino-7-(etanimidoilamino)-2-metilhept-5-enoico
EP1741709A1 (de) *	2005-06-28	2007-01-10	Sanofi-Aventis Deutschland GmbH	Heteroaryl substituierte Amide mit gesättigtem Linker, und deren Verwendung als Pharmaka
CN115990138A (zh) *	2015-01-14	2023-04-21	奇斯药制品公司	包含高纯度坎格雷洛的药物制剂以及制备和使用它们的方法

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AU3230895A (en) *	1994-08-18	1996-03-14	Chugai Seiyaku Kabushiki Kaisha	Amino acid derivative having nitrogen monoxide synthetase inhibitor activity
US5684008A (en) *	1994-11-09	1997-11-04	G. D. Searle & Co.	Aminotetrazole derivatives useful as nitric oxide synthase inhibitors

1994
- 1994-11-09 US US08/336,596 patent/US5684008A/en not_active Expired - Fee Related
1995
- 1995-11-08 KR KR1019970703106A patent/KR970707107A/ko not_active Ceased
- 1995-11-08 PT PT95937674T patent/PT790987E/pt unknown
- 1995-11-08 AT AT95937674T patent/ATE205484T1/de not_active IP Right Cessation
- 1995-11-08 BR BR9509629A patent/BR9509629A/pt not_active IP Right Cessation
- 1995-11-08 EP EP95937674A patent/EP0790987B1/de not_active Expired - Lifetime
- 1995-11-08 ES ES95937674T patent/ES2164164T3/es not_active Expired - Lifetime
- 1995-11-08 JP JP51609696A patent/JP3278165B2/ja not_active Expired - Fee Related
- 1995-11-08 WO PCT/US1995/014001 patent/WO1996015120A1/en not_active Ceased
- 1995-11-08 ES ES01104598T patent/ES2269240T3/es not_active Expired - Lifetime
- 1995-11-08 DK DK95937674T patent/DK0790987T3/da active
- 1995-11-08 DK DK01104598T patent/DK1113011T3/da active
- 1995-11-08 DE DE69522703T patent/DE69522703T2/de not_active Expired - Fee Related
- 1995-11-08 PT PT01104598T patent/PT1113011E/pt unknown
- 1995-11-08 RU RU97109847/04A patent/RU2152927C1/ru not_active IP Right Cessation
- 1995-11-08 EP EP01104598A patent/EP1113011B1/de not_active Expired - Lifetime
- 1995-11-08 US US08/817,971 patent/US5854251A/en not_active Expired - Fee Related
- 1995-11-08 CA CA002203237A patent/CA2203237C/en not_active Expired - Fee Related
- 1995-11-08 AU AU39711/95A patent/AU696527B2/en not_active Ceased
- 1995-11-08 DE DE69535148T patent/DE69535148T2/de not_active Expired - Fee Related
- 1995-11-08 AT AT01104598T patent/ATE334974T1/de not_active IP Right Cessation
- 1995-11-08 NZ NZ296019A patent/NZ296019A/en not_active IP Right Cessation
- 1995-11-08 CN CN95197112A patent/CN1065531C/zh not_active Expired - Fee Related
1998
- 1998-10-05 US US09/166,036 patent/US5919787A/en not_active Expired - Fee Related
1999
- 1999-03-12 US US09/267,266 patent/US6169089B1/en not_active Expired - Fee Related
2000
- 2000-10-13 US US09/687,350 patent/US6410542B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU696527B2 (en)	1998-09-10
WO1996015120A1 (en)	1996-05-23
ATE334974T1 (de)	2006-08-15
DE69522703D1 (de)	2001-10-18
JPH10508847A (ja)	1998-09-02
CA2203237A1 (en)	1996-05-23
ES2269240T3 (es)	2007-04-01
US5854251A (en)	1998-12-29
US6410542B1 (en)	2002-06-25
EP1113011A1 (de)	2001-07-04
ES2164164T3 (es)	2002-02-16
CN1065531C (zh)	2001-05-09
EP0790987B1 (de)	2001-09-12
DE69522703T2 (de)	2002-07-11
US6169089B1 (en)	2001-01-02
US5919787A (en)	1999-07-06
PT790987E (pt)	2002-02-28
RU2152927C1 (ru)	2000-07-20
BR9509629A (pt)	1998-01-06
JP3278165B2 (ja)	2002-04-30
US5684008A (en)	1997-11-04
EP1113011B1 (de)	2006-08-02
PT1113011E (pt)	2006-11-30
CN1171104A (zh)	1998-01-21
DK0790987T3 (da)	2001-11-12
DE69535148T2 (de)	2007-07-05
NZ296019A (en)	1998-09-24
DK1113011T3 (da)	2006-11-27
HK1036802A1 (en)	2002-01-18
KR970707107A (ko)	1997-12-01
EP0790987A1 (de)	1997-08-27
CA2203237C (en)	2008-06-03
AU3971195A (en)	1996-06-06
DE69535148D1 (de)	2006-09-14

Legal Events

Date	Code	Title	Description
2002-02-15	UEP	Publication of translation of european patent specification
2010-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE205484T1 (de)	2001-09-15	Aminotetrazol-derivate verwendbar als stickstoff- oxid-synthase inhibitoren
PT1140851E (pt)	2004-12-31	4-oxo-1,4-di-hidro-3-quinolinacarboxamidas como agentes antivirais
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