ATE205515T1 - Versteifte trimethin-cyaninfarbstoffe - Google Patents
Versteifte trimethin-cyaninfarbstoffeInfo
- Publication number
- ATE205515T1 ATE205515T1 AT98963218T AT98963218T ATE205515T1 AT E205515 T1 ATE205515 T1 AT E205515T1 AT 98963218 T AT98963218 T AT 98963218T AT 98963218 T AT98963218 T AT 98963218T AT E205515 T1 ATE205515 T1 AT E205515T1
- Authority
- AT
- Austria
- Prior art keywords
- atoms
- groups
- optionally
- cyanine dyes
- radical
- Prior art date
Links
- 239000000975 dye Substances 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical class [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
- 230000003595 spectral effect Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000013077 target material Substances 0.000 abstract 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0075—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Lasers (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99221297A | 1997-12-17 | 1997-12-17 | |
| PCT/US1998/026665 WO1999031181A1 (en) | 1997-12-17 | 1998-12-16 | Rigidized trimethine cyanine dyes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE205515T1 true ATE205515T1 (de) | 2001-09-15 |
Family
ID=25538049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98963218T ATE205515T1 (de) | 1997-12-17 | 1998-12-16 | Versteifte trimethin-cyaninfarbstoffe |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6686145B1 (de) |
| EP (1) | EP1042407B1 (de) |
| JP (1) | JP4927253B2 (de) |
| AT (1) | ATE205515T1 (de) |
| AU (1) | AU760598B2 (de) |
| CA (1) | CA2314188C (de) |
| DE (1) | DE69801682T2 (de) |
| DK (1) | DK1042407T3 (de) |
| ES (1) | ES2165711T3 (de) |
| WO (1) | WO1999031181A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133445A (en) | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
| CA2376955A1 (en) * | 1999-07-06 | 2001-01-11 | Surromed, Inc. | Bridged fluorescent dyes, their preparation and their use in assays |
| DE19937024A1 (de) * | 1999-08-05 | 2001-02-08 | Bayer Ag | Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker |
| EP1223197B1 (de) | 2001-01-03 | 2012-08-08 | Visen Medical, Inc. | Symmetrische, monofunktionalisierte Polymethinfarbstoffe als Markierungsreagenzien |
| EP1221465A1 (de) | 2001-01-03 | 2002-07-10 | Innosense S.r.l. | Symmetrische, monofunktionalisierte Polymethinfarbstoffe als Markierungsreagenzien |
| US7615646B2 (en) * | 2002-05-10 | 2009-11-10 | Carnegie Mellon University | Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups |
| JP5214967B2 (ja) | 2004-08-13 | 2013-06-19 | エポック バイオサイエンシズ インコーポレーティッド | ホスホン酸蛍光色素および複合体 |
| US7425221B2 (en) | 2004-09-13 | 2008-09-16 | L'oreal S.A. | Composition comprising at least one substituted derivative of carbocyanine, method for treating keratin fibers using it, device and use |
| FR2875131B1 (fr) * | 2004-09-13 | 2007-09-28 | Oreal | Composition comprenant au moins un derive substitue de carbocyanine, procede de traitement des fibres keratiniques la mettant en oeuvre, dispositif et utilisation |
| US7419511B2 (en) | 2004-09-13 | 2008-09-02 | L'oreal, S.A. | Compositions comprising at least one substituted carbocyanin derivative, processes for treating keratin fibers using them, device therefor and uses thereof |
| US7427301B2 (en) | 2004-09-13 | 2008-09-23 | L'ORéAL S.A. | Composition comprising at least one substituted carbocyanin derivative, process for treating keratin fibers using it, device therefor and use thereof |
| WO2006035207A2 (en) | 2004-09-30 | 2006-04-06 | Ge Healthcare Uk Limited | Fluorescent nucleotide analogues |
| US7381572B2 (en) | 2004-12-23 | 2008-06-03 | Rutgers, The State University Of New Jersey | Reagents and procedures for multi-label high-specificity labeling |
| US7282373B2 (en) | 2004-12-23 | 2007-10-16 | Rutgers, The State University Of New Jersey | Ultra-high specificity fluorescent labeling |
| EP1846754A4 (de) * | 2005-02-01 | 2008-10-08 | Sigma Aldrich Co | Erkennung von polyaminosäuren über trimethinyanin-färbungen |
| US7737281B2 (en) * | 2005-05-24 | 2010-06-15 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Purine based fluorescent dyes |
| US8357801B2 (en) | 2005-05-24 | 2013-01-22 | Enzo Life Sciences, Inc. | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits |
| US7569695B2 (en) * | 2005-05-24 | 2009-08-04 | Enzo Life Sciences, Inc. | Dyes for the detection or quantification of desirable target molecules |
| US8173819B2 (en) | 2005-09-02 | 2012-05-08 | Visen Medical, Inc. | Nicotinic and picolinic acid derived near-infrared fluorophores |
| ES2612738T3 (es) | 2005-09-02 | 2017-05-18 | Visen Medical, Inc. | Agentes de formación de imágenes fluorescentes biocompatibles |
| JP5106397B2 (ja) | 2005-09-02 | 2012-12-26 | ビセン メディカル， インコーポレイテッド | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
| US7972789B2 (en) * | 2005-11-28 | 2011-07-05 | Dako Denmark A/S | Dye compounds |
| US9250249B2 (en) | 2008-09-08 | 2016-02-02 | Enzo Biochem, Inc. | Autophagy and phospholipidosis pathway assays |
| US9334281B2 (en) * | 2008-09-08 | 2016-05-10 | Enzo Life Sciences, Inc. | Fluorochromes for organelle tracing and multi-color imaging |
| CA2749403A1 (en) | 2009-01-13 | 2010-09-02 | Glaxo Group Limited | Pyrimidinecarboxamide derivatives as inhibitors of syk kinase |
| GB201007203D0 (en) | 2010-04-29 | 2010-06-16 | Glaxo Group Ltd | Novel compounds |
| ES2678211T3 (es) | 2012-03-27 | 2018-08-09 | Ventana Medical Systems, Inc. | Conjugados de señalización y procedimientos de uso |
| US10473666B2 (en) * | 2015-07-16 | 2019-11-12 | Sfc Co., Ltd. | Dye compounds |
| EP3655408B1 (de) | 2017-08-24 | 2021-07-14 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Konformationale einschränkung von cyaninfluorophoren im fernrot- und nahinfrarotbereich |
| KR102777649B1 (ko) * | 2017-11-23 | 2025-03-11 | 에스에프씨 주식회사 | 표지용 염료 및 이를 포함하는 표지용 키트 |
| KR102593166B1 (ko) * | 2017-11-23 | 2023-10-25 | 에스에프씨 주식회사 | 표지용 염료 및 이를 포함하는 표지용 키트 |
| MX2021000470A (es) * | 2018-07-13 | 2021-06-23 | Quantum Si Inc | Etiquetas biconjugables y métodos de uso. |
| WO2023153739A1 (ko) * | 2022-02-10 | 2023-08-17 | 에스에프씨 주식회사 | 신규한 화합물 및 이의 용도 |
| EP4665402A1 (de) | 2023-02-17 | 2025-12-24 | Danmarks Tekniske Universitet | Copolymer-wirkstoff-konjugat zur behandlung von tumoren |
| WO2025144711A1 (en) * | 2023-12-29 | 2025-07-03 | Illumina, Inc. | Tricyclic polymethine dyes for nucleic acid sequencing |
| CN122036584A (zh) * | 2024-10-11 | 2026-05-15 | 深圳大学 | 一种荧光染料化合物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3915715A (en) | 1970-08-13 | 1975-10-28 | Eastman Kodak Co | Silver halide photographic materials containing a high weight ratio of gold to sulfur sensitizers and a sensitizing methine dye |
| US3753721A (en) | 1970-08-13 | 1973-08-21 | Eastman Kodak Co | Photographic materials |
| US3821233A (en) | 1970-10-30 | 1974-06-28 | Eastman Kodak Co | Rigidized carbocyanine dyes containing a pyrida-dipyridinium nucleus |
| US3854956A (en) | 1970-10-30 | 1974-12-17 | Eastman Kodak Co | Dyestuffs and spectral sensitizers for silver halide |
| US3679427A (en) | 1970-10-30 | 1972-07-25 | Eastman Kodak Co | Rigidized carbocyanine dyes and photographic emulsions |
| CA985493A (en) | 1971-03-22 | 1976-03-16 | Eastman Kodak Company | Dye lasers including rigidized carbocyanine dyes |
| US3864644A (en) | 1971-03-22 | 1975-02-04 | Eastman Kodak Co | Dye lasers including rigidized carbocyanine dyes |
| US3904637A (en) | 1972-04-19 | 1975-09-09 | Eastman Kodak Co | 7'a'h,8'a'h-bisbenzothiazolo(3,2-a;-3',2'-a)pyrano (3,2-c;5,6-c'+9 dipyridinium compounds and related derivatives thereof |
| ATE227322T1 (de) * | 1995-06-07 | 2002-11-15 | Univ Carnegie Mellon | Versteifte monomethin-cyaninfarbstoffe |
| US5658735A (en) | 1995-11-09 | 1997-08-19 | Biometric Imaging, Inc. | Cyclized fluorescent nucleic acid intercalating cyanine dyes and nucleic acid detection methods |
| US6133445A (en) | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
-
1998
- 1998-12-16 EP EP98963218A patent/EP1042407B1/de not_active Expired - Lifetime
- 1998-12-16 ES ES98963218T patent/ES2165711T3/es not_active Expired - Lifetime
- 1998-12-16 AU AU18288/99A patent/AU760598B2/en not_active Expired
- 1998-12-16 DK DK98963218T patent/DK1042407T3/da active
- 1998-12-16 JP JP2000539092A patent/JP4927253B2/ja not_active Expired - Lifetime
- 1998-12-16 DE DE69801682T patent/DE69801682T2/de not_active Expired - Lifetime
- 1998-12-16 AT AT98963218T patent/ATE205515T1/de active
- 1998-12-16 US US09/581,679 patent/US6686145B1/en not_active Expired - Lifetime
- 1998-12-16 CA CA002314188A patent/CA2314188C/en not_active Expired - Lifetime
- 1998-12-16 WO PCT/US1998/026665 patent/WO1999031181A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU1828899A (en) | 1999-07-05 |
| ES2165711T3 (es) | 2002-03-16 |
| DK1042407T3 (da) | 2001-12-27 |
| DE69801682T2 (de) | 2002-06-20 |
| US6686145B1 (en) | 2004-02-03 |
| DE69801682D1 (en) | 2001-10-18 |
| WO1999031181A1 (en) | 1999-06-24 |
| JP2002508428A (ja) | 2002-03-19 |
| AU760598B2 (en) | 2003-05-15 |
| EP1042407B1 (de) | 2001-09-12 |
| JP4927253B2 (ja) | 2012-05-09 |
| CA2314188C (en) | 2009-11-17 |
| EP1042407A1 (de) | 2000-10-11 |
| CA2314188A1 (en) | 1999-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |