ATE205515T1 - Versteifte trimethin-cyaninfarbstoffe - Google Patents

Versteifte trimethin-cyaninfarbstoffe

Info

Publication number
ATE205515T1
ATE205515T1 AT98963218T AT98963218T ATE205515T1 AT E205515 T1 ATE205515 T1 AT E205515T1 AT 98963218 T AT98963218 T AT 98963218T AT 98963218 T AT98963218 T AT 98963218T AT E205515 T1 ATE205515 T1 AT E205515T1
Authority
AT
Austria
Prior art keywords
atoms
groups
optionally
cyanine dyes
radical
Prior art date
Application number
AT98963218T
Other languages
English (en)
Inventor
Alan S Waggoner
Ratnakar B Mujumdar
Original Assignee
Univ Carnegie Mellon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Carnegie Mellon filed Critical Univ Carnegie Mellon
Application granted granted Critical
Publication of ATE205515T1 publication Critical patent/ATE205515T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0075—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Lasers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT98963218T 1997-12-17 1998-12-16 Versteifte trimethin-cyaninfarbstoffe ATE205515T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99221297A 1997-12-17 1997-12-17
PCT/US1998/026665 WO1999031181A1 (en) 1997-12-17 1998-12-16 Rigidized trimethine cyanine dyes

Publications (1)

Publication Number Publication Date
ATE205515T1 true ATE205515T1 (de) 2001-09-15

Family

ID=25538049

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98963218T ATE205515T1 (de) 1997-12-17 1998-12-16 Versteifte trimethin-cyaninfarbstoffe

Country Status (10)

Country Link
US (1) US6686145B1 (de)
EP (1) EP1042407B1 (de)
JP (1) JP4927253B2 (de)
AT (1) ATE205515T1 (de)
AU (1) AU760598B2 (de)
CA (1) CA2314188C (de)
DE (1) DE69801682T2 (de)
DK (1) DK1042407T3 (de)
ES (1) ES2165711T3 (de)
WO (1) WO1999031181A1 (de)

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US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
CA2376955A1 (en) * 1999-07-06 2001-01-11 Surromed, Inc. Bridged fluorescent dyes, their preparation and their use in assays
DE19937024A1 (de) * 1999-08-05 2001-02-08 Bayer Ag Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker
EP1221465A1 (de) 2001-01-03 2002-07-10 Innosense S.r.l. Symmetrische, monofunktionalisierte Polymethinfarbstoffe als Markierungsreagenzien
EP1223197B1 (de) 2001-01-03 2012-08-08 Visen Medical, Inc. Symmetrische, monofunktionalisierte Polymethinfarbstoffe als Markierungsreagenzien
JP4749718B2 (ja) * 2002-05-10 2011-08-17 カーネギー・メロン・ユニヴァーシティ 官能基を含有するキラルインドール中間体およびそれらの蛍光シアニン染料
EP1781675B1 (de) 2004-08-13 2014-03-26 Epoch Biosciences, Inc. Fluoreszierende phosphonatfarbstoffe und konjugate
US7425221B2 (en) 2004-09-13 2008-09-16 L'oreal S.A. Composition comprising at least one substituted derivative of carbocyanine, method for treating keratin fibers using it, device and use
US7419511B2 (en) 2004-09-13 2008-09-02 L'oreal, S.A. Compositions comprising at least one substituted carbocyanin derivative, processes for treating keratin fibers using them, device therefor and uses thereof
US7427301B2 (en) 2004-09-13 2008-09-23 L'ORéAL S.A. Composition comprising at least one substituted carbocyanin derivative, process for treating keratin fibers using it, device therefor and use thereof
FR2875131B1 (fr) * 2004-09-13 2007-09-28 Oreal Composition comprenant au moins un derive substitue de carbocyanine, procede de traitement des fibres keratiniques la mettant en oeuvre, dispositif et utilisation
US7445902B2 (en) 2004-09-30 2008-11-04 Ge Healthcare Uk Limited Fluorescent nucleotide analogues
US7381572B2 (en) 2004-12-23 2008-06-03 Rutgers, The State University Of New Jersey Reagents and procedures for multi-label high-specificity labeling
US7282373B2 (en) 2004-12-23 2007-10-16 Rutgers, The State University Of New Jersey Ultra-high specificity fluorescent labeling
EP1846754A4 (de) * 2005-02-01 2008-10-08 Sigma Aldrich Co Erkennung von polyaminosäuren über trimethinyanin-färbungen
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
US8357801B2 (en) 2005-05-24 2013-01-22 Enzo Life Sciences, Inc. Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
DK1937676T3 (en) 2005-09-02 2017-03-06 Visen Medical Inc Biocompatible fluorescent imaging compounds
CN101296927A (zh) 2005-09-02 2008-10-29 Visen医药公司 生物相容的含n,n-二取代磺酰胺的荧光染料标记
WO2007028118A2 (en) 2005-09-02 2007-03-08 Visen Medical, Inc. Nicotinic acid and picolinic acid derived near-infrared fluorophores
US7972789B2 (en) * 2005-11-28 2011-07-05 Dako Denmark A/S Dye compounds
US9250249B2 (en) 2008-09-08 2016-02-02 Enzo Biochem, Inc. Autophagy and phospholipidosis pathway assays
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
MX2011007499A (es) 2009-01-13 2011-08-04 Glaxo Group Ltd Derivados de pirimidin-carboxamida como inhibidores de la cinasa syk.
GB201007203D0 (en) 2010-04-29 2010-06-16 Glaxo Group Ltd Novel compounds
WO2013148498A1 (en) 2012-03-27 2013-10-03 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
CN107850601B (zh) * 2015-07-16 2021-06-29 Sfc株式会社 染料化合物
EP3655408B1 (de) * 2017-08-24 2021-07-14 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Konformationale einschränkung von cyaninfluorophoren im fernrot- und nahinfrarotbereich
KR102777649B1 (ko) * 2017-11-23 2025-03-11 에스에프씨 주식회사 표지용 염료 및 이를 포함하는 표지용 키트
KR102593166B1 (ko) * 2017-11-23 2023-10-25 에스에프씨 주식회사 표지용 염료 및 이를 포함하는 표지용 키트
EP3820943A1 (de) * 2018-07-13 2021-05-19 Quantum-si Incorporated Bikonjugierbare etiketten und verwendungsverfahren
WO2023153739A1 (ko) * 2022-02-10 2023-08-17 에스에프씨 주식회사 신규한 화합물 및 이의 용도
WO2024170742A1 (en) 2023-02-17 2024-08-22 Danmarks Tekniske Universitet Copolymer-drug conjugate for treatment of tumours
WO2025144711A1 (en) * 2023-12-29 2025-07-03 Illumina, Inc. Tricyclic polymethine dyes for nucleic acid sequencing
CN122036584A (zh) * 2024-10-11 2026-05-15 深圳大学 一种荧光染料化合物及其制备方法和应用

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US3915715A (en) 1970-08-13 1975-10-28 Eastman Kodak Co Silver halide photographic materials containing a high weight ratio of gold to sulfur sensitizers and a sensitizing methine dye
US3753721A (en) 1970-08-13 1973-08-21 Eastman Kodak Co Photographic materials
US3821233A (en) 1970-10-30 1974-06-28 Eastman Kodak Co Rigidized carbocyanine dyes containing a pyrida-dipyridinium nucleus
US3679427A (en) * 1970-10-30 1972-07-25 Eastman Kodak Co Rigidized carbocyanine dyes and photographic emulsions
US3854956A (en) 1970-10-30 1974-12-17 Eastman Kodak Co Dyestuffs and spectral sensitizers for silver halide
US3864644A (en) * 1971-03-22 1975-02-04 Eastman Kodak Co Dye lasers including rigidized carbocyanine dyes
CA985493A (en) 1971-03-22 1976-03-16 Eastman Kodak Company Dye lasers including rigidized carbocyanine dyes
US3904637A (en) 1972-04-19 1975-09-09 Eastman Kodak Co 7'a'h,8'a'h-bisbenzothiazolo(3,2-a;-3',2'-a)pyrano (3,2-c;5,6-c'+9 dipyridinium compounds and related derivatives thereof
GB2301832B (en) 1995-06-07 1998-03-11 Univ Carnegie Mellon Rigidized monomethine cyanine dyes
US5658735A (en) * 1995-11-09 1997-08-19 Biometric Imaging, Inc. Cyclized fluorescent nucleic acid intercalating cyanine dyes and nucleic acid detection methods
US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes

Also Published As

Publication number Publication date
EP1042407A1 (de) 2000-10-11
DE69801682T2 (de) 2002-06-20
EP1042407B1 (de) 2001-09-12
JP2002508428A (ja) 2002-03-19
JP4927253B2 (ja) 2012-05-09
ES2165711T3 (es) 2002-03-16
AU1828899A (en) 1999-07-05
CA2314188A1 (en) 1999-06-24
DE69801682D1 (en) 2001-10-18
WO1999031181A1 (en) 1999-06-24
AU760598B2 (en) 2003-05-15
US6686145B1 (en) 2004-02-03
CA2314188C (en) 2009-11-17
DK1042407T3 (da) 2001-12-27

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Legal Events

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UEP Publication of translation of european patent specification