ATE205850T1 - Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden - Google Patents

Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden

Info

Publication number: ATE205850T1
Authority: AT; Austria
Prior art keywords: treatment; chemotherapeutic; antiviral agents; pyrimidine nucleosides; toxic effects
Prior art date: 1991-07-05

Application number

AT92914215T

Other languages

English (en)

Inventor

Borstel Reid W Von

Michael K Bamat

Original Assignee

Pro Neuron Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-05

Filing date

1992-06-25

Publication date

2001-10-15

1992-06-25 Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE205850T1 publication Critical patent/ATE205850T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
239000003443 antiviral agent Substances 0.000 title abstract 2
239000002718 pyrimidine nucleoside Substances 0.000 title abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
230000000973 chemotherapeutic effect Effects 0.000 title 1
231100000331 toxic Toxicity 0.000 title 1
230000002588 toxic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
238000002512 chemotherapy Methods 0.000 abstract 1
229940127089 cytotoxic agent Drugs 0.000 abstract 1
210000000777 hematopoietic system Anatomy 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003230 pyrimidines Chemical class 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Hematology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT92914215T 1991-07-05 1992-06-25 Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden ATE205850T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72434091A	1991-07-05	1991-07-05
PCT/US1992/005324 WO1993001202A1 (en)	1991-07-05	1992-06-25	Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides

Publications (1)

Publication Number	Publication Date
ATE205850T1 true ATE205850T1 (de)	2001-10-15

Family

ID=24910042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92914215T ATE205850T1 (de)	1991-07-05	1992-06-25	Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden

Country Status (12)

Country	Link
EP (1)	EP0594667B1 (de)
JP (1)	JP2584947B2 (de)
KR (1)	KR100256144B1 (de)
AT (1)	ATE205850T1 (de)
AU (1)	AU667676B2 (de)
CA (2)	CA2111571C (de)
DE (1)	DE69232070T2 (de)
DK (1)	DK0594667T3 (de)
ES (1)	ES2160579T3 (de)
GR (1)	GR3036749T3 (de)
WO (1)	WO1993001202A1 (de)
ZA (1)	ZA924975B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5691320A (en)	1987-10-28	1997-11-25	Pro-Neuron, Inc.	Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
US6329350B1 (en)	1987-10-28	2001-12-11	Pro-Neuron, Inc.	Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US5968914A (en) *	1987-10-28	1999-10-19	Pro-Neuron, Inc.	Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
JP4408450B2 (ja)	1994-07-01	2010-02-03	ウェルスタットセラピューティクスコーポレイション	全身性炎症および炎症性肝炎の処置のためのピリミジンヌクレオチド前駆体
CA2189097A1 (en) *	1995-11-15	1997-05-16	Pin-Fang Lin	Composition and method of treating retroviral infection
US5719132A (en) *	1996-06-27	1998-02-17	Bristol-Myers Squibb Company	Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
US6875751B2 (en)	2000-06-15	2005-04-05	Idenix Pharmaceuticals, Inc.	3′-prodrugs of 2′-deoxy-β-L-nucleosides
DE10110355A1 (de)	2001-03-03	2002-09-12	Ulrich Walker	Bekämpfung von Nebenwirkungen
US6905669B2 (en)	2001-04-24	2005-06-14	Supergen, Inc.	Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US6982253B2 (en)	2002-06-05	2006-01-03	Supergen, Inc.	Liquid formulation of decitabine and use of the same
US7250416B2 (en)	2005-03-11	2007-07-31	Supergen, Inc.	Azacytosine analogs and derivatives
US7700567B2 (en)	2005-09-29	2010-04-20	Supergen, Inc.	Oligonucleotide analogues incorporating 5-aza-cytosine therein
CN102014919B (zh)	2008-03-03	2015-02-25	托斯克公司	减少毒性的甲氨蝶呤佐剂及其使用方法
EP3431142B1 (de)	2011-08-30	2020-06-17	Astex Pharmaceuticals, Inc.	Decitabinderivatformulierungen
WO2013055252A1 (ru) *	2011-10-14	2013-04-18	Закрытое Акционерное Общество " Производственно-Коммерческая Ассоциация Азт"	Соли эфиров карбомоилфосфоновой кислоты, являющиеся селективными ингибиторами продукции вируса иммунодефицита человека вич-1
AU2016287585B2 (en)	2015-07-02	2020-12-17	Otsuka Pharmaceutical Co., Ltd.	Lyophilized pharmaceutical compositions
US10874683B2 (en)	2016-03-10	2020-12-29	Emory University	N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN110121359A (zh) *	2016-11-11	2019-08-13	怀特黑德生物制剂研究所	人血浆培养基
RU2020108580A (ru)	2017-08-03	2021-09-03	Оцука Фармасьютикал Ко., Лтд.	Лекарственное соединение и способы его очистки
WO2020036982A1 (en)	2018-08-14	2020-02-20	Tosk, Inc.	Methods and compositions for treating mucositis
WO2020036974A1 (en) *	2018-08-14	2020-02-20	Tosk, Inc.	Methods and compositions for reducing radiation induced toxicity
WO2020036975A1 (en) *	2018-08-14	2020-02-20	Tosk, Inc.	Methods and compositions for reducing fluorouracil induced toxicity
US11446303B2 (en)	2019-06-21	2022-09-20	Tosk, Inc.	Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions
EP4178581A4 (de)	2020-07-07	2024-06-05	Tosk, Inc.	Uridinphosphorylasehemmer zur behandlung oder prävention von lungenerkrankungen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3100478A1 (de) *	1981-01-09	1982-08-12	Dr. Thilo & Co GmbH, 8021 Sauerlach	5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
DE3481191D1 (de) *	1983-07-20	1990-03-08	Teijin Ltd	Antineoplastisches mittel.
EP0712629B1 (de) *	1987-10-28	2003-06-18	Wellstat Therapeutics Corporation	Acyldeoxyribonukleosid-Derivate und Verwendungen davon
CA1321994C (en) *	1987-10-28	1993-09-07	Reid Von Borstel	Acylated uridine and cytidine and uses thereof
AU7623991A (en) *	1990-05-17	1991-11-21	Syntex (U.S.A.) Inc.	Antiviral agents
CA2444071C (en) *	1991-02-08	2008-10-07	Wellstat Therapeutics Corporation	Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis

1992
- 1992-06-25 CA CA002111571A patent/CA2111571C/en not_active Expired - Lifetime
- 1992-06-25 DE DE69232070T patent/DE69232070T2/de not_active Expired - Lifetime
- 1992-06-25 ES ES92914215T patent/ES2160579T3/es not_active Expired - Lifetime
- 1992-06-25 AT AT92914215T patent/ATE205850T1/de not_active IP Right Cessation
- 1992-06-25 JP JP5502244A patent/JP2584947B2/ja not_active Expired - Lifetime
- 1992-06-25 AU AU22544/92A patent/AU667676B2/en not_active Ceased
- 1992-06-25 DK DK92914215T patent/DK0594667T3/da active
- 1992-06-25 EP EP92914215A patent/EP0594667B1/de not_active Expired - Lifetime
- 1992-06-25 WO PCT/US1992/005324 patent/WO1993001202A1/en not_active Ceased
- 1992-06-25 CA CA002504078A patent/CA2504078C/en not_active Expired - Lifetime
- 1992-06-25 KR KR1019940700025A patent/KR100256144B1/ko not_active Expired - Lifetime
- 1992-07-03 ZA ZA924975A patent/ZA924975B/xx unknown
2001
- 2001-09-27 GR GR20010401606T patent/GR3036749T3/el unknown

Also Published As

Publication number	Publication date
ZA924975B (en)	1993-04-28
CA2111571C (en)	2005-08-23
EP0594667A4 (en)	1996-01-10
GR3036749T3 (en)	2001-12-31
DE69232070T2 (de)	2002-06-06
AU2254492A (en)	1993-02-11
JPH06508846A (ja)	1994-10-06
EP0594667B1 (de)	2001-09-19
CA2111571A1 (en)	1993-01-21
CA2504078C (en)	2007-08-28
WO1993001202A1 (en)	1993-01-21
KR100256144B1 (ko)	2000-05-15
EP0594667A1 (de)	1994-05-04
DK0594667T3 (da)	2001-11-12
ES2160579T3 (es)	2001-11-16
DE69232070D1 (de)	2001-10-25
AU667676B2 (en)	1996-04-04
CA2504078A1 (en)	1993-01-21
HK1003424A1 (en)	1998-10-30
JP2584947B2 (ja)	1997-02-26

Legal Events

Date	Code	Title
2002-02-15	UEP	Publication of translation of european patent specification
2003-03-15	EEFA	Change of the company name
2012-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE205850T1 (de)	2001-10-15	Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden
DK0526537T3 (da)	1995-10-02	5-Benzylbarbituratderivater
YU176191A (sh)	1994-01-20	Derivati hinazolina za pojačavanje antitumorne aktivnosti
DE69230140D1 (de)	1999-11-18	Antivirale nucleosidkombination
PL300068A1 (en)	1994-02-21	9-(substituted glycil) amido-6-demethyl-6-deoxytetracyclines, methods of obtaining such compounds as well as their organic and inorganic salts or metal complexes, pharmaceutical agent and veterinari agent
DK0604910T3 (da)	2000-07-31	Phosphonooxymethylethere af taxanderivater
DE69430611D1 (de)	2002-06-20	Phosphonooxymethyl oder Methylthiomethylether von Taxanderivaten als Antitumormittel
DE69908819D1 (de)	2003-07-17	Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
ATE267164T1 (de)	2004-06-15	9-(substituiertes glycyl)amido-6-(substituiert)-5-hydroxy-6-deoxy etracycline
FR2681862B1 (fr)	1993-11-12	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
MX9303711A (es)	1994-05-31	Nucleosidos de pirimida sustituida que tienen actividad anti-tumoral y anti-viral y composicion farmaceutica que los contiene.
DE69119074D1 (de)	1996-05-30	Kovalente-ther lipidnukleosid-konjugate
NZ229453A (en)	1991-08-27	A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
DK0489877T3 (da)	1996-02-05	Antiatherosklerotiske og antithrombotiske 2-amino-6-phenyl-4H-pyran-4-oner
IL99471A0 (en)	1992-08-18	Pharmaceutical compositions containing pyridylmethylsulphinyl-1h-benzimidazole derivatives as active ingredient therein
EP0453247A3 (de)	1991-11-06	Antivirale Verbindungen
MX9709749A (es)	1998-03-31	Metodo para reducir la toxicidad de agentes quimioterapeuticos y antivirales con nucleosidos de pirimidina acilados.
ATE230748T1 (de)	2003-01-15	Imidazotriazolopyrimidine als arzneimittel mit adenosinantagonistischer wirkung
KR960703127A (ko)	1996-06-19	구충제로서 유용한 14-치환된 마르크포틴 및 유도체(14-substituted marcfortin and derivatives useful as antiparasitic agents)
ES2073915T3 (es)	1995-08-16	6,9-bis(amino sustituido)benzo g)ftalazin-5,10-diona como agentes antitumorales.
WO1995013280A3 (en)	1995-06-15	1,3,8,10 tetrasubstituted derivatives of 4,5,6,7-tetrathiocino-(1,2-b:3,4-b')-diimidazolyl-2,9-dithione, their preparation and their use as antitumor agent
MX9102245A (es)	1992-07-08	Combinaciones de compuestos vainilloides y compuestos antivirales de nucleosido para el tratamiento de infecciones de herpes
IT9047939A0 (it)	1990-05-10	Derivati di microlidi polienici dotati di proprieta' antibiotiche, loro sale e composizioni farmaceutiche che li comprendono.
MX9203358A (es)	1992-07-01	Derivados de bencimidazol y composicines farmaceuticas que los contienen.