ATE205857T1 - Grosse, latente komplexe von tgf-beta2 und tgf- beta3 - Google Patents

Grosse, latente komplexe von tgf-beta2 und tgf- beta3

Info

Publication number: ATE205857T1
Authority: AT; Austria
Prior art keywords: tgf; beta; beta3; beta2; ltbp
Prior art date: 1992-01-27

Application number

AT93903627T

Other languages

English (en)

Inventor

Kohei Miyazono

Carl-Henrik Heldin

Anders Olofsson

Original Assignee

Ludwig Inst Cancer Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-27

Filing date

1993-01-19

Publication date

2001-10-15

1993-01-19 Application filed by Ludwig Inst Cancer Res filed Critical Ludwig Inst Cancer Res

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE205857T1 publication Critical patent/ATE205857T1/de

Links

ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 8
101800001155 Latency-associated peptide Proteins 0.000 abstract 1
102400000401 Latency-associated peptide Human genes 0.000 abstract 1
102100027017 Latent-transforming growth factor beta-binding protein 2 Human genes 0.000 abstract 1
101710178974 Latent-transforming growth factor beta-binding protein 2 Proteins 0.000 abstract 1
102000023732 binding proteins Human genes 0.000 abstract 1
108091008324 binding proteins Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT93903627T 1992-01-27 1993-01-19 Grosse, latente komplexe von tgf-beta2 und tgf- beta3 ATE205857T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/826,577 US5280109A (en)	1992-01-27	1992-01-27	Isolated, large latent complexes of TGF-β2 and TGF-β3, and new binding protein for latent form TGF-β1, TGF-β2 and TGF-β3 LTBP-2
PCT/US1993/000561 WO1993015114A1 (en)	1992-01-27	1993-01-19	Large, latent complexes of tgf-beta2 and tgf-beta3

Publications (1)

Publication Number	Publication Date
ATE205857T1 true ATE205857T1 (de)	2001-10-15

Family

ID=25246945

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93903627T ATE205857T1 (de)	1992-01-27	1993-01-19	Grosse, latente komplexe von tgf-beta2 und tgf- beta3

Country Status (9)

Country	Link
US (2)	US5280109A (de)
EP (1)	EP0624165B1 (de)
JP (1)	JP3390005B2 (de)
KR (1)	KR100234497B1 (de)
AT (1)	ATE205857T1 (de)
AU (1)	AU660213B2 (de)
CA (1)	CA2128784C (de)
DE (1)	DE69330784T2 (de)
WO (1)	WO1993015114A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5229495A (en) *	1991-06-18	1993-07-20	Ludwig Institute For Cancer Research	Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5811447A (en) *	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) *	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) *	1993-01-28	1998-06-23	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6395494B1 (en) *	1993-05-13	2002-05-28	Neorx Corporation	Method to determine TGF-β
US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6306421B1 (en)	1992-09-25	2001-10-23	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) *	1993-01-28	1997-01-21	Neorx Corporation	Method for identifying an agent which increases TGF-beta levels
US6663881B2 (en) *	1993-01-28	2003-12-16	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) *	1993-01-28	1999-11-09	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
DE69435137D1 (de) *	1993-05-13	2008-10-16	Poniard Pharmaceuticals Inc	Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US6074840A (en)	1994-02-18	2000-06-13	The Regents Of The University Of Michigan	Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5656450A (en) *	1994-05-27	1997-08-12	Board Of Regents, The University Of Texas System	Activation of latent transforming growth factor β by matrix vesicles
US20030083733A1 (en) *	1997-10-10	2003-05-01	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US20020091433A1 (en) *	1995-04-19	2002-07-11	Ni Ding	Drug release coated stent
US6099562A (en) *	1996-06-13	2000-08-08	Schneider (Usa) Inc.	Drug coating with topcoat
US5837313A (en) *	1995-04-19	1998-11-17	Schneider (Usa) Inc	Drug release stent coating process
EP0833624B1 (de)	1995-06-07	2007-11-07	Poniard Pharmaceuticals, Inc.	Vorbeugung und behandlung von kardiovaskulären beschwerden mit tamoxifen-analogen
AU6959898A (en)	1997-04-11	1998-11-11	David J. Grainger	Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
US6613083B2 (en) *	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4931548A (en) *	1987-01-30	1990-06-05	Techne Corporation	Heterodimer form of transforming growth factor-beta
US5177197A (en) *	1990-02-27	1993-01-05	Ludwig Institute For Cancer Research	Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein
ZA914750B (en) *	1990-06-20	1992-03-25	Bristol Myers Squibb Co	Methods of modulating blood pressure using tgf-beta and antagonists thereof

1992
- 1992-01-27 US US07/826,577 patent/US5280109A/en not_active Expired - Fee Related
1993
- 1993-01-19 WO PCT/US1993/000561 patent/WO1993015114A1/en not_active Ceased
- 1993-01-19 EP EP93903627A patent/EP0624165B1/de not_active Expired - Lifetime
- 1993-01-19 AU AU34817/93A patent/AU660213B2/en not_active Ceased
- 1993-01-19 AT AT93903627T patent/ATE205857T1/de not_active IP Right Cessation
- 1993-01-19 DE DE69330784T patent/DE69330784T2/de not_active Expired - Fee Related
- 1993-01-19 JP JP51333093A patent/JP3390005B2/ja not_active Expired - Fee Related
- 1993-01-19 CA CA002128784A patent/CA2128784C/en not_active Expired - Fee Related
- 1993-01-19 KR KR1019940702586A patent/KR100234497B1/ko not_active Expired - Fee Related
- 1993-07-15 US US08/092,331 patent/US5346993A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2128784C (en)	2002-04-30
US5346993A (en)	1994-09-13
WO1993015114A1 (en)	1993-08-05
EP0624165A4 (en)	1996-01-24
CA2128784A1 (en)	1993-08-05
US5280109A (en)	1994-01-18
JP3390005B2 (ja)	2003-03-24
JPH07503251A (ja)	1995-04-06
KR100234497B1 (ko)	1999-12-15
AU660213B2 (en)	1995-06-15
EP0624165A1 (de)	1994-11-17
AU3481793A (en)	1993-09-01
EP0624165B1 (de)	2001-09-19
DE69330784D1 (de)	2001-10-25
DE69330784T2 (de)	2002-05-23

Legal Events

Date	Code	Title	Description
2002-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE205857T1 (de)	2001-10-15	Grosse, latente komplexe von tgf-beta2 und tgf- beta3
DK0724456T3 (da)	2004-04-13	CD40-Antistoffer
ATE148130T1 (de)	1997-02-15	Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
NO20061455L (no)	2000-01-28	2,6 dioksopiperidin samt farmasoytiske preparater som inneholder disse
AP9200410A0 (en)	1992-07-31	Retroviral protease inhibitors.
DK0515544T3 (da)	1996-02-12	Steroidsulfataseinhibitorer
DK0601154T3 (da)	1998-02-23	BPC-peptider, deres fremstilling og anvendelse
DE69634438D1 (de)	2005-04-14	Von humanem hitzeschockprotein 60 hergeleitete peptide zur behandlung von diabetis, entsprechende zusammensetzungen, verfahren und kits
DE69418322D1 (de)	1999-06-10	Analoge für spezifische oligosaccharid-protein-wechselwirkungen und ihre verwendungen
IL132933A0 (en)	2001-03-19	Composition for the treatment of diarrheal disease
DE69433400D1 (de)	2004-01-22	Neue proteine von parasitischen würmern
DE68917837D1 (de)	1994-10-06	Peptid-Verbindungen.
DE69416518D1 (de)	1999-03-25	Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen
NO904292D0 (no)	1990-10-02	Fremgangsmaate for fremstilling av antikoagulerende peptider.
DE59809283D1 (de)	2003-09-18	Inhibitoren für den urokinaserezeptor
NO894880D0 (no)	1989-12-06	Fremgangsmaate for fremstilling av antikoagulerende peptider.
DE69122103D1 (de)	1996-10-17	Antigerinnungspeptide
DE69433745D1 (de)	2004-06-03	Modifizierte, verkürzte regulatoren des komplementsystems
DE69032574D1 (de)	1998-09-24	Antibakterielle- und antimalariapeptide
NO962204L (no)	1996-07-25	Dobbeltkjedede hemoregulatoriske peptider
FR2654430B1 (fr)	1995-01-06	Nouveaux derives de peptides, utilisables comme inhibiteurs des collagenases bacteriennes.
ATE204853T1 (de)	2001-09-15	Schädlingsbekämpfungsmittel