ATE206124T1 - Nachweisbar markierte markerverbindung mit einem fluorophor-rest , eine fluorescenz-probe mit der markerverbindung und verwendungen derselben. - Google Patents
Nachweisbar markierte markerverbindung mit einem fluorophor-rest , eine fluorescenz-probe mit der markerverbindung und verwendungen derselben.Info
- Publication number
- ATE206124T1 ATE206124T1 AT91911322T AT91911322T ATE206124T1 AT E206124 T1 ATE206124 T1 AT E206124T1 AT 91911322 T AT91911322 T AT 91911322T AT 91911322 T AT91911322 T AT 91911322T AT E206124 T1 ATE206124 T1 AT E206124T1
- Authority
- AT
- Austria
- Prior art keywords
- marker compound
- detectfully
- fluorescence sample
- labeled
- fluorophore
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 239000003550 marker Substances 0.000 title 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 239000000975 dye Substances 0.000 abstract 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011503 in vivo imaging Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0036—Porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0015—Phosphorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
- C09B47/04—Phthalocyanines abbreviation: Pc
- C09B47/045—Special non-pigmentary uses, e.g. catalyst, photosensitisers of phthalocyanine dyes or pigments
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
- C09B47/04—Phthalocyanines abbreviation: Pc
- C09B47/08—Preparation from other phthalocyanine compounds, e.g. cobaltphthalocyanineamine complex
- C09B47/24—Obtaining compounds having —COOH or —SO3H radicals, or derivatives thereof, directly bound to the phthalocyanine radical
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
- G01N2333/19—Rubella virus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52421290A | 1990-05-15 | 1990-05-15 | |
| PCT/US1991/003426 WO1991018007A1 (en) | 1990-05-15 | 1991-05-15 | Phthalocyanatopolyethylene glycol, and phthalocyanato saccharides as fluorescent digoxin reagents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE206124T1 true ATE206124T1 (de) | 2001-10-15 |
Family
ID=24088253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91911322T ATE206124T1 (de) | 1990-05-15 | 1991-05-15 | Nachweisbar markierte markerverbindung mit einem fluorophor-rest , eine fluorescenz-probe mit der markerverbindung und verwendungen derselben. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0528991B1 (de) |
| JP (1) | JPH05507518A (de) |
| AT (1) | ATE206124T1 (de) |
| CA (1) | CA2082934C (de) |
| DE (1) | DE69132744T2 (de) |
| ES (1) | ES2164043T3 (de) |
| WO (1) | WO1991018007A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060598A (en) * | 1990-05-15 | 2000-05-09 | Hyperion, Inc. | Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding |
| US5919922A (en) * | 1990-05-15 | 1999-07-06 | Hyperion, Inc. | Fluorescent dyes free of aggregation and serum binding |
| US5880287A (en) * | 1990-05-15 | 1999-03-09 | Hyperion, Inc. | Polyoxyhydrocarbyl related products and methods for fluorescence assays |
| TW235298B (de) * | 1992-02-27 | 1994-12-01 | Ciba Geigy | |
| CA2132708C (en) * | 1992-03-23 | 2005-05-10 | Robert F. Devlin | Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding |
| US5371199B1 (en) * | 1992-08-14 | 1995-12-26 | Univ Pennsylvania | Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor |
| US5817830A (en) * | 1992-08-14 | 1998-10-06 | Trustees Of The University Of Pennsylvania | Pyrrolic compounds |
| US5493017A (en) * | 1992-08-14 | 1996-02-20 | The Trustees Of The University Of Pennsylvania | Ring-metalated porphyrins |
| US5599924A (en) * | 1992-08-14 | 1997-02-04 | Trustees Of The University Of Pennsylvania | Electron-deficient porphyrins and processes and intermediates for preparing same |
| US5824799A (en) * | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
| US6238931B1 (en) | 1993-09-24 | 2001-05-29 | Biosite Diagnostics, Inc. | Fluorescence energy transfer in particles |
| US7083984B2 (en) | 1993-09-24 | 2006-08-01 | Biosite, Inc. | Hybrid phthalocyanine derivatives and their uses |
| US7322927B2 (en) | 1993-09-24 | 2008-01-29 | Biosite, Inc. | Hybrid phthalocyanine derivatives and their uses |
| EP0800831B9 (de) * | 1995-01-30 | 2004-11-10 | Daiichi Pure Chemicals Co., Ltd. | Diagnostisches markierungsmittel |
| JP3388753B2 (ja) * | 1995-03-23 | 2003-03-24 | バイオサイト インコーポレイテッド | 混成フタロシアニン誘導体およびその用途 |
| US5916481A (en) * | 1995-07-25 | 1999-06-29 | The Procter & Gamble Company | Low hue photobleaches |
| US5679661A (en) * | 1995-07-25 | 1997-10-21 | The Procter & Gamble Company | Low hue photodisinfectants |
| US6083486A (en) * | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| KR20010052616A (ko) * | 1998-06-05 | 2001-06-25 | 파라비 레이 | 텍사피린 콘쥬게이트 및 그 용도 |
| AU765509B2 (en) | 1998-08-28 | 2003-09-18 | Destiny Pharma Limited | Porphyrin derivatives, their use in photodynamic therapy and medical devices containing them |
| EP1159354A1 (de) * | 1999-03-05 | 2001-12-05 | Case Western Reserve University | Eine zusammensetzung enthaltend ein photo-oxidierendes mittel und verwendungen des mittels |
| US7005518B2 (en) | 2002-10-25 | 2006-02-28 | Li-Cor, Inc. | Phthalocyanine dyes |
| US8835000B2 (en) * | 2011-12-23 | 2014-09-16 | General Electric Company | High-density fluorescent dye clusters |
| JP7280577B2 (ja) * | 2019-04-22 | 2023-05-24 | 東洋インキScホールディングス株式会社 | 蛍光バイオイメージング方法 |
| BR112022020521A2 (pt) | 2020-04-10 | 2023-03-07 | Rakuten Medical Inc | Compostos de corante ftalocianina, conjugados e métodos de uso dos mesmos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0220686B1 (de) * | 1985-10-23 | 1992-12-30 | Nihon Medi-Physics Co., Ltd. | Porphyrinderivate, ihre Herstellung und Verwendung |
| JPS62249986A (ja) * | 1986-04-21 | 1987-10-30 | Hamari Yakuhin Kogyo Kk | ポルフイリン誘導体 |
| JPH07100714B2 (ja) * | 1987-03-03 | 1995-11-01 | 株式会社三和化学研究所 | ランプテロフラビン及びその製法 |
| JPH0690208B2 (ja) * | 1987-04-01 | 1994-11-14 | 株式会社日立製作所 | 自動分析装置 |
| DE3809671A1 (de) * | 1988-03-18 | 1989-09-28 | Schering Ag | Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
-
1991
- 1991-05-15 CA CA002082934A patent/CA2082934C/en not_active Expired - Lifetime
- 1991-05-15 DE DE69132744T patent/DE69132744T2/de not_active Expired - Fee Related
- 1991-05-15 AT AT91911322T patent/ATE206124T1/de not_active IP Right Cessation
- 1991-05-15 JP JP91510827A patent/JPH05507518A/ja active Pending
- 1991-05-15 WO PCT/US1991/003426 patent/WO1991018007A1/en not_active Ceased
- 1991-05-15 EP EP91911322A patent/EP0528991B1/de not_active Expired - Lifetime
- 1991-05-15 ES ES91911322T patent/ES2164043T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2082934C (en) | 2003-08-05 |
| DE69132744D1 (de) | 2001-10-31 |
| EP0528991B1 (de) | 2001-09-26 |
| WO1991018007A1 (en) | 1991-11-28 |
| DE69132744T2 (de) | 2002-10-10 |
| JPH05507518A (ja) | 1993-10-28 |
| EP0528991A1 (de) | 1993-03-03 |
| EP0528991A4 (en) | 1995-09-06 |
| CA2082934A1 (en) | 1991-11-16 |
| ES2164043T3 (es) | 2002-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE206124T1 (de) | Nachweisbar markierte markerverbindung mit einem fluorophor-rest , eine fluorescenz-probe mit der markerverbindung und verwendungen derselben. | |
| DE69132750D1 (de) | Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden | |
| BR9807734A (pt) | Composto para imunodiagnose de câncer de próstata e métodos para o uso dos memos | |
| CA2223418A1 (en) | Polyoxyhydrocarbyl related products and methods for fluorescence assays | |
| ATE207958T1 (de) | Äusserliche domäne von c-erbb-2:gp75 | |
| DE69033067D1 (de) | 4,7-dichlorfluoreszein-farbstoffe als molekulare sonden | |
| FI904975A0 (fi) | Tvaerbindade antikroppar och foerfaranden foer deras framstaellning. | |
| BG100192A (en) | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents | |
| NO891232L (no) | Arylhydrazoner. | |
| DE69006417D1 (de) | Neuer fluoreszierender Farbstoff. | |
| CA2082936A1 (en) | Fluorescent porphyrin, and fluorescent phthalocyanine-polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes | |
| SE8505458L (sv) | Bakteriofager som igenkennings- och identifieringsmedel | |
| BR9300639A (pt) | Particulas marcadoras para uso no ensaio de uma amostra de um fluido biologico,processo pra ensaiar uma amostra de fluido biologico,e,processo para ensaiar uma amostra de sangue | |
| FI904974A0 (fi) | Tvaerbundna antikroppar och processer foer deras framstaellning. | |
| DK0408509T3 (da) | Substituerede benzonitriler | |
| CA2132708A1 (en) | Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding | |
| DE69231495D1 (de) | Neue cocain-derivate und protein- und polypeptid-cocain-derivate, konjugate und markierte verbindungen | |
| FI954230L (fi) | Diagnostiikassa käytettävä monoklonaalinen vasta-ainekoostumus ja sitä sisältävä testipakkaus | |
| CA2289221A1 (en) | Labeled reagents for use in immunoassays and fluorescent compounds and complexes used therein |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |