ATE206425T1 - Indol-3-carbonyl und indol-3-sulfony derivate als antagonisten des plättchen aktivierenden faktors - Google Patents

Indol-3-carbonyl und indol-3-sulfony derivate als antagonisten des plättchen aktivierenden faktors

Info

Publication number
ATE206425T1
ATE206425T1 AT96911396T AT96911396T ATE206425T1 AT E206425 T1 ATE206425 T1 AT E206425T1 AT 96911396 T AT96911396 T AT 96911396T AT 96911396 T AT96911396 T AT 96911396T AT E206425 T1 ATE206425 T1 AT E206425T1
Authority
AT
Austria
Prior art keywords
indole
antagonists
platele
sulfony
carbonyl
Prior art date
Application number
AT96911396T
Other languages
English (en)
Inventor
George S Sheppard
Steven K Davidson
James B Summers
George M Carrera Jr
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE206425T1 publication Critical patent/ATE206425T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96911396T 1995-04-19 1996-03-25 Indol-3-carbonyl und indol-3-sulfony derivate als antagonisten des plättchen aktivierenden faktors ATE206425T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/424,911 US5567711A (en) 1995-04-19 1995-04-19 Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
PCT/US1996/004010 WO1996033196A1 (en) 1995-04-19 1996-03-25 Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists

Publications (1)

Publication Number Publication Date
ATE206425T1 true ATE206425T1 (de) 2001-10-15

Family

ID=23684396

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96911396T ATE206425T1 (de) 1995-04-19 1996-03-25 Indol-3-carbonyl und indol-3-sulfony derivate als antagonisten des plättchen aktivierenden faktors

Country Status (13)

Country Link
US (3) US5567711A (de)
EP (1) EP0821685B1 (de)
JP (1) JPH11503758A (de)
KR (1) KR19990007863A (de)
AT (1) ATE206425T1 (de)
AU (1) AU705237B2 (de)
CA (1) CA2218020A1 (de)
DE (1) DE69615676T2 (de)
DK (1) DK0821685T3 (de)
ES (1) ES2164240T3 (de)
IL (1) IL117723A (de)
PT (1) PT821685E (de)
WO (1) WO1996033196A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968933A (en) * 1994-08-26 1999-10-19 Auckland Division Cancer Society Of New Zealand Inc. DNA-targeted alkylating agents
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
EP2583675A1 (de) * 1998-02-02 2013-04-24 Trustees Of Tufts College Verwendung von Dipetidylpeptidasehemmer zur Regulierung des Glukosemetabolismus
US6916841B2 (en) * 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
DE19815026A1 (de) * 1998-04-03 1999-10-07 Hoechst Schering Agrevo Gmbh Substituierte Piperidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
US6747023B1 (en) 1998-08-11 2004-06-08 Daiichi Pharmaceutical Co., Ltd. Sulfonyl derivatives
AU2319100A (en) * 1999-01-28 2000-08-18 Nippon Shinyaku Co. Ltd. Amide derivatives and drug compositions
DE10000739A1 (de) * 2000-01-11 2001-07-12 Merck Patent Gmbh Piperidin- und Piperazinderivate
WO2001058869A2 (en) 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
DE60122939T2 (de) * 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
DK1474425T3 (da) * 2002-01-07 2006-09-25 Eisai Co Ltd Deazapuriner og anvendelser deraf
SE0201635D0 (sv) * 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
TW200307542A (en) * 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
TW200401641A (en) 2002-07-18 2004-02-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
SE0301569D0 (sv) * 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) * 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
US7157471B2 (en) 2003-08-25 2007-01-02 Boehringer Ingelheim International Gmbh Haloalkyl- and piperidine-substituted benzimidazole-derivatives
CA2536787C (en) * 2003-08-25 2012-02-21 Boehringer Ingelheim International Gmbh Haloalkyl- and piperidine-substituted benzimidazole-derivatives
US7504401B2 (en) * 2003-08-29 2009-03-17 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
SE0303180D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
US7723360B2 (en) * 2004-08-06 2010-05-25 Boehringer Ingelheim International Gmbh Alkyl-and piperidine-substituted benzimidazole derivatives
GB0500604D0 (en) * 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
EP2392571A3 (de) * 2005-07-29 2012-03-14 F. Hoffmann-La Roche AG Indol-3-yl-Carbonyl-Piperidin- und Piperazinderivate
US7645752B2 (en) * 2006-01-13 2010-01-12 Wyeth Llc Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors
JP2009538289A (ja) * 2006-05-26 2009-11-05 アストラゼネカ・アクチエボラーグ ビアリールまたはヘテロアリール置換インドール
US20080280891A1 (en) * 2006-06-27 2008-11-13 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
HUE044867T2 (hu) 2011-05-12 2019-11-28 Proteostasis Therapeutics Inc Proteosztázis szabályzók
EP2968285A4 (de) * 2013-03-13 2016-12-21 Flatley Discovery Lab Verbindungen und verfahren zur behandlung von zystischer fibrose
KR102129842B1 (ko) 2013-10-02 2020-07-06 주식회사 대웅제약 술포닐인돌 유도체 및 이의 제조방법
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT98673B (pt) * 1990-08-15 1999-01-29 British Bio Technology Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de benzimidazole e de seus intermediarios
GB9102997D0 (en) * 1991-02-13 1991-03-27 Pfizer Ltd Therapeutic agents
GB9107398D0 (en) * 1991-04-09 1991-05-22 British Bio Technology Compounds
IE922293A1 (en) * 1991-07-17 1993-01-27 Abbott Lab Platelet activating factor antagonists
GB9200245D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles

Also Published As

Publication number Publication date
MX9708032A (es) 1997-11-29
EP0821685B1 (de) 2001-10-04
PT821685E (pt) 2002-03-28
ES2164240T3 (es) 2002-02-16
DE69615676T2 (de) 2002-07-11
CA2218020A1 (en) 1996-10-24
JPH11503758A (ja) 1999-03-30
IL117723A (en) 2000-07-26
DE69615676D1 (de) 2001-11-08
WO1996033196A1 (en) 1996-10-24
KR19990007863A (ko) 1999-01-25
US5643922A (en) 1997-07-01
DK0821685T3 (da) 2002-01-21
EP0821685A1 (de) 1998-02-04
US5654305A (en) 1997-08-05
US5567711A (en) 1996-10-22
IL117723A0 (en) 1996-07-23
AU5429596A (en) 1996-11-07
AU705237B2 (en) 1999-05-20

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Legal Events

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UEP Publication of translation of european patent specification
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