ATE206763T1 - Verfahren zur herstellung von n-substituierten polyhydroxy-stickstoffhaltigen heterocyclen - Google Patents
Verfahren zur herstellung von n-substituierten polyhydroxy-stickstoffhaltigen heterocyclenInfo
- Publication number
- ATE206763T1 ATE206763T1 AT93870047T AT93870047T ATE206763T1 AT E206763 T1 ATE206763 T1 AT E206763T1 AT 93870047 T AT93870047 T AT 93870047T AT 93870047 T AT93870047 T AT 93870047T AT E206763 T1 ATE206763 T1 AT E206763T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- polyhydroxy
- amino
- producing
- nitrogen
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 N-substituted amino compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 150000001539 azetidines Chemical class 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 150000008276 mannosamines Chemical class 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- 150000003053 piperidines Chemical class 0.000 abstract 2
- 150000003235 pyrrolidines Chemical class 0.000 abstract 2
- WQZGKKKJIJFFOK-IVMDWMLBSA-N D-allopyranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@@H]1O WQZGKKKJIJFFOK-IVMDWMLBSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-VSOAQEOCSA-N L-altropyranose Chemical compound OC[C@@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-VSOAQEOCSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000005580 one pot reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/851,818 US5401645A (en) | 1992-03-16 | 1992-03-16 | Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE206763T1 true ATE206763T1 (de) | 2001-10-15 |
Family
ID=25311760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93870047T ATE206763T1 (de) | 1992-03-16 | 1993-03-15 | Verfahren zur herstellung von n-substituierten polyhydroxy-stickstoffhaltigen heterocyclen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5401645A (de) |
| EP (2) | EP1132370A3 (de) |
| JP (1) | JPH0638780A (de) |
| AT (1) | ATE206763T1 (de) |
| CA (1) | CA2091668C (de) |
| DE (1) | DE69330905T2 (de) |
| DK (1) | DK0624652T3 (de) |
| ES (1) | ES2164653T3 (de) |
| PT (1) | PT624652E (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ120398A3 (cs) | 1995-09-08 | 1998-12-16 | Novo Nordisk A/S | Použití 2-alkylpyrrolidinových derivátů pro přípravu léčiva pro léčbu diabetu, 2-alkylpyrrolidiné deriváty |
| DE60037664T2 (de) | 1999-08-10 | 2008-12-24 | The Chancellor, Masters And Scholars Of The University Of Oxford | Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel |
| KR100446483B1 (ko) | 2000-03-31 | 2004-09-01 | 미시간 스테이트 유니버시티 | 옥심 또는 이민으로부터 1,5-디데옥시-1,5-이미노 헥시톨제조방법 |
| ATE327220T1 (de) * | 2001-03-19 | 2006-06-15 | Lonza Ag | Verfahren zur herstellung von 2-hydroxymethyl- pyrolidin-3,4-diolen |
| US6479713B1 (en) * | 2001-10-23 | 2002-11-12 | Battelle Memorial Institute | Hydrogenolysis of 5-carbon sugars, sugar alcohols, and other methods and compositions for reactions involving hydrogen |
| AT502145B1 (de) * | 2005-03-24 | 2012-01-15 | Univ Graz Tech | Glycosidase-hemmendes iminoalditol |
| EP3782655A1 (de) | 2005-05-17 | 2021-02-24 | Amicus Therapeutics, Inc. | Verfahren zur behandlung der pompe-krankheit unter verwendung von 1-deoxynojirimycin und derivaten |
| DE102005058542A1 (de) * | 2005-12-08 | 2007-06-14 | Merck Patent Gmbh | Erythruloseester als UV Filter |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| CN102727437A (zh) | 2006-08-02 | 2012-10-17 | 牛津大学院长校长专家委员会 | 病毒感染的脂质体治疗 |
| CA2666814A1 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
| KR20100127842A (ko) * | 2008-03-26 | 2010-12-06 | 유니버시티 오브 옥스퍼드 | 소포체 표적화 리포좀 |
| EP2410989A2 (de) * | 2009-03-27 | 2012-02-01 | The Chancellor, Masters and Scholars of the University of Oxford | Liposome zur senkung des cholesterinspiegels |
| ES2374352B1 (es) * | 2010-08-03 | 2013-01-24 | Consejo Superior De Investigaciones Científicas (Csic) | Proceso de obtención de derivados de azetidinas. |
| CN102399228B (zh) * | 2010-09-08 | 2013-10-16 | 中国科学院成都生物研究所 | N-烷基多羟基哌啶衍生物的制备方法 |
| JP2021514200A (ja) | 2018-01-26 | 2021-06-10 | 浙江工▲業▼大学 | グルコノバクターオキシダンスのソルビトールデヒドロゲナーゼおよびコエンザイムピロロキノリンキニーネの合成を促進する方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5317677B2 (de) * | 1973-09-25 | 1978-06-09 | ||
| DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
| DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
| DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
| DE3049446A1 (de) * | 1980-12-30 | 1982-07-29 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 1,5-didesoxy-1,5-imino-d-glucitol und dessen n-derivaten |
| JPS5911188A (ja) * | 1982-07-12 | 1984-01-20 | Mitsubishi Gas Chem Co Inc | Ｄ−グルコサミン酸の製造法 |
| JPS5914785A (ja) * | 1982-07-19 | 1984-01-25 | Mitsubishi Gas Chem Co Inc | 新規微生物 |
| JPS5914787A (ja) * | 1982-07-19 | 1984-01-25 | Mitsubishi Gas Chem Co Inc | 新規微生物 |
| JPS5914786A (ja) * | 1982-07-19 | 1984-01-25 | Mitsubishi Gas Chem Co Inc | 新規微生物 |
| DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
| DE3814549A1 (de) * | 1987-10-30 | 1989-05-18 | Bayer Ag | N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
| DK0477160T3 (da) * | 1990-09-20 | 1996-05-20 | Monsanto Co | Fremgangsmåde til fremstilling af N-substitueret 1-deoxynojirimycin |
-
1992
- 1992-03-16 US US07/851,818 patent/US5401645A/en not_active Expired - Fee Related
-
1993
- 1993-03-15 ES ES93870047T patent/ES2164653T3/es not_active Expired - Lifetime
- 1993-03-15 DE DE69330905T patent/DE69330905T2/de not_active Expired - Fee Related
- 1993-03-15 EP EP01103591A patent/EP1132370A3/de not_active Withdrawn
- 1993-03-15 DK DK93870047T patent/DK0624652T3/da active
- 1993-03-15 EP EP93870047A patent/EP0624652B1/de not_active Expired - Lifetime
- 1993-03-15 JP JP5054256A patent/JPH0638780A/ja active Pending
- 1993-03-15 AT AT93870047T patent/ATE206763T1/de not_active IP Right Cessation
- 1993-03-15 PT PT93870047T patent/PT624652E/pt unknown
- 1993-03-15 CA CA002091668A patent/CA2091668C/en not_active Expired - Fee Related
-
1994
- 1994-12-08 US US08/351,845 patent/US5695969A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT624652E (pt) | 2002-03-28 |
| EP1132370A3 (de) | 2004-03-10 |
| DE69330905D1 (de) | 2001-11-15 |
| DK0624652T3 (da) | 2001-11-12 |
| US5695969A (en) | 1997-12-09 |
| ES2164653T3 (es) | 2002-03-01 |
| US5401645A (en) | 1995-03-28 |
| DE69330905T2 (de) | 2002-08-08 |
| EP1132370A2 (de) | 2001-09-12 |
| EP0624652B1 (de) | 2001-10-10 |
| EP0624652A1 (de) | 1994-11-17 |
| CA2091668C (en) | 2003-05-20 |
| JPH0638780A (ja) | 1994-02-15 |
| CA2091668A1 (en) | 1993-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |