ATE206765T1 - Verfahren zum nachweis eines genetischen defektes,assoziert mit thrombose und/oder mangelhafter anticoagulanz-reaktion auf aktiviertes protein c - Google Patents

Verfahren zum nachweis eines genetischen defektes,assoziert mit thrombose und/oder mangelhafter anticoagulanz-reaktion auf aktiviertes protein c

Info

Publication number
ATE206765T1
ATE206765T1 AT97201766T AT97201766T ATE206765T1 AT E206765 T1 ATE206765 T1 AT E206765T1 AT 97201766 T AT97201766 T AT 97201766T AT 97201766 T AT97201766 T AT 97201766T AT E206765 T1 ATE206765 T1 AT E206765T1
Authority
AT
Austria
Prior art keywords
thrombosis
detecting
activated protein
defective
genetic defect
Prior art date
Application number
AT97201766T
Other languages
English (en)
Inventor
Rogier Maria Bertina
Pieter Hendrik Reitsma
Original Assignee
Univ Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE206765(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Leiden filed Critical Univ Leiden
Application granted granted Critical
Publication of ATE206765T1 publication Critical patent/ATE206765T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97201766T 1994-02-14 1995-02-14 Verfahren zum nachweis eines genetischen defektes,assoziert mit thrombose und/oder mangelhafter anticoagulanz-reaktion auf aktiviertes protein c ATE206765T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP94200377 1994-02-14

Publications (1)

Publication Number Publication Date
ATE206765T1 true ATE206765T1 (de) 2001-10-15

Family

ID=8216642

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95909724T ATE166110T1 (de) 1994-02-14 1995-02-14 Verfahren zum nachweis eines genetischen defektes, assoziert mit thrombose und/oder mangelhafter anticoagulanz-reaktion auf aktiviertem protein c
AT97201766T ATE206765T1 (de) 1994-02-14 1995-02-14 Verfahren zum nachweis eines genetischen defektes,assoziert mit thrombose und/oder mangelhafter anticoagulanz-reaktion auf aktiviertes protein c

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT95909724T ATE166110T1 (de) 1994-02-14 1995-02-14 Verfahren zum nachweis eines genetischen defektes, assoziert mit thrombose und/oder mangelhafter anticoagulanz-reaktion auf aktiviertem protein c

Country Status (14)

Country Link
US (3) US6518016B1 (de)
EP (2) EP0807691B1 (de)
JP (2) JP3163105B2 (de)
KR (1) KR100384251B1 (de)
AT (2) ATE166110T1 (de)
AU (1) AU690644B2 (de)
CA (1) CA2159907C (de)
DE (3) DE69523179T2 (de)
DK (2) DK0807691T3 (de)
ES (2) ES2166948T3 (de)
FI (1) FI117977B (de)
GR (2) GR960300034T1 (de)
PT (1) PT807691E (de)
WO (1) WO1995021938A1 (de)

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WO1997007240A1 (en) * 1995-08-21 1997-02-27 Akzo Nobel N.V. T-pa polymorphism and use thereof in diagnosis of risk of thrombus associated disease
US20030143759A1 (en) * 1995-10-20 2003-07-31 Bjorn Dahlback Assays for determining anticoagulant cofactor activity
US5766869A (en) * 1995-11-30 1998-06-16 Ahs Hospital Corp. Factor V ratio blood test for susceptibility to thromboembolism
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US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
AT404993B (de) * 1997-01-13 1999-04-26 Immuno Ag Verfahren zur bestimmung eines proteins mit einer mutation
US6451526B1 (en) * 1998-01-20 2002-09-17 Mayo Foundation For Medical Education And Research Simplified mutation detection
DE19802377A1 (de) 1998-01-22 1999-08-19 Max Planck Gesellschaft Verwendung von Inhibitoren für die Behandlung von RTK-Überfunktions-bedingten Störungen, insbesondere von Krebs
US6270973B1 (en) 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
US6270974B1 (en) 1998-03-13 2001-08-07 Promega Corporation Exogenous nucleic acid detection
US6335162B1 (en) 1998-03-13 2002-01-01 Promega Corporation Nucleic acid detection
US6312902B1 (en) 1998-03-13 2001-11-06 Promega Corporation Nucleic acid detection
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6391551B1 (en) 1998-03-13 2002-05-21 Promega Corporation Detection of nucleic acid hybrids
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US7090975B2 (en) 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
US6703211B1 (en) 1998-03-13 2004-03-09 Promega Corporation Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
DE19840897A1 (de) * 1998-09-08 2000-03-09 Dirk Happich Faktor V-Leiden-Test
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (de) * 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Vorselektion und Isolierung eines Einzelnukleotidpolymorphismus
DE19848665A1 (de) * 1998-10-22 2000-04-27 Bayer Ag Ein automatisierbarer Schnelltest zum direkten Nachweis der APC Resistenz Mutation mit spezifischen Primern und Probes
WO2000049181A1 (en) * 1999-02-18 2000-08-24 Promega Corporation Multiplex method for nucleic acid detection
WO2000062036A1 (en) * 1999-04-12 2000-10-19 Nanogen/Becton Dickinson Partnership Amplification and separation of nucleic acid sequences using strand displacement amplification and bioelectronic microchip technology
US6238868B1 (en) * 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US6582920B2 (en) 2000-09-01 2003-06-24 Gen-Probe Incorporated Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations
WO2002046476A2 (en) * 2000-10-27 2002-06-13 Abbott Laboratories Genotyping using partially-complementary probes
US6855509B2 (en) 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
DE60212717T2 (de) * 2002-03-13 2007-06-28 Borealis Technology Oy Inspektionsapparat für deformierte rohre
US20030177850A1 (en) * 2002-03-19 2003-09-25 The Washington Post Company System and method for verifying the roll roundness of rolls of paper used for newspapers
US20050026168A1 (en) * 2002-12-13 2005-02-03 Genesis Group Inc. Method for the detection of risk factors associated with myocardial infarction
US20050032066A1 (en) * 2003-08-04 2005-02-10 Heng Chew Kiat Method for assessing risk of diseases with multiple contributing factors
FR2866349B1 (fr) * 2004-02-12 2008-05-16 Biomerieux Sa Procede de diagnostic/pronostic d'une thrombose
US20090004175A1 (en) * 2004-07-16 2009-01-01 Novo Nordick Health Care A/G Methods for Optimizing Forming Vlla-Based Hemostatic Treatment
EP1623996A1 (de) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verbessertes Verfahren zur Auswahl eines Proteins von einer Bibliothek
WO2006027111A1 (en) * 2004-09-06 2006-03-16 Zlb Behring Gmbh Modified coagulation factor viii with enhanced stability
KR100655658B1 (ko) * 2005-07-26 2006-12-08 삼성전자주식회사 게이트 전극 구조물과 그 제조 방법 및 이를 갖는 반도체트랜지스터와 그 제조 방법
EP1982008A4 (de) * 2006-01-12 2009-09-30 Univ British Columbia Mit dem protein-c-pathway assoziierte polymorphismen als prädiktoren der reaktion auf die verabreichung von aktiviertem protein c oder einer protein-c-ähnlichen verbindung
US20070207188A1 (en) * 2006-02-16 2007-09-06 Miller Debra L Cocoa products and methods of treating cardiovascular conditions with sugar-free cocoa
WO2008020090A1 (es) * 2006-08-18 2008-02-21 Laboratorios Indas, S.A. Método y kit para diagnosticar el riesgo de desarrollar una enfermedad trombótica venosa
US20100036263A1 (en) * 2008-08-07 2010-02-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20090163856A1 (en) * 2007-12-19 2009-06-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Treatment indications informed by a prior implant information
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20090292214A1 (en) * 2008-05-22 2009-11-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8636670B2 (en) * 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US20090292213A1 (en) * 2008-05-21 2009-11-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US9717896B2 (en) * 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
PT2535424E (pt) 2011-06-16 2015-10-29 Gendiag Exe Sl Snps associados a doença tromboembólica
AR101185A1 (es) * 2014-07-11 2016-11-30 Novo Nordiks As Anticuerpos anti-factor v o factor v activado
CN115298306A (zh) * 2020-03-13 2022-11-04 居里公司 转谷氨酰胺酶变体

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US5051357A (en) * 1989-07-14 1991-09-24 Board Of Trustees Operating Michigan State University Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor
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US5874256A (en) * 1995-06-06 1999-02-23 Rijks Universiteit Leiden Method for diagnosing an increased risk for thrombosis or a genetic defect causing thrombosis and kit for use with the same
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Also Published As

Publication number Publication date
JP3163105B2 (ja) 2001-05-08
EP0696325A1 (de) 1996-02-14
FI954855L (fi) 1995-11-17
FI117977B (fi) 2007-05-15
KR960702007A (ko) 1996-03-28
EP0807691A2 (de) 1997-11-19
DK0696325T3 (da) 1999-03-01
DE696325T1 (de) 1996-08-29
EP0807691A3 (de) 1998-03-11
DE69523179T2 (de) 2002-06-06
WO1995021938A1 (en) 1995-08-17
EP0807691B1 (de) 2001-10-10
ATE166110T1 (de) 1998-05-15
CA2159907C (en) 2006-12-12
AU1809195A (en) 1995-08-29
ES2090001T1 (es) 1996-10-16
US5910576A (en) 1999-06-08
DK0807691T3 (da) 2002-02-04
ES2090001T3 (es) 1998-08-01
US6558913B1 (en) 2003-05-06
AU690644B2 (en) 1998-04-30
CA2159907A1 (en) 1995-08-17
JP2001242170A (ja) 2001-09-07
JPH08509383A (ja) 1996-10-08
GR3027579T3 (en) 1998-11-30
US6518016B1 (en) 2003-02-11
GR960300034T1 (en) 1996-06-30
ES2166948T3 (es) 2002-05-01
KR100384251B1 (ko) 2003-09-19
PT807691E (pt) 2002-04-29
JP3439458B2 (ja) 2003-08-25
DE69502451T2 (de) 1998-09-24
EP0696325B1 (de) 1998-05-13
DE69523179D1 (de) 2001-11-15
FI954855A0 (fi) 1995-10-12
DE69502451D1 (de) 1998-06-18

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