ATE207459T1 - O-malonyltyrosyl-verbindungen, o-malonyltyrosyl- verbindungen enthaltende peptide und ihre verwendung - Google Patents
O-malonyltyrosyl-verbindungen, o-malonyltyrosyl- verbindungen enthaltende peptide und ihre verwendungInfo
- Publication number
- ATE207459T1 ATE207459T1 AT96910637T AT96910637T ATE207459T1 AT E207459 T1 ATE207459 T1 AT E207459T1 AT 96910637 T AT96910637 T AT 96910637T AT 96910637 T AT96910637 T AT 96910637T AT E207459 T1 ATE207459 T1 AT E207459T1
- Authority
- AT
- Austria
- Prior art keywords
- malonyltyrosyl
- compounds
- compound
- peptides
- present
- Prior art date
Links
- -1 O-MALONYLTYROSYL COMPOUNDS Chemical class 0.000 title abstract 10
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 238000001212 derivatisation Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/414,520 US5688992A (en) | 1995-03-31 | 1995-03-31 | O-malonyltryrosyl compounds, O-malonyltryrosyl compound-containing peptides, and use thereof |
| PCT/US1996/004311 WO1996030332A1 (en) | 1995-03-31 | 1996-03-29 | O-malonyltyrosyl compounds, o-malonyltyrosyl compound-containing peptides, and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE207459T1 true ATE207459T1 (de) | 2001-11-15 |
Family
ID=23641810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96910637T ATE207459T1 (de) | 1995-03-31 | 1996-03-29 | O-malonyltyrosyl-verbindungen, o-malonyltyrosyl- verbindungen enthaltende peptide und ihre verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5688992A (de) |
| EP (1) | EP0820433B1 (de) |
| JP (1) | JP3929490B2 (de) |
| AT (1) | ATE207459T1 (de) |
| AU (1) | AU708929B2 (de) |
| CA (1) | CA2215827C (de) |
| DE (1) | DE69616303T2 (de) |
| WO (1) | WO1996030332A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL119029A0 (en) * | 1996-08-07 | 1996-11-14 | Yeda Res & Dev | Long-acting drugs and pharamaceutical compositions comprising them |
| US5994522A (en) * | 1997-01-24 | 1999-11-30 | Washington University | BLNK proteins |
| DE69824433D1 (en) * | 1997-08-28 | 2004-07-15 | Biovitrum Ab | Proteintyrosinphosphatase inhibitoren |
| US6410585B1 (en) * | 1997-08-28 | 2002-06-25 | Scott D. Larsen | Inhibitors of protein tyrosine phosphatase |
| US6156784A (en) * | 1997-12-18 | 2000-12-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as phosphotyrosine mimics |
| WO2000027802A1 (en) * | 1998-11-12 | 2000-05-18 | Ariad Pharmaceuticals, Inc. | Bicyclic signal transduction inhibitors, compositions containing them & uses thereof |
| US6307090B1 (en) | 1999-01-22 | 2001-10-23 | The United States Of America As Represented By The Department Of Health And Human Services | Acylated oligopeptide derivatives having cell signal inhibiting activity |
| US7226991B1 (en) * | 1999-03-23 | 2007-06-05 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Phenylalanine derivatives |
| WO2000056760A1 (en) * | 1999-03-23 | 2000-09-28 | The United States Of America, Represented By Secretary, Department Of Health And Human Services | Phenylalanine derivatives |
| ES2222753T3 (es) * | 1999-04-15 | 2005-02-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compuestos utiles como mimeticos de fosfotirosina. |
| AU780697B2 (en) | 1999-10-22 | 2005-04-14 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Inhibition of cell motility and angiogenesis by inhibitors of the GRB2 SH2-domain |
| US7871981B2 (en) * | 1999-10-22 | 2011-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell motility, angiogenesis, and metastasis |
| US7425537B2 (en) * | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
| WO2002016407A2 (en) * | 2000-08-22 | 2002-02-28 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Sh2 domain binding inhibitors |
| US20040138104A1 (en) * | 2003-01-14 | 2004-07-15 | The Government Of The United States Of America Represented By The Secretary, | Peptides |
| US20050119163A1 (en) | 2003-09-18 | 2005-06-02 | The Government Of The United States Of America, As Represented By The Secretary, | SH2 domain binding inhibitors |
| EP3919070B1 (de) | 2013-03-14 | 2024-10-16 | Children's Medical Center Corporation | Verwendung von cd36 zur identifizierung von krebspatienten zur behandlung mit einem psap peptid |
| IT202000004849A1 (it) * | 2020-03-06 | 2021-09-06 | Univ Degli Studi Di Roma “Tor Vergata” | Peptidi e loro usi |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5200546A (en) * | 1991-09-30 | 1993-04-06 | The United States Of America As Represented By The Department Of Health And Human Services | Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis |
| US5264607A (en) * | 1991-09-30 | 1993-11-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Process of making benzylic α,α-diflurophosphonates from benzylic α-ketophosphorates |
| WO1994007913A1 (en) * | 1992-09-25 | 1994-04-14 | Warner-Lambert Company | Peptide antagonists of sh2 binding and therapeutic uses thereof |
| WO1994008600A1 (en) * | 1992-10-09 | 1994-04-28 | Joslin Diabetes Center | Inhibition of signal transduction molecules |
-
1995
- 1995-03-31 US US08/414,520 patent/US5688992A/en not_active Expired - Lifetime
-
1996
- 1996-03-29 JP JP52966596A patent/JP3929490B2/ja not_active Expired - Lifetime
- 1996-03-29 EP EP96910637A patent/EP0820433B1/de not_active Expired - Lifetime
- 1996-03-29 CA CA2215827A patent/CA2215827C/en not_active Expired - Lifetime
- 1996-03-29 AT AT96910637T patent/ATE207459T1/de not_active IP Right Cessation
- 1996-03-29 DE DE69616303T patent/DE69616303T2/de not_active Expired - Lifetime
- 1996-03-29 WO PCT/US1996/004311 patent/WO1996030332A1/en not_active Ceased
- 1996-03-29 AU AU53776/96A patent/AU708929B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0820433A1 (de) | 1998-01-28 |
| WO1996030332A1 (en) | 1996-10-03 |
| DE69616303D1 (de) | 2001-11-29 |
| JPH11505520A (ja) | 1999-05-21 |
| AU5377696A (en) | 1996-10-16 |
| CA2215827C (en) | 2010-08-10 |
| CA2215827A1 (en) | 1996-10-03 |
| AU708929B2 (en) | 1999-08-19 |
| JP3929490B2 (ja) | 2007-06-13 |
| US5688992A (en) | 1997-11-18 |
| DE69616303T2 (de) | 2004-08-12 |
| EP0820433B1 (de) | 2001-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |