ATE208628T1 - Neue antithrombotische formulierung, verfahren zur herstellung und gebrauch davon - Google Patents

Neue antithrombotische formulierung, verfahren zur herstellung und gebrauch davon

Info

Publication number
ATE208628T1
ATE208628T1 AT95940490T AT95940490T ATE208628T1 AT E208628 T1 ATE208628 T1 AT E208628T1 AT 95940490 T AT95940490 T AT 95940490T AT 95940490 T AT95940490 T AT 95940490T AT E208628 T1 ATE208628 T1 AT E208628T1
Authority
AT
Austria
Prior art keywords
antithrbotic
formulation
new
production
new antithrbotic
Prior art date
Application number
AT95940490T
Other languages
English (en)
Inventor
Jan-Erik Loefroth
Anna-Lena Ungell
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE208628T1 publication Critical patent/ATE208628T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT95940490T 1994-12-02 1995-11-29 Neue antithrombotische formulierung, verfahren zur herstellung und gebrauch davon ATE208628T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9404196A SE9404196D0 (sv) 1994-12-02 1994-12-02 New antithrombotic formulation
PCT/SE1995/001425 WO1996016671A1 (en) 1994-12-02 1995-11-29 New antithrombotic formulation, process for its manufacturing, and use thereof

Publications (1)

Publication Number Publication Date
ATE208628T1 true ATE208628T1 (de) 2001-11-15

Family

ID=20396207

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95940490T ATE208628T1 (de) 1994-12-02 1995-11-29 Neue antithrombotische formulierung, verfahren zur herstellung und gebrauch davon

Country Status (27)

Country Link
US (1) US5795896A (de)
EP (1) EP0799052B1 (de)
JP (1) JPH10513438A (de)
CN (1) CN1168635A (de)
AR (1) AR002254A1 (de)
AT (1) ATE208628T1 (de)
AU (1) AU689994B2 (de)
BR (1) BR9509853A (de)
CA (1) CA2206459A1 (de)
CZ (1) CZ147097A3 (de)
DE (1) DE69523943T2 (de)
DK (1) DK0799052T3 (de)
EE (1) EE03338B1 (de)
ES (1) ES2168395T3 (de)
FI (1) FI972332L (de)
HU (1) HU216631B (de)
IL (1) IL116153A (de)
IS (1) IS4483A (de)
NO (1) NO972475D0 (de)
NZ (1) NZ297118A (de)
PL (1) PL320692A1 (de)
PT (1) PT799052E (de)
SE (1) SE9404196D0 (de)
SK (1) SK61797A3 (de)
TR (1) TR199501517A2 (de)
WO (1) WO1996016671A1 (de)
ZA (1) ZA9510242B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6984627B1 (en) * 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
GB9526273D0 (en) * 1995-12-21 1996-02-21 Astra Ab New prodrugs
SE9602145D0 (sv) * 1996-05-31 1996-05-31 Astra Ab New improved formulation for treatment of thromboembolism
US6423334B1 (en) * 1997-10-01 2002-07-23 Elan Corporation, Plc Composition and method for enhancing transport across gastrointestinal tract cell layers
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
AR023819A1 (es) 1999-05-03 2002-09-04 Astrazeneca Ab FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION
SE9902550D0 (sv) * 1999-07-02 1999-07-02 Astra Ab New crystalline forms
SE9904377D0 (sv) * 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
SE0101932D0 (sv) * 2001-05-31 2001-05-31 Astrazeneca Ab Pharmaceutical combinations
CN100350977C (zh) * 2001-06-14 2007-11-28 大塚制药株式会社 药物组合物
SE0103590D0 (sv) * 2001-10-26 2001-10-26 Astrazeneca Ab New Combination
SE0203349D0 (sv) * 2002-11-12 2002-11-12 Astrazeneca Ab New use
CN100513398C (zh) 2002-12-03 2009-07-15 Axys药物公司 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物
US7345093B2 (en) * 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
US8268791B2 (en) * 2004-08-25 2012-09-18 Aegis Therapeutics, Llc. Alkylglycoside compositions for drug administration
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
US20060046962A1 (en) * 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
US20090047347A1 (en) * 2005-07-29 2009-02-19 Aegis Therapeutics, Inc. Compositions for Drug Administration
US8226949B2 (en) 2006-06-23 2012-07-24 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
RU2354647C2 (ru) 2007-06-28 2009-05-10 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе
US20090258865A1 (en) 2008-03-28 2009-10-15 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
US8541360B2 (en) * 2008-11-19 2013-09-24 Ben Venue Laboratories, Inc. Parenteral formulations comprising sugar-based esters and ethers
US8440631B2 (en) 2008-12-22 2013-05-14 Aegis Therapeutics, Llc Compositions for drug administration
US20100215730A1 (en) * 2009-02-20 2010-08-26 Intrepid Therapeutics, Inc. Compositions for Nasal Administration of Phenothiazines
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
CA2781529C (en) 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes comprising docetaxel
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
PT3415139T (pt) 2011-06-14 2022-06-20 Neurelis Inc Administração de benzodiazepina
JP6941224B2 (ja) 2018-02-06 2021-09-29 イージス セラピューティクス，エルエルシー 疾患の処置のための鼻腔内エピネフリン製剤及び方法
CA3221395A1 (en) 2021-06-10 2022-12-15 Neurelis, Inc. Methods and compositions for treating seizure disorders in pediatric patients

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
US4395401A (en) * 1981-09-09 1983-07-26 Smithkline Beckman Corporation Renally active dipeptides
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
PT84170B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
DE3606480A1 (de) * 1986-02-28 1987-09-03 Behringwerke Ag Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (de) * 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV Protease-Hemmer
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
US5110812A (en) * 1990-06-04 1992-05-05 Bristol-Myers Squibb Co. Azetidin-2-one derivatives as serine protease inhibitors
US5037819A (en) * 1990-06-04 1991-08-06 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
TW201303B (de) * 1990-07-05 1993-03-01 Hoffmann La Roche
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
GB9019558D0 (en) * 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
GB9024129D0 (en) * 1990-11-06 1990-12-19 Thrombosis Research Trust Inhibitors and substrates of thrombin
KR920703558A (ko) * 1990-11-15 1992-12-18 원본미기재 메타-치환 페닐알라닌 유도체
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
CZ333492A3 (en) * 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives

Also Published As

Publication number Publication date
FI972332A0 (fi) 1997-06-02
DE69523943T2 (de) 2002-06-27
SE9404196D0 (sv) 1994-12-02
IL116153A0 (en) 1996-01-31
JPH10513438A (ja) 1998-12-22
EP0799052B1 (de) 2001-11-14
CA2206459A1 (en) 1996-06-06
TR199501517A2 (tr) 1996-07-21
NZ297118A (en) 1998-12-23
AR002254A1 (es) 1998-03-11
NO972475L (no) 1997-05-30
DE69523943D1 (de) 2001-12-20
EE03338B1 (et) 2001-02-15
ES2168395T3 (es) 2002-06-16
SK61797A3 (en) 1998-03-04
HUT77655A (hu) 1998-07-28
CN1168635A (zh) 1997-12-24
FI972332A7 (fi) 1997-06-02
HU216631B (hu) 1999-07-28
CZ147097A3 (cs) 1998-02-18
US5795896A (en) 1998-08-18
DK0799052T3 (da) 2002-02-25
WO1996016671A1 (en) 1996-06-06
MX9703975A (es) 1997-09-30
IS4483A (is) 1997-05-16
AU689994B2 (en) 1998-04-09
NO972475D0 (no) 1997-05-30
ZA9510242B (en) 1996-06-03
FI972332L (fi) 1997-06-02
BR9509853A (pt) 1997-12-30
PL320692A1 (en) 1997-10-27
AU4191596A (en) 1996-06-19
PT799052E (pt) 2002-05-31
IL116153A (en) 1999-11-30
EP0799052A1 (de) 1997-10-08

Similar Documents

Publication Publication Date Title
DE69523943D1 (de) Neue antithrombotische formulierung, verfahren zur herstellung und gebrauch davon
DE69528111D1 (de) Biosensor und Verfahren zur Herstellung desselben
DE69429873D1 (de) Teilchenförmige aromazusammenstellungen und verfahren zur herstellung derselben
EP0674181A3 (de) Mikromechanisches Bauelement und Verfahren zur Herstellung desselben.
DE69527054D1 (de) Retroreflektierender gegenstand und verfahren zur herstellung
DE69835139D1 (de) Fäulnisverhindernde emulsionsbeschichtungszusammensetzung, verfahren zur herstellung und mit dieser fäulnisverhindernden zusammensetzung beschichteter gegenstand
EP0875074A4 (de) Halbleiterbauelemente und verfahren zur herstellung
DE69710487D1 (de) Stabiler standbeutel und verfahren zur herstellung
DE69829181D1 (de) Verbesserte trennsäulen und verfahren zur herstellung der verbesserten trennsäulen
DE69101685D1 (de) Katalytische Eisen-Antimon-Molybdän-Zusammensetzung und Verfahren zur Herstellung derselben.
DE69805112D1 (de) Biosensor und Verfahren zur Herstellung desselben
DE69516424D1 (de) Lamellenschleifscheibe, verfahren und vorrichtung zur herstellung derselben
DE69819015D1 (de) Norbonenpolymer und verfahren zur herstellung
DE69522324D1 (de) Farblampe und verfahren zur herstellung derselben
DE69519739D1 (de) Epdm zusammensetzungen und verfahren zur herstellung davon
DE69512365D1 (de) Wässerige Tintenzusammensetzung und Verfahren zur Herstellung derselben
DE69522399D1 (de) Verfahren zur Herstellung von 1,2-Benzisothiazol-3-onen
DE69113025D1 (de) Drei neue nichtpolyglutamisierende deazaaminopterine und verfahren zur herstellung.
DE69511248D1 (de) Polycarbomate, verfahren zur herstellung von polycarbomaten und verfahren zur herstellung von polyisocyanaten
DE59503847D1 (de) Verfahren zur Herstellung von 3,5-Dimethylpyrazol-blockierten Polyisocyanaten
DE69622051D1 (de) Verfahren zur herstellung von 2,4-dihydroxy-pyridin und 2,4-dihydroxy-3-nitropyridin
ATE290003T1 (de) Verfahren zur herstellung von pyrazolo-(4,3- d)pyrimidin-7-ones und zwischenprodukte davon
DE69515697D1 (de) Blockcopolymere und verfahren zur herstellung
DE69834613D1 (de) Halbleiterbauelement und verfahren zur dessen herstellung
DE69515937D1 (de) Blattmaterial und verfahren zur herstellung desselben

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee