ATE209032T1 - Retinoid-formulierungen in porösen mikrokugeln für verringerte irritation und verbesserte stabilität - Google Patents

Retinoid-formulierungen in porösen mikrokugeln für verringerte irritation und verbesserte stabilität

Info

Publication number
ATE209032T1
ATE209032T1 AT96111446T AT96111446T ATE209032T1 AT E209032 T1 ATE209032 T1 AT E209032T1 AT 96111446 T AT96111446 T AT 96111446T AT 96111446 T AT96111446 T AT 96111446T AT E209032 T1 ATE209032 T1 AT E209032T1
Authority
AT
Austria
Prior art keywords
porous microspheres
improved stability
reduced irritation
retinoid formulations
retinoid
Prior art date
Application number
AT96111446T
Other languages
English (en)
Inventor
Michael Froix
Sergio Nacht
Masha Pukshansky
Original Assignee
Enhanced Derm Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enhanced Derm Technologies Inc filed Critical Enhanced Derm Technologies Inc
Application granted granted Critical
Publication of ATE209032T1 publication Critical patent/ATE209032T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0279—Porous; Hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT96111446T 1995-12-29 1996-07-16 Retinoid-formulierungen in porösen mikrokugeln für verringerte irritation und verbesserte stabilität ATE209032T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/581,126 US5851538A (en) 1995-12-29 1995-12-29 Retinoid formulations in porous microspheres for reduced irritation and enhanced stability

Publications (1)

Publication Number Publication Date
ATE209032T1 true ATE209032T1 (de) 2001-12-15

Family

ID=24323987

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96111446T ATE209032T1 (de) 1995-12-29 1996-07-16 Retinoid-formulierungen in porösen mikrokugeln für verringerte irritation und verbesserte stabilität

Country Status (11)

Country Link
US (1) US5851538A (de)
EP (1) EP0781551B1 (de)
JP (1) JP2960022B2 (de)
KR (1) KR100262117B1 (de)
AT (1) ATE209032T1 (de)
AU (1) AU697584B2 (de)
CA (1) CA2184433C (de)
DE (1) DE69617181T2 (de)
DK (1) DK0781551T3 (de)
ES (1) ES2168414T3 (de)
PT (1) PT781551E (de)

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Also Published As

Publication number Publication date
EP0781551B1 (de) 2001-11-21
EP0781551A1 (de) 1997-07-02
ES2168414T3 (es) 2002-06-16
CA2184433A1 (en) 1997-06-30
DE69617181T2 (de) 2002-06-06
KR970032851A (ko) 1997-07-22
DE69617181D1 (de) 2002-01-03
JP2960022B2 (ja) 1999-10-06
KR100262117B1 (ko) 2000-07-15
DK0781551T3 (da) 2002-05-21
US5851538A (en) 1998-12-22
CA2184433C (en) 2000-01-18
PT781551E (pt) 2002-04-29
JPH09183722A (ja) 1997-07-15
AU697584B2 (en) 1998-10-08
AU5831096A (en) 1997-07-03

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