ATE209489T1 - Taxane mit pyridyl-substituierter seitenkette - Google Patents

Taxane mit pyridyl-substituierter seitenkette

Info

Publication number
ATE209489T1
ATE209489T1 AT94912838T AT94912838T ATE209489T1 AT E209489 T1 ATE209489 T1 AT E209489T1 AT 94912838 T AT94912838 T AT 94912838T AT 94912838 T AT94912838 T AT 94912838T AT E209489 T1 ATE209489 T1 AT E209489T1
Authority
AT
Austria
Prior art keywords
pyridyl
taxanes
side chain
substituted side
substituted
Prior art date
Application number
AT94912838T
Other languages
English (en)
Inventor
Robert A Holton
Kasthuri Rengan
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/095,085 external-priority patent/US5489601A/en
Application filed by Univ Florida State filed Critical Univ Florida State
Application granted granted Critical
Publication of ATE209489T1 publication Critical patent/ATE209489T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT94912838T 1993-03-22 1994-03-21 Taxane mit pyridyl-substituierter seitenkette ATE209489T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3485293A 1993-03-22 1993-03-22
US08/095,085 US5489601A (en) 1991-09-23 1993-07-20 Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
PCT/US1994/003094 WO1994021252A1 (en) 1993-03-22 1994-03-21 Taxanes having a pyridyl substituted side-chain

Publications (1)

Publication Number Publication Date
ATE209489T1 true ATE209489T1 (de) 2001-12-15

Family

ID=26711461

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94912838T ATE209489T1 (de) 1993-03-22 1994-03-21 Taxane mit pyridyl-substituierter seitenkette

Country Status (12)

Country Link
EP (1) EP0690712B1 (de)
JP (1) JPH08508471A (de)
AT (1) ATE209489T1 (de)
AU (1) AU702492B2 (de)
CA (1) CA2158863C (de)
DE (1) DE69429253T2 (de)
DK (1) DK0690712T3 (de)
ES (1) ES2164100T3 (de)
IL (1) IL109049A (de)
PT (1) PT690712E (de)
TW (1) TW438772B (de)
WO (1) WO1994021252A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19605024A1 (de) * 1996-01-31 1997-08-07 Schering Ag Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
HUP0600302A2 (en) * 2000-02-02 2006-07-28 Univ Florida State Res Found C10 ester substituted taxanes as antitumor agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0690712A1 (de) 1996-01-10
AU702492B2 (en) 1999-02-25
ES2164100T3 (es) 2002-02-16
AU684768B2 (en) 1998-01-08
DK0690712T3 (da) 2002-03-18
IL109049A0 (en) 1994-06-24
CA2158863C (en) 2006-12-19
PT690712E (pt) 2002-05-31
WO1994021252A1 (en) 1994-09-29
CA2158863A1 (en) 1994-09-29
EP0690712A4 (de) 1995-11-20
JPH08508471A (ja) 1996-09-10
EP0690712B1 (de) 2001-11-28
IL109049A (en) 2006-12-31
DE69429253T2 (de) 2002-06-13
AU6522994A (en) 1994-10-11
TW438772B (en) 2001-06-07
AU5637398A (en) 1998-04-30
DE69429253D1 (de) 2002-01-10

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee