ATE209689T1 - Verfahren zur herstellung von steroidverbindungen - Google Patents
Verfahren zur herstellung von steroidverbindungenInfo
- Publication number
- ATE209689T1 ATE209689T1 AT97910556T AT97910556T ATE209689T1 AT E209689 T1 ATE209689 T1 AT E209689T1 AT 97910556 T AT97910556 T AT 97910556T AT 97910556 T AT97910556 T AT 97910556T AT E209689 T1 ATE209689 T1 AT E209689T1
- Authority
- AT
- Austria
- Prior art keywords
- methyl
- hydroxylation
- acyloxy
- carbamoyl
- acyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 STEROID COMPOUNDS Chemical class 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 230000033444 hydroxylation Effects 0.000 abstract 2
- 238000005805 hydroxylation reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005189 alkyl hydroxy group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/02—Dehydrogenating; Dehydroxylating
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9622884.6A GB9622884D0 (en) | 1996-11-02 | 1996-11-02 | A method for th e preparation of steroids in the pregene class |
| PCT/GB1997/003003 WO1998020151A1 (en) | 1996-11-02 | 1997-10-31 | A method for the preparation of steroid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE209689T1 true ATE209689T1 (de) | 2001-12-15 |
Family
ID=10802374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97910556T ATE209689T1 (de) | 1996-11-02 | 1997-10-31 | Verfahren zur herstellung von steroidverbindungen |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0941361B1 (de) |
| AT (1) | ATE209689T1 (de) |
| DE (1) | DE69708679D1 (de) |
| GB (2) | GB9622884D0 (de) |
| WO (1) | WO1998020151A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2448039A1 (en) * | 2001-06-18 | 2002-12-27 | Pharmacia & Upjohn Company | Process to prepare 11.beta., 17.alpha.,21-trihydroxy-6.alpha.-methylpregna-1,4-diene-3,20-dione 21-acetate |
| CA2448037A1 (en) * | 2001-06-18 | 2002-12-27 | Pharmacia & Upjohn Company | Process to prepare 11.beta.,17.alpha.,21-trihydroxy-6.alpha.-methylpregna-1,4-diene-3,20-dione 21-acetate |
| EP1587818A4 (de) * | 2003-01-21 | 2010-10-13 | Merck Sharp & Dohme | 17-carbomoyloxycortisolderivate als selektive modulatoren des glucocorticoidrezeptors |
| CN1978457B (zh) * | 2005-12-05 | 2010-06-09 | 浙江大学 | 6α-甲基强的松龙及其衍生物的生产方法 |
| EP2093285B1 (de) * | 2008-02-20 | 2016-07-06 | The University of the West Indies | Verfahren zur Biokatalyse unter Verwendung von Fadenpilzen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH399453A (de) * | 1961-06-06 | 1965-09-30 | Ciba Geigy | Verfahren zur mikrobiologischen Oxydation von Steroiden |
| SE427116B (sv) * | 1976-07-06 | 1983-03-07 | Larsson Per Olof | Transformation av steroider och antibiotika med immobiliserade levande mikroorganismer som aktiveras |
| ATE3878T1 (de) * | 1980-06-21 | 1983-07-15 | Schering Aktiengesellschaft Berlin Und Bergkamen | Verfahren zur herstellung von 11-betahydroxysteroiden. |
| DE3133082A1 (de) * | 1981-08-18 | 1983-03-10 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue hydrocortison-derivate, ihre herstellung und verwendung |
| EP0095894A3 (de) * | 1982-05-31 | 1985-01-02 | Ohta Seiyaku Kabushiki Kaisha. | 6-Alpha Methyl Prednisolon Derivate |
| GB8730216D0 (en) * | 1987-12-29 | 1988-02-03 | Lepetit Spa | Process for preparation of pregnenooxazolines |
-
1996
- 1996-11-02 GB GBGB9622884.6A patent/GB9622884D0/en active Pending
-
1997
- 1997-10-31 DE DE69708679T patent/DE69708679D1/de not_active Expired - Lifetime
- 1997-10-31 GB GB9723076A patent/GB2318790B/en not_active Expired - Lifetime
- 1997-10-31 WO PCT/GB1997/003003 patent/WO1998020151A1/en not_active Ceased
- 1997-10-31 AT AT97910556T patent/ATE209689T1/de active
- 1997-10-31 EP EP97910556A patent/EP0941361B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69708679D1 (de) | 2002-01-10 |
| WO1998020151A9 (en) | 1999-06-17 |
| EP0941361B1 (de) | 2001-11-28 |
| EP0941361A1 (de) | 1999-09-15 |
| GB2318790B (en) | 2001-04-04 |
| WO1998020151A1 (en) | 1998-05-14 |
| GB9622884D0 (en) | 1997-01-08 |
| GB9723076D0 (en) | 1998-01-07 |
| GB2318790A (en) | 1998-05-06 |
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