ATE21099T1 - 4-aminobuttersaeure-derivate und diese enthaltende, insbesondere auf das zentralnervensystem wirksame, arzneimittel. - Google Patents

4-aminobuttersaeure-derivate und diese enthaltende, insbesondere auf das zentralnervensystem wirksame, arzneimittel.

Info

Publication number: ATE21099T1
Authority: AT; Austria
Prior art keywords: group; alkyl group; carbon atoms; integer; linear
Prior art date: 1980-08-27

Application number

AT81401299T

Other languages

English (en)

Inventor

Jean-Pierre Chambon

Jean-Charles Molimard

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-08-27

Filing date

1981-08-13

Publication date

1986-08-15

1981-08-13 Application filed by Sanofi Sa filed Critical Sanofi Sa

1986-08-15 Application granted granted Critical

1986-08-15 Publication of ATE21099T1 publication Critical patent/ATE21099T1/de

Links

BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title abstract 5
210000003169 central nervous system Anatomy 0.000 title 1
239000003814 drug Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 6
125000004432 carbon atom Chemical group C* 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 4
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
150000001408 amides Chemical class 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000003884 phenylalkyl group Chemical group 0.000 abstract 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT81401299T 1980-08-27 1981-08-13 4-aminobuttersaeure-derivate und diese enthaltende, insbesondere auf das zentralnervensystem wirksame, arzneimittel. ATE21099T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8018609A FR2489319A1 (fr)	1980-08-27	1980-08-27	Derives de l'acide amino-4 butyrique et les medicaments, actifs notamment sur le systeme nerveux central, en contenant
EP81401299A EP0046707B1 (de)	1980-08-27	1981-08-13	4-Aminobuttersäure-Derivate und diese enthaltende, insbesondere auf das Zentralnervensystem wirksame, Arzneimittel

Publications (1)

Publication Number	Publication Date
ATE21099T1 true ATE21099T1 (de)	1986-08-15

Family

ID=9245433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT81401299T ATE21099T1 (de)	1980-08-27	1981-08-13	4-aminobuttersaeure-derivate und diese enthaltende, insbesondere auf das zentralnervensystem wirksame, arzneimittel.

Country Status (15)

Country	Link
EP (1)	EP0046707B1 (de)
JP (1)	JPS5772949A (de)
AT (1)	ATE21099T1 (de)
AU (1)	AU547392B2 (de)
CA (1)	CA1208230A (de)
DE (1)	DE3175030D1 (de)
DK (1)	DK378781A (de)
ES (1)	ES8206445A1 (de)
FR (1)	FR2489319A1 (de)
GR (1)	GR75299B (de)
IE (1)	IE52415B1 (de)
NO (1)	NO156608C (de)
NZ (1)	NZ198110A (de)
PT (1)	PT73558B (de)
ZA (1)	ZA815662B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5378729A (en) *	1985-02-15	1995-01-03	Research Corporation Technologies, Inc.	Amino acid derivative anticonvulsant
CA1340902C (en) *	1985-02-15	2000-02-22	Harold L. Kohn	Amino acid derivative anticonvulsant
US5654301A (en) *	1985-02-15	1997-08-05	Research Corporation Technologies, Inc.	Amino acid derivative anticonvulsant
CA1320734C (en) *	1986-02-04	1993-07-27	Suntory Limited	Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
US5198458A (en) *	1986-02-04	1993-03-30	Suntory Limited	Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same
NZ222045A (en) *	1986-08-21	1989-10-27	Res Corp Technologies Inc	From diamides up to tetrapeptides for use as anticanvulsants
US4992472A (en) *	1987-06-16	1991-02-12	The United States Of America As Represented By The Department Of Health And Human Services	Chemical differentiating agents
US5770625A (en) *	1988-02-08	1998-06-23	The Trustees Of Columbia University In The City Of New York	Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
DE3915755A1 (de) *	1989-05-13	1990-11-29	Bayer Ag	Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung
DE3915756A1 (de) *	1989-05-13	1990-11-29	Bayer Ag	Cyclopropanoylaminosaeureamid-derivate
CA2017217C (en) *	1989-05-19	2002-02-19	Harold L. Kohn	Amino acid derivative anticonvulsant
DE4102042A1 (de) *	1991-01-24	1992-07-30	Bayer Ag	Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide
US5585358A (en) *	1993-07-06	1996-12-17	Yissum Research Development Corporation Of The Hebrew University Of Jerusalem	Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
US6037472A (en) *	1993-11-04	2000-03-14	Syntex (U.S.A.) Inc.	Matrix metalloprotease inhibitors
IL114483A0 (en) *	1994-07-12	1995-11-27	Yissum Res Dev Co	Glycinamide derivatives pharmaceutical compositions containing the same and methods utilizing the same
EP1202720A4 (de) *	1999-08-10	2004-02-25	Uab Research Foundation	Verwendung von gaba-agonisten zur behandlung von spastischen erkrankungen, konvulsionen und epilepsie
RU2166497C1 (ru) *	2000-02-25	2001-05-10	Специальное конструкторско-технологическое бюро "Технолог" Санкт-Петербургского государственного технологического института (технического университета)	Способ получения 3-фенил-4-аминомасляной кислоты или хлоргидрата 3-фенил-4-аминомасляной кислоты
US6555585B2 (en) *	2000-07-21	2003-04-29	Teva Pharmaceutical Industries, Ltd.	Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder
RU2202538C2 (ru) *	2001-05-04	2003-04-20	Савельев Евгений Александрович	Способ получения 4-аминомасляной кислоты
EP1604656A1 (de)	2004-06-09	2005-12-14	Schwarz Pharma Ag	Neue Verwendung von Peptidverbindungen zur Behandlung von amyotropher Lateralsklerose (ALS)
TW200829238A (en) *	2006-11-30	2008-07-16	Cenerx Biopharma Inc	Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB732415A (en) *	1952-07-12	1955-06-22	Ruhrchemie Ag	Process for the production of aroylated aminocarboxylic acids
US3022314A (en) *	1955-06-20	1962-02-20	Upjohn Co	Alpha-phenyl-omega-amino-alkanamides
IE33790B1 (en) *	1968-06-04	1974-10-30	Beecham Group Ltd	Derivatives of n-acylaminoacid amides

1980
- 1980-08-27 FR FR8018609A patent/FR2489319A1/fr active Granted
1981
- 1981-08-11 IE IE1835/81A patent/IE52415B1/en unknown
- 1981-08-11 GR GR65767A patent/GR75299B/el unknown
- 1981-08-13 EP EP81401299A patent/EP0046707B1/de not_active Expired
- 1981-08-13 AT AT81401299T patent/ATE21099T1/de not_active IP Right Cessation
- 1981-08-13 DE DE8181401299T patent/DE3175030D1/de not_active Expired
- 1981-08-17 ZA ZA815662A patent/ZA815662B/xx unknown
- 1981-08-18 AU AU74259/81A patent/AU547392B2/en not_active Ceased
- 1981-08-20 NZ NZ198110A patent/NZ198110A/en unknown
- 1981-08-21 CA CA000384370A patent/CA1208230A/en not_active Expired
- 1981-08-24 PT PT73558A patent/PT73558B/pt unknown
- 1981-08-26 NO NO812890A patent/NO156608C/no unknown
- 1981-08-26 JP JP56132669A patent/JPS5772949A/ja active Pending
- 1981-08-26 DK DK378781A patent/DK378781A/da not_active Application Discontinuation
- 1981-08-26 ES ES505004A patent/ES8206445A1/es not_active Expired

Also Published As

Publication number	Publication date
EP0046707B1 (de)	1986-07-30
NZ198110A (en)	1984-12-14
AU7425981A (en)	1982-03-04
EP0046707A1 (de)	1982-03-03
NO156608B (no)	1987-07-13
ES505004A0 (es)	1982-08-16
ZA815662B (en)	1982-08-25
PT73558A (fr)	1981-09-01
IE811835L (en)	1982-02-27
CA1208230A (en)	1986-07-22
PT73558B (fr)	1982-11-03
AU547392B2 (en)	1985-10-17
IE52415B1 (en)	1987-10-28
JPS5772949A (en)	1982-05-07
NO812890L (no)	1982-03-01
NO156608C (no)	1987-10-21
FR2489319B1 (de)	1984-04-06
GR75299B (de)	1984-07-13
DE3175030D1 (en)	1986-09-04
ES8206445A1 (es)	1982-08-16
DK378781A (da)	1982-02-28
FR2489319A1 (fr)	1982-03-05

Legal Events

Date	Code	Title	Description
1987-01-15	UEP	Publication of translation of european patent specification
1990-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU547392B2 (en)	1985-10-17	Derivatives of 4-amino butyric acid and their use as sedatives
ATE136882T1 (de)	1996-05-15	Carbamidsäureester-derivate, mittel und herstellungsverfahren
GB1138405A (en)	1969-01-01	Morpholine derivatives
ES8300699A1 (es)	1982-11-01	Procedimiento para la preparacion de derivados del indol.
ES8604543A1 (es)	1986-02-01	Procedimiento para la obtencion de derivados piperazinicos
FR2222097A1 (de)	1974-10-18
GB1419699A (de)	1975-12-31
NO870319D0 (no)	1987-01-27	Tianaftenderivater og fremgangsmaate til fremstilling derav
DE3060367D1 (en)	1982-06-24	Derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicines
GB1191609A (en)	1970-05-13	Use of Oxalic Acid Diamides as Stabilizers for Polyolefins
GB1304786A (de)	1973-01-31
DE3576330D1 (de)	1990-04-12	3-(indan-5-yloxy (oder thio))-cyclopentancarbonsaeure-analogeund sie enthaltendes behandlungsmittel.
ES446444A1 (es)	1977-10-16	Procedimientos de preparacion de compuestos que contienen fluor.
ES394484A1 (es)	1974-02-16	Procedimiento para la preparacion de derivados 1,4-benzo- diazepinicos.
GB1057742A (en)	1967-02-08	N-substituted octadecadienoic acid amides
ATE6063T1 (de)	1984-02-15	Cycloalkano-thiazolyloxamidsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel.
ES379188A3 (es)	1972-09-01	Un procedimiento de preparacion de derivados de adamantano.
ZA843975B (en)	1985-01-30	Substituted acetamides and their use as phytotoxic substances
ES394638A3 (es)	1973-12-01	Procedimiento para la preparacion de amidas n-sustituidas en los acidos dialquiltiofosfomercaptoacetidos de elevado poder insecticida.
ES433898A1 (es)	1976-11-16	Procedimiento para la preparacion de nuevas bencilaminas.
ES277617A2 (es)	1962-12-16	Procedimiento para preparar amidas de ácido 0,0-di(fluoro-alkil)-ditiofosforilacéticos
GB1050468A (de)
FR2284597A1 (fr)	1976-04-09	Derives 2-imino d'imidazoles substitues et compositions reglant le developpement des plantes, a base de ces derives
ES472090A2 (es)	1979-10-16	Mejoras introducidas en el objeto de la patente principal n.451407 por:procedimiento para preparar derivados de amidoxi-ma
ES433892A1 (es)	1976-12-16	Procedimiento para la preparacion de nuevas bencilaminas.