ATE211138T1 - Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel - Google Patents

Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel

Info

Publication number: ATE211138T1
Authority: AT; Austria
Prior art keywords: beta; carboline derivatives; production process; medicinal products; melatonin agonists
Prior art date: 1994-09-14

Application number

AT95931243T

Other languages

English (en)

Inventor

Jean-Bernard Fourtillan

Marianne Fourtillan

Jean-Claude Jacquesy

Marie-Paule Jouannetaud

Bruno Violeau

Omar Appartement Karam

Troubadour

Original Assignee

Macef

Besins Iscovesco Sa Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-14

Filing date

1995-09-14

Publication date

2002-01-15

1995-09-14 Application filed by Macef, Besins Iscovesco Sa Lab filed Critical Macef

2002-01-15 Application granted granted Critical

2002-01-15 Publication of ATE211138T1 publication Critical patent/ATE211138T1/de

Links

AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title abstract 3
YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title 1
239000000556 agonist Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title 1
229960003987 melatonin Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 abstract 2
239000002537 cosmetic Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1
-1 medicinal Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Psychology (AREA)
Reproductive Health (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Cosmetics (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT95931243T 1994-09-14 1995-09-14 Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel ATE211138T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9410964A FR2724384B1 (fr)	1994-09-14	1994-09-14	Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament
PCT/FR1995/001179 WO1996008490A1 (fr)	1994-09-14	1995-09-14	NOUVEAUX DERIVES DE β-CARBOLINE ET D'ANALOGUES A STRUCTURE NAPHTALENIQUE AGONISTES DE LA MELATONINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT

Publications (1)

Publication Number	Publication Date
ATE211138T1 true ATE211138T1 (de)	2002-01-15

Family

ID=9466929

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95931243T ATE211138T1 (de)	1994-09-14	1995-09-14	Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel

Country Status (13)

Country	Link
US (1)	US6048868A (de)
EP (1)	EP0781281B1 (de)
JP (1)	JP4051712B2 (de)
CN (1)	CN1046514C (de)
AT (1)	ATE211138T1 (de)
AU (1)	AU3475595A (de)
DE (1)	DE69524774T2 (de)
DK (1)	DK0781281T3 (de)
ES (1)	ES2169147T3 (de)
FR (1)	FR2724384B1 (de)
PT (1)	PT781281E (de)
WO (1)	WO1996008490A1 (de)
ZA (1)	ZA961898B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2724384B1 (fr) *	1994-09-14	1999-04-16	Cemaf	Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament
FR2754262B1 (fr) *	1996-10-08	1998-10-30	Synthelabo	Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2765582B1 (fr) *	1997-07-03	1999-08-06	Synthelabo	Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique
FR2765581B1 (fr) *	1997-07-03	1999-08-06	Synthelabo	Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique
HUP0101234A3 (en) *	1998-03-17	2002-12-28	Besins Iscovesco Lab	Betha-carboline derivatives, process for their preparation and pharmaceutical compositions thereof
FR2792937B1 (fr) *	1999-04-27	2001-08-10	Cemaf	NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT
UA74826C2 (en)	2000-05-17	2006-02-15	Ortho Mcneil Pharm Inc	?-carboline derivatives as phosphodiesterase inhibitors
FR2824829B1 (fr) *	2001-05-16	2005-06-03	Macef	Nouveaux derives de dihydroimidazo [5,1-a]-beta-carboline, leur procede de preparation et leur application a titre de medicament
EP1483283A4 (de)	2002-03-13	2007-04-11	Signum Biosciences Inc	Modulation der proteinmethylierung und phosphoproteinphosphat
US7872133B2 (en) *	2003-06-23	2011-01-18	Ono Pharmaceutical Co., Ltd.	Tricyclic heterocycle compound
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
US7767689B2 (en)	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
UA92317C2 (ru)	2004-03-15	2010-10-25	Пи-Ти-Си ТЕРАПЬЮТИКС, ИНК.	Производные карболина, пригодные для ингибирования развития кровеносных сосудов
EP1829874B1 (de) *	2004-12-22	2014-02-12	Ono Pharmaceutical Co., Ltd.	Tricyclische verbindung und deren verwendung
CA2601777A1 (en) *	2005-02-03	2006-08-10	Signum Biosciences, Inc.	Compositions and methods for enhancing cognitive function
US7923041B2 (en)	2005-02-03	2011-04-12	Signum Biosciences, Inc.	Compositions and methods for enhancing cognitive function
FR2898358B1 (fr) *	2006-03-08	2008-05-30	Macef Sa	Association d'un antagoniste du recepteur 5ht2 et d'activateur du recepteur 5ht2 par modulation allosterique et leurs utilisations comme produits medicaux
FR2908768A1 (fr) *	2006-06-19	2008-05-23	Fourtillan Snc	DERIVES DE 3H,11H-OXAZOLO (3',4':1,2)PYRIDO(3,4-b)INDOLE ET LEUR UTILISATION EN THERAPEUTIQUE
FR2904973A1 (fr) *	2006-08-18	2008-02-22	Fourtillan Snc	Derives de 1-methylidene-pyrido[3,4-b]indole et leur utilisation en therapeutique.
FR2912405A1 (fr) *	2007-02-08	2008-08-15	Fourtillan Snc	Derives des imidazo[1',5':1,6]pyrido[3,4-b]indoles et leur utilisation en therapeutique
FR2912747A1 (fr) *	2007-02-19	2008-08-22	Fourtillan Snc	Derives des 1-(1-hydoxy-3-oxo-propen-1-yl)-1,2,3,3a,8,8a-hexahydro- pyrrolo[2,3-b)indoles et leur utilisation en therapeutique
WO2008103470A2 (en)	2007-02-21	2008-08-28	Trustees Of Columbia University In The City Of New York	Oncogenic-ras-signal dependent lethal compounds
FR2916200A1 (fr) *	2007-05-18	2008-11-21	Fourtillan Snc	Nouveaux derives des 1,2,3,4,6,7,12,12a-octahydro pyrazino[1',2':1,6]pyrido[3,4-b]indoles, leur preparation et leur utilisation en therapeutique
AU2009239430B2 (en)	2008-04-21	2015-01-22	Signum Biosciences, Inc.	Compounds, compositions and methods for making the same
CA2975985A1 (fr)	2015-02-04	2016-08-11	Soeur Josefa Menendez	Systeme therapeutique transdermique contenant de la valentonine et son utilisation comme medicament
FI130627B (en) *	2021-03-31	2023-12-18	Equinorm Ltd	Novel heterocyclic compounds and their use
CN121159533A (zh) *	2025-11-20	2025-12-19	昆明医科大学	一种噻吩乙酰基四氢-β-咔啉类化合物及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR3395E (fr) *	1904-03-23	1904-10-27	Georges Felix Coffignon	Cordon métallique
ES273769A1 (es) *	1961-01-18	1962-06-01	Geigy Ag J R	Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
FR1524953A (fr) *	1962-03-26	1968-05-17	Konink Pharmaceutische Fabrike	Procédé de préparation des dérivés de la quinolizine
FR3395M (fr) *	1963-07-30	1965-06-28	Roussel Uclaf	Nouveau médicament notamment pour le traitement des états neurodépressifs et des psychoses d'anxiété.
GB1055203A (en) *	1964-09-16	1967-01-18	Ici Ltd	-ß-carboline derivatives, a process for their manufacture, and compositions containing them
US3718657A (en) *	1970-12-03	1973-02-27	Abbott Lab	Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines
US4336260A (en) *	1977-12-08	1982-06-22	The Dow Chemical Company	Method and compositions using 1-aryl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid for treating depression
EP0017727A1 (de) *	1979-04-10	1980-10-29	Ciba-Geigy Ag	Polysubstituierte Diazatricyclen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
FR2455044A1 (fr) *	1979-04-26	1980-11-21	Synthelabo	Pyrido-indoles et leur application en therapeutique
DE3621413A1 (de) *	1986-06-26	1988-01-07	Boehringer Ingelheim Kg	Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung
US5283343A (en) *	1987-08-17	1994-02-01	Whitby Research, Inc.	2-aryl substituted N-acetyltryptamines and process of preparing such
US5093352A (en) *	1988-11-14	1992-03-03	Whitby Research, Inc.	Antidepressant agents
FR2663935A1 (fr) *	1990-06-27	1992-01-03	Adir	Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE4104257A1 (de) *	1991-02-13	1992-08-20	Boehringer Ingelheim Kg	Verwendung von anellierten tetrahydropyridinessigsaeurederivaten fuer die behandlung neurologischer erkrankungen
US5206377A (en) *	1991-12-05	1993-04-27	Whitby Research, Inc.	Compounds useful as antiproliferative agents
FR2724384B1 (fr) *	1994-09-14	1999-04-16	Cemaf	Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

1994
- 1994-09-14 FR FR9410964A patent/FR2724384B1/fr not_active Expired - Fee Related
1995
- 1995-09-14 AT AT95931243T patent/ATE211138T1/de not_active IP Right Cessation
- 1995-09-14 WO PCT/FR1995/001179 patent/WO1996008490A1/fr not_active Ceased
- 1995-09-14 DK DK95931243T patent/DK0781281T3/da active
- 1995-09-14 EP EP95931243A patent/EP0781281B1/de not_active Expired - Lifetime
- 1995-09-14 AU AU34755/95A patent/AU3475595A/en not_active Abandoned
- 1995-09-14 DE DE69524774T patent/DE69524774T2/de not_active Expired - Lifetime
- 1995-09-14 JP JP50996096A patent/JP4051712B2/ja not_active Expired - Fee Related
- 1995-09-14 CN CN95195692A patent/CN1046514C/zh not_active Expired - Fee Related
- 1995-09-14 PT PT95931243T patent/PT781281E/pt unknown
- 1995-09-14 ES ES95931243T patent/ES2169147T3/es not_active Expired - Lifetime
1996
- 1996-03-08 ZA ZA961898A patent/ZA961898B/xx unknown
1998
- 1998-03-17 US US09/042,990 patent/US6048868A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0781281A1 (de)	1997-07-02
DE69524774D1 (de)	2002-01-31
AU3475595A (en)	1996-03-29
EP0781281B1 (de)	2001-12-19
JP4051712B2 (ja)	2008-02-27
CN1046514C (zh)	1999-11-17
FR2724384A1 (fr)	1996-03-15
US6048868A (en)	2000-04-11
ZA961898B (en)	1996-09-17
ES2169147T3 (es)	2002-07-01
JPH10505606A (ja)	1998-06-02
DE69524774T2 (de)	2002-09-19
DK0781281T3 (da)	2002-04-15
WO1996008490A1 (fr)	1996-03-21
FR2724384B1 (fr)	1999-04-16
PT781281E (pt)	2002-08-30
CN1161039A (zh)	1997-10-01

Legal Events

Date	Code	Title
2002-06-15	UEP	Publication of translation of european patent specification
2002-08-15	EEFA	Change of the company name
2011-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE211138T1 (de)	2002-01-15	Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel
DE59808281D1 (de)	2003-06-12	Disubstituierte bicyclische heterocyclen, ihre herstellung und ihre verwendung als arzneimittel
AR003220A1 (es)	1998-07-08	Derivados acilados de melatonina; composicion farmaceutica y cosmetica y el uso de los mismos para la preparacion de un medicamento.
DE59410330D1 (de)	2003-11-27	Ectoin und Ectoinderivate als Feuchtigkeitsspender in Kosmetikprodukten
PL322015A1 (en)	1998-01-05	Derivatives of hydroxylamine useful as compounds enhancing production of accompanying molecular protein and ethod of obtaining them
YU43694A (sh)	1997-07-31	Magnezijum omeprazol i postupak za dobijanje ovog jedinjenja
ATE188965T1 (de)	2000-02-15	Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln
DE69026496D1 (de)	1996-05-15	Analoge von vitamin a und ihre verwendung, insbesondere als cytotrophische und cytoprotective substanzen sowie diese substanzen enthaltende arzneimittel
HUT51269A (en)	1990-04-28	Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same
ZA934550B (en)	1994-01-27	Derivatives in the vitamin D series with modifications in 20-position, process for their production,intermediate products for this process,pharmaceutical prepartions containing these derivatives as well as their use for the production of pharmaceutical agents
ATE188469T1 (de)	2000-01-15	Alkoxy-4(1h)-pyridon-derivative, verfahren zu deren herstellung und deren verwendung als arzneimittel
ATE223912T1 (de)	2002-09-15	Pyridylalkan-säureamide als cytostatika und immunosupressive arzneimittel
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IL88971A (en)	1993-07-08	Disubstituted pyridines, process and intermediates, their preparation and pharmaceutical compositions containing them
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