ATE212632T1 - Nicht-klassische antifolate - Google Patents
Nicht-klassische antifolateInfo
- Publication number
- ATE212632T1 ATE212632T1 AT96114189T AT96114189T ATE212632T1 AT E212632 T1 ATE212632 T1 AT E212632T1 AT 96114189 T AT96114189 T AT 96114189T AT 96114189 T AT96114189 T AT 96114189T AT E212632 T1 ATE212632 T1 AT E212632T1
- Authority
- AT
- Austria
- Prior art keywords
- amino
- hydroxy
- antifolates
- classic
- acid
- Prior art date
Links
- 229940127074 antifolate Drugs 0.000 title 1
- 239000004052 folic acid antagonist Substances 0.000 title 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 101000606741 Homo sapiens Phosphoribosylglycinamide formyltransferase Proteins 0.000 abstract 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 abstract 1
- 102100039654 Phosphoribosylglycinamide formyltransferase Human genes 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000008430 aromatic amides Chemical class 0.000 abstract 1
- 229960000304 folic acid Drugs 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- 229960002989 glutamic acid Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US347195P | 1995-09-08 | 1995-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE212632T1 true ATE212632T1 (de) | 2002-02-15 |
Family
ID=21706027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96114189T ATE212632T1 (de) | 1995-09-08 | 1996-09-04 | Nicht-klassische antifolate |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5786358A (de) |
| EP (1) | EP0761668B1 (de) |
| JP (1) | JPH09165387A (de) |
| AT (1) | ATE212632T1 (de) |
| CA (1) | CA2184783A1 (de) |
| DE (1) | DE69618875D1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6066639A (en) * | 1996-05-01 | 2000-05-23 | The Trustees Of Princeton University | 5,6,7,8-tetrahydropyrido[2,3-D]pyrimidines |
| WO1997049705A1 (en) * | 1996-06-25 | 1997-12-31 | The Trustees Of Princeton University | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES |
| US7098241B2 (en) * | 2002-12-16 | 2006-08-29 | Hoffmann-La Roche Inc. | Thiophene hydroxamic acid derivatives |
| AU2008237932C1 (en) * | 2007-04-11 | 2014-04-24 | Merck & Cie | 18 F-labelled folates |
| EP2266984A1 (de) * | 2009-06-26 | 2010-12-29 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Pyrido[2,3-d]pyrimidine als Wnt Antagonisten zur Behandlung von Krebs und Arthritis |
| JP5784295B2 (ja) * | 2010-09-28 | 2015-09-24 | 国立大学法人 岡山大学 | 新規分岐状アミノ酸、新規分岐状アミノ酸と蛍光性アミノ酸の複合体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684653A (en) * | 1985-03-08 | 1987-08-04 | The Trustees Of Princeton University | Pyrido(2,3-d)pyrimidine derivatives |
| US4818819A (en) * | 1986-10-20 | 1989-04-04 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
| US4895946A (en) * | 1987-10-26 | 1990-01-23 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
| US4889859A (en) * | 1988-02-05 | 1989-12-26 | The Trustees Of Princeton University | Pyrido[2,3-d]pyrimidine derivatives |
| DK172753B1 (da) * | 1988-05-25 | 1999-06-28 | Lilly Co Eli | N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat |
| US5144012A (en) * | 1988-08-08 | 1992-09-01 | Eli Lilly And Company | Cytotoxic drug conjugates |
| US5008391A (en) * | 1989-07-07 | 1991-04-16 | Eli Lilly And Company | Enantioselective synthesis of antifolates |
| ZA913730B (en) * | 1990-05-30 | 1992-02-26 | Ici Plc | Anti-tumor compounds |
| US5159079A (en) * | 1991-12-20 | 1992-10-27 | Eli Lilly And Company | 2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids |
| JPH0782174A (ja) * | 1993-09-17 | 1995-03-28 | Takeda Chem Ind Ltd | 抗腫瘍剤 |
-
1996
- 1996-09-04 DE DE69618875T patent/DE69618875D1/de not_active Expired - Lifetime
- 1996-09-04 CA CA002184783A patent/CA2184783A1/en not_active Abandoned
- 1996-09-04 US US08/708,351 patent/US5786358A/en not_active Expired - Fee Related
- 1996-09-04 EP EP96114189A patent/EP0761668B1/de not_active Expired - Lifetime
- 1996-09-04 JP JP8234557A patent/JPH09165387A/ja not_active Withdrawn
- 1996-09-04 AT AT96114189T patent/ATE212632T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09165387A (ja) | 1997-06-24 |
| EP0761668A2 (de) | 1997-03-12 |
| US5786358A (en) | 1998-07-28 |
| EP0761668A3 (de) | 1997-11-19 |
| DE69618875D1 (de) | 2002-03-14 |
| EP0761668B1 (de) | 2002-01-30 |
| CA2184783A1 (en) | 1997-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |