ATE213631T1 - Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität - Google Patents

Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität

Info

Publication number: ATE213631T1
Authority: AT; Austria
Prior art keywords: pyridopyrane; anxiolytic; benzo; derivatives; anticonvulsive activity
Prior art date: 1991-06-13

Application number

AT92911170T

Other languages

English (en)

Inventor

J M Evans

M Thompson

Neil Upton

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-13

Filing date

1992-06-11

Publication date

2002-03-15

1992-06-11 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2002-03-15 Application granted granted Critical

2002-03-15 Publication of ATE213631T1 publication Critical patent/ATE213631T1/de

Links

FEAVXMPFTQROEI-UHFFFAOYSA-N 2h-pyrano[3,2-b]pyridine Chemical class C1=CN=C2C=CCOC2=C1 FEAVXMPFTQROEI-UHFFFAOYSA-N 0.000 title 1
230000002082 anti-convulsion Effects 0.000 title 1
239000002249 anxiolytic agent Substances 0.000 title 1
230000000949 anxiolytic effect Effects 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010026749 Mania Diseases 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrane Compounds (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

AT92911170T 1991-06-13 1992-06-11 Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität ATE213631T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB919112721A GB9112721D0 (en)	1991-06-13	1991-06-13	Novel treatment
PCT/GB1992/001045 WO1992022293A1 (en)	1991-06-13	1992-06-11	Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity

Publications (1)

Publication Number	Publication Date
ATE213631T1 true ATE213631T1 (de)	2002-03-15

Family

ID=10696586

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92911170T ATE213631T1 (de)	1991-06-13	1992-06-11	Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität

Country Status (17)

Country	Link
EP (2)	EP1108718A3 (de)
JP (3)	JP3449716B2 (de)
KR (1)	KR100287969B1 (de)
AT (1)	ATE213631T1 (de)
AU (1)	AU660686B2 (de)
CA (1)	CA2111223C (de)
DE (1)	DE69232437T2 (de)
DK (1)	DK0587645T3 (de)
ES (1)	ES2173081T3 (de)
GB (1)	GB9112721D0 (de)
IE (2)	IE20020955A1 (de)
MX (1)	MX9202803A (de)
NZ (2)	NZ264745A (de)
PT (1)	PT100583B (de)
SG (1)	SG48284A1 (de)
WO (1)	WO1992022293A1 (de)
ZA (1)	ZA924267B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5453421A (en) *	1992-09-11	1995-09-26	E. R. Squibb & Sons, Inc.	Aryl and heterocyclic substituted propenamide derivatives
GB9225860D0 (en) *	1992-12-11	1993-02-03	Smithkline Beecham Plc	Novel treatment
ES2143541T3 (es) *	1992-12-11	2000-05-16	Smithkline Beecham Plc	Composicion farmaceutica que contiene compuestos de tipo biciclico.
KR100254106B1 (ko) *	1994-06-09	2000-05-01	타이도 나오카타	4-퀴놀리논 유도체 또는 그의 염
GB9411635D0 (en)	1994-06-10	1994-08-03	Smithkline Beecham Plc	Novel treatment
EP0764159B1 (de) *	1994-06-10	2000-08-09	Smithkline Beecham Plc	C-4 amid substituierte verbindungen und deren verwendung als therapeutische mittel
ATE250052T1 (de) *	1994-06-10	2003-10-15	Smithkline Beecham Plc	Benzopyrane und deren verwendung als heilmittel
AU739678B2 (en) *	1994-06-10	2001-10-18	Smithkline Beecham Plc	Benzopyrans and their use as therapeutic agents
GB9425502D0 (en) *	1994-12-17	1995-02-15	Smithkline Beecham Plc	Novel receptor
US6245893B1 (en)	1994-12-17	2001-06-12	Smithkline Beecham P.L.C.	Receptor that binds anti-convulsant compounds
US5612323A (en) *	1995-06-07	1997-03-18	Bristol-Myers Squibb Company	Phosphinic ester substituted benzopyran derivatives
US5869478A (en) *	1995-06-07	1999-02-09	Bristol-Myers Squibb Company	Sulfonamido substituted benzopyran derivatives
US5629429A (en) *	1995-06-07	1997-05-13	Bristol-Myers Squibb Company	Process for preparing 4-arylamino-benzopyran and related compounds
US5612370A (en) *	1995-06-07	1997-03-18	Bristol-Myers Squibb Company	Phenylglycine and phenylalaninen amido benzopyran derivatives
EP0906283A1 (de) *	1996-06-17	1999-04-07	Smithkline Beecham Plc	Substituierte benzamide derivate und deren verwendung als antikonvulsive mittel
GB9619492D0 (en) *	1996-09-18	1996-10-30	Smithkline Beecham Plc	Novel treatment
DZ2446A1 (fr) *	1997-03-18	2003-01-11	Smithkline Beecham Plc	Nouveaux composés
GB9812683D0 (en)	1998-06-12	1998-08-12	Smithkline Beecham Plc	Novel compounds
GB9813949D0 (en) *	1998-06-29	1998-08-26	Smithkline Beecham Plc	Novel compounds
CN101921347B (zh)	2004-01-07	2014-07-30	生化学工业株式会社	透明质酸衍生物及含有其的药剂
US7576094B2 (en)	2004-12-13	2009-08-18	Eli Lilly And Company	Spiro derivatives as lipoxygenase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2064514B (en) *	1979-10-29	1984-01-18	Maruko Pharmaceutical Co	Flavan compounds and acid addition salts thereof and pharmaceutical compositions thereof
DE3479726D1 (de) *	1983-05-18	1989-10-19	Beecham Group Plc	Benzopyran derivatives.
DE3682331D1 (de) *	1985-06-08	1991-12-12	Beecham Group Plc	Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
PT84806B (pt) *	1986-05-03	1989-12-29	Beecham Group Plc	Processo para a preparacao de benzopiranos
FR2639349B1 (fr) *	1988-11-23	1991-02-22	Sanofi Sa	Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant

1991
- 1991-06-13 GB GB919112721A patent/GB9112721D0/en active Pending
1992
- 1992-06-11 ES ES92911170T patent/ES2173081T3/es not_active Expired - Lifetime
- 1992-06-11 NZ NZ264745A patent/NZ264745A/en unknown
- 1992-06-11 AT AT92911170T patent/ATE213631T1/de not_active IP Right Cessation
- 1992-06-11 SG SG1996008698A patent/SG48284A1/en unknown
- 1992-06-11 WO PCT/GB1992/001045 patent/WO1992022293A1/en not_active Ceased
- 1992-06-11 ZA ZA924267A patent/ZA924267B/xx unknown
- 1992-06-11 MX MX9202803A patent/MX9202803A/es not_active IP Right Cessation
- 1992-06-11 CA CA002111223A patent/CA2111223C/en not_active Expired - Fee Related
- 1992-06-11 EP EP01200951A patent/EP1108718A3/de not_active Withdrawn
- 1992-06-11 JP JP51078992A patent/JP3449716B2/ja not_active Expired - Fee Related
- 1992-06-11 EP EP92911170A patent/EP0587645B1/de not_active Expired - Lifetime
- 1992-06-11 AU AU18917/92A patent/AU660686B2/en not_active Ceased
- 1992-06-11 KR KR1019930703872A patent/KR100287969B1/ko not_active Expired - Fee Related
- 1992-06-11 PT PT100583A patent/PT100583B/pt not_active IP Right Cessation
- 1992-06-11 NZ NZ243108A patent/NZ243108A/en unknown
- 1992-06-11 DK DK92911170T patent/DK0587645T3/da active
- 1992-06-11 DE DE69232437T patent/DE69232437T2/de not_active Expired - Fee Related
- 1992-07-01 IE IE20020955A patent/IE20020955A1/en not_active IP Right Cessation
- 1992-07-01 IE IE191092A patent/IE921910A1/en not_active Application Discontinuation
2002
- 2002-01-24 JP JP2002015835A patent/JP2002255958A/ja active Pending
2003
- 2003-09-03 JP JP2003311700A patent/JP2004002478A/ja active Pending

Also Published As

Publication number	Publication date
JPH06507893A (ja)	1994-09-08
CA2111223A1 (en)	1992-12-23
DK0587645T3 (da)	2002-06-03
WO1992022293A1 (en)	1992-12-23
IE20020955A1 (en)	2003-10-01
DE69232437D1 (de)	2002-04-04
CA2111223C (en)	1998-06-09
EP0587645A1 (de)	1994-03-23
JP2002255958A (ja)	2002-09-11
SG48284A1 (en)	1998-04-17
ES2173081T3 (es)	2002-10-16
ZA924267B (en)	1993-12-10
EP1108718A2 (de)	2001-06-20
AU1891792A (en)	1993-01-12
PT100583A (pt)	1993-09-30
NZ264745A (en)	1997-03-24
DE69232437T2 (de)	2002-10-31
PT100583B (pt)	1999-07-30
KR940701252A (ko)	1994-05-28
EP1108718A3 (de)	2003-02-05
GB9112721D0 (en)	1991-07-31
JP2004002478A (ja)	2004-01-08
IE921910A1 (en)	1992-12-16
HK1019004A1 (en)	2000-01-14
KR100287969B1 (ko)	2001-05-02
AU660686B2 (en)	1995-07-06
EP0587645B1 (de)	2002-02-27
NZ243108A (en)	1996-08-27
JP3449716B2 (ja)	2003-09-22
MX9202803A (es)	1992-12-01

Legal Events

Date

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2003-02-15

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Ref document number: 0587645

Country of ref document: EP

2005-03-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69232437D1 (de)	2002-04-04	Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität
MX9603593A (es)	1997-03-29	Derivados de quinazolina.
IL190780A0 (en)	2008-11-03	Heterocyclic substituted aminoazacycles useful as central nervous system agents
SG46641A1 (en)	1998-02-20	1,3-Substituted cycloalkenes and cycloalkanes as central nervous system agents
DE3789967D1 (de)	1994-07-07	Anwendung von monoaminakridinen bei mangelerscheinungen des cholinergen nervensystems.
ZA944739B (en)	1995-10-10	Amide and urea derivatives having anti-hypercholesteremic activity their preparation and their therapeutic uses
GB9711650D0 (en)	1997-07-30	Compounds useful in therapy
DE69327913D1 (de)	2000-04-06	1,2,4-Oxadiazolyl-Phenoxyalkyl-isoxazole und ihre Anwendung als antivirale Mittel
GR3015144T3 (en)	1995-05-31	Quinuclidine derivatives.
FR2683819B1 (fr)	1994-02-11	Derives de quinoleine, leur procede de preparation et leur application en therapeutique.
ATE171374T1 (de)	1998-10-15	Verwendung von 1-(aminoalkyl)-3-quinoxalin-2-on derivaten zur herstellung von neuroprotektiven mitteln
DE69226703D1 (de)	1998-09-24	Imidazo (4,5-c)pyridinderivate als paf antagonisten
IL101506A0 (en)	1992-12-30	Use of 2-iminothiazolidin-4-one derivatives as novel pharmaceutical active ingredients
HU914024D0 (en)	1992-03-30	Method for producing 1,3-dioxolane derivatives and pharmaceutical preparatives containing said active agents
ATE184282T1 (de)	1999-09-15	Cyclopropan-derivate und diese enthaltende antivirale mittel
DE59103080D1 (de)	1994-11-03	9-Amino-2-phenylbicyclo[3.3.1]nonane und 9-Amino-2-phenylbicyclo[3.3.1]-non-2-ene und diese enthaltende therapeutische Mittel.
JO1825B1 (en)	1995-07-05	Therapeutic agents