ATE213832T1 - Nachweissystem mit fluorometer - Google Patents

Nachweissystem mit fluorometer

Info

Publication number
ATE213832T1
ATE213832T1 AT93908431T AT93908431T ATE213832T1 AT E213832 T1 ATE213832 T1 AT E213832T1 AT 93908431 T AT93908431 T AT 93908431T AT 93908431 T AT93908431 T AT 93908431T AT E213832 T1 ATE213832 T1 AT E213832T1
Authority
AT
Austria
Prior art keywords
time
detection
histogram
compile
photon
Prior art date
Application number
AT93908431T
Other languages
English (en)
Inventor
Robert Marlin Studholme
David Arthur Blau
Original Assignee
Hyperion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperion Inc filed Critical Hyperion Inc
Application granted granted Critical
Publication of ATE213832T1 publication Critical patent/ATE213832T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Geophysics And Detection Of Objects (AREA)
AT93908431T 1992-03-23 1993-03-22 Nachweissystem mit fluorometer ATE213832T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/855,238 US5323008A (en) 1992-03-23 1992-03-23 Fluorometer detection system
PCT/US1993/002540 WO1993019358A1 (en) 1992-03-23 1993-03-22 Fluorometer detection system

Publications (1)

Publication Number Publication Date
ATE213832T1 true ATE213832T1 (de) 2002-03-15

Family

ID=25320715

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93908431T ATE213832T1 (de) 1992-03-23 1993-03-22 Nachweissystem mit fluorometer

Country Status (8)

Country Link
US (1) US5323008A (de)
EP (1) EP0632887B1 (de)
JP (2) JPH07505467A (de)
AT (1) ATE213832T1 (de)
CA (2) CA2132707C (de)
DE (1) DE69331629T2 (de)
ES (1) ES2173093T3 (de)
WO (1) WO1993019358A1 (de)

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US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6992761B2 (en) * 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
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US6326605B1 (en) 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
JPH11132953A (ja) * 1997-10-29 1999-05-21 Bunshi Bio Photonics Kenkyusho:Kk 蛍光寿命測定方法および装置
US6121053A (en) * 1997-12-10 2000-09-19 Brookhaven Science Associates Multiple protocol fluorometer and method
WO2000015101A1 (en) * 1998-09-11 2000-03-23 Spectrx, Inc. Multi-modal optical tissue diagnostic system
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
AU2775899A (en) * 1998-02-20 1999-09-06 Ljl Biosystems, Inc. Broad range light detection system
AU5223899A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
AU5667599A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
AU3005400A (en) 1999-02-23 2000-09-14 Ljl Biosystems, Inc. Frequency-domain light detection device
JP2001078175A (ja) * 1999-07-07 2001-03-23 Fuji Photo Film Co Ltd 蛍光観察装置
JP2001070227A (ja) 1999-07-07 2001-03-21 Fuji Photo Film Co Ltd 蛍光観察装置
US6402986B1 (en) 1999-07-16 2002-06-11 The Trustees Of Boston University Compositions and methods for luminescence lifetime comparison
US6690463B2 (en) 2000-02-10 2004-02-10 Evotec Biosystems Ag Fluorescence intensity and lifetime distribution analysis
US6447995B1 (en) 2000-10-04 2002-09-10 Genvec, Inc. Utilizing intrinsic fluorescence to detect adenovirus
ATE403142T1 (de) * 2000-12-21 2008-08-15 Evotec Ag Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikeln
US20030136921A1 (en) * 2002-01-23 2003-07-24 Reel Richard T Methods for fluorescence detection that minimizes undesirable background fluorescence
JP4074136B2 (ja) * 2002-05-29 2008-04-09 浜松ホトニクス株式会社 蛍光寿命分布画像測定装置およびその測定方法
US20030224354A1 (en) * 2002-05-30 2003-12-04 Introgen Therapeutics Inc. Quantifying viral particles with intrinsic fluorescence
JP4188653B2 (ja) * 2002-10-01 2008-11-26 浜松ホトニクス株式会社 蛍光測定装置
US7371524B2 (en) * 2003-06-17 2008-05-13 Hannjorg Hereth Substituted azaporphyrins as fluorescence labels
JP2008517280A (ja) * 2004-10-18 2008-05-22 マクオーリー ユニヴァーシティ 蛍光検出
US7391512B2 (en) * 2004-12-22 2008-06-24 Avago Technologies General Ip Pte. Ltd. Integrated optoelectronic system for measuring fluorescence or luminescence emission decay
JP4652868B2 (ja) * 2005-03-30 2011-03-16 独立行政法人産業技術総合研究所 蛍光分析方法
EP1886122A4 (de) * 2005-05-30 2013-12-04 Jerker Widengren Vorrichtung, verfahren und computerprogramm für spektroskopische messungen und analyse
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US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
DE102006048346A1 (de) * 2006-10-12 2008-04-17 Eppendorf Ag Verfahren zur Vorrichtung zur quantitativen Echtzeitanalyse von fluoreszierenden Proben
KR100885927B1 (ko) * 2007-10-16 2009-02-26 광주과학기술원 형광수명 측정 방법 및 장치
WO2009089315A1 (en) * 2008-01-08 2009-07-16 Kinase Scientific, Llc Method to detect hemolytic streptococcus and optoelectronically determine results
DE102008018475A1 (de) 2008-04-11 2009-10-15 Carl Zeiss Ag Vorrichtung und Verfahren zur Lumineszenzmessung
US8104512B2 (en) * 2008-09-25 2012-01-31 Masco Corporation Of Indiana Spout tip retention method
US20100279299A1 (en) * 2009-04-03 2010-11-04 Helixis, Inc. Devices and Methods for Heating Biological Samples
WO2011031377A1 (en) * 2009-09-09 2011-03-17 Helixis, Inc. Optical system for multiple reactions
DE102010047237B4 (de) * 2010-08-13 2021-07-01 Leica Microsystems Cms Gmbh Verfahren zum Trennen von Detektionssignalen im Strahlengang einer optischen Einrichtung
US9222850B2 (en) * 2013-03-14 2015-12-29 Axonoptics, Llc Integrated optics reflectometer
US9557243B2 (en) 2012-03-14 2017-01-31 Axonoptics Llc Integrated optics reflectometer
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Also Published As

Publication number Publication date
EP0632887A4 (de) 1995-11-22
JP2002323448A (ja) 2002-11-08
US5323008A (en) 1994-06-21
ES2173093T3 (es) 2002-10-16
EP0632887B1 (de) 2002-02-27
CA2538701A1 (en) 1993-09-30
EP0632887A1 (de) 1995-01-11
DE69331629T2 (de) 2002-08-14
CA2538701C (en) 2006-11-28
WO1993019358A1 (en) 1993-09-30
CA2132707C (en) 2006-06-13
DE69331629D1 (de) 2002-04-04
JPH07505467A (ja) 1995-06-15
CA2132707A1 (en) 1993-09-30

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