ATE215082T1 - Herboxidien-derivate und ihre herstellung aus einer streptomyces gex1 kultur - Google Patents
Herboxidien-derivate und ihre herstellung aus einer streptomyces gex1 kulturInfo
- Publication number
- ATE215082T1 ATE215082T1 AT96120927T AT96120927T ATE215082T1 AT E215082 T1 ATE215082 T1 AT E215082T1 AT 96120927 T AT96120927 T AT 96120927T AT 96120927 T AT96120927 T AT 96120927T AT E215082 T1 ATE215082 T1 AT E215082T1
- Authority
- AT
- Austria
- Prior art keywords
- gex1
- herboxidia
- streptomyces
- culture
- derivatives
- Prior art date
Links
- 101150079351 GEX1 gene Proteins 0.000 title abstract 2
- 241000187747 Streptomyces Species 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34370295 | 1995-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE215082T1 true ATE215082T1 (de) | 2002-04-15 |
Family
ID=18363596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96120927T ATE215082T1 (de) | 1995-12-28 | 1996-12-27 | Herboxidien-derivate und ihre herstellung aus einer streptomyces gex1 kultur |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5719179A (de) |
| EP (1) | EP0781772B1 (de) |
| AT (1) | ATE215082T1 (de) |
| AU (1) | AU703922B2 (de) |
| CA (1) | CA2194043C (de) |
| DE (1) | DE69620128T2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2546345A1 (de) | 2008-06-04 | 2013-01-16 | Eisai R&D Management Co., Ltd. | DNA-codierendes, an der Biosynthese von Herboxidien beteiligtes Polypeptid |
| US8865761B1 (en) | 2012-08-07 | 2014-10-21 | The University Of Notre Dame Du Lac | Regulation of cholesterol homeostasis |
| CA3056389A1 (en) | 2017-03-15 | 2018-09-20 | Eisai R&D Management Co., Ltd. | Spliceosome mutations and uses thereof |
| US11807631B2 (en) | 2017-07-26 | 2023-11-07 | Purdue Research Foundation | Herboxidiene derivatives and uses thereof |
| SG11202102419VA (en) | 2018-12-13 | 2021-04-29 | Eisai R&D Man Co Ltd | Herboxidiene splicing modulator antibody-drug conjugates and methods of use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0622770A (ja) * | 1992-03-05 | 1994-02-01 | Takeda Chem Ind Ltd | 化合物ｔａｎ−１６０９，その製造法および用途 |
-
1996
- 1996-12-24 AU AU76497/96A patent/AU703922B2/en not_active Ceased
- 1996-12-24 US US08/772,941 patent/US5719179A/en not_active Expired - Lifetime
- 1996-12-27 EP EP96120927A patent/EP0781772B1/de not_active Expired - Lifetime
- 1996-12-27 AT AT96120927T patent/ATE215082T1/de active
- 1996-12-27 DE DE69620128T patent/DE69620128T2/de not_active Expired - Fee Related
- 1996-12-27 CA CA002194043A patent/CA2194043C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69620128T2 (de) | 2002-11-07 |
| EP0781772A1 (de) | 1997-07-02 |
| AU7649796A (en) | 1997-07-03 |
| EP0781772B1 (de) | 2002-03-27 |
| CA2194043C (en) | 2005-02-22 |
| AU703922B2 (en) | 1999-04-01 |
| US5719179A (en) | 1998-02-17 |
| DE69620128D1 (de) | 2002-05-02 |
| CA2194043A1 (en) | 1997-06-29 |
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