ATE215612T1 - Methode zur dissoziation von biotin komplexen - Google Patents
Methode zur dissoziation von biotin komplexenInfo
- Publication number
- ATE215612T1 ATE215612T1 AT97926469T AT97926469T ATE215612T1 AT E215612 T1 ATE215612 T1 AT E215612T1 AT 97926469 T AT97926469 T AT 97926469T AT 97926469 T AT97926469 T AT 97926469T AT E215612 T1 ATE215612 T1 AT E215612T1
- Authority
- AT
- Austria
- Prior art keywords
- dissociation
- biotin complexes
- biotin
- complexes
- complex
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/649,876 US6022688A (en) | 1996-05-13 | 1996-05-13 | Method for dissociating biotin complexes |
| PCT/US1997/008052 WO1997043617A2 (en) | 1996-05-13 | 1997-05-13 | Method for dissociating biotin complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE215612T1 true ATE215612T1 (de) | 2002-04-15 |
Family
ID=24606585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97926469T ATE215612T1 (de) | 1996-05-13 | 1997-05-13 | Methode zur dissoziation von biotin komplexen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6022688A (de) |
| EP (1) | EP0914471B1 (de) |
| JP (1) | JP2000510702A (de) |
| AT (1) | ATE215612T1 (de) |
| AU (1) | AU714707B2 (de) |
| CA (1) | CA2253582A1 (de) |
| DE (1) | DE69711632T2 (de) |
| WO (1) | WO1997043617A2 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436635B1 (en) * | 1992-11-06 | 2002-08-20 | Boston University | Solid phase sequencing of double-stranded nucleic acids |
| US5795714A (en) * | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
| DE69433811T2 (de) | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US6194144B1 (en) | 1993-01-07 | 2001-02-27 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
| US20060063193A1 (en) * | 1995-04-11 | 2006-03-23 | Dong-Jing Fu | Solid phase sequencing of double-stranded nucleic acids |
| US7803529B1 (en) | 1995-04-11 | 2010-09-28 | Sequenom, Inc. | Solid phase sequencing of biopolymers |
| US5830655A (en) | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US6146854A (en) * | 1995-08-31 | 2000-11-14 | Sequenom, Inc. | Filtration processes, kits and devices for isolating plasmids |
| AU2069597A (en) * | 1996-03-04 | 1997-09-22 | Genetrace Systems, Inc. | Methods of screening nucleic acids using mass spectrometry |
| US6022688A (en) * | 1996-05-13 | 2000-02-08 | Sequenom, Inc. | Method for dissociating biotin complexes |
| US5777324A (en) * | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
| US5965363A (en) * | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
| EP1164203B1 (de) * | 1996-11-06 | 2007-10-10 | Sequenom, Inc. | DNA-Diagnostik mittels Massenspektrometrie |
| US7285422B1 (en) | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| EP0963443B1 (de) * | 1996-12-10 | 2006-03-08 | Sequenom, Inc. | Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung |
| US6323351B1 (en) | 1997-06-30 | 2001-11-27 | The Dow Chemical Company | Process for the direct oxidation of olefins to olefin oxides |
| US6207370B1 (en) | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| US6225061B1 (en) | 1999-03-10 | 2001-05-01 | Sequenom, Inc. | Systems and methods for performing reactions in an unsealed environment |
| US20010049438A1 (en) * | 1999-03-19 | 2001-12-06 | Dix Connie Kim | Purification of primer extension products |
| US20020009394A1 (en) | 1999-04-02 | 2002-01-24 | Hubert Koster | Automated process line |
| US7668658B2 (en) * | 1999-10-13 | 2010-02-23 | Sequenom, Inc. | Methods for generating databases and databases for identifying polymorphic genetic markers |
| US7917301B1 (en) | 2000-09-19 | 2011-03-29 | Sequenom, Inc. | Method and device for identifying a biological sample |
| US20030207297A1 (en) * | 1999-10-13 | 2003-11-06 | Hubert Koster | Methods for generating databases and databases for identifying polymorphic genetic markers |
| JP2001245698A (ja) * | 1999-11-22 | 2001-09-11 | Xiao Bing Wang | 核酸検出法 |
| DE60137722D1 (de) * | 2000-06-13 | 2009-04-02 | Univ Boston | Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung |
| US6958214B2 (en) | 2000-07-10 | 2005-10-25 | Sequenom, Inc. | Polymorphic kinase anchor proteins and nucleic acids encoding the same |
| US20020142483A1 (en) | 2000-10-30 | 2002-10-03 | Sequenom, Inc. | Method and apparatus for delivery of submicroliter volumes onto a substrate |
| GB0102568D0 (en) * | 2001-02-01 | 2001-03-21 | Magnetic Biosolutions Sweden A | Method |
| US20030036057A1 (en) * | 2001-03-09 | 2003-02-20 | Andreas Braun | Genes and polymorphisms associated with cardiovascular disease and their use |
| US20020155587A1 (en) | 2001-04-20 | 2002-10-24 | Sequenom, Inc. | System and method for testing a biological sample |
| WO2003092581A2 (en) * | 2001-07-16 | 2003-11-13 | Hk Pharmaceuticals, Inc. | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| US20030111494A1 (en) * | 2001-10-26 | 2003-06-19 | Sequenom, Inc. | Method and apparatus for high-throughput sample handling process line |
| US20030166007A1 (en) * | 2002-01-28 | 2003-09-04 | Mds Proteomics Inc. | Chemical proteomics |
| WO2003064704A1 (en) * | 2002-01-28 | 2003-08-07 | Mds Proteomics, Inc. | Chemical proteomics |
| AU2003215083A1 (en) * | 2002-02-06 | 2003-09-02 | Tethys Bioscience, Inc. | Method and apparatus for validating dna sequences without sequencing |
| KR20020041344A (ko) * | 2002-02-26 | 2002-06-01 | 김희태 | 멤브레인 크로마토그래프 기법을 활용하여핵산중합반응으로 증폭된 핵산을 검출하는 방법 |
| AU2003224674A1 (en) * | 2002-03-11 | 2003-09-29 | Hk Pharmaceuticals, Inc. | Compounds and methods for analyzing the proteome |
| WO2003093296A2 (en) * | 2002-05-03 | 2003-11-13 | Sequenom, Inc. | Kinase anchor protein muteins, peptides thereof, and related methods |
| US20060183106A1 (en) * | 2002-10-18 | 2006-08-17 | Adam Siddiqui-Jain | Processes for identifying quadruplex-targeted antiviral molecules |
| AU2003298733B2 (en) * | 2002-11-27 | 2009-06-18 | Agena Bioscience, Inc. | Fragmentation-based methods and systems for sequence variation detection and discovery |
| WO2004064972A2 (en) * | 2003-01-16 | 2004-08-05 | Hk Pharmaceuticals, Inc. | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| CA2513899C (en) * | 2003-01-29 | 2013-03-26 | 454 Corporation | Methods of amplifying and sequencing nucleic acids |
| US20070141570A1 (en) * | 2003-03-07 | 2007-06-21 | Sequenom, Inc. | Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods |
| EP1618216A2 (de) * | 2003-04-25 | 2006-01-25 | Sequenom, Inc. | Auf fragmentierung beruhende verfahren und systeme zur de-novo-sequenzierung |
| US8048627B2 (en) | 2003-07-05 | 2011-11-01 | The Johns Hopkins University | Method and compositions for detection and enumeration of genetic variations |
| EP2107129B1 (de) | 2003-07-31 | 2012-08-22 | Sequenom, Inc. | Verfahren für Multiplex-Polymerasekettenreaktionen auf hohem Niveau und homogene Massenausdehnungsreaktionen zur Genotypisierung von Polymorphismen |
| WO2005074417A2 (en) * | 2003-09-03 | 2005-08-18 | Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
| WO2005024068A2 (en) * | 2003-09-05 | 2005-03-17 | Sequenom, Inc. | Allele-specific sequence variation analysis |
| US7927797B2 (en) * | 2004-01-28 | 2011-04-19 | 454 Life Sciences Corporation | Nucleic acid amplification with continuous flow emulsion |
| US7608394B2 (en) | 2004-03-26 | 2009-10-27 | Sequenom, Inc. | Methods and compositions for phenotype identification based on nucleic acid methylation |
| CA2561381C (en) * | 2004-03-26 | 2015-05-12 | Sequenom, Inc. | Base specific cleavage of methylation-specific amplification products in combination with mass analysis |
| JP2008512129A (ja) * | 2004-09-10 | 2008-04-24 | セクエノム,インコーポレイティド | 核酸の広範囲配列分析法 |
| US20090291437A1 (en) * | 2005-11-02 | 2009-11-26 | O'brien Sean | Methods for targeting quadruplex sequences |
| CA2654165A1 (en) | 2006-06-05 | 2007-12-13 | Cancer Care Ontario | Assessment of risk for colorectal cancer |
| EP2243834A1 (de) | 2007-03-05 | 2010-10-27 | Cancer Care Ontario | Abschätzung des Kolorektalkarzinomrisikos |
| US8097422B2 (en) | 2007-06-20 | 2012-01-17 | Salk Institute For Biological Studies | Kir channel modulators |
| WO2009039122A2 (en) | 2007-09-17 | 2009-03-26 | Sequenom, Inc. | Integrated robotic sample transfer device |
| EP2217721A4 (de) * | 2007-10-29 | 2013-01-09 | Univ California | Osteoarthritis-gentherapie |
| US20100159506A1 (en) * | 2008-07-25 | 2010-06-24 | Cellscape Corporation | Methods and systems for genetic analysis of fetal nucleated red blood cells |
| WO2010087994A2 (en) | 2009-01-30 | 2010-08-05 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
| JP5686098B2 (ja) * | 2009-09-17 | 2015-03-18 | Jsr株式会社 | アビジンとビオチン誘導体の解離方法及び解離剤 |
| US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
| WO2013019361A1 (en) * | 2011-07-07 | 2013-02-07 | Life Technologies Corporation | Sequencing methods |
| ES3011307T3 (en) | 2012-02-23 | 2025-04-07 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| EP3250928A1 (de) * | 2015-01-26 | 2017-12-06 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Verfahren zur quantitativen freisetzung von biotinylierten peptiden und proteinen aus streptavidin-komplexen |
| CN108026560A (zh) | 2015-09-25 | 2018-05-11 | 豪夫迈·罗氏有限公司 | 在低共熔溶剂中使用分选酶的转酰胺反应 |
| WO2017050866A1 (en) | 2015-09-25 | 2017-03-30 | F. Hoffmann-La Roche Ag | Novel soluble sortase a |
| CN108138204B (zh) | 2015-09-25 | 2021-12-31 | 豪夫迈·罗氏有限公司 | 使用分选酶a生产硫酯的方法 |
| US12048753B2 (en) | 2015-10-01 | 2024-07-30 | Whitehead Institute For Biomedical Research | Labeling of antibodies |
| EP3365453A2 (de) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Verfahren, kits, mittel und vorrichtungen zur transduktion |
| MX2018004875A (es) | 2015-10-22 | 2018-08-01 | Juno Therapeutics Gmbh | Metodos para cultivar celulas y kits y aparatos para ello. |
| EP3436578B1 (de) | 2016-03-30 | 2022-01-19 | F. Hoffmann-La Roche AG | Verbesserte sortase |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| JP7786949B2 (ja) * | 2020-02-03 | 2025-12-16 | イルミナ インコーポレイテッド | ビオチン-ストレプトアビジン切断組成物及びライブラリ断片切断 |
| EP4264246A4 (de) * | 2020-12-18 | 2024-11-13 | Arizona Board of Regents on behalf of Arizona State University | Verfahren zur herstellung bioelektronischer proteinvorrichtungen |
| WO2026002230A1 (en) * | 2024-06-28 | 2026-01-02 | Syncell (Taiwan) Inc. | Kits for biotin-streptavidin pulldown system and method |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283342A (en) * | 1992-06-09 | 1994-02-01 | Neorx Corporation | Biotinylated small molecules |
| US4282287A (en) | 1980-01-24 | 1981-08-04 | Giese Roger W | Biochemical avidin-biotin multiple-layer system |
| DE3476218D1 (en) * | 1983-02-24 | 1989-02-23 | Ciba Geigy Ag | Reactive dyes, their preparation and their use |
| US4762881A (en) | 1987-01-09 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Photoreactive benzoylphenylalanines and related peptides |
| US5252743A (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| WO1991011533A1 (en) * | 1990-01-26 | 1991-08-08 | E.I. Du Pont De Nemours And Company | Method for isolating primer extension products from template-directed dna polymerase reactions |
| US5387505A (en) * | 1990-05-04 | 1995-02-07 | Eastman Kodak Company | Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage |
| US5292444A (en) * | 1992-10-02 | 1994-03-08 | Exxon Research And Engineering Company | Lube oil compositions containing fullerene-grafted polymers |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| DE69433811T2 (de) * | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| US5527675A (en) * | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| US5643722A (en) | 1994-05-11 | 1997-07-01 | Trustees Of Boston University | Methods for the detection and isolation of proteins |
| JP3612092B2 (ja) * | 1994-09-07 | 2005-01-19 | 株式会社日立製作所 | Dnaの分離・分取法及びその解析法 |
| US5830655A (en) | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US5605708A (en) | 1995-09-11 | 1997-02-25 | Cummins Eagle, Inc. | Rounder apparatus for processing bakery dough |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| US6022688A (en) * | 1996-05-13 | 2000-02-08 | Sequenom, Inc. | Method for dissociating biotin complexes |
| US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| DE69735112T2 (de) | 1996-11-06 | 2006-09-07 | Sequenom, Inc., San Diego | Verfahren zur Analyse und Vorrichtung |
| EP1164203B1 (de) | 1996-11-06 | 2007-10-10 | Sequenom, Inc. | DNA-Diagnostik mittels Massenspektrometrie |
| WO1998020019A1 (en) | 1996-11-06 | 1998-05-14 | Sequenom, Inc. | Compositions and methods for immobilizing nucleic acids to solid supports |
-
1996
- 1996-05-13 US US08/649,876 patent/US6022688A/en not_active Expired - Lifetime
-
1997
- 1997-05-13 DE DE69711632T patent/DE69711632T2/de not_active Expired - Lifetime
- 1997-05-13 AU AU31232/97A patent/AU714707B2/en not_active Ceased
- 1997-05-13 EP EP97926469A patent/EP0914471B1/de not_active Expired - Lifetime
- 1997-05-13 JP JP09541041A patent/JP2000510702A/ja not_active Ceased
- 1997-05-13 CA CA002253582A patent/CA2253582A1/en not_active Abandoned
- 1997-05-13 WO PCT/US1997/008052 patent/WO1997043617A2/en not_active Ceased
- 1997-05-13 AT AT97926469T patent/ATE215612T1/de not_active IP Right Cessation
-
1999
- 1999-06-21 US US09/337,388 patent/US6303309B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU3123297A (en) | 1997-12-05 |
| JP2000510702A (ja) | 2000-08-22 |
| AU714707B2 (en) | 2000-01-06 |
| EP0914471A2 (de) | 1999-05-12 |
| CA2253582A1 (en) | 1997-11-20 |
| DE69711632T2 (de) | 2002-10-24 |
| HK1018967A1 (en) | 2000-01-14 |
| US6303309B1 (en) | 2001-10-16 |
| US6022688A (en) | 2000-02-08 |
| DE69711632D1 (de) | 2002-05-08 |
| WO1997043617A3 (en) | 1998-02-19 |
| EP0914471B1 (de) | 2002-04-03 |
| WO1997043617A2 (en) | 1997-11-20 |
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