ATE217195T1 - Verwendung von cilastatin, glutathione und n- acetyl-l-cysteine zur herstellung eines arzneimittels zur verbesserung der resorption von carbapenem oder penem antibiotika im magen-darm- trakt - Google Patents

Verwendung von cilastatin, glutathione und n- acetyl-l-cysteine zur herstellung eines arzneimittels zur verbesserung der resorption von carbapenem oder penem antibiotika im magen-darm- trakt

Info

Publication number: ATE217195T1
Authority: AT; Austria
Prior art keywords: cilastatin; glutathione; cysteine; acetyl; absorption
Prior art date: 1991-02-01

Application number

AT92101563T

Other languages

English (en)

Inventor

Osamu Sugita

Yasushi Kanai

Takumi Kojima

Original Assignee

Suntory Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-01

Filing date

1992-01-30

Publication date

2002-05-15

1991-02-01 Priority claimed from JP3147791A external-priority patent/JP3178726B2/ja

1991-02-01 Priority claimed from JP03147891A external-priority patent/JP3161741B2/ja

1991-02-01 Priority claimed from JP3147591A external-priority patent/JP3377219B2/ja

1991-02-01 Priority claimed from JP03147691A external-priority patent/JP3148263B2/ja

1992-01-30 Application filed by Suntory Ltd filed Critical Suntory Ltd

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE217195T1 publication Critical patent/ATE217195T1/de

Links

RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 title abstract 4
108010024636 Glutathione Proteins 0.000 title abstract 2
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title abstract 2
238000010521 absorption reaction Methods 0.000 title abstract 2
DHSUYTOATWAVLW-WFVMDLQDSA-N cilastatin Chemical compound CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O DHSUYTOATWAVLW-WFVMDLQDSA-N 0.000 title abstract 2
229960004912 cilastatin Drugs 0.000 title abstract 2
229960003180 glutathione Drugs 0.000 title abstract 2
239000003242 anti bacterial agent Substances 0.000 title 1
229940088710 antibiotic agent Drugs 0.000 title 1
YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
210000001035 gastrointestinal tract Anatomy 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 title 1
102000004860 Dipeptidases Human genes 0.000 abstract 1
108090001081 Dipeptidases Proteins 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salt Chemical class 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
210000002919 epithelial cell Anatomy 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
JWEQRJSCTFBRSI-PCLIKHOPSA-N rboxylate Chemical compound COC(=O)C1C(N2C3=O)C4=CC=CC=C4OC1(C)N=C2S\C3=C\C(C=1)=CC=C(OC)C=1COC1=CC=CC=C1C JWEQRJSCTFBRSI-PCLIKHOPSA-N 0.000 abstract 1
210000000813 small intestine Anatomy 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT92101563T 1991-02-01 1992-01-30 Verwendung von cilastatin, glutathione und n- acetyl-l-cysteine zur herstellung eines arzneimittels zur verbesserung der resorption von carbapenem oder penem antibiotika im magen-darm- trakt ATE217195T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP3147791A JP3178726B2 (ja)	1991-02-01	1991-02-01	抗菌剤組成物
JP03147891A JP3161741B2 (ja)	1991-02-01	1991-02-01	ペネム類の消化管吸収改善剤および改善方法
JP3147591A JP3377219B2 (ja)	1991-02-01	1991-02-01	経口抗菌組成物
JP03147691A JP3148263B2 (ja)	1991-02-01	1991-02-01	抗菌性組成物

Publications (1)

Publication Number	Publication Date
ATE217195T1 true ATE217195T1 (de)	2002-05-15

Family

ID=27459440

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT92101563T ATE217195T1 (de)	1991-02-01	1992-01-30	Verwendung von cilastatin, glutathione und n- acetyl-l-cysteine zur herstellung eines arzneimittels zur verbesserung der resorption von carbapenem oder penem antibiotika im magen-darm- trakt
AT01118037T ATE297205T1 (de)	1991-02-01	1992-01-30	Orale antibakterielle zusammensetzung und verfahren zur verbesserung der resorption von penem oder carbapenem antibiotika im magen-darm- traktus

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT01118037T ATE297205T1 (de)	1991-02-01	1992-01-30	Orale antibakterielle zusammensetzung und verfahren zur verbesserung der resorption von penem oder carbapenem antibiotika im magen-darm- traktus

Country Status (5)

Country	Link
US (2)	US5354748A (de)
EP (2)	EP1161947B1 (de)
AT (2)	ATE217195T1 (de)
DE (2)	DE69232598T2 (de)
ES (2)	ES2244529T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6896899B2 (en) *	1996-12-31	2005-05-24	Antioxidant Pharmaceuticals Corp.	Pharmaceutical preparations of glutathione and methods of administration thereof
EP0957901B1 (de)	1996-12-31	2009-11-18	Antioxidant Pharmaceuticals Corporation	Pharmazeutische glutathionpräparate und methoden zu dern verabreichung
EP0966974B1 (de) *	1998-01-13	2004-12-01	Daiichi Suntory Pharma Co., Ltd.	Antibakterille zusammensetzung zur topischen anwendung, enthaltend faropenem
CN1198611C (zh) *	1999-09-17	2005-04-27	第一三得利制药株式会社	药物抗菌剂组合物
US20040202714A1 (en) *	1999-10-12	2004-10-14	Daiichi Suntory Pharma Co., Ltd.	Oral pharmaceutical composition
US8148356B2 (en)	2005-08-24	2012-04-03	Cumberland Pharmaceuticals, Inc.	Acetylcysteine composition and uses therefor
WO2012129493A1 (en) *	2011-03-24	2012-09-27	Seachaid Pharmaceuticals, Inc.	Vancomycin derivatives
CN103371977A (zh) *	2012-04-25	2013-10-30	秦引林	一种泰比培南酯颗粒及其制备方法
US9913801B2 (en) *	2013-02-15	2018-03-13	Your Energy Systems, LLC	Treatment of evolving bacterial resistance diseases including Klebsiella pneumoniae with liposomally formulated glutathione

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4668504A (en) *	1970-11-18	1987-05-26	Merck & Co., Inc.	Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics
US4301074A (en) *	1977-11-17	1981-11-17	Merck & Co., Inc.	6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4168314A (en) *	1977-11-17	1979-09-18	Merck & Co., Inc.	6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
NZ190994A (en) *	1978-07-24	1981-10-19	Merck & Co Inc	Z-2-acylamino-3-monosubstituted propenoates
US4616038A (en) *	1978-07-24	1986-10-07	Merck & Co., Inc.	Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4880793A (en) *	1978-07-24	1989-11-14	Merck & Co., Inc.	Combination of thienamycin-type antibiotics with dipeptidase inhibitors
AR244550A1 (es) *	1978-07-24	1993-11-30	Merck & Co Inc	Procedimiento para obtener una composicion de antibioticos del tipo de la tienamicina con inhibidores de la dipeptidasa
US4272437A (en) *	1978-12-18	1981-06-09	Bristol-Myers Company	Antibacterial agents, and 4-thio azetidinone intermediates
US4539208A (en) *	1980-09-17	1985-09-03	Merck & Co., Inc.	Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4378314A (en) *	1979-09-21	1983-03-29	Bristol Myers Company	Antibacterial agents and metal containing azetidinone intermediates therefore
IE50333B1 (en) *	1979-11-02	1986-04-02	Merck & Co Inc	Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate
US4386030A (en) *	1979-12-31	1983-05-31	Merck & Co., Inc.	Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
PT73640B (en) *	1980-09-17	1983-10-19	Merck & Co Inc	Process for preparing chemical compounds selectively inhibit the metabolism of dipeptidase
US4406902A (en) *	1980-09-17	1983-09-27	Merck & Co., Inc.	Dipeptidase inhibitors
NZ201471A (en) *	1981-08-10	1985-09-13	Merck & Co Inc	Antibacterial compositions containing penems and dipeptidase inhibitors
JPH075463B2 (ja) *	1985-03-09	1995-01-25	サントリー株式会社	抗菌剤
US4739113A (en) *	1986-05-30	1988-04-19	Merck & Co., Inc.	Bis(cyclopropanecarboxamido)alkadienedioic acids as renal dipeptidase inhibitors
US5061730A (en) *	1987-01-26	1991-10-29	Fujisawa Pharmaceutical Co., Ltd.	Carboxylic acid derivatives
US4866171A (en) *	1987-04-11	1989-09-12	Lederle (Japan), Ltd.	(1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
US5061729A (en) *	1988-06-08	1991-10-29	Biogal Gyogyszergyar	Pharmaceutical composition and process for preparing the same
EP0406863B1 (de) *	1989-07-06	1995-05-24	Banyu Pharmaceutical Co., Ltd.	Cyclische Derivate des Amidinylthiocarbapenems
CA2022382A1 (en) *	1989-08-02	1991-02-03	Susumu Nakagawa	Piperidylthiocarbapenem derivatives

1992
- 1992-01-30 DE DE69232598T patent/DE69232598T2/de not_active Expired - Fee Related
- 1992-01-30 AT AT92101563T patent/ATE217195T1/de not_active IP Right Cessation
- 1992-01-30 DE DE69233529T patent/DE69233529T2/de not_active Expired - Fee Related
- 1992-01-30 EP EP01118037A patent/EP1161947B1/de not_active Expired - Lifetime
- 1992-01-30 ES ES01118037T patent/ES2244529T3/es not_active Expired - Lifetime
- 1992-01-30 ES ES92101563T patent/ES2176179T3/es not_active Expired - Lifetime
- 1992-01-30 EP EP92101563A patent/EP0497353B1/de not_active Expired - Lifetime
- 1992-01-30 AT AT01118037T patent/ATE297205T1/de not_active IP Right Cessation
- 1992-01-31 US US07/828,571 patent/US5354748A/en not_active Expired - Fee Related
1995
- 1995-04-18 US US08/425,223 patent/US5637612A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1161947A3 (de)	2002-07-03
US5354748A (en)	1994-10-11
US5637612A (en)	1997-06-10
EP0497353B1 (de)	2002-05-08
DE69232598D1 (de)	2002-06-13
EP0497353A3 (en)	1992-12-02
DE69233529T2 (de)	2005-11-24
EP1161947A2 (de)	2001-12-12
ES2244529T3 (es)	2005-12-16
ES2176179T3 (es)	2002-12-01
DE69232598T2 (de)	2002-11-21
EP0497353A2 (de)	1992-08-05
EP1161947B1 (de)	2005-06-08
DE69233529D1 (de)	2005-07-14
ATE297205T1 (de)	2005-06-15

Legal Events

Date	Code	Title	Description
2002-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
AU2490297A (en)	1998-01-08	Use of strontium salts for the production of pharmaceutical compositions intended for the treatment of arthrosis
AU2118488A (en)	1989-02-23	Improvements in or relating to methods of treating damaged skin
EP0217580A3 (de)	1990-11-07	Therapeutische Nukleoside
AU6684894A (en)	1994-12-12	Bicyclic amide derivatives and their use as muscle relaxants
ATE217195T1 (de)	2002-05-15	Verwendung von cilastatin, glutathione und n- acetyl-l-cysteine zur herstellung eines arzneimittels zur verbesserung der resorption von carbapenem oder penem antibiotika im magen-darm- trakt
AU5586790A (en)	1990-11-29	Substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphonamides and-cyanamides, processes for their preparation and their use in medicaments
EP0235589A3 (en)	1989-12-13	Use of quinolone and naphthyridine antibiotics for the manufacture of ophthalmic medicaments
DE69723864D1 (en)	2003-09-04	Ethyliden-derivate tricyclyscher carbapenems
EP0342587A3 (de)	1991-05-22	Thienotriazolodiazepine und ihre pharmazeutische Verwendung
AU7828491A (en)	1992-01-02	Novel 3,3'-dithiobis (propionic acids) and esters thereof
GR3015052T3 (en)	1995-05-31	Antibiotic GE 2270 factors A1, A2, A3 and H.
AU4734993A (en)	1994-03-24	Nutrient or medicinal compositions for administration to ruminants
MY104109A (en)	1993-12-31	Antibacterial 9-deoxo-9a-allyl and propargyl-9a-aza-9a-homoerythromycin a derivatives.
CA2037779A1 (en)	1991-09-09	Antibiotic ge 2270 factors b1, b2, c1, c2, d1, d2, e and t
AU5707090A (en)	1991-01-31	Hair treatment composition
NO159767C (no)	1989-02-08	Anvendelse av et hjelpestoff som tilsetning til beta-laktamantibiotikum for aa oeke absorpsjonsgraden av antibiotikumet i blodet ved oral administrering.
AU545885B2 (en)	1985-08-08	Oral absorption of glycosidic antibiotics
GR3026590T3 (en)	1998-07-31	Antibiotics ge 37468 a, b and c.
IE782383L (en)	1979-06-03	Monic acid derivatives
GB8818789D0 (en)	1988-09-07	Crystalline(5r 6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penem-carboxylic acid & pharmaceutical formulation
GR3004095T3 (de)	1993-03-31
EP0359062A3 (de)	1991-04-10	Antibiotikum GE 2270
AU2776389A (en)	1989-08-03	Beta-lactam antibiotics, processes for their preparation and their use as and in medicaments
GB9323404D0 (en)	1994-01-05	Pharmaceuticals
ES8402302A1 (es)	1984-02-01	Un procedimiento para la preparacion de derivados de 7-oxo-1-azabiciclo (3,2-0) hepteno.