ATE218861T1 - Vasculäre hypertrophicsuppressor - Google Patents

Vasculäre hypertrophicsuppressor

Info

Publication number: ATE218861T1
Authority: AT; Austria
Prior art keywords: optionally substituted; ring; hetero; residue; suppressor
Prior art date: 1993-02-25

Application number

AT94102790T

Other languages

English (en)

Inventor

Kohei Nishikawa

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-25

Filing date

1994-02-24

Publication date

2002-06-15

1994-02-24 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218861T1 publication Critical patent/ATE218861T1/de

Links

230000002792 vascular Effects 0.000 title abstract 2
230000001969 hypertrophic effect Effects 0.000 title 1
125000005842 heteroatom Chemical group 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
150000001721 carbon Chemical class 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000001450 anions Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
General Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Vascular Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT94102790T 1993-02-25 1994-02-24 Vasculäre hypertrophicsuppressor ATE218861T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP3663093		1993-02-25

Publications (1)

Publication Number	Publication Date
ATE218861T1 true ATE218861T1 (de)	2002-06-15

Family

ID=12475158

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94102790T ATE218861T1 (de)	1993-02-25	1994-02-24	Vasculäre hypertrophicsuppressor

Country Status (6)

Country	Link
US (2)	US5508297A (de)
EP (1)	EP0612523B1 (de)
AT (1)	ATE218861T1 (de)
CA (1)	CA2115985A1 (de)
DE (1)	DE69430766T2 (de)
ES (1)	ES2173895T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19820151A1 (de) *	1998-05-06	1999-11-11	Hexal Ag	Transdermales therapeutisches System zur Anwendung von Candesartan
PL356422A1 (en) *	2000-02-18	2004-06-28	Takeda Chemical Industries, Ltd.	Tnf-alpha inhibitors
CA2420055C (en) *	2000-08-25	2010-06-01	Takeda Chemical Industries, Ltd.	Fibrinogen-lowering agent
US7546089B2 (en) *	2004-12-23	2009-06-09	Triquint Semiconductor, Inc.	Switchable directional coupler for use with RF devices
AR065850A1 (es) *	2007-03-28	2009-07-08	Takeda Pharmaceutical	Composicion farmaceutica solida que comprende un derivado de benzimidazol-7-carboxilato y un agente de control de ph
WO2018002673A1 (en)	2016-07-01	2018-01-04	N4 Pharma Uk Limited	Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0400835A1 (de) *	1989-05-15	1990-12-05	Merck & Co. Inc.	Substituierte Benzimidazole als Angiotensin II-Hemmer
DE69013607T2 (de) *	1989-08-02	1995-03-02	Takeda Chemical Industries Ltd	Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung.
IL95975A (en) *	1989-10-24	1997-06-10	Takeda Chemical Industries Ltd	N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
US5250554A (en) *	1989-10-24	1993-10-05	Takeda Chemical Industries, Ltd.	Benzimidazole derivatives useful as angiotensin II inhibitors
EP0430300A3 (en) *	1989-12-01	1992-03-25	Takeda Chemical Industries, Ltd.	Xanthine derivatives, their production and use
EP0434038A1 (de) *	1989-12-22	1991-06-26	Takeda Chemical Industries, Ltd.	Kondensierte Imidazolderivate, ihre Herstellung und Verwendung
US5162326A (en) *	1990-02-15	1992-11-10	Takeda Chemical Industries, Ltd.	Pyrimidinedione derivatives, their production and use
US5284661A (en) *	1990-02-22	1994-02-08	Takeda Chemical Industries, Ltd.	Fused thiophene derivatives, their production and use
CA2037630C (en) *	1990-03-07	2001-07-03	Akira Morimoto	Nitrogen-containing heterocylic compounds, their production and use
US5196444A (en) *	1990-04-27	1993-03-23	Takeda Chemical Industries, Ltd.	1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5166143A (en) *	1990-05-31	1992-11-24	E. R. Squibb & Sons, Inc.	Method for preventing onset of restenosis after angioplasty employing an ace inhibitor
ES2121773T3 (es) *	1990-06-08	1998-12-16	Hoechst Marion Roussel Inc	Derivados de bencimidazol, su procedimiento de preparacion, productos intermedios, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
AU636066B2 (en) *	1990-10-30	1993-04-08	Takeda Chemical Industries Ltd.	Thienoimidazole derivatives, their production and use
GB9027200D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
DE4225756A1 (de) *	1992-01-22	1994-03-10	Thomae Gmbh Dr K	Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TW274551B (de) *	1991-04-16	1996-04-21	Takeda Pharm Industry Co Ltd
US5210211A (en) *	1991-06-21	1993-05-11	Warner-Lambert Company	4-(1h-pyrrol-1-yl) imidazoles with angiotension ii antagonist activity
IL102183A (en) *	1991-06-27	1999-11-30	Takeda Chemical Industries Ltd	Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
ATE264323T1 (de) *	1992-09-14	2004-04-15	Takeda Chemical Industries Ltd	Heterocyclische verbindungen und ihre verwendung als angiotensin ii antagonisten
EP0603712B1 (de) *	1992-12-22	2001-08-16	Takeda Chemical Industries, Ltd.	Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung

1994
- 1994-02-18 CA CA002115985A patent/CA2115985A1/en not_active Abandoned
- 1994-02-24 DE DE69430766T patent/DE69430766T2/de not_active Expired - Fee Related
- 1994-02-24 US US08/201,122 patent/US5508297A/en not_active Expired - Fee Related
- 1994-02-24 AT AT94102790T patent/ATE218861T1/de not_active IP Right Cessation
- 1994-02-24 EP EP94102790A patent/EP0612523B1/de not_active Expired - Lifetime
- 1994-02-24 ES ES94102790T patent/ES2173895T3/es not_active Expired - Lifetime
1996
- 1996-01-18 US US08/588,240 patent/US5736561A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5508297A (en)	1996-04-16
DE69430766T2 (de)	2003-02-06
DE69430766D1 (de)	2002-07-18
CA2115985A1 (en)	1994-08-26
EP0612523B1 (de)	2002-06-12
ES2173895T3 (es)	2002-11-01
EP0612523A1 (de)	1994-08-31
US5736561A (en)	1998-04-07

Legal Events

Date	Code	Title	Description
2002-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
HUP0002476A2 (hu)	2001-08-28	Aminvegyületek, előállításuk és alkalmazásuk
ATE327230T1 (de)	2006-06-15	Piperidinverbindungen und diese enthaltenden medikamente
PT1063228E (pt)	2005-05-31	Derivados de cicloalcenos processo para a sua preparacao e utilizacao
DE69407409D1 (de)	1998-01-29	Azolylamin-derivat
PT733621E (pt)	2002-09-30	Novos derivados de imidazole e processo para a sua preparacao
FI944417A0 (fi)	1994-09-23	Atsoliyhdisteet, niiden valmistus ja käyttö
NO972887L (no)	1997-08-20	Piperidineddiksyrederivater anvendelige som fibrinogen-antagonistmiddel
EP0293771A3 (de)	1990-10-17	Cephalosporinverbindungen und sie enthaltende pharmazeutische Präparate
DE69430766D1 (de)	2002-07-18	Vasculäre Hypertrophicsuppressor
ATE203020T1 (de)	2001-07-15	Schwefel enthaltende heterocyclische verbindungen
EP0648760A3 (de)	1995-06-28	Triazin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung.
AP2000002008A0 (en)	2000-12-31	Tetrahydroquinoline derivatives as glycine antagonists.
DE69423529D1 (de)	2000-04-27	Arzneizusammensetzungen enthaltend Argatrobananaloge
EP0603712A3 (en)	1994-07-13	Heterocyclic compounds having angiotensin ii antagonistic activity and use thereof.
MY108849A (en)	1996-11-30	Novel compound
DE69416683D1 (de)	1999-04-01	Benzolactam-derivate
TW259785B (en)	1995-10-11	Chemical compounds
ATE168679T1 (de)	1998-08-15	Neue tetracyclische verbindungen
DE69014930D1 (de)	1995-01-26	Aralkylamin-Verbindungen.
DE60116656D1 (de)	2006-04-06	Verfahren zur Herstellung Antibakterieller Verbindungen vom Carbapenem-Typ
DE69016266D1 (de)	1995-03-09	Aminoketonverbindungen.
GB9104833D0 (en)	1991-04-17	Heterocyclic compounds
ES2053792T3 (es)	1994-08-01	Procedimiento de preparacion de un compuesto oximino de tiazol.