ATE219102T1 - Stabilisierte sulfonat- und sulfatderivate von hirudin - Google Patents

Stabilisierte sulfonat- und sulfatderivate von hirudin

Info

Publication number: ATE219102T1
Authority: AT; Austria
Prior art keywords: hirudin; sulfonate; stabilized; sulfate derivatives; derivatives
Prior art date: 1990-02-13

Application number

AT91102011T

Other languages

English (en)

Inventor

John L Krstenansky

Simon J T Mao

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-13

Filing date

1991-02-13

Publication date

2002-06-15

1991-02-13 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE219102T1 publication Critical patent/ATE219102T1/de

Links

102000007625 Hirudins Human genes 0.000 title 1
108010007267 Hirudins Proteins 0.000 title 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 title 1
229940006607 hirudin Drugs 0.000 title 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 title 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229940127090 anticoagulant agent Drugs 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Detergent Compositions (AREA)

AT91102011T 1990-02-13 1991-02-13 Stabilisierte sulfonat- und sulfatderivate von hirudin ATE219102T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US47931790A	1990-02-13	1990-02-13

Publications (1)

Publication Number	Publication Date
ATE219102T1 true ATE219102T1 (de)	2002-06-15

Family

ID=23903519

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91102011T ATE219102T1 (de)	1990-02-13	1991-02-13	Stabilisierte sulfonat- und sulfatderivate von hirudin

Country Status (10)

Country	Link
US (1)	US5541161A (de)
EP (1)	EP0443429B1 (de)
JP (1)	JP2899430B2 (de)
AT (1)	ATE219102T1 (de)
AU (1)	AU641215B2 (de)
CA (1)	CA2035917C (de)
DE (1)	DE69133033T2 (de)
DK (1)	DK0443429T3 (de)
ES (1)	ES2174819T3 (de)
IE (1)	IE910469A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6005071A (en) *	1987-01-23	1999-12-21	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5789540A (en) *	1987-01-23	1998-08-04	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
DE4103649A1 (de) *	1991-02-07	1992-08-13	Basf Ag	Neue antikoagulatorisch wirksame peptide
ATE142642T1 (de) *	1991-03-05	1996-09-15	Japan Energy Corp	Hirudinanalog oder dessen salz, dessen herstellung und das als aktiven bestandteil enthaltende antikoagulanz
EP0998942A4 (de)	1997-01-20	2006-08-16	Japan Energy Corp	Verfahren zur stabilisierung von peptiden und gefriergetrochnete medizinische zusammensetzungen mit diesen
US7550425B2 (en) *	2000-06-16	2009-06-23	Zealand Pharma A/S	Diuretic peptide conjugates
AU2002338896B2 (en)	2001-05-21	2006-04-27	F.Hoffman-La Roche Ag	Quinoline derivatives as ligands for the neuropeptide Y receptor
US20050154011A1 (en) *	2003-02-20	2005-07-14	The Procter & Gamble Company	Tetrahydroisoquinolnyl sulfamic acids
ATE480561T1 (de)	2004-10-19	2010-09-15	Lonza Ag	Verfahren zur festphasen-peptidsynthese
SI3464336T1 (sl)	2016-06-01	2022-06-30	Athira Pharma, Inc.	Spojine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
EP0209061B1 (de) *	1985-07-17	1994-01-12	Hoechst Aktiengesellschaft	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
CA1341032C (en) *	1987-01-23	2000-06-20	John L. Krstenansky	Anticoagulant peptides
CA1328540C (en) *	1987-05-21	1994-04-12	John L. Krstenansky	Cyclic anticoagulant peptides
CA1340646C (en) *	1987-05-21	1999-07-13	John L. Krstenansky	Cyclic anticoagulant peptides
EP0333356A3 (de) *	1988-03-04	1990-12-19	Biogen, Inc.	Hirudin-Peptide
ES2052062T3 (es) *	1988-06-11	1994-07-01	Ciba Geigy Ag	Nuevos polipeptidos con actividad anticoagulante.

1991
- 1991-02-07 AU AU70890/91A patent/AU641215B2/en not_active Ceased
- 1991-02-07 CA CA002035917A patent/CA2035917C/en not_active Expired - Fee Related
- 1991-02-08 JP JP3037725A patent/JP2899430B2/ja not_active Expired - Fee Related
- 1991-02-12 IE IE046991A patent/IE910469A1/en unknown
- 1991-02-13 ES ES91102011T patent/ES2174819T3/es not_active Expired - Lifetime
- 1991-02-13 DE DE69133033T patent/DE69133033T2/de not_active Expired - Fee Related
- 1991-02-13 AT AT91102011T patent/ATE219102T1/de not_active IP Right Cessation
- 1991-02-13 DK DK91102011T patent/DK0443429T3/da active
- 1991-02-13 EP EP91102011A patent/EP0443429B1/de not_active Expired - Lifetime
1993
- 1993-09-17 US US08/123,576 patent/US5541161A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5541161A (en)	1996-07-30
ES2174819T3 (es)	2002-11-16
CA2035917C (en)	2001-10-02
AU641215B2 (en)	1993-09-16
AU7089091A (en)	1991-08-15
EP0443429B1 (de)	2002-06-12
EP0443429A1 (de)	1991-08-28
DK0443429T3 (da)	2002-09-30
CA2035917A1 (en)	1991-08-14
DE69133033D1 (de)	2002-07-18
IE910469A1 (en)	1991-08-14
JP2899430B2 (ja)	1999-06-02
DE69133033T2 (de)	2003-02-06
JPH04211097A (ja)	1992-08-03

Legal Events

Date	Code	Title	Description
2002-12-15	UEP	Publication of translation of european patent specification
2005-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
FI904851A0 (fi)	1990-10-02	Radiomaerkta antikoagulantpeptider.
ATE120206T1 (de)	1995-04-15	Peptide, die die bindung des von-willebrand- faktors inhibieren.
DE69133033D1 (de)	2002-07-18	Stabilisierte Sulfonat- und Sulfatderivate von Hirudin
DE69013750D1 (de)	1994-12-08	Antagonisten von excitatorischen Aminosäuren.
DE3873907D1 (de)	1992-09-24	Substituierte alkylamide von teicoplanin-verbindungen.
FI882359A0 (fi)	1988-05-19	Cykliska antikoagulationspeptider. pi path slues6208 s880524 mlues6205 m881102
DK278488D0 (da)	1988-05-20	Cycliske peptider med antikoagulerende virkning
DK226889D0 (da)	1989-05-09	Alkoholpeptidderivat samt anvendelse deraf til mindskning af blodkoagulation
FI904852A0 (fi)	1990-10-02	Antikoagulantpeptider.
FI895844A0 (fi)	1989-12-07	Koagulation foerhindrande peptider.
DE69120158D1 (de)	1996-07-18	Hirudin-Analoge mit Antiblutplättchen-Aktivität
FI930265A0 (fi)	1993-01-22	Antikoagulantpeptider
DK0606756T3 (da)	1997-12-01	Anvendelse af disulfonylmethaner til bekæmpelse af parasitter
ATE139519T1 (de)	1996-07-15	Stabilisiertes 141b
DE3877015D1 (de)	1993-02-11	Antikoerper enthaltende stabilisierte waesserige zusammensetzung.
JO1654B1 (en)	1991-11-27	The pioneer of the water scale