ATE219354T1 - Verbesserte kristallstrukturen - Google Patents

Verbesserte kristallstrukturen

Info

Publication number: ATE219354T1
Authority: AT; Austria
Prior art keywords: crystals; crystal structures; improved crystal; compositions; lactose
Prior art date: 1998-03-26

Application number

AT99917842T

Other languages

English (en)

Inventor

Christopher Marriott

Gary Peter Martin

Xian Ming Zeng

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-26

Filing date

1999-03-24

Publication date

2002-07-15

1999-03-24 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2002-07-15 Application granted granted Critical

2002-07-15 Publication of ATE219354T1 publication Critical patent/ATE219354T1/de

Links

239000013078 crystal Substances 0.000 title abstract 4
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 abstract 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 abstract 1
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 abstract 1
229960000289 fluticasone propionate Drugs 0.000 abstract 1
WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 abstract 1
229960001361 ipratropium bromide Drugs 0.000 abstract 1
KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 abstract 1
229960001375 lactose Drugs 0.000 abstract 1
239000008101 lactose Substances 0.000 abstract 1
229960001021 lactose monohydrate Drugs 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229960005018 salmeterol xinafoate Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Otolaryngology (AREA)
Medicinal Preparation (AREA)
Glass Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Liquid Crystal Substances (AREA)
Saccharide Compounds (AREA)

AT99917842T 1998-03-26 1999-03-24 Verbesserte kristallstrukturen ATE219354T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9806477.7A GB9806477D0 (en)	1998-03-26	1998-03-26	Improved crystals
PCT/EP1999/001966 WO1999048475A1 (en)	1998-03-26	1999-03-24	Improved crystal structure

Publications (1)

Publication Number	Publication Date
ATE219354T1 true ATE219354T1 (de)	2002-07-15

Family

ID=10829300

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99917842T ATE219354T1 (de)	1998-03-26	1999-03-24	Verbesserte kristallstrukturen

Country Status (11)

Country	Link
US (1)	US6875449B1 (de)
EP (1)	EP1067903B1 (de)
JP (1)	JP4312380B2 (de)
AT (1)	ATE219354T1 (de)
AU (1)	AU3598199A (de)
CA (1)	CA2325551A1 (de)
DE (1)	DE69901895T2 (de)
ES (1)	ES2178422T3 (de)
GB (1)	GB9806477D0 (de)
WO (1)	WO1999048475A1 (de)
ZA (1)	ZA200005032B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0016040D0 (en) *	2000-06-29	2000-08-23	Glaxo Group Ltd	Novel process for preparing crystalline particles
WO2003013633A1 (en) *	2001-08-09	2003-02-20	Glaxo Group Limited	Inhalation device with a pharmaceutical composition
RU2007133547A (ru)	2005-02-10	2009-03-20	Глаксо Груп Лимитед (GB)	Способы получения лактозы с использованием методов предварительной сортировки и приготовляемые из нее фармацевтические композиции
DE102005009194B4 (de) *	2005-03-01	2006-12-14	Hpp-Hommel Pharmaceuticals Production Gmbh	Verfahren zur Herstellung von polymorph stabilem Triamcinolonacetonid
GB0617171D0 (en) *	2006-08-31	2006-10-11	Generics Uk Ltd	Novel compositions and methods
IL186290A0 (en) *	2007-09-25	2008-01-20	Medimop Medical Projects Ltd	Liquid drug delivery devices for use with syringe having widened distal tip
CN101239996B (zh) *	2008-01-04	2010-10-27	华南理工大学	一种高剪切力微晶乳糖制备方法
US8323360B2 (en) *	2008-06-30	2012-12-04	3M Innovative Properties Company	Method of crystallization
US9326538B2 (en)	2010-04-07	2016-05-03	Kraft Foods Group Brands Llc	Intermediate moisture bar using a dairy-based binder
US9232807B2 (en)	2011-09-30	2016-01-12	Kraft Foods Group Brands Llc	Dairy-based foods having high levels of lactose
CN107880091B (zh)	2012-05-08	2020-12-18	尼科斯眼药公司	疏水性治疗剂的制剂、其制备方法及应用
US8765725B2 (en)	2012-05-08	2014-07-01	Aciex Therapeutics, Inc.	Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
US9815865B2 (en)	2013-01-07	2017-11-14	Nicox Ophthalmics, Inc.	Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
GB201711233D0 (en)	2017-07-12	2017-08-23	Aston Particle Tech Ltd	Coating method
CN113476428B (zh) *	2021-01-28	2022-03-29	朗天药业(湖北)有限公司	一种吸入用硫酸沙丁胺醇溶液及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57134498A (en) *	1981-02-12	1982-08-19	Hayashibara Biochem Lab Inc	Anhydrous crystalline maltitol and its preparation and use
GB9001635D0 (en) *	1990-01-24	1990-03-21	Ganderton David	Aerosol carriers
SE9302777D0 (sv)	1993-08-27	1993-08-27	Astra Ab	Process for conditioning substances
CA2146999A1 (en) *	1992-10-16	1994-04-28	Stephen John Douglas	Taste-masking compositions of ranitidine
US5747445A (en) *	1993-06-24	1998-05-05	Astra Aktiebolag	Therapeutic preparation for inhalation
GB9501841D0 (en)	1995-01-31	1995-03-22	Co Ordinated Drug Dev	Improvements in and relating to carrier particles for use in dry powder inhalers
SE9501384D0 (sv) *	1995-04-13	1995-04-13	Astra Ab	Process for the preparation of respirable particles
DK0828495T3 (da)	1995-06-01	2003-02-24	Searle & Co	Misoprostolholdige faste stabiliserede dispersioner
US6129905A (en) *	1997-04-21	2000-10-10	Aeropharm Technology, Inc.	Aerosol formulations containing a sugar as a dispersant
US6309623B1 (en) *	1997-09-29	2001-10-30	Inhale Therapeutic Systems, Inc.	Stabilized preparations for use in metered dose inhalers
CA2346345C (en) *	1998-10-15	2005-04-26	The Procter & Gamble Company	Method for making a nanoporous granular material and a detergent composition

1998
- 1998-03-26 GB GBGB9806477.7A patent/GB9806477D0/en not_active Ceased
1999
- 1999-03-24 AU AU35981/99A patent/AU3598199A/en not_active Abandoned
- 1999-03-24 ES ES99917842T patent/ES2178422T3/es not_active Expired - Lifetime
- 1999-03-24 CA CA002325551A patent/CA2325551A1/en not_active Abandoned
- 1999-03-24 AT AT99917842T patent/ATE219354T1/de not_active IP Right Cessation
- 1999-03-24 JP JP2000537525A patent/JP4312380B2/ja not_active Expired - Lifetime
- 1999-03-24 WO PCT/EP1999/001966 patent/WO1999048475A1/en not_active Ceased
- 1999-03-24 DE DE69901895T patent/DE69901895T2/de not_active Expired - Lifetime
- 1999-03-24 US US09/646,111 patent/US6875449B1/en not_active Expired - Lifetime
- 1999-03-24 EP EP99917842A patent/EP1067903B1/de not_active Expired - Lifetime
2000
- 2000-09-20 ZA ZA200005032A patent/ZA200005032B/en unknown

Also Published As

Publication number	Publication date
DE69901895T2 (de)	2002-12-19
ES2178422T3 (es)	2002-12-16
GB9806477D0 (en)	1998-05-27
ZA200005032B (en)	2001-09-20
WO1999048475A1 (en)	1999-09-30
EP1067903A1 (de)	2001-01-17
AU3598199A (en)	1999-10-18
DE69901895D1 (de)	2002-07-25
JP4312380B2 (ja)	2009-08-12
JP2002507471A (ja)	2002-03-12
CA2325551A1 (en)	1999-09-30
US6875449B1 (en)	2005-04-05
EP1067903B1 (de)	2002-06-19

Legal Events

Date	Code	Title	Description
2002-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69901895D1 (de)	2002-07-25	Verbesserte kristallstrukturen
USD518298S1 (en)	2006-04-04	Paper product
USD490707S1 (en)	2004-06-01	Prescription bottle cap
DZ3478A1 (fr)	2002-04-18	Monohydrate cristallin, procede pour sa fabrication et son utilisation pour la fabrication d'un medicament.
BR0301017A (pt)	2004-08-17	Cristalização graduada de acabamentos de contêineres
IL152470A0 (en)	2003-06-24	Pharmaceutical composition comprising micronised formoterol and micronised glucocorticosteroid
DE60018455D1 (de)	2005-04-07	Doppelfolien vakuuminjektionsverfahren zur herstellung eines verbundwerkstoffes und damit hergestellter verbundwerkstoff
WO2002000209A3 (en)	2003-01-16	Gabapentin analogues for sleep disorders
USD493003S1 (en)	2004-07-13	Glass panel
BR9206100A (pt)	1994-08-02	Processo para o isolamento de tubos
CA2114446A1 (en)	1994-07-30	Draft Tube, Direct Contact Cryogenic Crystallizer
JP2005509503A5 (de)	2006-01-05
EP1544275A4 (de)	2008-12-31	Mechanolumineszenzstoff und dessen herstellung
AU2003280640A1 (en)	2004-05-25	Sodium chondroitin sulfate, chondroitin sulfate-containing material and processes for producing the same
USD502552S1 (en)	2005-03-01	Glass panel
FR2786426B1 (fr)	2002-01-25	Procede de traitement thermique d'un materiau ligno-cellulosique avec elimination de l'oxygene en phase gazeuse
USD415184S (en)	1999-10-12	Apparatus for manufacturing a semiconductor for a liquid crystal display
USD511103S1 (en)	2005-11-01	Bottle
AU2001229441A1 (en)	2001-07-24	Use of antagonists of plasminogen activator inhibitor-1 (pai-1) for the treatment of asthma and chronic obstructive pulmonary disease
USD415776S (en)	1999-10-26	Apparatus for manufacturing a semiconductor for a liquid crystal display
HUT56754A (en)	1991-10-28	Method for forming and applying particularly heat-insulating foam material by the help of mixing head working at low pressure and formed for at least two material components, lubricating head for carrying out the method and insulating material produced by the method
USD354673S (en)	1995-01-24	Rebar spacer
USD489705S1 (en)	2004-05-11	Vacuum tubes of a radio
IL162919A0 (en)	2005-11-20	Process for the production of 6.alpha.,9.alpha-difluoro-17.alpha.-(1-oxo-propoxy)-11.bedroxy-16.alpha.-methyl-3-oxo-androst-1,4-diene-17.b
FR2721037B1 (fr)	1998-04-17	Mélange pour la fabrication de produits profilés en matière plastique à base de polycaprolactone, plaques et attelles orthopédiques réalisées à partir de ces mélanges.