ATE219660T1 - Mittel zum einbringen polyanionischer materialien in zellen - Google Patents

Mittel zum einbringen polyanionischer materialien in zellen

Info

Publication number
ATE219660T1
ATE219660T1 AT95932591T AT95932591T ATE219660T1 AT E219660 T1 ATE219660 T1 AT E219660T1 AT 95932591 T AT95932591 T AT 95932591T AT 95932591 T AT95932591 T AT 95932591T AT E219660 T1 ATE219660 T1 AT E219660T1
Authority
AT
Austria
Prior art keywords
cells
polyanionic materials
polyanionic
introducing
agent
Prior art date
Application number
AT95932591T
Other languages
English (en)
Inventor
Steven Michial Ansell
Barbara Mui
Michael Hope
Original Assignee
Inex Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/442,267 external-priority patent/US5753613A/en
Application filed by Inex Pharmaceuticals Corp filed Critical Inex Pharmaceuticals Corp
Application granted granted Critical
Publication of ATE219660T1 publication Critical patent/ATE219660T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95932591T 1994-09-30 1995-09-29 Mittel zum einbringen polyanionischer materialien in zellen ATE219660T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31639994A 1994-09-30 1994-09-30
US08/442,267 US5753613A (en) 1994-09-30 1995-05-16 Compositions for the introduction of polyanionic materials into cells
PCT/CA1995/000553 WO1996010390A1 (en) 1994-09-30 1995-09-29 Novel compositions for the introduction of polyanionic materials into cells

Publications (1)

Publication Number Publication Date
ATE219660T1 true ATE219660T1 (de) 2002-07-15

Family

ID=26980411

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95932591T ATE219660T1 (de) 1994-09-30 1995-09-29 Mittel zum einbringen polyanionischer materialien in zellen

Country Status (5)

Country Link
US (1) US5785992A (de)
EP (1) EP1179340A3 (de)
AT (1) ATE219660T1 (de)
CA (1) CA2200952C (de)
DE (1) DE69527206T2 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674908A (en) 1993-12-20 1997-10-07 Life Technologies, Inc. Highly packed polycationic ammonium, sulfonium and phosphonium lipids
US6989434B1 (en) 1994-02-11 2006-01-24 Invitrogen Corporation Reagents for intracellular delivery of macromolecules
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7422902B1 (en) * 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US5981501A (en) * 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
EP0855184A1 (de) * 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Pharmazeutisches Präparat das ein Polynukleotid und ein Antigen enthält, insbesondere zur Impfung
US5965542A (en) * 1997-03-18 1999-10-12 Inex Pharmaceuticals Corp. Use of temperature to control the size of cationic liposome/plasmid DNA complexes
WO1998051278A2 (en) 1997-05-14 1998-11-19 Inex Pharmaceuticals Corporation High efficiency encapsulation of charged therapeutic agents in lipid vesicles
US6268534B1 (en) * 1998-02-23 2001-07-31 Ribozyme Pharmaceuticals, Inc. Process for the synthesis of N,N-Dioleyl-N,N-Dimethylammonium Chloride
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
ES2296419T3 (es) 1998-11-12 2008-04-16 Invitrogen Corporation Reactivos de transfeccion.
DE19909115A1 (de) * 1999-03-03 2000-09-07 Florian Lang Verwendung von Ceramiden zur Behandlung cystischer Fibrose
CN1228041C (zh) * 1999-07-15 2005-11-23 英耐克斯药品股份有限公司 脂质包埋的治疗剂的制备方法
US7094423B1 (en) 1999-07-15 2006-08-22 Inex Pharmaceuticals Corp. Methods for preparation of lipid-encapsulated therapeutic agents
US20050249794A1 (en) * 1999-08-27 2005-11-10 Semple Sean C Compositions for stimulating cytokine secretion and inducing an immune response
AU7725500A (en) * 1999-09-30 2001-04-30 National Jewish Medical And Research Center Method for inhibition of pathogenic microorganisms
WO2001095935A1 (en) * 2000-01-20 2001-12-20 Ottawa Health Research Institute Immunostimulatory nucleic acids for inducing a th2 immune response
US20030096414A1 (en) 2001-03-27 2003-05-22 Invitrogen Corporation Culture medium for cell growth and transfection
US20030125292A1 (en) * 2001-11-07 2003-07-03 Sean Semple Mucoscal vaccine and methods for using the same
US7223887B2 (en) * 2001-12-18 2007-05-29 The University Of British Columbia Multivalent cationic lipids and methods of using same in the production of lipid particles
US20050163832A1 (en) * 2002-02-13 2005-07-28 Vladimir Torchilin Intracellular delivery of therapeutic agents
US20040009944A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Methylated immunostimulatory oligonucleotides and methods of using the same
US20040013649A1 (en) * 2002-05-10 2004-01-22 Inex Pharmaceuticals Corporation Cancer vaccines and methods of using the same
WO2004053104A2 (en) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5’ cpg nucleic acids and methods of use
AU2004204456A1 (en) * 2003-01-09 2004-07-29 Invitrogen Corporation Cellular delivery and activation polypeptide-nucleic acid complexes
CN101291653B (zh) 2003-07-16 2012-06-27 普洛体维生物治疗公司 脂质包封的干扰rna
EP1660671A4 (de) * 2003-08-04 2007-09-12 Bayer Pharmaceuticals Corp Verfahren zum screening und zur identifizierung von verbindungen
WO2005034979A2 (en) * 2003-10-11 2005-04-21 Inex Pharmaceuticals Corporation Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
TWI235440B (en) * 2004-03-31 2005-07-01 Advanced Semiconductor Eng Method for making leadless semiconductor package
EP1766035B1 (de) 2004-06-07 2011-12-07 Protiva Biotherapeutics Inc. Lipidverkapselte interferenz-rna
WO2006133022A2 (en) 2005-06-03 2006-12-14 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
CN101346393B (zh) 2005-11-02 2015-07-22 普洛体维生物治疗公司 修饰的siRNA分子及其应用
WO2008074487A2 (en) * 2006-12-19 2008-06-26 Novosom Ag Lipids and lipid assemblies comprising transfection enhancer elements
LT2494993T (lt) 2007-05-04 2018-12-27 Marina Biotech, Inc. Aminorūgščių lipidai ir jų panaudojimas
WO2008141275A1 (en) 2007-05-11 2008-11-20 The Johns Hopkins University Biomarkers for melanoma
EP2238251B1 (de) 2007-12-27 2015-02-11 Protiva Biotherapeutics Inc. Silencing der polo-like-kinase-expression unter verwendung von interferenz-rna
AU2009236219B8 (en) 2008-04-15 2015-06-25 Arbutus Biopharma Corporation Silencing of CSN5 gene expression using interfering RNA
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
WO2009137095A2 (en) 2008-05-08 2009-11-12 The Johns Hopkins University Compositions and methods for modulating an immune response
WO2009155100A1 (en) 2008-05-30 2009-12-23 Yale University Targeted oligonucleotide compositions for modifying gene expression
JP5777519B2 (ja) 2008-10-09 2015-09-09 テクミラ ファーマシューティカルズ コーポレイション 改良されたアミノ脂質および核酸の送達方法
CA2739046A1 (en) 2008-10-16 2010-04-22 Marina Biotech, Inc. Process and compositions for liposomal and effective delivery of nucleic acids
EP2430168B1 (de) 2009-05-16 2016-12-21 Kunyuan Cui Zusammensetzung mit kationischen amphiphilen und colipiden zur abgabe von heilmittelmolekülen
JP5766188B2 (ja) 2009-07-01 2015-08-19 プロチバ バイオセラピューティクス インコーポレイティッド 固形腫瘍に治療剤を送達するための脂質製剤
WO2011011447A1 (en) 2009-07-20 2011-01-27 Protiva Biotherapeutics, Inc. Compositions and methods for silencing ebola virus gene expression
CA2775092A1 (en) 2009-09-23 2011-03-31 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes expressed in cancer
WO2011056682A1 (en) 2009-10-27 2011-05-12 The University Of British Columbia Reverse head group lipids, lipid particle compositions comprising reverse headgroup lipids, and methods for the delivery of nucleic acids
WO2011120023A1 (en) 2010-03-26 2011-09-29 Marina Biotech, Inc. Nucleic acid compounds for inhibiting survivin gene expression uses thereof
WO2011133584A2 (en) 2010-04-19 2011-10-27 Marina Biotech, Inc. Nucleic acid compounds for inhibiting hras gene expression and uses thereof
WO2011139842A2 (en) 2010-04-28 2011-11-10 Marina Biotech, Inc. Nucleic acid compounds for inhibiting fgfr3 gene expression and uses thereof
EP2569276B1 (de) 2010-05-12 2021-02-24 Arbutus Biopharma Corporation Neue kationische lipide und verfahren zu ihrer verwendung
WO2011141704A1 (en) 2010-05-12 2011-11-17 Protiva Biotherapeutics, Inc Novel cyclic cationic lipids and methods of use
JP5913292B2 (ja) 2010-05-14 2016-04-27 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド 代謝を調節する組成物および方法
MX373121B (es) 2010-05-14 2020-04-30 Dana Farber Cancer Inst Inc Composiciones y metodos para el tratamiento de leucemia.
US20130164380A1 (en) 2010-06-17 2013-06-27 Actogenix Nv Compositions and methods for treating inflammatory conditions
NZ611427A (en) 2010-12-06 2015-08-28 Penn State Res Found Compositions and methods relating to proliferative diseases
US10849975B2 (en) 2011-02-03 2020-12-01 Thomas Jefferson University Multivalent vaccines for rabies virus and filoviruses
CA2856117A1 (en) 2011-11-17 2013-05-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Auto-recognizing therapeutic rna/dna chimeric nanoparticles (np)
US20150240238A1 (en) 2011-11-17 2015-08-27 The Regents Of The University Of California Therapeutic rna switches compositions and methods of use
EP2792368A4 (de) * 2011-12-12 2015-09-30 Kyowa Hakko Kirin Co Ltd Lipid-nanopartikel mit kombinationen aus kationischen lipiden
EP2792367A4 (de) * 2011-12-12 2015-09-30 Kyowa Hakko Kirin Co Ltd Lipid-nanopartikel für ein arzneimittelverabreichungssystem mit kationischen lipiden
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
WO2013106358A1 (en) 2012-01-10 2013-07-18 Hussain M Mahmood Method of treating hyperlipidemia and atherosclerosis with mir-30c
NZ700075A (en) 2012-02-24 2016-05-27 Protiva Biotherapeutics Inc Trialkyl cationic lipids and methods of use thereof
EP2856172A4 (de) 2012-05-25 2016-03-02 Univ Vermont Zusammensetzungen und verfahren zum testen der thrombozytenreaktivität und behandlungsauswahl
WO2014142995A1 (en) 2013-03-15 2014-09-18 The Penn State Research Foundation Compositions and methods including leelamine and arachidonyl trifluoromethyl ketone relating to treatment of cancer
EP3003295A1 (de) 2013-03-15 2016-04-13 The Penn State Research Foundation Zusammensetzungen und verfahren mit celecoxib und plumbagin zur behandlung von krebs
TW201534578A (zh) 2013-07-08 2015-09-16 Daiichi Sankyo Co Ltd 新穎脂質
WO2015011633A1 (en) 2013-07-23 2015-01-29 Protiva Biotherapeutics, Inc. Compositions and methods for delivering messenger rna
CN106572974B (zh) 2014-07-15 2021-04-23 生命技术公司 用于将分子有效递送到细胞的具有脂质聚集体的组合物和方法
CR20170174A (es) 2014-10-02 2017-11-07 Protiva Biotherapeutics Inc Composiciones y métodos para el silenciamiento de la expresión cénica del virus de la hepatitis b
US20180245074A1 (en) 2015-06-04 2018-08-30 Protiva Biotherapeutics, Inc. Treating hepatitis b virus infection using crispr
EP3329003A2 (de) 2015-07-29 2018-06-06 Arbutus Biopharma Corporation Zusammensetzungen und verfahren zur ausschaltung einer hepatitis-b-virus-genexpression
EP3340967B1 (de) 2015-08-24 2024-05-22 Halo-Bio Rnai Therapeutics, Inc. Polynukleotid-nanopartikel zur modulation der genexpression und verwendungen davon
EP3373939A4 (de) 2015-11-10 2019-06-26 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University Mittel und verfahren zur verringerung der tumorigenität von krebsstammzellen
US11998540B2 (en) 2015-12-11 2024-06-04 The General Hospital Corporation Compositions and methods for treating drug-tolerant glioblastoma
US11041170B2 (en) 2016-04-04 2021-06-22 Thomas Jefferson University Multivalent vaccines for rabies virus and coronaviruses
AU2017286980B2 (en) 2016-06-30 2023-10-26 Arbutus Biopharma Corporation Compositions and methods for delivering messenger RNA
MA45999A (fr) 2016-08-22 2019-06-26 Arbutus Biopharma Corp Anticorps anti-pd-1, ou leurs fragments, pour le traitement de l'hépatite b
US20210155959A1 (en) 2018-04-06 2021-05-27 Children's Medical Center Corporation Compositions and methods for somatic cell reprogramming and modulating imprinting
JP2021534101A (ja) 2018-08-09 2021-12-09 ヴェルソー セラピューティクス， インコーポレイテッド Ｃｃｒ２及びｃｓｆ１ｒを標的とするためのオリゴヌクレオチド組成物ならびにその使用
EP3958868A4 (de) 2019-04-22 2023-01-18 The Penn State Research Foundation Verfahren und zusammensetzungen zur hemmung von aldehyd-dehydrogenasen für die behandlung von krebs
CN114375334B (zh) 2019-06-07 2026-03-20 斯克里贝治疗公司 工程化CasX系统
WO2021145821A1 (en) * 2020-01-13 2021-07-22 Carmine Therapeutics Pte. Ltd. Nucleic acid loaded red blood cell extracellular vesicles
US20230150926A1 (en) 2020-03-17 2023-05-18 Genevant Sciences Gmbh Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells
EP4161552A1 (de) 2020-06-05 2023-04-12 The Broad Institute, Inc. Zusammensetzungen und verfahren zur behandlung von neoplasien
EP4256054A1 (de) 2020-12-03 2023-10-11 Scribe Therapeutics Inc. Manipulierte crispr-systeme vom typ 2
KR20230122081A (ko) 2020-12-18 2023-08-22 제네반트 사이언시즈 게엠베하 Peg 지질 및 지질 나노입자
CN117940133A (zh) 2021-06-08 2024-04-26 C4医药公司 用于突变braf的降解的治疗剂
US20230042860A1 (en) 2021-07-15 2023-02-09 Turn Biotechnologies, Inc. Polycistronic expression vectors
WO2023288287A2 (en) 2021-07-15 2023-01-19 Turn Biotechnologies, Inc. Synthetic, persistent rna constructs and methods of use for cell rejuvenation and for treatment
WO2023288288A1 (en) 2021-07-15 2023-01-19 Turn Biotechnologies, Inc. Synthetic, persistent rna constructs with on/off mechanism for controlled expression and methods of use
JP2024534523A (ja) 2021-09-21 2024-09-20 スクライブ・セラピューティクス・インコーポレイテッド 操作されたｃａｓｘリプレッサー系
JP2024539512A (ja) 2021-10-22 2024-10-28 セイル バイオメディシンズ インコーポレイテッド Ｍｒｎａワクチン組成物
CN118488834A (zh) 2021-11-23 2024-08-13 赛欧生物医药股份有限公司 细菌源性脂质组合物和其用途
EP4452239A1 (de) 2021-12-20 2024-10-30 Sail Biomedicines, Inc. Zusammensetzungen mit mrna und lipidrekonstruierten pflanzenbotenstoffpackungen
US20250332112A1 (en) 2022-01-31 2025-10-30 Genevant Sciences Gmbh Ionizable cationic lipids for lipid nanoparticles
WO2023220603A1 (en) 2022-05-09 2023-11-16 Regeneron Pharmaceuticals, Inc. Vectors and methods for in vivo antibody production
EP4534108A1 (de) 2022-05-30 2025-04-09 Kyushu University, National University Corporation Zusammensetzung mit anionischem langkettigem lipid zur abschwächung der hautbarrierefunktion und dispersion mit komplex mit kationischem langkettigem lipid
US20230392188A1 (en) 2022-06-02 2023-12-07 Perkinelmer Health Sciences, Inc. Electrophoresis-mediated characterization of dna content of adeno-associated virus capsids
US20250333767A1 (en) 2022-06-02 2025-10-30 Scribe Therapeutics Inc. Engineered class 2 type v crispr systems
EP4314267A1 (de) 2022-06-07 2024-02-07 Scribe Therapeutics Inc. Zusammensetzungen und verfahren zum targeting von pcsk9
EP4536819A1 (de) 2022-06-07 2025-04-16 Scribe Therapeutics Inc. Zusammensetzungen und verfahren zum targeting von pcsk9
AU2023314808A1 (en) 2022-07-29 2025-03-20 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
EP4612184A1 (de) 2022-11-04 2025-09-10 Regeneron Pharmaceuticals, Inc. An die calcium-spannungsabhängige kanalhilfsuntereinheit gamma 1 (cacng1) bindende proteine und cacng1-vermittelte abgabe an skelettmuskeln
WO2024102434A1 (en) 2022-11-10 2024-05-16 Senda Biosciences, Inc. Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
WO2024107765A2 (en) 2022-11-14 2024-05-23 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
WO2024159172A1 (en) 2023-01-27 2024-08-02 Senda Biosciences, Inc. A modified lipid composition and uses thereof
AU2024248139A1 (en) 2023-03-29 2025-09-25 Scribe Therapeutics Inc. Compositions and methods for the targeting of pcsk9
TW202444914A (zh) 2023-03-29 2024-11-16 美商斯奎柏治療公司 抑制子融合蛋白系統
AU2024242151A1 (en) 2023-03-29 2025-09-25 Scribe Therapeutics Inc. Compositions and methods for the targeting of lpa
WO2024220625A1 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids
WO2024220712A2 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Vaccine compositions
WO2024220752A2 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Rna therapeutic compositions
WO2024226499A1 (en) 2023-04-24 2024-10-31 The Broad Institute, Inc. Compositions and methods for modifying fertility
JP7544425B1 (ja) 2023-08-01 2024-09-03 ＮＯＶＩＧＯ Ｐｈａｒｍａ株式会社 固体粒子分散製剤
WO2025052278A1 (en) 2023-09-05 2025-03-13 Genevant Sciences Gmbh Pyrrolidine based cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells
WO2025096975A1 (en) 2023-11-02 2025-05-08 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods of enhancing immune cell therapies by runx2 modulation
WO2025240940A1 (en) 2024-05-17 2025-11-20 Scribe Therapeutics Inc. Compositions and methods for the targeting of apolipoprotein c3
WO2026050217A2 (en) 2024-08-27 2026-03-05 Iovance Biotherapeutics, Inc. Engineered artificial antigen presenting cells and lipid nanoparticles for tumor infiltrating lymphocyte expansion

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394372A (en) * 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
JPS6072831A (ja) * 1983-09-29 1985-04-24 Kao Corp ベシクル用組成物
GB2147243B (en) * 1983-10-01 1986-10-15 Standard Telephones Cables Ltd Applying thermoplastics sleeve to crush resistant tubing
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4946787A (en) * 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5234767A (en) * 1987-03-13 1993-08-10 Micro-Pak, Inc. Hybrid paucilamellar lipid vesicles
FR2645866B1 (fr) * 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
US5286634A (en) * 1989-09-28 1994-02-15 Stadler Joan K Synergistic method for host cell transformation
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5279833A (en) * 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5885613A (en) * 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes

Also Published As

Publication number Publication date
DE69527206D1 (de) 2002-08-01
EP1179340A2 (de) 2002-02-13
US5785992A (en) 1998-07-28
EP1179340A3 (de) 2003-05-07
DE69527206T2 (de) 2003-02-27
CA2200952C (en) 2006-04-11
CA2200952A1 (en) 1996-04-11

Similar Documents

Publication Publication Date Title
ATE219660T1 (de) Mittel zum einbringen polyanionischer materialien in zellen
BR8101853A (pt) Composicao alvejante liquida,processo para a preparacao de uma composicao alvejante liquida e processo para alvejamento
IE801820L (en) Antipode.
DE3164470D1 (en) Anthraquinone dyes, process for their preparation, their use, as well as liquid-crystal material containing anthraquinone dyes
BR9505773A (pt) Compostos diquaternários úteis como ativadores de alvejamento e composiçoes contendo os mesmos
BR9306242A (pt) Processo para preparaçao de composiçoes detergentes líquidas tixotrópicas
BR8605393A (pt) Processo para producao de um po adequado para uso como composicao detergente granular e po
DE68908211D1 (de) Dispersionsmittel fuer zement, verfahren zu ihrer herstellung und verfahren zum verleihen von fluidisierungseigenschaften an diese mittel enthaltende hydraulische zementzusammensetzungen.
BR9002720A (pt) Processo para produzir particulas detergentes altamente attivas,particulas assim obtidas e composicao compreendendo as mesmas
DE69019430D1 (de) 2-Alkyl-4-Methoxy-5-Aminophenol oder deren Salz, oder 2-Alkyl-4-Methoxy-5-substituiertes Aminophenol oder deren Salz und Färbemittel für keratinische Fasern, die diese enthalten.
BR8705812A (pt) Po detergente,processo para a preparacao de um po detergente e composicao detergente granular
BR8003149A (pt) Composicao liquida,aquosa,concentrada,para amaciamento de tecidos e processo para preparacao de uma composicao
FI970099A7 (fi) 3-fenyylipyratsolijohdannaisia sisältävät fungisidiset koostumukset li sääntyvän kasvimateriaalin käsittelemiseksi, uudet 3-fenyylipyratsolij ohdannaiset ja niiden fungisidinen käyttö
IT8048663A0 (it) Composizioni chimiche utili come agenti di collaggio per la carta eprocedimento di produzione
GB2059619B (en) Contrast colourant for photopolymerizable compositions
AU6211580A (en) Sulphur concrete compositions
PT76641B (en) Process for the preparation of sunscreen compositions containing one or more vinylog amides as protection agents
BR9004746A (pt) Composicao;processo para preparacao de borracha;composicao de borracha
BR8404190A (pt) Polimero adequado para uso como mascara de soldagem;composicao liquida;composicao fotopolimerizavel;composicao liquida fotopolimerizavel;processo para preparar polimero:processo para produzir mascara de soldagem no"hot melt"
ATE46518T1 (de) Sialosylcerebroside und verfahren zu ihrer herstellung.
FI911023A7 (fi) Menetelmä alkyylitetrahydroantrahydrokinonien valmistamiseksi ja näitä sisältävät työliuokset antrakinonimenetelmällä suoritettavaa vetyperoksidivalmistusta varten
PT1030648E (pt) Composicao tintorial contendo uma pirazol-¬1,5-a|-pirimidina como base de oxidacao e um acoplador piridinico e processo de tintura
PT77238B (de) Substituierte tert.-butanol-derivate verfahren zu ihrer herstellung und diese enthaltende antimykotische mittel
IT8349304A0 (it) Composti poliazoici, loro preparazione e loro impiego come coloranti
ID27440A (id) Proses untuk menyiapkan penengah-penengah

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties