ATE220332T1 - Behandlung von hepatitis b mit thymosin alpha 1 und lamivudin - Google Patents

Behandlung von hepatitis b mit thymosin alpha 1 und lamivudin

Info

Publication number: ATE220332T1
Authority: AT; Austria
Prior art keywords: lamivudine; hepatitis; treatment; antiviral; effective amount
Prior art date: 1998-09-25

Application number

AT99969679T

Other languages

English (en)

Inventor

Ying-Kit Leung

Original Assignee

Sciclone Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-25

Filing date

1999-09-22

Publication date

2002-07-15

1999-09-22 Application filed by Sciclone Pharmaceuticals Inc filed Critical Sciclone Pharmaceuticals Inc

2002-07-15 Application granted granted Critical

2002-07-15 Publication of ATE220332T1 publication Critical patent/ATE220332T1/de

Links

JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 title abstract 2
229960001627 lamivudine Drugs 0.000 title abstract 2
208000006454 hepatitis Diseases 0.000 title 1
231100000283 hepatitis Toxicity 0.000 title 1
230000000840 anti-viral effect Effects 0.000 abstract 3
241000700721 Hepatitis B virus Species 0.000 abstract 1
108010078233 Thymalfasin Proteins 0.000 abstract 1
102400000800 Thymosin alpha-1 Human genes 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229960004396 famciclovir Drugs 0.000 abstract 1
GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 abstract 1
229960004231 thymalfasin Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2292—Thymosin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT99969679T 1998-09-25 1999-09-22 Behandlung von hepatitis b mit thymosin alpha 1 und lamivudin ATE220332T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US10177198P	1998-09-25	1998-09-25
US09/168,869 US6288033B1 (en)	1998-09-25	1998-10-09	Treatment of hepatitis B infection with thymosin alpha 1 in combination with lamivudine or in combination with lamivudine and famciclovir
PCT/US1999/021954 WO2000018417A2 (en)	1998-09-25	1999-09-22	Treatment of hepatitis b infection with thymosin alpha 1 and lamivudine

Publications (1)

Publication Number	Publication Date
ATE220332T1 true ATE220332T1 (de)	2002-07-15

Family

ID=26798617

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99969679T ATE220332T1 (de)	1998-09-25	1999-09-22	Behandlung von hepatitis b mit thymosin alpha 1 und lamivudin

Country Status (16)

Country	Link
US (1)	US6288033B1 (de)
EP (1)	EP1115420B1 (de)
JP (1)	JP2002525333A (de)
CN (1)	CN1183964C (de)
AT (1)	ATE220332T1 (de)
AU (1)	AU757833B2 (de)
BR (1)	BR9913951A (de)
CA (1)	CA2345462A1 (de)
DE (1)	DE69902103T2 (de)
DK (1)	DK1115420T3 (de)
ES (1)	ES2181502T3 (de)
HK (1)	HK1041215B (de)
MX (1)	MXPA01003105A (de)
PT (1)	PT1115420E (de)
TR (1)	TR200100845T2 (de)
WO (1)	WO2000018417A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003039582A (ja) *	2001-07-19	2003-02-13	Three M Innovative Properties Co	湿潤防滑性シート及び湿潤防滑構造体
US6855346B2 (en) *	2001-10-05	2005-02-15	Tzu-Sheng Wu	Pharmaceutical composition having prophylactic effects on lamivudine-related disease relapse and drug resistance and methods of using the same
DE60224435T2 (de) *	2001-10-26	2009-01-02	Rhode Island Hospital	Thymosin-augmentation bei genetischer immunisierung
US20060259603A1 (en) *	2005-05-16	2006-11-16	Shrader Anthony G	User based - workflow and business process management
WO2007037790A2 (en) *	2005-06-08	2007-04-05	Elan Corporation, Plc	Modified release famciclovir compositions
CN101437535B (zh) *	2006-05-02	2013-01-30	希格马托制药工业公司	胸腺素α1单独地或与PTX3或更昔洛韦联合在治疗巨细胞病毒感染中的用途
ES2288118B1 (es) *	2006-05-10	2008-11-01	Bcn Peptides, S.A.	Procedimiento para sintetizar timosinas.
CN102458470B (zh) *	2009-05-08	2016-01-20	赛生制药有限公司	作为疫苗增强剂的α胸腺素肽
EP2675272A4 (de) *	2011-02-09	2015-03-11	Sciclone Pharmaceuticals Inc	Thymosin-alpha-peptid zur prävention, linderung und behandlung von infektionen
WO2014124092A2 (en) *	2013-02-07	2014-08-14	Tobira Therapeutics, Inc.	Lamivudine salts
US11136378B2 (en) *	2015-11-30	2021-10-05	HBVtech LLC	Methods of curing HBV infection and providing complete protection against HBV infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8904855D0 (en)	1989-03-03	1989-04-12	Beecham Group Plc	Pharmaceutical treatment
US5308833A (en)	1992-02-06	1994-05-03	Sciclone Pharmaceuticals	Method for treating hepatitis B carriers with minimal disease
WO1994001125A1 (en)	1992-07-13	1994-01-20	Sherman Kenneth E	Composition and method of treating hepatitis b
US5939423A (en)	1997-04-16	1999-08-17	Sciclone Pharmaceuticals, Inc.	Treatment of hepatitis B infection with thymosin alpha 1 and famciclovir

1998
- 1998-10-09 US US09/168,869 patent/US6288033B1/en not_active Expired - Fee Related
1999
- 1999-09-22 PT PT99969679T patent/PT1115420E/pt unknown
- 1999-09-22 DK DK99969679T patent/DK1115420T3/da active
- 1999-09-22 WO PCT/US1999/021954 patent/WO2000018417A2/en not_active Ceased
- 1999-09-22 AU AU60570/99A patent/AU757833B2/en not_active Ceased
- 1999-09-22 JP JP2000571935A patent/JP2002525333A/ja not_active Withdrawn
- 1999-09-22 HK HK02102845.1A patent/HK1041215B/zh not_active IP Right Cessation
- 1999-09-22 TR TR2001/00845T patent/TR200100845T2/xx unknown
- 1999-09-22 AT AT99969679T patent/ATE220332T1/de active
- 1999-09-22 MX MXPA01003105A patent/MXPA01003105A/es active IP Right Grant
- 1999-09-22 CA CA002345462A patent/CA2345462A1/en not_active Abandoned
- 1999-09-22 BR BR9913951-0A patent/BR9913951A/pt not_active Application Discontinuation
- 1999-09-22 CN CNB998113824A patent/CN1183964C/zh not_active Expired - Lifetime
- 1999-09-22 EP EP99969679A patent/EP1115420B1/de not_active Expired - Lifetime
- 1999-09-22 DE DE69902103T patent/DE69902103T2/de not_active Expired - Lifetime
- 1999-09-22 ES ES99969679T patent/ES2181502T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK1115420T3 (da)	2002-11-04
AU6057099A (en)	2000-04-17
EP1115420A2 (de)	2001-07-18
ES2181502T3 (es)	2003-02-16
TR200100845T2 (tr)	2001-10-22
DE69902103D1 (de)	2002-08-14
CA2345462A1 (en)	2000-04-06
HK1041215B (zh)	2005-08-26
EP1115420B1 (de)	2002-07-10
CN1183964C (zh)	2005-01-12
US6288033B1 (en)	2001-09-11
JP2002525333A (ja)	2002-08-13
HK1041215A1 (en)	2002-07-05
WO2000018417A2 (en)	2000-04-06
CN1320041A (zh)	2001-10-31
AU757833B2 (en)	2003-03-06
WO2000018417A3 (en)	2000-07-06
BR9913951A (pt)	2001-06-12
MXPA01003105A (es)	2003-05-15
PT1115420E (pt)	2002-11-29
DE69902103T2 (de)	2003-02-27

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Legal Events

Date	Code	Title	Description
2003-01-15	UEP	Publication of translation of european patent specification