ATE220407T1 - Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheiten - Google Patents
Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheitenInfo
- Publication number
- ATE220407T1 ATE220407T1 AT99109726T AT99109726T ATE220407T1 AT E220407 T1 ATE220407 T1 AT E220407T1 AT 99109726 T AT99109726 T AT 99109726T AT 99109726 T AT99109726 T AT 99109726T AT E220407 T1 ATE220407 T1 AT E220407T1
- Authority
- AT
- Austria
- Prior art keywords
- uncharged
- subunit
- subunits
- based polymers
- phosphorus containing
- Prior art date
Links
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 title abstract 2
- 239000011574 phosphorus Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 title 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- MHCMWGPPLOSCJY-UHFFFAOYSA-N 4-$l^{1}-azanylmorpholine Chemical compound [N]N1CCOCC1 MHCMWGPPLOSCJY-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
- C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Peptides Or Proteins (AREA)
- Polyamides (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45405789A | 1989-12-20 | 1989-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE220407T1 true ATE220407T1 (de) | 2002-07-15 |
Family
ID=23803120
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91902085T ATE312834T1 (de) | 1989-12-20 | 1990-12-20 | Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheiten |
| AT99109726T ATE220407T1 (de) | 1989-12-20 | 1990-12-20 | Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheiten |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91902085T ATE312834T1 (de) | 1989-12-20 | 1990-12-20 | Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheiten |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP0506830B1 (de) |
| JP (2) | JP3398378B2 (de) |
| KR (1) | KR0167574B1 (de) |
| AT (2) | ATE312834T1 (de) |
| AU (1) | AU655164B2 (de) |
| CA (1) | CA2069869C (de) |
| DE (2) | DE69033986T2 (de) |
| WO (1) | WO1991009033A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166315A (en) * | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5405938A (en) * | 1989-12-20 | 1995-04-11 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| AU7135498A (en) * | 1997-04-17 | 1998-11-11 | Antivirals Inc. | Method of treating restenosis by antisense targeting of cmv |
| US20010024783A1 (en) * | 1999-01-29 | 2001-09-27 | Avi Biopharma, Inc. | Non-invasive method for detecting target RNA |
| KR20010102992A (ko) * | 1999-01-29 | 2001-11-17 | 추후보정 | 표적 ｒｎａ를 검출하는 비-침입적 방법 |
| US6875747B1 (en) | 1999-05-24 | 2005-04-05 | Avi Bio Pharma, Inc. | Antisense to c-myc for treatment of polycystic kidney disease |
| EP1185637B1 (de) * | 1999-05-24 | 2008-07-23 | Avi Biopharma, Inc. | Antisense gegen c-myc zur behandlung von polyzystischer nierenkrankheit |
| US6677153B2 (en) * | 1999-11-29 | 2004-01-13 | Avi Biopharma, Inc. | Antisense antibacterial method and composition |
| KR20020079768A (ko) * | 2000-01-04 | 2002-10-19 | 에이브이아이 바이오파마 인코포레이티드 | 안티센스 항박테리아 세포분열 조성물 및 방법 |
| WO2006085973A2 (en) | 2004-07-02 | 2006-08-17 | Avi Biopharma, Inc. | Antisense antibacterial method and compound |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| ES2657400T3 (es) * | 2006-05-10 | 2018-03-05 | Sarepta Therapeutics, Inc. | Análogos de oligonucleótidos que tienen enlaces intersubunitarios catiónicos |
| CA2884340C (en) * | 2007-11-15 | 2017-07-25 | Sarepta Therapeutics, Inc. | Method of synthesis of morpholino oligomers |
| AU2013202731B2 (en) * | 2010-05-28 | 2016-04-21 | Sarepta Therapeutics, Inc. | Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups |
| JP2013530154A (ja) * | 2010-05-28 | 2013-07-25 | サレプタ セラピューティクス， インコーポレイテッド | 修飾されたサブユニット間結合および／または末端基を有するオリゴヌクレオチドアナログ |
| TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
| PL2623507T3 (pl) | 2010-09-30 | 2017-03-31 | Nippon Shinyaku Co., Ltd. | Pochodna kwasu morfolinonukleinowego |
| BR112014011875B1 (pt) * | 2011-11-18 | 2022-01-04 | Sarepta Therapeutics, Inc | Oligonucleotídeos funcionalmente modificados e subunidades dos mesmos |
| CN108611349A (zh) | 2011-12-28 | 2018-10-02 | 日本新药株式会社 | 反义核酸 |
| CA2868174A1 (en) | 2012-03-20 | 2013-09-26 | Sarepta Therapeutics, Inc. | Boronic acid conjugates of oligonucleotide analogues |
| CN105228999B (zh) | 2013-05-24 | 2021-03-02 | 味之素株式会社 | 吗啉代寡核苷酸的制备方法 |
| RU2702424C2 (ru) | 2014-03-12 | 2019-10-08 | Ниппон Синяку Ко., Лтд. | Антисмысловые нуклеиновые кислоты |
| WO2015194520A1 (ja) | 2014-06-17 | 2015-12-23 | 日本新薬株式会社 | アンチセンス核酸 |
| EP3208277A4 (de) * | 2014-10-14 | 2018-06-13 | Ajinomoto Co., Inc. | Morpholin-oligonukleotid-herstellungsverfahren |
| CN113717239B (zh) | 2015-01-21 | 2024-12-24 | 味之素株式会社 | 沉淀促进剂以及使用其的沉淀方法 |
| WO2016196897A1 (en) | 2015-06-04 | 2016-12-08 | Sarepta Therapeutics, Inc. | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
| CN113913426B (zh) | 2015-09-15 | 2024-08-02 | 日本新药株式会社 | 反义核酸 |
| JP6875684B2 (ja) | 2015-09-16 | 2021-05-26 | 日本新薬株式会社 | 筋萎縮症治療用アンチセンス核酸 |
| CN109937042B (zh) * | 2016-09-20 | 2023-06-27 | 科罗拉多州立大学董事会法人团体 | 使用亚磷酰胺化学法合成主链修饰的吗啉代寡核苷酸和嵌合体 |
| EP3792269A4 (de) | 2018-05-10 | 2022-06-22 | Nippon Shinyaku Co., Ltd. | Verfahren zur herstellung einer oligonukleidsäureverbindung |
| CN112399849A (zh) | 2018-06-26 | 2021-02-23 | 日本新药株式会社 | 含有反义寡核苷酸的组合物及其在迪谢内肌营养不良症的治疗中的用途 |
| GB201821269D0 (en) | 2018-12-28 | 2019-02-13 | Nippon Shinyaku Co Ltd | Myostatin signal inhibitor |
| WO2021095875A1 (ja) | 2019-11-13 | 2021-05-20 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| JP7689078B2 (ja) | 2019-11-13 | 2025-06-05 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| MX2022007491A (es) | 2019-12-19 | 2022-08-15 | Nippon Shinyaku Co Ltd | Acido nucleico antisentido que permite la omision de exones. |
| AU2020411964A1 (en) | 2019-12-26 | 2022-06-16 | National Center Of Neurology And Psychiatry | Antisense nucleic acid that induces skipping of exon 50 |
| PE20230237A1 (es) | 2020-02-28 | 2023-02-07 | Nippon Shinyaku Co Ltd | Acidos nucleicos antisentido que inducen la omision del exon 51 |
| WO2022214692A1 (en) | 2021-04-09 | 2022-10-13 | Bachem Holding Ag | Pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates |
| AU2022266379A1 (en) | 2021-04-28 | 2023-11-09 | Nippon Shinyaku Co., Ltd. | Method for producing oligonucleic acid compound |
| EP4342498A4 (de) | 2021-05-13 | 2025-01-08 | National University Corporation Chiba University | Antisense-oligomer |
| EP4349987A1 (de) | 2021-05-28 | 2024-04-10 | Sumitomo Pharma Co., Ltd. | Antisense nukleinsäure |
| AU2022298028A1 (en) | 2021-06-23 | 2023-12-21 | National Center Of Neurology And Psychiatry | Combination of antisense oligomers |
| WO2023282346A1 (ja) | 2021-07-08 | 2023-01-12 | 日本新薬株式会社 | 析出抑制剤 |
| IL310003A (en) | 2021-07-08 | 2024-03-01 | Nippon Shinyaku Co Ltd | Nephrotoxicity reducing agent |
| JPWO2023282344A1 (de) | 2021-07-08 | 2023-01-12 | ||
| US20240390508A1 (en) | 2021-08-21 | 2024-11-28 | Takeda Pharmaceutical Company Limited | Human transferrin receptor binding peptide-drug conjugate |
| AU2022424485A1 (en) | 2021-12-27 | 2024-07-11 | Nippon Shinyaku Co., Ltd. | Method for producing oligonucleic acid compound |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5661386A (en) * | 1985-03-15 | 1986-10-13 | Stirchak, E. | Stereoregular polynucleotide-binding polymers |
-
1990
- 1990-12-20 DE DE69033986T patent/DE69033986T2/de not_active Expired - Lifetime
- 1990-12-20 DE DE69034213T patent/DE69034213T2/de not_active Expired - Lifetime
- 1990-12-20 EP EP91902085A patent/EP0506830B1/de not_active Expired - Lifetime
- 1990-12-20 AT AT91902085T patent/ATE312834T1/de not_active IP Right Cessation
- 1990-12-20 WO PCT/US1990/007563 patent/WO1991009033A1/en not_active Ceased
- 1990-12-20 AT AT99109726T patent/ATE220407T1/de not_active IP Right Cessation
- 1990-12-20 AU AU71642/91A patent/AU655164B2/en not_active Expired
- 1990-12-20 JP JP50289191A patent/JP3398378B2/ja not_active Expired - Lifetime
- 1990-12-20 KR KR1019920701479A patent/KR0167574B1/ko not_active Expired - Lifetime
- 1990-12-20 CA CA002069869A patent/CA2069869C/en not_active Expired - Lifetime
- 1990-12-20 EP EP99109726A patent/EP0962463B1/de not_active Expired - Lifetime
-
2001
- 2001-06-13 JP JP2001179272A patent/JP2002167441A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69033986D1 (de) | 2002-08-14 |
| JPH05504563A (ja) | 1993-07-15 |
| JP3398378B2 (ja) | 2003-04-21 |
| JP2002167441A (ja) | 2002-06-11 |
| KR920703584A (ko) | 1992-12-18 |
| WO1991009033A1 (en) | 1991-06-27 |
| AU655164B2 (en) | 1994-12-08 |
| ATE312834T1 (de) | 2005-12-15 |
| KR0167574B1 (ko) | 1999-01-15 |
| DE69034213D1 (de) | 2006-01-19 |
| EP0506830A1 (de) | 1992-10-07 |
| CA2069869A1 (en) | 1991-06-21 |
| AU7164291A (en) | 1991-07-18 |
| DE69033986T2 (de) | 2003-03-13 |
| EP0962463A1 (de) | 1999-12-08 |
| EP0962463B1 (de) | 2002-07-10 |
| DE69034213T2 (de) | 2006-08-24 |
| EP0506830B1 (de) | 2005-12-14 |
| EP0506830A4 (en) | 1993-01-07 |
| CA2069869C (en) | 1995-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |