ATE220410T1 - Glykosaminoglykane mit hoher antithrombotischer wirkung - Google Patents

Glykosaminoglykane mit hoher antithrombotischer wirkung

Info

Publication number
ATE220410T1
ATE220410T1 AT98917065T AT98917065T ATE220410T1 AT E220410 T1 ATE220410 T1 AT E220410T1 AT 98917065 T AT98917065 T AT 98917065T AT 98917065 T AT98917065 T AT 98917065T AT E220410 T1 ATE220410 T1 AT E220410T1
Authority
AT
Austria
Prior art keywords
glycosaminoglycans
high antithrombotic
antithrombotic effect
salt
resulfation
Prior art date
Application number
AT98917065T
Other languages
English (en)
Inventor
Benito Casu
Annamaria Naggi
Giangiacomo Torri
Original Assignee
Inalco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inalco Spa filed Critical Inalco Spa
Application granted granted Critical
Publication of ATE220410T1 publication Critical patent/ATE220410T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT98917065T 1997-03-24 1998-03-24 Glykosaminoglykane mit hoher antithrombotischer wirkung ATE220410T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000678A IT1290814B1 (it) 1997-03-24 1997-03-24 Glicosaminoglicani aventi elevata attivita' antitrombotica
PCT/EP1998/001714 WO1998042754A2 (en) 1997-03-24 1998-03-24 Glycosaminoglycans having high antithrombotic activity

Publications (1)

Publication Number Publication Date
ATE220410T1 true ATE220410T1 (de) 2002-07-15

Family

ID=11376585

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98917065T ATE220410T1 (de) 1997-03-24 1998-03-24 Glykosaminoglykane mit hoher antithrombotischer wirkung

Country Status (12)

Country Link
US (1) US6197943B1 (de)
EP (1) EP0970130B1 (de)
JP (1) JP2001518133A (de)
KR (1) KR20000075663A (de)
AT (1) ATE220410T1 (de)
AU (1) AU7040598A (de)
CA (1) CA2285383C (de)
DE (1) DE69806468T2 (de)
DK (1) DK0970130T3 (de)
ES (1) ES2180161T3 (de)
IT (1) IT1290814B1 (de)
WO (1) WO1998042754A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2161615B1 (es) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
US6977248B1 (en) * 1999-08-25 2005-12-20 Massachusetts Institute Of Technology Pharmaceutical preparations for the inhibition of herpes simplex virus 1 entry
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US8227449B2 (en) * 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
JP2002080371A (ja) * 2000-06-23 2002-03-19 Seikagaku Kogyo Co Ltd プラスミノーゲンアクチベーター活性促進剤
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
ITMI20011633A1 (it) * 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
JP4828795B2 (ja) 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
BR0312179A (pt) * 2002-06-18 2005-04-05 Glycores 2000 Srl Processo para preparação de derivado de epik5-n-o-supersulfato, composição farmacêutica e composição cosmética contendo o mesmo e seu uso
US20040171819A1 (en) * 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
ITMI20031618A1 (it) 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
AU2008100725B4 (en) * 2008-07-04 2008-10-02 Parnell Technologies Pty Ltd A sulfated polysaccharide compound for clinical use
ES2817779T3 (es) * 2010-01-19 2021-04-08 Momenta Pharmaceuticals Inc Evaluación de preparaciones de heparina
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CA3217273A1 (en) 2021-05-12 2022-11-17 Li Fu Methods of manufacturing a high molecular weight heparin compound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained
FR2538404B1 (de) * 1982-12-28 1985-08-23 Anic Spa
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
GB8519416D0 (en) * 1985-08-01 1985-09-04 Unilever Plc Oligosaccharides
EP0333243A3 (de) * 1988-03-10 1989-09-27 Akzo N.V. Sulphatiertes K5-Antigen und seine Fragmente
IT1217458B (it) * 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
IT1237518B (it) * 1989-11-24 1993-06-08 Renato Conti Eparine supersolfatate
JPH04202401A (ja) * 1990-11-30 1992-07-23 Terumo Corp ヘパリン誘導体の製造法
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
FR2704861B1 (fr) * 1993-05-07 1995-07-28 Sanofi Elf Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
CA2285383C (en) 2006-09-26
DE69806468T2 (de) 2003-02-27
DE69806468D1 (de) 2002-08-14
ITMI970678A1 (it) 1998-09-24
KR20000075663A (ko) 2000-12-26
CA2285383A1 (en) 1998-10-01
WO1998042754A3 (en) 1998-12-23
ES2180161T3 (es) 2003-02-01
DK0970130T3 (da) 2002-11-04
US6197943B1 (en) 2001-03-06
EP0970130A2 (de) 2000-01-12
EP0970130B1 (de) 2002-07-10
WO1998042754A2 (en) 1998-10-01
AU7040598A (en) 1998-10-20
IT1290814B1 (it) 1998-12-11
JP2001518133A (ja) 2001-10-09

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee